著者

Chen-Long Wu Shih-Bin Su Jin-Luh Chen Hung-Jung Lin How-Ran Guo

出版者

(公社)日本産業衛生学会

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.50, no.2, pp.99-102, 2008 (Released:2008-04-10)

参考文献数

14

被引用文献数

16 35

著者

Izumi Yasuhiko Matsumura Atsuko Wakita Seiko Akagi Ken-Ichi Fukuda Hiroyuki Kume Toshiaki Irie Kazuhiro Takada-Takatori Yuki Sugimoto Hachiro Hashimoto Tadashi Akaike Akinori

出版者

Elsevier Inc.

雑誌

Free radical biology & medicine (ISSN:08915849)

巻号頁・発行日

vol.53, no.4, pp.669-679, 2012-06-27

被引用文献数

43

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青ジソから老化やメタボリックシンドローム予防に有望な生体内抗酸化力を高める成分を発見. 京都大学プレスリリース. 2012-08-06.

著者

Byung-Jae KANG Hak-Hyun RYU Sung-Su PARK Yongsun KIM Heung-Myong WOO Wan Hee KIM Oh-Kyeong KWEON

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.7, pp.827-836, 2012 (Released:2012-08-04)

参考文献数

35

被引用文献数

8 24

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Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) are a promising source of cells for bone tissue engineering. Matrigel is a basement membrane extract containing multiple extracellular components. This mixture may promote the osteogenic differentiation of MSCs and provide a more appropriate microenvironment for transplanted cells. Here, we investigated the effect of Matrigel on the osteogenic potential of Ad-MSCs. Canine Ad-MSCs were cultured in 2D and 3D matrices and implanted into subcutaneous pouches of dogs either with or without Matrigel. Culture mineralization, cell adhesion efficiency, cell proliferation, osteoid matrix production and alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase activities were quantified and compared. Ad-MSCs grown in 2D cultures with Matrigel showed higher levels of calcium deposition and ALP activity than those grown in the absence of Matrigel under osteogenic conditions. In 3D cultures, the cells cultivated with Matrigel showed greater attachment, proliferation and osteogenic differentiation than those grown without Matrigel. In vivo, Ad-MSCs implanted with Matrigel showed higher osteogenic potential than those without Matrigel. In conclusion, these data suggest that the use of Matrigel can increase the osteogenic potential of canine Ad-MSCs.

著者

Ai WATABE Kiwamu HANAZONO Takahiro KOMATSU Dah-Renn FU Yoshifumi ENDO Tsuyoshi KADOSAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.7, pp.937-943, 2012 (Released:2012-08-04)

参考文献数

22

被引用文献数

2 4

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To evaluate the relationship among immune status and increased morbidity and mortality, peripheral blood lymphocytes (CD3+, CD4+, CD8+ and CD21+ cells) from 32 healthy dogs over 8 years of age were analyzed. Twenty-five of the 32 dogs were followed-up for 3 years after the analysis; and 14 dogs were found to be diseased, and nine dogs died. There was no notable difference between the ages of the dogs that died compared with the ones that survived. The relative percentage of CD4+ and the CD4+:CD8+ ratio decreased notably in dogs falling ill compared with healthy dogs. The relative percentage of CD3+ lymphocytes showed a notable decrease in dogs that died within 3 years in comparison with dogs that survived. In a discriminant analysis of morbidity and mortality, most patients were correctly classified as diseased or not and surviving or dead, respectively. These results indicate that the immunophenotypes of peripheral blood lymphocytes in older dogs offer promise as parameters for evaluating mortality and morbidity.

著者

Ryota NOMURA Mitsuyuki SHIRAI Yukio KATO Masaru MURAKAMI Kazuhiko NAKANO Norihiko HIRAI Tetsuya MIZUSAWA Shuhei NAKA Yoshie YAMASAKI Michiyo MATSUMOTO-NAKANO Takashi OOSHIMA Fumitoshi ASAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.7, pp.885-891, 2012 (Released:2012-08-04)

