著者

Junichiro Irie Emi Inagaki Masataka Fujita Hideaki Nakaya Masanori Mitsuishi Shintaro Yamaguchi Kazuya Yamashita Shuhei Shigaki Takashi Ono Hideo Yukioka Hideyuki Okano Yo-ichi Nabeshima Shin-ichiro Imai Masato Yasui Kazuo Tsubota Hiroshi Itoh

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ19-0313, (Released:2019-11-02)

被引用文献数

8 115

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Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear. We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men. A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN. Clinical findings and parameters, and the pharmacokinetics of NMN metabolites were investigated for 5 h after each intervention. Ophthalmic examination and sleep quality assessment were also conducted before and after the intervention. The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature. Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN. Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention. Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration. The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.

著者

Ryo Misawa Yuma Takanashi Yo Su Chih-Wei Chang Yoshiaki Kai

出版者

The Japanese Society of Systematic Zoology

雑誌

Species Diversity (ISSN:13421670)

巻号頁・発行日

vol.28, no.2, pp.245-253, 2023-11-09 (Released:2023-11-09)

参考文献数

20

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Two large specimens [310–476 mm standard length (SL)] of the genus Hoplostethus Cuvier in Cuvier and Valenciennes, 1829, collected from Iwate and Okinawa prefectures, Japan, were recently discovered and identified as Hoplostethus grandperrini Roberts and Gomon, 2012 on the basis of the following characteristics: large body size, exceeding 300 mm SL; abdominal scutes strong; pectoral fins light red; caudal-fin tip without black pigmentation; upper margin of eye almost horizontally level with lateral-line origin; predorsal scales not enlarged; fin spines moderately thickened; pectoral-fin tip not reaching anal-fin origin; anterior part of oral cavity, including underside of tongue, without black pigmentation; 15–17 pectoral-fin rays; 21 predorsal scales; and 13 or 14 abdominal scutes. Furthermore, a molecular phylogenetic analysis of a partial sequence of the mtDNA COI gene from one of the specimens placed it in the same clade as H. grandperrini previously recorded from Taiwan, with an uncorrected p-distance between both specimens of 0.19%. Hoplostethus grandperrini was originally described on the basis of two specimens collected off New Caledonia, with only one additional specimen having been reported (from southern Taiwan). The Japanese specimens are the first records of the species from Japan, the fourth and fifth specimens known, and the Iwate Prefecture specimen the northernmost record of the species.

著者

秋岡 陽 Yo Akioka

出版者

フェリス女学院大学

雑誌

フェリス女学院大学音楽学部紀要 (ISSN:13410601)

巻号頁・発行日

vol.10, pp.3-65, 2010-03

著者

Nobutoshi OTA Genki N. KANDA Hiroyuki MORIGUCHI Yusufu AISHAN Yigang SHEN Rikuhiro G. YAMADA Hiroki R. UEDA Yo TANAKA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.35, no.10, pp.1141-1147, 2019-10-10 (Released:2019-10-10)

参考文献数

24

被引用文献数

5

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Microfluidic devices are important platforms to culture and observe biological tissues. Compared with conventional setups, microfluidic devices have advantages in perfusion, including an enhanced delivery of nutrients and gases to tissues. However, explanted tissues can maintain their functions for only hours to days in microfluidic devices, although their observations are desired for weeks. The suprachiasmatic nucleus (SCN) is a brain region composed of heterogeneous cells to control the biological clock system through synchronizing individual cells in this region. The synchronized and complicated cell–cell interactions of SCN cells are difficult to reproduce from seeded cells. Thus, the viability of explanted SCN contributes to the study of SCN functions. In this paper, we propose a new perfusion platform combining a PDMS microfluidic device with a porous membrane to culture an explanted SCN for 25 days. We expect that this platform will provide a universal interface for microfluidic manipulation of tissue explants.

著者

Yo-ko CHINEN Kei SHIRAISHI Hideo MOROOKA Harumi MOROOKA

出版者

The Textile Machinery Society of Japan

雑誌

Journal of Textile Engineering (ISSN:13468235)

巻号頁・発行日

vol.55, no.2, pp.45-51, 2009-04-15 (Released:2009-07-18)

参考文献数

11

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Bust silhouette is one of several very important aesthetic points in the appeal of a women’s body, and it is also well known that an attractive silhouette is influenced by both inner and outer garments. Some odd protrusions can appear in outerwear because of the underlying brassiere, in particular, in spring-into-autumn apparel. As a result, many young Japanese women experience discomfort related to this silhouette. Thus we investigated the relationship between the brassiere and the bust silhouette in knit shirt. The experimental results are as follows: (1) unnatural protrusions result from four causes: the seam, the cup line, the trim lace, and the malformed top part of the brassiere, (2) seamless cup type brassiere makes a contribution to a beautiful bust silhouette, and (3) characteristics of the half-cup type brassiere which produces the worst bust silhouette in knit shirt are the total angle of cup top (BθU + BθL) ≤ 155°, the curved height of the under-cup line (BBL) ≤ 6 mm, and the compression recovery (RC) ≤ 50%.

