著者

森川 茂廣 来見 良誠 仲 成幸 塩見 尚礼 村山 浩之 村上 耕一郎 Hasnine A. Haque 犬伏 俊郎 谷 徹

出版者

特定非営利活動法人 Microwave Surgery研究会

雑誌

Journal of Microwave Surgery (ISSN:09177728)

巻号頁・発行日

no.29, pp.33-38, 2011

---

We started microwave ablation therapy of liver tumors under MR image guidance with an open configuration MR scanner. The combination of these two was quite feasible. At the beginning, preparations of MR compatible electrodes and a noise-eliminating filter were required. After the measurements against the noise, microwave irradiation did not disturb MR images and temperature changes could be monitored using MR temperature maps, which were useful for the real-time evaluation of therapeutic effects. In addition, MR temperature maps could be used to investigate the condition of microwave ablation with newly developed instruments and applications. The encounter of microwave ablation with MR imaging made a breakthrough in the image-guided minimally invasive therapy. Further developments of new technologies for therapeutic procedures are expected from this combination.

著者

Masanori A. Murayama Nagisa Arimitsu Jun Shimizu Naruyoshi Fujiwara Kenji Takai Yoko Okada Chieko Hirotsu Erika Takada Tomoko Suzuki Noboru Suzuki

出版者

Japanese Association for Laboratory Animal Science

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

vol.70, no.3, pp.387-397, 2021 (Released:2021-08-06)

参考文献数

71

被引用文献数

1 6

---

Elderly patients with dementia suffer from cognitive dysfunctions and neuropsychiatric symptoms (NPS) such as anxiety and depression. Alzheimer’s disease (AD) is a form of age-related dementia, and loss of cholinergic neurons is intimately associated with development of AD symptoms. We and others have reported that neural cell transplantation ameliorated cognitive dysfunction in AD model mice. It remains largely unclear whether neural cell transplantation ameliorates the NPS of AD. It would be interesting to determine whether NPS correlates with cognitive dysfunctions before and after neural cell transplantation in AD model mice. Based on the revalidation of our previous data from a Morris water maze test, we found that neural cell transplantation improved anxiety and depression significantly and marginally affected locomotion activity in AD mice. A correlation analysis revealed that the spatial learning function of AD mice was correlated with their NPS scores both before and after cell transplantation in a similar manner. In contrast, in the mice subjected to cell transplantation, spatial reference memory function was not correlated with NPS scores. These results suggested the neural cell transplantation in the AD model mice significantly improved NPS to the same degree as cognitive dysfunctions, possibly via distinct mechanisms, such as the cholinergic and GABAergic systems.

著者

Masanori A. Murayama Nagisa Arimitsu Jun Shimizu Naruyoshi Fujiwara Kenji Takai Yoshiki Ikeda Yoko Okada Chieko Hirotsu Erika Takada Tomoko Suzuki Noboru Suzuki

出版者

Japanese Association for Laboratory Animal Science

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

vol.70, no.3, pp.398-405, 2021 (Released:2021-08-06)

参考文献数

61

被引用文献数

1 4

---

Alzheimer’s disease (AD) is a prevalent neurological disorder affecting memory function in elderly persons. Indeed, AD exhibits abnormality in cognitive behaviors and higher susceptibility to neuropsychiatric symptoms (NPS). Various factors including aging, sex difference and NPS severity, are implicated during in development of AD. In this study, we evaluated behavioral abnormalities of AD model, PDAPP transgenic mice at young age using the Morris Water Maze test, which was established to assess hippocampal-dependent learning and memory. We found that female AD model mice exhibited spatial learning dysfunction and highly susceptible to NPS such as anxiety and depression, whereas spatial reference memory function was comparable in female PDAPP Tg mice to female wild type (WT) mice. Spatial learning function was comparable in male AD model mice to male WT mice. Multiple regression analysis showed that spatial learning dysfunction was associated with NPS severity such as anxiety and depression. Furthermore, the analysis showed that spatial reference memory function was associated with status of depression, but not anxiety. Thus, these results suggest female dominance of spatial learning dysfunction in the AD model mice accompanying increased NPS severity. The understandings of AD model may be useful for the development of therapeutic agents and methods in human AD.

著者

WAI Engene K. FINKELSTEIN Joel A. TANGENTE Ronald P. HOLDEN Lori CHOW Edward FORD Michael YEE Albert

雑誌

Spine (ISSN:03622436)

巻号頁・発行日

vol.28, no.5, pp.508-512, 2003-03-01

参考文献数

23

被引用文献数

8 5

著者

CHARPENTIER A.

雑誌

Archive de Physiologie normale et pathologiques

巻号頁・発行日

vol.3, pp.122-135, 1891

被引用文献数

1

著者

DONDA A.

雑誌

Mol. Cell. Endocrinol.

巻号頁・発行日

vol.90, 1993

被引用文献数

1 18

著者

DONDA A.

雑誌

Neuroendocrinology

巻号頁・発行日

vol.49, pp.389-394, 1989

被引用文献数

2 15

著者

DONDA A.