参考文献数

18

被引用文献数

8 16

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Porphyromonas gulae, a gram-negative black-pigmented anaerobe, is a pathogen for periodontitis in dogs. An approximately 41-kDa fimbrial subunit protein (FimA) encoded by fimA is regarded as associated with periodontitis. In the present study, the fimA genes of 17 P. gulae strains were sequenced, and classified into two major types. The generation of phylogenetic trees based on the deduced amino acid sequence of FimA of P. gulae strains along with sequences from several strains of Porphyromonas gingivalis, a major cause of human periodontitis, revealed that the two types of FimA (types A and B) of P. gulae were similar to type I FimA and types II and III FimA of P. gingivalis, respectively. A PCR system for classification was established based on differences in the nucleotide sequences of the fimA genes. Analysis of 115 P. gulae-positive oral swab specimens from dogs revealed that 42.6%, 22.6%, and 26.1% of them contained type A, type B, and both type A and B fimA genes, respectively. Experiments with a mouse abscess model demonstrated that the strains with type B fimA caused significantly greater systemic inflammation than those with type A. These results suggest that the FimA proteins of P. gulae are diverse with two major types and that strains with type B fimA could be more virulent.

著者

Masayuki Hayakawa Hideki Yamamura Youji Nakagawa Yoshika Kawa Yukikazu Hayashi Taku Misonou Hidehiro Kaneko Noriko Kikushima Terumi Takahashi Shuhei Yamasaki Yoshinobu Uegaki Akihiro Terasawa Kiyotoshi Takao Tomokazu Mori Ken-ichi Ago Nanako Saito Tatsuya Hasegawa

出版者

日本放線菌学会

雑誌

日本放線菌学会誌 (ISSN:09145818)

巻号頁・発行日

vol.24, no.2, pp.58-62, 2010-12-25 (Released:2010-12-15)

参考文献数

28

被引用文献数

4 8 5

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In this study, we investigated the taxonomic diversity of actinomycetes isolated from swine manure compost that had undergone self-heating. Pretreatment with sodium dodecyl sulfate and subsequent cultivation of the compost sample on humic acid-vitamin agar at 30 and 50°C resulted in the selective isolation of 125 actinomycete strains. These isolates were classified using a combination of morphological characterization and 16S rDNA sequence analysis, with sequence similarities of ≥97% and ≥99% used to identify isolates at genus and species level, respectively. The isolated actinomycete assemblage consisted of a diverse array of species, with the 125 isolates falling into 10 families, 15 genera, and 22 species. The most dominant thermophilic actinomycetes were Saccharomonospora (Sam.) viridis and Thermobifida fusca, followed by Actinomadura spp. Other species that were frequently isolated at 30°C included Glycomyces spp., Nocardiopsis (Nop.) alba, Nop. composta, Rhodococcus rhodochrous, and Sam. azurea.

著者

全 在紋 Jae-moon Chun 桃山学院大学経営学部

出版者

桃山学院大学総合研究所

雑誌

桃山学院大学経済経営論集 = ST. ANDREW'S UNIVERSITY ECONOMIC AND BUSINESS REVIEW (ISSN:02869721)

