著者

Akira Yamamoto

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.15, no.6, pp.304-305, 2008 (Released:2008-12-23)

参考文献数

22

被引用文献数

8 24

著者

Takamitsu YAMAMOTO Yoichi KATAYAMA Toshiki OBUCHI Kazutaka KOBAYASHI Hideki OSHIMA Chikashi FUKAYA

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.52, no.7, pp.475-481, 2012 (Released:2012-07-25)

参考文献数

32

被引用文献数

3 32

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Minimally conscious state (MCS) is characterized by inconsistent but clearly discernible behavioral evidence of consciousness, and can be distinguished from coma and the vegetative state (VS). Ten MCS patients were evaluated neurologically and electrophysiologically over 3 months after the onset of brain injury, and were treated by spinal cord stimulation (SCS). A flexible four-contact, cylinder electrode was inserted into the epidural space of the cervical vertebrae, and placed at the C2-C4 levels. Stimulation was applied for 5 minutes every 30 minutes during the daytime at an intensity that produced motor twitches of the upper extremities. We used 5 Hz for SCS, considering that the induced muscle twitches can be a useful functional neurorehabilitation for MCS patients. Eight of the 10 MCS patients satisfied the electrophysiological inclusion criteria, which we proposed on the basis of the results of deep brain stimulation for the treatment of patients in the VS. Seven patients recovered from MCS following SCS therapy, and were able to carry out functional interactive communication and/or demonstrate the functional use of two different objects. Cervical SCS increased cerebral blood flow (CBF) diffusely in the brain, and CBF increased by 22.2% during the stimulation period compared with CBF before stimulation in MCS patients (p < 0.0001, paired t-test). Five-Hz cervical SCS could increase CBF and induce muscle twitches of the upper extremities. This SCS therapy method may be suitable for treating MCS.

著者

Shinobu Sugihara Ichiro Hisatome Masanari Kuwabara Koichiro Niwa Nani Maharani Masahiko Kato Kazuhide Ogino Toshihiro Hamada Haruaki Ninomiya Yukihito Higashi Kimiyoshi Ichida Kazuhiro Yamamoto

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-14-1267, (Released:2015-02-23)

参考文献数

41

被引用文献数

10 82

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Background:Uric acid (UA) serves as an antioxidant in vascular endothelial cells. UA transporter 1 (URAT1) encoded by SLC22A12 is expressed in the kidney and vessels and its loss of function causes hypouricemia. The purpose of this study was to examine whether there is any endothelial dysfunction in patients with hypouricemia.Methods and Results:Twenty-six patients with hypouricemia (<2.5 mg/dl) and 13 healthy control subjects were enrolled. Endothelial function was evaluated using flow-mediated dilation (FMD). mRNA of UA transporters expressed in cultured human umbilical endothelial cells (HUVEC) was detected on RT-PCR. There was a positive correlation between FMD and serum UA in the hypouricemia group. URAT1 loss-of-function mutations were found in the genome of 21 of 26 patients with hypouricemia, and not in the other 5. In the hypouricemia groups, serum UA in homozygous and compound heterozygous patients was significantly lower than in other groups, suggesting that severity of URAT1 dysfunction may influence the severity of hypouricemia. Thirteen of 16 hypouricemia subjects with homozygous and compound heterozygote mutations had SUA <0.8 mg/dl and their FMD was lower than in other groups. HUVEC do not express mRNA of URAT1, suggesting the null role of URAT1 in endothelial function.Conclusions:Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients.

著者

山本 直人 YAMAMOTO Naoto

出版者

名古屋大学文学部

雑誌

名古屋大学文学部研究論集 (ISSN:04694716)

巻号頁・発行日

no.59, pp.61-72, 2013

著者

山本 直人 YAMAMOTO Naoto

出版者

名古屋大学文学部

雑誌

名古屋大学文学部研究論集. 史学 (ISSN:04694716)

巻号頁・発行日

vol.58, pp.113-130, 2012-03-31

著者

Suzuki K. Barbiellini B. Orikasa Y. Go N. Sakurai H. Kaprzyk S. Itou M. Yamamoto K. Uchimoto Y. Wang Yung Jui Hafiz H. Bansil A. Sakurai Y.

出版者

American Physical Society

雑誌

Physical Review Letters (ISSN:00319007)

巻号頁・発行日

vol.114, no.8, 2015-02-25

被引用文献数

41

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リチウムイオン二次電池の電池電極反応に寄与する電子軌道の解明 -マンガン酸リチウム系正電極材料設計に新たな指針-.京都大学プレスリリース. 2015-02-05.