著者

長谷川 洋 Yo Hasegawa

出版者

金城学院大学

雑誌

金城学院大学論集. 人文科学編 = Treatises and Studies by the Facalty of Kinjo Gakuin University. Studies in Humanities (ISSN:18800351)

巻号頁・発行日

vol.11, no.2, pp.190-209, 2015-03-31

著者

Seung Kyu Park Dae Jung Yang Yo Han Uhm Jong Hyuk Yoon Je Ho Kim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.3, pp.361-364, 2018 (Released:2018-03-02)

参考文献数

19

被引用文献数

3 14

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[Purpose] The purpose of this study was to examine the effects of extracorporeal shock wave therapy (ESWT) on upper extremity muscle tone in chronic stroke patients. [Subjects and Methods] For this study, 30 stroke patients participated in this study and they were divided into ESWT group and sham-ESWT group, each group consisted of 15 patients. ESWT and sham-ESWT was performed by the patients for two times a week, for eight weeks. MyotonPRO was used to measure muscle tone. [Results] According to the results of the comparisons between the groups, after intervention, upper extremity muscle tone were significantly higher in the ESWT group than in the sham-ESWT group. [Conclusion] This study showed that ESWT is effective for improving decrease of muscle tone in chronic stroke patients.

著者

Junichiro Irie Emi Inagaki Masataka Fujita Hideaki Nakaya Masanori Mitsuishi Shintaro Yamaguchi Kazuya Yamashita Shuhei Shigaki Takashi Ono Hideo Yukioka Hideyuki Okano Yo-ichi Nabeshima Shin-ichiro Imai Masato Yasui Kazuo Tsubota Hiroshi Itoh

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.67, no.2, pp.153-160, 2020 (Released:2020-02-28)

参考文献数

21

被引用文献数

22 115

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Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear. We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men. A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN. Clinical findings and parameters, and the pharmacokinetics of NMN metabolites were investigated for 5 h after each intervention. Ophthalmic examination and sleep quality assessment were also conducted before and after the intervention. The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature. Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN. Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention. Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration. The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.

著者

早川 陽 Yo HAYAKAWA

出版者

昭和女子大学近代文化研究所

雑誌

昭和女子大学近代文化研究所紀要 = Bulletin of the Institute of Modern Culture, Showa Women’s University (ISSN:24369128)

巻号頁・発行日

no.17, pp.44-65, 2022-01-01

著者

Yo-Han Uhm Dae-Jung Yang

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.2, pp.300-303, 2018 (Released:2018-02-28)

参考文献数

11

被引用文献数

2

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[Purpose] The purpose of this study was to examine the effect of computerized postural control training using whole body vibration on lower limb muscle activity and cerebral cortical activation in acute stroke patients. [Subjects and Methods] Thirty stroke patients participated and were divided into groups of 10, a group of the computerized postural control training using whole body vibration (Group I), the computerized postural control training combined with aero step (Group II) and computerized postural control training (Group III). MP100 was used to measure lower limb muscle activity, and QEEG-8 was used to measure cerebral cortical activation. [Results] Comparison of muscle activity and cerebral cortical activation before and after intervention between groups showed that Group I had significant differences in lower limb muscle activity and cerebral cortical activation compared to Groups II and III. [Conclusion] This study showed that whole body vibration combined computerized postural control training is effective for improving muscle activity and cerebral cortex activity in stroke patients.

著者

Kenji Iwaku Jaeduk Yoshimura Noh Eiji Sasaki Nami Suzuki Tosiaki Kameda Sakiko Kobayashi Ai Yoshihara Hidemi Ohye Natsuko Watanabe Miho Suzuki Masako Matsumoto Yo Kunii Koji Mukasa Kiminori Sugino Koichi Ito

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.61, no.9, pp.875-881, 2014 (Released:2014-09-29)

参考文献数

20

被引用文献数

2 11

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Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, screening of children with thyroid ultrasonography has been carried out, yielding numerous findings, suggesting a possible influence from the Accident. We report thyroid ultrasonographic findings, used by similar device at Fukushima Prefecture’s study, at Ito-hospital. Of the 2721 children aged 15 or less who visited our hospital between January 2005 and March 2013, 1214 children (330 boys and 884 girls; median age, 12; range of age, 4-15) were covered by evaluation of thyroid ultrasonographic findings, excluding children known in advance to have thyroid disease on the basis of disease history, palpation and blood tests. Among these 1214 children, 709 children (58.4%) were found cysts (≤5 mm in 665 cases) by ultrasonography, 43 children (3.5%) were found nodules (≤5 mm in 18 cases) and 9 children (5.2%) were found an intrathyroid ectopic thymus. Analysis of the data before and after the Accident using the same device, involving age adjustment on the basis of the standard population in 2010, showed no difference in the incidence rate of cysts or nodules. In children examined, the incidence rate of cyst formation (particularly ≤5 mm) was higher, and there was no difference in the incidence rate of cysts or nodules between the pre- and post-accident period.