巻号頁・発行日

vol.44, no.3, pp.77-125, 2002-12-20

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The conclusions reached in this paper can be summarized as follows : (1) We should distinguish meta-language from object language. Our thoughts become confused and lost in a maze when the ranks of the language are confused, which is the problem that often arises when addressing linguistic significance in international accounting. In order to think clearly, the distinction between the meta-language for control (accounting standards) and that for description (language for standards and language for disclosure) must be made clear. All three meta-languages mentioned above can be designed as uniform language or as auxiliary language. (2) There is very little chance that each of the above three meta-languages will ever be transformed into a world-wide uniform language in accounting, as suggested by the failure of linguistic imperialism and the delay in the popularization of Esperanto. The meta-languages may become the international auxiliary language, at most, because language is not only a means of communication but is also at one with the culture (values) to which the language speakers belong. (3) Professor Ijiri points out that the effort to establish a world-wide uniform language should be much easier in accounting than in Esperanto because of the fundamental commonality of accounting as a language. According to him, this is because there is no difference in the fundamental structure of the recording in double-entry bookkeeping that has been adopted by most nations. However, an analysis of Ijiri's international accounting theory using Saussure's linguistics reveals that while his theory addresses the syntagmatic relation (double-entry bookkeeping) in accounting language, it does not give any consideration to the paradigmatic relation. (4) The significance of double-entry bookkeeping is overestimated not only by professor Ijiri but also by accountants in general. It is especially overestimated by many accounting researchers, both inside and outside Japan. Double-entry bookkeeping, without a doubt, is often considered one of the accounting postulates (the premises of accounting). Meanwhile, the significance of other accounting systems, such as single-entry bookkeeping, is seldom given any consideration. Both the double-entry and single-entry bookkeeping systems have merits and demerits. Nevertheless, a deep-rooted tendency to blindly advocate double-entry bookkeeping is prevalent among accountants. (5) Language is not merely a means of communication. More importantly, it determines human perception, thought, and behavior. According to Saussure's linguistics, accounting as the language of business holds not only a decisionmaking function but also an accountability function that strictly controls the perception, thought, and behavior of businessmen. However, the executive officers of the International Accounting Standards Board do not fully acknowledge this issue. (6) In recent years, accounting fraud has been severely punished in many developed countries. This fact can unmistakably be attributed to intercultural conflicts, or conflicts between the values of everyday language (benefit of the general public) and the values of accounting language (performance of the corporation). Such conflicts arise because the perception, thought, and behavior of the businessmen are strongly bound by the accounting language. In other words, corporate scandals will arise as long as there is an accounting system in the company, just as traffic accidents will occur as long as there are vehicles on the road. (7) Linguistic imperialism in International Accounting Standards (IAS) arises when companies try to seek comparability and at the same time reduce cost. We must resist such imperialism. We cannot expect IAS to be accepted as the only accounting system in all countries (IAS Only). Instead, IAS should be adopted as an additional accounting system (IAS Plus). In short, listed companies should make two kinds of financial statements, i.e., one for domestic and the other for international stakeholders, because additional costs are inevitable when companies compete in a borderless capital market. (8) Each country has its own accounting standards. The international consensus is that there needs to be common accounting standards that can be applied to companies worldwide. However, no company should be forced to adopt such common standards exclusively. After all, the effort to promote the harmonisation and convergence of various accounting standards could only benefit a selected few borderless companies. Furthermore, it is likely that such an effort would result in the diversification of accounting standards. In other words, the development of common standards may be equivalent to the creation of another new language (another new culture).

著者

倉本 真一 平 朝彦 Bangs Nathan L. SHIPLEY Thomas H. MOORE Gregory F. EW99-07 08 航海乗船研究者

出版者

Tokyo Geographical Society

雑誌

地學雜誌 (ISSN:0022135X)

巻号頁・発行日

vol.109, no.4, pp.531-539, 2000-08-25

被引用文献数

10 19

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A three-dimensional seismic survey was carried out at the western Nankai Trough accretionary wedge from June 18 to August 18, 1999. This experiment was Japan-U.S. collaborative investigation on seismogenic zones. The cruise imaged an 8 X 80 km area with 81, 80km-long, high quality, seismic reflection lines, all of which have nearly continuous coverage.<BR>The main objective of our experiment was to image the plate boundary fault at which major earthquakes and tsunamis are generated. Our primary goal is to image the thrust and identify the boundary between aseismic and seismic zones for a large inter-plate earthquake.<BR>On-board two-dimensional data processing has been carried out. This gives us a significantly clear image of the inner structure of the accretionary wedge at our survey area. One impressive image of the profile shows the large thrust slice zone that is classified by our interpretation. A number of out-of-sequence thrusts have developed and are concentrated in the area where the water depth is approximately 4, 000 to 3, 000m. A decollement plane touches the oceanic plate (layer II) down at there in first. We identified that the boundary between the stable sliding zone (ocean-ward) and the unstable stick slip zone (landward) is located there. We propose that the boundary is the up-dip limit of the seismogenic zone. Further data processing is ongoing. A true three-dimensional structure will reveal much more details and a clear image of seismogenic zone at the Nankai subduction margin.