雑誌

Eur. J. Immunol.

巻号頁・発行日

vol.26, 1996

被引用文献数

3 57

著者

Fahad Y. Al-Juhaimi Kashif Ghafoor Mehmet Musa Özcan Nurhan Uslu Elfadıl E Babiker Isam A. Mohamed Ahmed Omer N. Alsawmahi

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.70, no.5, pp.607-613, 2021 (Released:2021-05-01)

参考文献数

36

被引用文献数

5

---

The oil recovery from Alyanak apricot kernel was 36.65% in control (unroasted) and increased to 43.77% in microwave-roasted kernels. The total phenolic contents in extracts from apricot kernel were between 0.06 (oven-roasted) and 0.20 mg GAE/100 g (microwave-roasted) while the antioxidant activity varied between 2.55 (oven-roasted) and 19.34% (microwave-roasted). Gallic acid, 3,4-dihydroxybenzoic acid, (+)-catechin and 1,2-dihydroxybenzene were detected as the key phenolic constituents in apricot kernels. Gallic acid contents varied between 0.53 (control) and 1.10 mg/100 g (microwave-roasted) and 3,4-dihydroxybenzoic acid contents were between 0.10 (control) and 0.35 mg/100 g (microwave-roasted). Among apricot oil fatty acids, palmitic acid contents ranged from 4.38 (oven-roasted) to 4.76% (microwave-roasted); oleic acid contents were between 65.73% (oven-roasted) and 66.15% (control) and linoleic acid contents varied between 26.55 (control) and 27.12% (oven-roasted).

著者

島田 義則 内田 成明 山中 千代衛 河崎 善一郎 山中 龍彦 藤原 閲夫 石窪 雄二 川端 欣哉 長坂 幸二 滝沢 靖史 林 昶煥 井澤 靖和 丸山 和伸 野黒 隆 藤井 淳 仁木 秀明 北嶋 巌 大知 渉之 山口 直洋 藤川 知栄美 原 民夫 鈴木 将之 山神 晋 酒屋 典之 大道 博行 H. Fiedorowicz A. Bartnikc 中山 斌義 八木 隆志 広瀬 秀男 草間 秀晃 大前 吾一 林 茂樹 本田 一匡 小島 勇夫 村井 健介 遠山 祐典 加藤 義章 S. Sebban A. Klisnik P. Zeitaun H. Tang Y. Gu G. Huang S. Wang Huajing TANG Takahisa JITSUNO 真家 大樹 永田 豊 小原 實 緑川 克美 岡坂 和遵 尾方 明日香 河内 哲哉 安藤 剛三 島村 暁 中本 智士 吉田 弘樹 阪上 幸男 廣瀬 厚三 山下 泰弘 福田 剛士 下田 大介 小松 義治 中野 人志 服部 哲治 小鹿 沙織 桑原 研爾 高橋 栄一 松本 裕治 加藤 進 大和田野 芳郎 奥田 功 津田 紀生 山田 諄 武田 和也 河島 信樹 橋本 和久 杉本 隆爾 山田 純子 早坂 高雅 中野 葉子

出版者

The Laser Society of Japan

雑誌

レーザー研究 (ISSN:03870200)

巻号頁・発行日

vol.27, no.Supplement, pp.55-56,59, 1999 (Released:2010-08-25)

著者

早川 達 A B

出版者

日経BP社

雑誌

日経ドラッグインフォメーションpremium

巻号頁・発行日

no.181, pp.PE17-24, 2012-11

---

北海道薬科大学薬物治療学分野教授。POS(Problem Oriented System)に基づく薬歴管理の第一人者。著書に『POS薬歴がすぐ書ける「薬歴スキルアップ」虎の巻』基本疾患篇、慢性疾患篇、専門疾患篇など。 今回は、友愛薬局勝田台店に来局した74歳男性、花岡二郎さん(仮名)の薬歴をオーディットしました。

著者

SONNINEN A.

雑誌

Scand J Log Phon

巻号頁・発行日

vol.17, pp.95-106, 1992

被引用文献数

1 7

著者

Christodoulidis Emilios A. 宇佐美 誠

出版者

南山大学社会倫理研究所

雑誌

社会と倫理 (ISSN:13440616)

巻号頁・発行日

no.15, pp.44-50, 2003

著者

Christodoulidis Emilios A. 宇佐美 誠

出版者

南山大学社会倫理研究所

雑誌

社会と倫理 (ISSN:13440616)

巻号頁・発行日

no.15, pp.4-19, 2003

著者

Maeda Shiro Tsukada Shuichi Kanazawa Akio SEKINE Akihiro TSUNODA Tatsuhiko KOYA Daisuke MAEGAWA Hiroshi KASHIWAGI Atsunori BABAZONO Tetsuya MATSUDA Masafumi TANAKA Yasushi FUJIOKA Tomoaki HIROSE Hiroshi EGUCHI Takashi OHNO Yoichi GROVES Christopher J. HATTERSLEY Andrew T. HITMAN Graham A. WALKER Mark KAKU Kohei IWAMOTO Yasuhiko KAWAMORI Ryuzo KIKKAWA Ryuichi KAMATANI Naoyuki MCCARTHY Mark I. NAKAMURA Yusuke

出版者

Springer-Verlag Tokyo

雑誌

Journal of human genetics (ISSN:14345161)

巻号頁・発行日

vol.50, no.6, pp.283-292, 2005-06-01

参考文献数

32

被引用文献数

5

著者

STERN M. HALTER J. BUSER A. ROVO A. DIRNHOFER S. HAUSERMANN P.