著者

Yo Akiyama Manabu Kanazawa Maiko Iwaki Tamaki Hada Yumika Soeda Ryosuke Otake Kenta Kashiwazaki Yuriko Komagamine Natsuko Murakami Atsushi Takaichi Noriyuki Wakabayashi Shunsuke Minakuchi

出版者

Japan Prosthodontic Society

雑誌

Journal of Prosthodontic Research (ISSN:18831958)

巻号頁・発行日

pp.JPR_D_22_00100, (Released:2023-02-02)

参考文献数

17

被引用文献数

3

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Purpose: Although digital removable partial dentures have been previously described, there have been no reports on how to fabricate them in one piece. This study proposes a new method for fabricating patient-specific digital removable partial dentures using a custom plate.Methods: First, a gypsum model was scanned using a laboratory scanner and a removable partial denture was designed using computer-aided design (CAD) software based on standard tessellation language data. The metal clasp was fabricated from Ti-6Al-4V using a 3D printer. For custom plate fabrication, a resin plate frame was designed using computer-aided design (CAD) software and fabricated using a 3D printer. An artificial tooth and metal clasp were fixed on the base surface of the frame, an auto-polymerizing resin was poured into the frame for the denture base, and the artificial tooth and metal clasp were packed to form a custom plate. The plate was cut using a milling machine. Subsequently, the support attached to the denture was removed and polished for complete fabrication of the denture.Conclusions: Our novel removable partial denture fabrication method is more efficient than the conventional method. The obtained removable partial dentures demonstrated satisfactory accuracy.

著者

Hyunho SHIN Hun-Joo LEE Yo-Han YOO Woong LEE

出版者

The Japan Society of Mechanical Engineers

雑誌

JSME International Journal Series A Solid Mechanics and Material Engineering (ISSN:13447912)

巻号頁・発行日

vol.47, no.1, pp.35-41, 2004 (Released:2004-07-15)

参考文献数

16

被引用文献数

4 10

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A determination procedure for element elimination criterion in finite element simulation of high-strain-rate impact and penetration phenomena, occurring between tungsten heavy alloy long-rod penetrators and steel targets, has been presented with some demonstrations for the validity of the established criterion. The element elimination criterion for the two types of materials have been determined by comparing the simulated depth of penetration (DOP) and deformed shape of the penetrator with previously available experimental results. Although the criterion affects the simulated DOP significantly at the studied impact velocity of 1500m/s, once established, they are shown to be valid in predicting the DOP in the impact velocity range between 1100 and 1750m/s. The events of partial penetration with severe material deformation such as critical ricochet angle and ricochet phenomenology have also been successfully predicted using the established criterion in the similar impact velocity range. Thus it is suggested that the determination procedure for the suitable element erosion criterion is prerequisite in simulating high-strain-rate impact/penetration phenomena and the criterion established by the procedure is useful in fairly broad range of the velocity and for other similar high-strain-rate events.

著者

Nobutoshi OTA Yaxiaer YALIKUN Nobuyuki TANAKA Yigang SHEN Yusufu AISHAN Yuki NAGAHAMA Minoru OIKAWA Yo TANAKA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

pp.18P568, (Released:2019-01-25)

被引用文献数

8

著者

秋岡 陽 Yo Akioka

出版者

フェリス女学院大学

雑誌

フェリス女学院大学音楽学部紀要 (ISSN:13410601)

巻号頁・発行日

no.10, pp.3-65, 2010-03

著者

Yo Muraki Midori Yamasaki Hirohisa Takeuchi Kimio Tohyama Noriyasu Sano Takanori Matsuo

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

pp.c17-00811, (Released:2018-01-06)