著者

collected by Milman Parry edited and translated by Albert Bates Lord = Srpsko-hrvatske junačke pjesme / sakupio Milman Parry uredio i preveo na engleski Albert Bates Lord

出版者

Serbian Academy of Sciences

巻号頁・発行日

1954

著者

Mari VAINIONPÄÄ Marja RAEKALLIO Elina TUHKALAINEN Hannele HÄNNINEN Noora ALHOPURO Maija SAVOLAINEN Jouni JUNNILA Anna HIELM-BJÖRKMAN Marjatta SNELLMAN Outi VAINIO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0180, (Released:2012-07-09)

被引用文献数

1 15

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The objective of this study was to compare the method of thermography by using three different resolution thermal cameras and basic software for thermographic images, separating the two persons taking the thermographic images (thermographers) from the three persons interpreting the thermographic images (interpreters). This was accomplished by studying the repeatability between thermographers and interpreters. Forty-nine client-owned dogs of 26 breeds were enrolled in the study. The thermal cameras used were of different resolutions—80 × 80, 180 × 180 and 320 × 240 pixels. Two trained thermographers took thermographic images of the hip area in all dogs using all three cameras. A total of six thermographic images per dog were taken. The thermographic images were analysed using appropriate computer software, the FLIR QuickReport 2.1. Three trained interpreters independently evaluated the mean temperatures of hip joint areas of the six thermographic images of each dog. The repeatability between thermographers was >0.975 with the two higher-resolution cameras and 0.927 with the lowest resolution camera. The repeatability between interpreters was >0.97 with each camera. Thus the between-interpreter variation was small. The repeatability between thermographers and interpreters was considered high enough to encourage further studies with thermographic imaging in dogs.

著者

Haengbok CHEON Wooshin CHOI Youngjae LEE Donghoon LEE Juhyung KIM Ji-Houn KANG Kijeong NA Jinhwa CHANG Dongwoo CHANG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.11-0579, (Released:2012-07-06)

被引用文献数

5 19

---

The aim of this study was to assess age-related changes and anatomic variation in trabecular bone mineral density (tBMD) using quantitative computed tomography (QCT) in normal cats. Seventeen normal cats were included in this study and divided into the following 3 age groups: <6 months (n=4); 2–5 years (n=10); and >6 years (n=3). A computed tomographic scan of each vertebra from the 12th thoracic to the 7th lumbar spine, and the pelvis was performed with a bone-density phantom (50, 100, and 150 mg/cm3, calcium hydroxyapatite, CIRS phantom®). On the central transverse section, the elliptical region of interest (ROI) was drawn to measure the mean Hounsfield unit (HU) value. Those values were converted to equivalent tBMD (mg/cm3) by use of the bone-density phantom and linear regression analysis (r2>0.95). The mean tBMD value of the thoracic vertebrae (369.4 ± 31.8 mg/cm3) was significantly higher than that of the lumbar vertebrae (285 ± 58.1 mg/cm3). The maximum tBMD occurred at the T12, T13, and L1 levels in all age groups. There was a statistically significant difference in the mean tBMD value among the 3 age groups at the T12 (P<0.001), T13 (P<0.001), and L4 levels (P=0.013), respectively. The present study suggests that age-related changes and anatomic variation in tBMD values should be considered when assessing tBMD using QCT in cats with bone disorders.

著者

Chun-Ho PARK Daisuke KOJIMA Hitoshi HATAI Satoshi INOUE Toshifumi OYAMADA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.787-790, 2012 (Released:2012-07-04)

参考文献数

15

被引用文献数

3 5

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Traumatic neuroma of the cervical spinal cord was diagnosed in a 14-year-old male mixed-breed dog. A gross view showed two intradural extramedullary masses, measuring 1 and 0.6 cm in length and 0.7 and 0.4 cm in diameter, attached to the left side of the spinal cord at the level of the sixth and seventh cervical vertebrae. Microscopically, the cervical spinal masses comprised interlacing fascicles of axons and Schwann cells surrounded by collagenous stroma. Immunohistochemically, the fascicles were stained positively for neurofilament and S-100 proteins. Ultrastructurally, variably sized myelinated fibers and onion bulb-like structures were observed. To our knowledge, this is the first report of a traumatic neuroma in the cervical spinal cord of a dog.

著者

Dong-In JUNG Ju-Won KIM Hee-Myung PARK

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.765-769, 2012 (Released:2012-07-04)

参考文献数

16

被引用文献数

2 6

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A 4-year-old intact female Pekingese dog was presented with ataxia and seizure episodes. Based on magnetic resonance imaging and cerebrospinal fluid analysis results, meningoencephalitis of unknown etiology was suspected. The present case survived for 1,096 days under cyclosporine plus prednisolone therapy and was definitively diagnosed with necrotizing meningoencephalitis. This report describes the clinical findings, serial magnetic resonance imaging characteristics and pathologic features of a necrotizing meningoencephalitis and long-term survival after cyclosporine with prednisolone therapy.