著者

Yu ISHIDA Futoshi NAKAMURA Hiroki KANZATO Daisuke SAWADA Naoyuki YAMAMOTO Hiroko KAGATA Masato OH-IDA Haruo TAKEUCHI Shigeru FUJIWARA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.69, no.9, pp.1652-1660, 2005 (Released:2005-09-23)

参考文献数

31

被引用文献数

88

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A placebo-controlled, single-blind study was conducted to evaluate the effects of Lactobacillus acidophilus strain L-92 (L-92) on the symptoms of Japanese cedar-pollen allergy. This study was carried out during the 2002 and 2003 seasons of Japanese cedar pollination. Twenty-three in-house volunteers were asked to drink 100 ml of heat-treated milk fermented with L-92 containing 5×1010 of the bacteria, twice a day, for 6 consecutive weeks. A similar study was carried out during the 2003 season for 10 weeks, but the daily dose of bacteria was 2×1010. A significant improvement of the ocular symptom-medication score (SMS) was observed in 2002 and of the score of distress of life in 2003. These data show that a daily oral intake of not less than 2×1010 heat-treated L-92 cells improved the symptoms of Japanese cedar pollinosis, thereby contributing to reduce the dose of concomitant medications. However, no blood parameter was significantly affected in these trials.

著者

Torahiko TERADA Ryûzô YAMAMOTO Tetu WATANABE

出版者

The Japan Academy

雑誌

Proceedings of the Imperial Academy (ISSN:03699846)

巻号頁・発行日

vol.10, no.1, pp.10-12, 1934 (Released:2008-03-19)

参考文献数

1

著者

山本 歩 Ayumu Yamamoto

出版者

関西学院大学人文学会

雑誌

人文論究 (ISSN:02866773)

巻号頁・発行日

vol.64, no.3, pp.1-18, 2014-12

著者

Nakagawa Takayuki Kumakawa Kozo Usami Shin-ichi Hato Naohito Tabuchi Keiji Takahashi Mariko Fujiwara Keizo Sasaki Akira Komune Shizuo Sakamoto Tatsunori Hiraumi Harukazu Yamamoto Norio Tanaka Shiro Tada Harue Yamamoto Michio Yonezawa Atsushi Ito-Ihara Toshiko Ikeda Takafumi Shimizu Akira Tabata Yasuhiko Ito Juichi

出版者

BioMed Central Ltd.

雑誌

BMC medicine (ISSN:17417015)

巻号頁・発行日

vol.12, 2014-11-19

被引用文献数

74

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突発性難聴に対する新規治療法の有効性を報告. 京都大学プレスリリース. 2014-12-10.

著者

ガン トン Yamamoto Masayuki K. Hashiguchi Hiroyuki Okamoto Hajime Yamamoto Mamoru

出版者

社団法人日本気象学会

雑誌

大会講演予講集

巻号頁・発行日

vol.104, 2013-10-31

著者

山田 満 山本 真弓 ヤマダ ミツル ヤマモト マユミ Mitsuru Yamada Mayumi Yamamoto

雑誌

和洋女子大学紀要. 家政系編

巻号頁・発行日

vol.41, pp.35-42, 2001-03-31

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近年アレルギー疾患が増加する傾向にあり,アレルギー患者は国民の3分の1という高率になるという。そこで食物アレルゲンの一つである牛乳を対象として,牛乳の殺菌温度別アレルゲン性を測定し,アレルギー発症との関係について動物実験により比較検討を行った。抗原として低温殺菌牛乳(63℃30分),超高温殺菌牛乳(130℃2秒)および煮沸乳(100℃20分)を用い,マウス,ラットの腹腔内に注射し感作させた。アレルギー反応の確認はマウス血清IgE抗体値の測定と,ラット平滑筋のSchultz-Dale反応による抗原体反応によって確認した。その結果,低温殺菌乳に比べ超高温殺菌乳のマウス血清IgE抗体含有率の方が有意に高いことが分かった(P<0.05)。超高温殺菌乳と煮沸乳のIgE平均含有率の間には有意差は認められなかったが,高温で加熱時間の長いほどIgE値の高くなる傾向がみられた。一方,ラットによるSchultz-Dale反応でも低温殺菌乳では平滑筋の収縮は見られなかったが,超高温殺菌乳と煮沸乳では1分以内に著しい筋肉の収縮が認められた。これらのことより低温殺菌乳は,超高温殺菌乳に比較してアレルゲン性が弱く,加熱温度の高くなるほどアレルゲン量が増加し,アレルギー発症の原因になりやすいのではないかと考えられる。

著者

永野マドセン 泰子 山元 淑乃 楊 元 Nagano Madsen Yasuko Yamamoto Yoshino Yang Yuan

出版者

琉球大学留学生センター

雑誌

留学生教育 : 琉球大学留学生センター紀要 (ISSN:13488368)

