著者
Ken T. Murata Hidenobu Watanabe Kazunori Yamamoto Eizen Kimura Masahiro Tanaka Osamu Tatebe Kentaro Ukawa Kazuya Muranaga Yutaka Suzuki Hirotsugu Kojima
出版者
(社)電子情報通信学会
雑誌
IEICE Communications Express (ISSN:21870136)
巻号頁・発行日
vol.3, no.2, pp.74-79, 2014-02-25 (Released:2014-02-25)
参考文献数
6
被引用文献数
4 7

A variety of satellite missions are carried out every year. Most of the satellites yield big data, and high-performance data processing technologies are expected. We have been developing a cloud system (the NICT Science Cloud) for big data analyses of Earth and Space observations via spacecraft. In the present study, we propose a new technique to process big data considering the fact that high-speed I/O (data file read and write) is important compared with data processing speed. We adopt a task scheduler, the Pwrake, for easy development and management of parallel data processing. Using a set of long-time scientific satellite observation data (GEOTAIL satellite), we examine the performance of the system on the NICT Science Cloud. We successfully archived high-speed data processing more than 100 times faster than those on traditional data processing environments.
著者
Hideyuki Yamamoto Sayomi Higa-Nakamine Nobuhiro Noguchi Noriko Maeda Yutaka Kondo Seikichi Toku Ichiro Kukita Kazuhiro Sugahara
出版者
(公社)日本薬理学会
雑誌
Journal of Pharmacological Sciences (ISSN:13478613)
巻号頁・発行日
pp.13R11CP, (Released:2014-02-19)
参考文献数
28
被引用文献数
2 17

Four transmembrane tyrosine kinases constitute the ErbB protein family: epidermal growth factor receptor (EGFR) or ErbB1, ErbB2, ErbB3, and ErbB4. In general, the structure and mechanism of the activation of these members are similar. However, significant differences in homologous desensitization are known between EGFR and ErbB4. Desensitization of ligand-occupied EGFR occurs by endocytosis, while that of ErbB4 occurs by selective cleavage at the cell surface. Because ErbB4 is abundantly expressed in neurons from fetal to adult brains, elucidation of the desensitization mechanism is important to understand neuronal development and synaptic functions. Recently, it has become clear that heterologous desensitization of EGFR and ErbB4 are induced by endocytosis and cleavage, respectively, similar to homologous desensitization. It has been reported that heterologous desensitization of EGFR is induced by serine phosphorylation of EGFR via the p38 mitogen-activated protein kinase (p38 MAP kinase) pathway in various cell lines, including alveolar epithelial cells. In contrast, the protein kinase C pathway is involved in ErbB4 cleavage. In this review, we will describe recent advances in the desensitization mechanisms of EGFR and ErbB4, mainly in alveolar epithelial cells and hypothalamic neurons, respectively.
著者
TAKADA JUN HOSHI MASAHARU NAGATOMO TSUNETO YAMAMOTO MASAYOSHI ENDO SATORU TAKATSUJI TOSHIHIRO YOSHIKAWA ISAO GUSEV BORIS I. SAKERBAEV ALEXANDER K. TCHAIJUNUSOVA NAILYA.J.
出版者
日本放射線影響学会
雑誌
Journal of radiation research (ISSN:04493060)
巻号頁・発行日
vol.40, no.4, pp.337-344, 1999-12
被引用文献数
13 33 44