著者

Markus MELLOH Achim ELFERING Cornelia ROLLI SALATHÉ Anja KÄSER Thomas BARZ Christoph RÖDER Jean-Claude THEIS

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.MS1335, (Released:2012-05-30)

被引用文献数

9 19

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This study examines predictors of sickness absence in patients presenting to a health practitioner with acute/subacute low back pain (LBP). Aims of this study were to identify baseline-variables that detect patients with a new LBP episode at risk of sickness absence and to identify prognostic models for sickness absence at different time points after initial presentation. Prospective cohort study investigating 310 patients presenting to a health practitioner with a new episode of LBP at baseline, three-, six-, twelve-week and six-month follow-up, addressing work-related, psychological and biomedical factors. Multivariate logistic regression analysis was performed to identify baseline-predictors of sickness absence at different time points. Prognostic models comprised ‘job control’, ‘depression’ and ‘functional limitation’ as predictive baseline-factors of sickness absence at three and six-week follow-up with ‘job control’ being the best single predictor (OR 0.47; 95%CI 0.26–0.87). The six-week model explained 47% of variance of sickness absence at six-week follow-up (p<0.001). The prediction of sickness absence beyond six-weeks is limited, and health practitioners should re-assess patients at six weeks, especially if they have previously been identified as at risk of sickness absence. This would allow timely intervention with measures designed to reduce the likelihood of prolonged sickness absence.

著者

edited by Jeffrey F. Hamburger and Anne-Marie Bouché

出版者

Department of Art and Archaeology, Princeton University in association with Princeton University Press

巻号頁・発行日

2006

著者

Miyuki Owada Y-h.Taguchi

雑誌

研究報告バイオ情報学(BIO)

巻号頁・発行日

vol.2012, no.17, pp.1-2, 2012-06-21

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Promoter methylation is an important factor for gene expression regulation. Especially, it can control target gene regulation semipermanently. Thus, for example, it is used for tissue specific gene expression regulation. Recently, brain tissue promoter methylation patterns turn out to be more personalized than those in other tissues. In this paper, we try finding which genes are specifically methylated among individuals.Promoter methylation is an important factor for gene expression regulation. Especially, it can control target gene regulation semipermanently. Thus, for example, it is used for tissue specific gene expression regulation. Recently, brain tissue promoter methylation patterns turn out to be more personalized than those in other tissues. In this paper, we try finding which genes are specifically methylated among individuals.

著者

Kohei Iijima Y-h.Taguchi

雑誌

研究報告バイオ情報学(BIO)

巻号頁・発行日

vol.2012, no.18, pp.1-2, 2012-06-21

---

Gene expression development during cell differentiation is a key factor to understand the mechanism of development. However, conventional gene expression analysis cannot distinguish among individual cell expression. In this paper, we re-analyze single cell gene expression measurements obtained by next gene sequencing technology during differentiation from mouse ES cell to MEF.Gene expression development during cell differentiation is a key factor to understand the mechanism of development. However, conventional gene expression analysis cannot distinguish among individual cell expression. In this paper, we re-analyze single cell gene expression measurements obtained by next gene sequencing technology during differentiation from mouse ES cell to MEF.

著者

Shigeharu Ishida Hideaki Umeyama Mitsuo Iwadate Y-h.Taguchi

雑誌

研究報告バイオ情報学(BIO)

巻号頁・発行日

vol.2012, no.12, pp.1-6, 2012-06-21

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Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested.Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested.

著者

Averroes (Ibn Rushd) of Cordoba translated and with introduction and notes by Richard C. Taylor with Thérèse-Anne Druart subeditor

出版者

Yale University Press

巻号頁・発行日

2009

著者

KAWAKAMI Kiyobumi TAKAI-KAWAKAMI Kiyoko MASUDA Naoe SUZUKI Makoto SHIMIZU Yukiko YANAIHARA Takumi

出版者

北海道大学教育学部附属乳幼児発達臨床センター=FACULTY OF EDUCATION, HOKKAIDO UNIVERSITY

雑誌

乳幼児発達臨床センター年報=RESEARCH AND CLINICAL CENTER FOR CHILD DEVELOPMENT Annual Report (ISSN:03868435)

巻号頁・発行日

vol.24, pp.25-33, 2002-03