巻号頁・発行日

no.10, pp.17-34, 2013-03

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中国語雲南方言の単一話者による日本語音声を分析し、その全体像を把握した。日本人が聞いて不自然でかつ学習効果が少ないと思われる問題点は「子音の強さ」、濁音が清音になる、および「ら行」の音であった。これらについては音響分析により日本人母語話者との差異を指摘した。母音については、狭母音と広母音の差が少ない中国語の特徴がそっくり日本語の母音のパターンに移されていることが観察された。これらの結果から、雲南方言でも北京方言同様、子音の問題が大きいことが明らかになった。Japanese speech sounds produced by a single Chinese speaker was analyzed. The results showed three areas that are most problematic: obstruents being too strong, voiced obstruent become voiceless, and the realization of /r/ is different. For these, spectrographic analyses showed the difference between a native Japanese speaker and the Chinese learner. The Chinese vowel formant pattern was nearly directly transferred to the Japanese vowel pattern and little effect of learning was observed.

著者

Soichiro YOKOYAMA Hiroyuki IIZUKA Masahito YAMAMOTO

出版者

一般社団法人 日本機械学会

雑誌

Journal of Advanced Mechanical Design, Systems, and Manufacturing (ISSN:18813054)

巻号頁・発行日

vol.8, no.5, pp.JAMDSM0073-JAMDSM0073, 2014 (Released:2014-10-31)

参考文献数

19

被引用文献数

1

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We propose an efficient heuristic method for job-shop scheduling problems (JSP) with the objective of total weighted tardiness minimization. The proposed method uses schedule reconstructions by priority rules to guide a local search towards promising solutions. Typically priority rules determine the whole schedule and thus in corporating it with local search procedure is difficult. In our proposed method, a priority rule decides a schedule within an arbitrary selected time window and the rest of the schedule is determined by the schedule obtained by a conventional local search method. The priority rule is given by a linear combination of simple priority rules. To improve a schedule efficiently, an appropriate set of time window and gains of the linear combined priority rule is required. Therefore, we optimize the set of time window and rule gains with genetic algorithm. This rule-based reconstruction procedure and the conventional local search procedure are alternately applied to a current solution. In the experiments, the efficiency of rule-based reconstruction procedure is verified and the proposed method is compared with one of the most effective existing methods. The results show that the proposed method outperforms the existing method on large problems with sufficient computational time. The average performance is particularly improved due to the ability of rule-based reconstruction procedure to escape from local optima of the conventional local search procedure efficiently.

著者

Eto Moe Sakai Saeko Yamamoto Tomoka Kagitani-Shimono Kuriko Mohri Ikuko Taniike Masako

出版者

JAPAN SOCIETY FOR RESEARCH ON EMOTIONS

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.22, no.1, pp.28-39, 2014

被引用文献数

1

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Individuals with autism spectrum disorder have difficulties recognizing emotional information, especially from facial expressions. The present study investigated facial expression recognition ability among 17 children with high-functioning autism spectrum disorder and 26 typically developing children. Three facial expression tasks were used: the Eyes Task, the Morphed Faces Task, and the Movie Stills Task with and without faces. Children were asked to adapt emotional words for stimuli (eye stimuli and emotional scenes) or rate emotional intensity from facial expressions. Results showed that children with high-functioning autism spectrum disorder had difficulties perceiving subtle fear, complex emotions, and using contextual information appropriately in the absence of faces. These findings suggest that difficulty in recognizing emotional information from not only facial expressions but also contextual cues could provide a basis for understanding to social deficits among children with high-functioning autism spectrum disorder.

著者

Yoshinori INOUE Atsushi YAMAMOTO

出版者

クロマトグラフィー科学会

雑誌

CHROMATOGRAPHY (ISSN:13428284)

巻号頁・発行日

vol.35, no.2, pp.63-72, 2014-08-10 (Released:2014-08-26)

参考文献数

94

被引用文献数

6

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High-performance liquid chromatography (HPLC) has great contribution in the analysis of the carbohydrates. Various separation modes such as ion exchange chromatography, size exclusion chromatography and partition chromatography have been applied to HPLC of mono- and oligosaccharides. Among them, partition chromatography with a polar stationary phase and aqueous mobile phase, called aqueous normal phase partition (ANP) chromatography, has been used in various fields, and is widely used for the separation of reducing sugars. Currently, this separation mode is considered to be a type of "hydrophilic interaction chromatography (HILIC)". As the use of HILIC mode increases, many novel stationary phases being available for the separation of reducing sugars have been developed. This article focuses on the separation of reducing sugars by ANP (HILIC) mode, and summarizes the traditional and/or recent stationary phases for the separation of reducing sugars. The applicability of various kinds of stationary phases to solid-phase extraction (SPE) of saccharides is also described.