参考文献数

36

被引用文献数

6

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Pulmonary hypertension (PH) is a life-threatening lung disease. Despite the availability of several approved drugs, the development of a new treatment method is needed because of poor prognosis. Tissue selective drug delivery systems can avoid the adverse effects of current therapy and enhance efficacy. We evaluated the possibility of delivering drugs to the lungs of a PH rat model using fluorescence dye-labeled nanosized liposomes. To evaluate the tissue distribution following systemic exposure, fluorescent dye-labeled, 40-180 nm liposomes with and without polyethylene glycol (PEG) were intravenously administered to a monocrotaline-induced PH (MCT) rat model and tissue fluorescence was measured. Fluorescent dye-containing liposomes were intratracheally administered to the MCT model to evaluate the distribution of the liposome-encapsulated compound following local administration to reduce systemic exposure. The lung vascular permeability, plasma concentration of surfactant protein (SP)-D, lung reactive oxygen species (ROS) production, and macrophage marker gene cluster of differentiation (CD68) expression were measured. PEG and 80-nm liposome accumulation in the lung was elevated in the MCT model compared to that in normal rats. The intratracheally administered liposomes were delivered selectively to the lungs of the MCT model. The lung vascular permeability, plasma SP-D concentration, and CD68 expression were significantly elevated in the lungs of the MCT model, and were all significantly and positively correlated to liposome lung accumulation. Liposomes can accumulate in the lungs of an MCT model by enhancing vascular permeability by the inflammatory response. Therefore, drug encapsulation in liposomes could be an effective method of drug delivery in patients with PH.

著者

早川 陽 Yo HAYAKAWA

出版者

昭和女子大学近代文化研究所

雑誌

学苑 = Gakuen (ISSN:13480103)

巻号頁・発行日

no.964, pp.38-62, 2021-02-01

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This paper explores descriptions of natural planting as a hobby in the book, Shumi Taikan published in 1935, focusing on bonsai. The study explains how the number of cultural pundits who enjoyed hobbies and built relationships with each other increased in early Showa Japan.Chapter 1 describes the community and context surrounding bonsai and explains its importance. Earlier studies on the history of bonsai are also examined. Chapter 2 summarizes hobbies related to natural planting that are described in Shumi Taikan. Chapter 3 classifies bonsai pundits by experience and describes their characteristics. Chapter 4 summarizes the construction of hobby organizations by area and name of organization and also appraises a large-scale exhibition held at Hibiya Park.This study verifies that an increasing number of publications by bonsai pundits and of botanical centers on natural planting as a hobby in early Showa Japan resulted in widespread recognition of bonsai. Bonsai was initially recognized as a new type of culture that was considered harmonious with sencha and suitable as ornaments for tokonoma. Thereafter, hobby groups were systematically formed and small- to large-scale exhibitions were held. Bonsai was favorably received by the public, leading to an increase in exhibitions. Bonsai developed into an art form from the time it came to be considered unique to Japan, rather than as part of Asian culture in general.

著者

和田 豊 川端 洋 坂野 文菜 加藤 隆一 加藤 信治 堀 恵一 Wada Yutaka Kawabata Yo Banno Ayana Kato Ryuichi Kato Nobuji Hori Keiichi

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

第1回ハイブリッドロケットシンポジウム 講演集 = Proceedings of the 1st Hybrid Rocket Symposium

巻号頁・発行日

2018-06

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第1回ハイブリッドロケットシンポジウム(2018年6月28日-29日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)), 相模原市, 神奈川県

著者

YO

出版者

社団法人情報科学技術協会

雑誌

ドクメンテーション研究 (ISSN:00125180)

巻号頁・発行日

vol.18, no.1, 1968-01-15

著者

早川 陽 Yo Hayakawa

雑誌

學苑 = GAKUEN (ISSN:13480103)

巻号頁・発行日

vol.896, pp.2-18, 2015-06-01

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In the field of Japanese art education, the pigments employed in traditional Japanese paintings are rarely used, though using them in an educational context could be very valuable in imparting an understanding of Bijutsu Bunka(art culture)currently required in curriculum guidelines. In an attempt to explore how they can be adopted in today's art education, this paper explores two Japanese traditional painting technique books from the Taisho Period and highlights the common characteristics of the pigments described in the books and compares them with pigments that have survived from those times, or have been more recently developed for use in traditional-style paintings. The origins of various Japanese pigments are organized in such a way that they can be used as educational material. In order to provide background for this research, the first chapter considers how Japanese traditional paintings are created, displayed and enjoyed today. Also the significance of Bijutsu Bunka, which was newly specified in curriculum guidelines, is discussed. The second chapter, focusing on the refinement and elutriation of pigments used in Japanese traditional paintings, categorizes and organizes the features of the pigments used. The third chapter refers to the above two books and considers the changes made since then in the types of the pigment. The final chapter summarizes the characteristics of the pigments and gives a general view of how they were traditionally used and concludes that the pigments, many of which have been refined by elutriation, can be utilized effectively in the field of art education today. The author believes that intercourse between the past and present, and understanding and appreciating traditional art, offer new possibilities in the future of art education.