Accumulated external radiation doses of residents near the Semipalatinsk nuclear test site of the former USSR are presented as a results of study by the thermoluminescence technique for bricks sampled at several settlements in 1995 and 1996. The external doses that we evaluated from exposed bricks were up to about 100 cGy for resident. The external doses at several points in the center of Semipalatinsk City ranged from a background level to 60 cGy, which was remarkably high compared with the previously reported values based on military data. INTRODUCTION A total of 459 nuclear tests were conducted by the former Union of Soviet Socialist Republics (USSR) between 1949 and 1989 at the Semipalatinsk nuclear test site (SNTS) of Kazakhstan, including 87 atmospheric, 26 on the ground, and 346 underground explosions1). The total release of the energy equivalent of trinitrotoluene (TNT) of about 18 Mt was eleven hundred times that of the Hiroshima atomic bomb. However, previous reports concerning the effects of radiation on residents near the SNTS based on data provided by the Defense Department of the former USSR2, 3) did not involve direct experimental data concerning the effective equivalent dose. They just measured some doses for particular settlements after some nuclear explosions. These did not indicate an integrated dose of the residents of all the explosions. The technique of thermoluminescence dosimetry (TLD), which had been successfully applied in dosimetry for the Hiroshima and Nagasaki atomic bombs4, 5), enabled us to evaluate the accumulated external gamma ray doses of all the nuclear explosions at specific places in the Semipalatinsk test site. The TLD technique is well-established not only for instantaneous exposure as in A-bombs (Hiroshima and Nagasaki)6) but also in prolonged exposure to natural radiation, which is used in dating7). Moreover, this technique was applicable for dosimetry studies of radioactive fallout as shown in studies of the Chernobyl accident8,9).
著者
Sekimoto S. Watanabe C. Minami H. Yamamoto T. Kashiwagi T. Klemm Richard A. Kadowaki K.
出版者
American Institute of Physics
雑誌
Applied physics letters (ISSN:00036951)
巻号頁・発行日
vol.103, no.18, pp.182601, 2013-10
被引用文献数
67 5

Using a modified mesa structure of high-Tc superconducting Bi2Sr2CaCu2O8+δ with a thin underlaying base superconductor (∼3 μm), the effective working temperature of the continuous and monochromatic terahertz emitter is extended up to 70 K, and the maximum power of ∼30 μW at 0.44 THz is achieved at the relatively high temperature of T b = 55 K in a low bias current retrapping region. The diverging behavior of the intensity occurring at 55 K in the low current regime without hot spot formation may provide us an important clue for the stronger THz radiation from intrinsic Josephson junction devices.
著者
Eri Yamamoto Jun Kobayashi Keiko Kanamaru Toshiaki Miura Fujio Watanabe Noriyuki Kobayashi Masanobu Hasatani
出版者
公益社団法人 化学工学会
雑誌
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)
巻号頁・発行日
vol.36, no.3, pp.348-352, 2003 (Released:2003-11-15)
参考文献数
10
被引用文献数
5 6

A new hydrophilic method for achieving a high-performance adsorbent by impregnating silica into pores of activated carbon has been proposed. In the process, silica-gel was synthesized in the pores of activated carbon after inserting a sodium silicate solution into the pores. Three types of activated carbon were tested to produce hydrophilic activated carbon and to investigate the hydrophilicity by measuring the adsorption isotherms of water vapor and pore structure characteristics. The proposed method worked effectively for adding hydrophilicity to activated carbon, since all of adsorption isotherms of the material treated with this method shifted to a lower region of water vapor pressure than that of the raw material. The shift to a lower relative pressure of adsorption isotherm was maximum when the concentration of sodium silicate solution was 1 mass%.
著者
Md. Mottaleb HOSSAIN Md. Abdullah-AL HUMAYUN Md. Tanvir HASAN Ashraful Ghani BHUIYAN Akihiro HASHIMOTO Akio YAMAMOTO
出版者
一般社団法人 電子情報通信学会
雑誌
IEICE Transactions on Electronics (ISSN:09168524)
巻号頁・発行日
vol.E95.C, no.2, pp.255-261, 2012-02-01 (Released:2012-02-01)
参考文献数
26
被引用文献数
2 9