著者

Noriaki SAKAMOTO Eiichi ISHIKAWA Yasunobu NAKAI Hiroyoshi AKUTSU Tetsuya YAMAMOTO Kei NAKAI Masanari SHIIGAI Hideo TSURUSHIMA Tomonori ISOBE Shingo TAKANO Koji TSUBOI Akira MATSUMURA

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.52, no.12, pp.878-884, 2012 (Released:2012-12-25)

参考文献数

27

被引用文献数

9 30 5

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Intracranial hemangioblastomas (HBs) are hypervascular neoplasms mainly located in the posterior fossa of the central nervous system. Preoperative embolization of the feeding arteries is one proposal for reduction of intraoperative hemorrhage, although indications for the procedures should be evaluated carefully due to the potential complications. This retrospective study investigated clinical outcomes and complications of 15 patients with HBs in the posterior fossa to evaluate the safety and effectiveness of endovascular procedures as well as angiographical procedures. Surgical excision without presurgical embolization was performed in 8 cases, and excision with presurgical embolization was performed in 7 cases, using Guglielmi detachable coils with or without polyvinyl alcohol (GDC ± PVA) in 4 cases and only n-butyl 2-cyanoacrylate (NBCA) in 3 cases. The embolization was applied for selected cases in which feeding arteries were located in a deep site and hard to coagulate surgically. Partial embolization was achieved in 5 cases, and all feeders were successfully embolized in 2 cases. Total removal was achieved in 12 cases, and subtotal/partial removal was achieved in 3 cases. Subarachnoid hemorrhage with intratumoral hemorrhage occurred in 1 case during the angiographic procedure and in 1 case during the embolization procedures. The mean volume of intraoperative blood loss was clearly less in the NBCA group than in the GDC ± PVA group. HBs are mainly located in the posterior cranial fossa, so the risk of severe clinical complication may be high if vascular problems occur. In our series, presurgical embolization using NBCA made tumor removal safe and reduced bleeding volume in posterior fossa HBs.

著者

山本 紀生 ヤマモト ノリオ Norio Yamamoto

雑誌

国際研究論叢 : 大阪国際大学紀要 = OIU journal of international studies

巻号頁・発行日

vol.17, no.1, pp.211-216, 2003-10-30

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This paper is a translation of the 4th chapter of Histoire et Doctrines de la Comptabilit・by J.H. Vlaemminck, published in 1956. No accounting documents remain from ancient Rome, however literary works show debit and credit accounting methods. Ancient Rome did not use the double entry system.

著者

山本 紀生[訳] ヤマモト ノリオ Norio Yamamoto

雑誌

国際研究論叢 : 大阪国際大学紀要 = OIU journal of international studies

巻号頁・発行日

vol.16, no.2, pp.289, 2003-03-31

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This paper is a translation of the 3rd chapter of the fist section of Histoire et Doctrines de la comptabilite by J.H.Vlaemminck, published in 1956.In Ancient Greek, the fist banks were temples. We can discover traces of Hellenic accounting in them. However Athenian banks were established as private enterprises, and as such shared many of the features of modern Financial institutions.

著者

M. YAMAMOTO T. TAKADA S. NAGAO T. KOIKE K. SHIMADA M. HOSHI K. ZHUMADILOV T. SHIMA M. FUKUOKA T. IMANAKA S. ENDO A. SAKAGUCHI S. KIMURA

出版者

GEOCHEMICAL SOCIETY OF JAPAN

雑誌

GEOCHEMICAL JOURNAL (ISSN:00167002)

巻号頁・発行日

vol.46, no.4, pp.341-353, 2012-08-20 (Released:2013-11-08)

参考文献数

11

被引用文献数

59 24

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A field survey was carried out soon after the Fukushima Dai-ichi Nuclear Power Plant accident. Gamma-ray emitting radionuclides and plutonium isotopes in a series of soil samples collected from the heavily contaminated areas outside the 20-km exclusion zone, as well as from Okuma Town adjacent to the plant, were measured. Volatile radionuclides such as 131I, 134Cs, and 137Cs contributed largely to the released radioactivity. Higher depositions of these nuclides were observed in areas to the northwestern—including Okuma Town and Iitate Village, which is at a distance of 25-45 km from the plant. The results obtained were consistent with the levels and distributions estimated later by the Japan-USA joint-survey (Asahi Shimbun Company, 2011). Trace amounts of plutonium isotopes originating from the accident were detected mainly in soil samples from Iitate Village and in limited soil samples from Okuma Town. The detected levels of 239,240Pu contamination due to the accident were considered to be less than a millionth those of the 137Cs contamination.