雑誌

International journal of hematology (ISSN:09255710)

巻号頁・発行日

vol.87, no.2, pp.108-109, 2008-03-15

著者

Luis A. González-Ortega Andrés A. Acosta-Osorio Peter Grube-Pagola Carolina Palmeros-Exsome Cynthia Cano-Sarmiento Rebeca García-Varela Hugo S. García

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.69, no.2, pp.123-131, 2020 (Released:2020-02-05)

参考文献数

43

被引用文献数

1 12

---

Curcumin is a bioactive compound with proven antioxidant and anti-inflammatory activities, but has low water solubility and dermal absorption. The inflammatory process is considered as the biological response to damage induced by various stimuli. If this process fails to self-regulate, it becomes a potential risk of cancer. The objective of this work was to evaluate the anti-inflammatory activity of curcumin administered to mice with induced atrial edema using two topical vehicles: organogels and O/W-type nanogels at pH 7, Organogels and O/W-type nanogels at pH 7 were prepared, characterized and the anti-inflammatory activity was assessed. A histopathological analysis of mouse ears was performed and two gel formulations were selected. Thermograms of organogels indicated that increasing the gelling agent improved the stability of the system. Deformation sweeps confirmed a viscoelastic behavior characteristic of gels in both systems. During the anti-inflammatory activity evaluations, the nanogels demonstrated greater activity (61.8 %) than organogels; Diclofenac® (2-(2,6-dichloranilino) phenylacetic acid), used as a control medication achieved the highest inhibition (85.4%); however, the drug produced the death of 2 (40%) of the study subjects caused by secondary adverse events. Histopathological analysis confirmed the data.

著者

Naotsugu Iwakami Toshiyuki Nagai Toshiaki A. Furukawa Kunihiro Nishimura Toshihisa Anzai

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.1, pp.10-16, 2020-01-10 (Released:2020-01-10)

参考文献数

34

被引用文献数

2 1

---

Prediction models are combinations of predictors to assess the risks of specific endpoints such as the presence or prognosis of a disease. Many novel predictors have been developed, modelling techniques have been evolving, and prediction models are currently abundant in the medical literature, especially in cardiovascular medicine, but evidence is still lacking regarding how to use them. Recent methodological advances in systematic reviews and meta-analysis have enabled systematic evaluation of prediction model studies and quantitative analysis to identify determinants of model performance. Knowing what is critical to model performance, under what circumstances model performance remains adequate, and when a model might require further adjustment and improvement will facilitate effective utilization of prediction models and will enhance diagnostic and prognostic accuracy in clinical practice. In this review article, we provide a current methodological overview of the attempts to implement evidence-based utilization of prognostic prediction models for all potential model users, including patients and their families, health-care providers, administrators, researchers, guideline developers and policy makers.

著者

Paula Goes Caio S. Dutra Mário R. P. Lisboa Delane V. Gondim Renata Leitão Gerly A. C. Brito Rodrigo O. Rego

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.4, pp.569-574, 2016 (Released:2016-12-23)

参考文献数

29

被引用文献数

15 46

---

This pilot study evaluated the clinical efficacy of a mouthwash containing 1% Matricaria chamomilla L. (MTC) extract in reducing gingival inflammation and plaque formation in patients undergoing orthodontic treatment with fixed appliances. This randomized, double-blind, placebo-controlled study enrolled a total of 30 males and females (age, 10-40 years) with fixed orthodontic appliances and a minimum of 20 natural teeth. The participants were allocated to three groups (n = 10 each) and asked to rinse with 15 mL of a placebo, 0.12% chlorhexidine (CHX), or 1% MTC mouthwash, immediately after brushing for 1 min, in the morning and evening, for 15 days. Data (mean ± SD) on visible plaque index (VPI) and gingival bleeding index (GBI) were recorded on days 1 and 15. The placebo group exhibited increases in VPI and GBI (10.2% and 23.1%, respectively) from day 1 to day 15. As compared with placebo, VPI and GBI significantly decreased in the MTC group (−25.6% and −29.9%, respectively) and the CHX group (−39.9% and −32.0%, respectively). In summary, MTC reduced biofilm accumulation and gingival bleeding in patients with gingivitis, probably because of its antimicrobial and anti-inflammatory activities.(J Oral Sci 58, 569-574, 2016)

著者

D・A・V・ハルナック著 山田保雄訳

出版者

久島千枝

巻号頁・発行日

1997