著者
Sho Takeda Taisuke Togawa Kei-ichiro Mishiba Katsuyuki T. Yamato Yuji Iwata Nozomu Koizumi
出版者
Japanese Society for Plant Biotechnology
雑誌
Plant Biotechnology (ISSN:13424580)
巻号頁・発行日
vol.39, no.3, pp.303-310, 2022-09-25 (Released:2022-09-25)
参考文献数
37
被引用文献数
2

The unfolded protein response (UPR) or the endoplasmic reticulum (ER) stress response is a homeostatic cellular response conserved in eukaryotes to alleviate the accumulation of unfolded proteins in the ER. In the present study, we characterized the UPR in the liverwort Marchantia polymorpha to obtain insights into the conservation and divergence of the UPR in the land plants. We demonstrate that the most conserved UPR transducer in eukaryotes, IRE1, is conserved in M. polymorpha, which harbors a single gene encoding IRE1. We showed that MpIRE1 mediates cytoplasmic splicing of mRNA encoding MpbZIP7, a M. polymorpha homolog of bZIP60 in flowering plants, and upregulation of ER chaperone genes in response to the ER stress inducer tunicamycin. We further showed that MpIRE1 also mediates downregulation of genes encoding secretory and membrane proteins in response to ER stress, indicating the conservation of regulated IRE1-dependent decay of mRNA. Consistent with their roles in the UPR, Mpire1ge and Mpbzip7ge mutants exhibited higher sensitivity to ER stress. Furthermore, an Mpire1ge mutant also exhibited retarded growth even without ER stress inducers, indicating the importance of MpIRE1 for vegetative growth in addition to alleviation of ER stress. The present study provides insights into the evolution of the UPR in land plants.
著者
Masatsune Takeda Shane T. Ahyong Naoya Ohtsuchi Hironori Komatsu
出版者
National Museum of Nature and Sciece
雑誌
国立科学博物館研究報告A類(動物学) (ISSN:18819052)
巻号頁・発行日
vol.48, no.4, pp.147-191, 2022-11-22 (Released:2022-11-22)
参考文献数
165

The crabs collected by the RV Hakuhō Maru (KH-72-1 cruise) in the South China Sea are recorded as the fourth part following the previous three parts of the series (Sulu Sea and Sibutu Passage, Timor Sea, and Sahul Shelf). They are mostly shallow water inhabitants, representing 35 species of 31 genera in 13 families, with two new species of the family Epialtidae, Naxioides elongatus sp. nov. and Samadinia hakuhoae sp. nov. Taxonomic comments are given for each species. In this fourth and final part, biogeographic notes on all the species collected by RV Hakuhō Maru (KH-72-1 cruise) are briefly summarized, together with a list of the crabs collected by the RV Hakuhō Maru (KH-73-2 cruise) in the South China Sea.
著者
中田 力 西澤 正豊 藤井 幸彦 鈴木 清隆 KWEE Ingrid L. KNIGHT Robert T.
出版者
新潟大学
雑誌
基盤研究(S)
巻号頁・発行日
2004

本研究は、本邦唯一のヒト用超高磁場(7.0T)装置を用いた高分解能画像を開発し、特定疾患における組織特性を反映するコントラスト画像法を導入することにより、組織標本に匹敵する臨床生体顕微鏡を開発することを目的とした。様々な技術開発を行い、SusceptibilityWeighted Imaging(SWI)を導入した生体顕微鏡法では、世界に先駆けて、最終園標とされたAlzheimer病の老人斑の画像化にも成功した。
著者
Faniel S. Matsuura T. Mineshige S. Sekine Y. Koga T.
出版者
American Physical Society
雑誌
Physical Review B (ISSN:10980121)
巻号頁・発行日
vol.83, no.11, pp.115309, 2011-03-15
被引用文献数
48

We report the determination of the intrinsic spin-orbit interaction (SOI) parameters for In0.53Ga0.47As/In0.52Al0.48As quantum wells (QWs) from the analysis of the weak antilocalization effect. We show that the Dresselhaus SOI is mostly negligible in this system and that the intrinsic parameter for the Rashba effect, a_[SO] ≣ 1 α/< Ez >, is given to be a_[SO]m*/m_[e] = (1.46-1.51 x 10^[-17] N_[S] [m^[-2]]) e Å^[2], where α is the Rashba SOI coefficient, < Ez > is the expected electric field within the QW, m*/m_[e] is the electron effective mass ratio, and N_[S] is the sheet carrier density. These values for a_[SO]m* were also confirmed by the observation of beatings in the Shubnikov-de Haas oscillations in our most asymmetric QW sample.
著者
Masamichi KUWAJIMA Hiroaki FUJIHARA Hiroyoshi SEI Asako UMEHARA Masako SEI Tomi T. TSUDA Akiko SUKENO Tatsuya OKAMOTO Akiko INUBUSHI Yoichi UETA Toshio DOI Hiroshi KIDO
出版者
The Japan Endocrine Society
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
vol.54, no.6, pp.911-925, 2007 (Released:2008-02-20)
参考文献数
46
被引用文献数
13 14

The mechanism of onset of hypoglycemia in patients with carnitine deficiency has yet to be determined. Using mice with systemic carnitine deficiency (JVS mice), we examined this mechanism, focusing on the weaning period (days 14-28 postpartum). For normal mice, the survival rate was 100%, and no hypoglycemia was observed at all. Gastric lactose began to decrease on day 17, and cellulose increased sharply in amount thereafter. For JVS mice, the survival rate was 77% on day 14 and 28% on day 28. From day 21 on, hypoglycemia was noted. Gastric lactose had disappeared almost completely by day 17, and cellulose was almost undetectable from days 14 to 28. Expression of orexin mRNA in the hypothalamus did not differ between JVS and normal mice on day 14, but was suppressed in JVS mice on days 21 and 28. When JVS mice were fed a carnitine-rich diet, suppression of expression of orexin mRNA in hypothalamus was eliminated, and on day 28 lactose and cellulose were detected in the stomach without hypoglycemia. In conclusion, the suppression of the expression of orexin in the hypothalamus during the weaning period may be involved in the marked anorexia in JVS mice, which eventually leads to death from hypoglycemia.
著者
R. G. Baker T. A. Palumbo 山本 壮兵衛
出版者
一般社団法人 表面技術協会
雑誌
金属表面技術 (ISSN:00260614)
巻号頁・発行日
vol.34, no.6, pp.249-253, 1983-06-01 (Released:2009-10-30)
参考文献数
40
被引用文献数
1 1