This paper reports on a theoretical study and modeling of a 1.55µm quantum dot heterostructure laser using InN as a promising candidate for the first time. Details of design and theoretical analysis of probability distribution of the optical transition energy, threshold current density, modal gain, and differential quantum efficiency are presented considering a single layer of quantum dots. Dependence of threshold current density on the RMS value of quantum dot size fluctuations and the cavity length is studied. A low threshold current density of ∼51Acm-2 is achieved at room temperature for a cavity length of 640µm. An external differential efficiency of ∼65% and a modal gain of ∼12.5cm-1 are obtained for the proposed structure. The results indicate that the InN based quantum dot laser is a promising one for the optical communication system.
著者
Masafumi AKISAKA Liu ASATO Yin-Ching CHAN Makoto SUZUKI Tatsu UEZATO Shigeru YAMAMOTO
出版者
Center for Academic Publications Japan
雑誌
Journal of Nutritional Science and Vitaminology (ISSN:03014800)
巻号頁・発行日
vol.42, no.3, pp.241-248, 1996 (Released:2009-04-28)
参考文献数
14
被引用文献数
12 20

Energy and nutrient requirements of younger people have been well studied, unlike that of centenarians. The average life span of the Japanese is the longest in the world, and the population of the very aged is rapidly growing. In addition, the average life span of Okinawan people is the longest in all of Japan. Their food habits also differ from other parts of Japan. To obtain basic dietary information, we surveyed 21 centenarians in Okinawa (17 women and 4 men). The dietary survey was done by one 24h recall method, as was done for centenarians living throughout Japan (3). The energy intake of the Okinawan centenarians living at home was about 1, 100 kcal/day for both sexes, which was similar to that of centenarians throughout Japan. Energy, some nutrient intakes and food consumption pattern (in terms of food groups) were different from those of the centenarians throughout Japan. We also measured their heights, weights, hematological values and activities of daily living (ADL). Comparison between the nutrient intakes and the recommended dietary allowances (RDAs) estimated for the centenarians showed that the estimated RDA of energy for the Okinawan centenarians might be less than their actual intakes.
著者
Sungjin CHOI I-Li LIU Kenichi YAMAMOTO Muneki HONNAMI Takamasa SAKAI Shinsuke OHBA Ryosuke ECHIGO Shigeki SUZUKI Ryouhei NISHIMURA Ung-Il CHUNG Nobuo SASAKI Manabu MOCHIZUKI
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.13-0054, (Released:2013-10-25)
被引用文献数
3 8

We investigated biodegradability and new bone formation after implantation of tetrapod-shaped granular artificial bone (Tetrabone®) or β-tricalcium phosphate granules (β-TCP) in experimental critical-size defects in dogs, which were created through medial and lateral femoral condyles. The defect was packed with Tetrabone® (Tetrabone group) or β-TCP (β-TCP group) or received no implant (control group). Computed tomography (CT) was performed at 0, 4 and 8 weeks after implantation. Micro-CT and histological analysis were conducted to measure the non-osseous tissue rate and the area and distribution of new bone tissue in the defect at 8 weeks after implantation. On CT, β-TCP was gradually resorbed, while Tetrabone® showed minimal resorption at 8 weeks after implantation. On micro-CT, non-osseous tissue rate of the control group was significantly higher compared with the β-TCP and Tetrabone groups (P<0.01), and that of the β-TCP group was significantly higher compared with the Tetrabone group (P<0.05). On histology, area of new bone tissue of the β-TCP group was significantly greater than those of the Tetrabone and control groups (P<0.05), and new bone distribution of the Tetrabone group was significantly greater than those of the β-TCP and control groups (P<0.05). These results indicate differences in biodegradability and connectivity of intergranule pore structure between study samples. In conclusion, Tetrabone® may be superior for the repair of large bone defects in dogs.
著者
山本 哲也 YAMAMOTO Tetsuya
出版者
名古屋大学附属図書館研究開発室
雑誌
名古屋大学附属図書館研究年報 (ISSN:1348687X)
巻号頁・発行日
vol.10, pp.13-23, 2012-03-31 (Released:2012-04-18)

Many parts of work in libraries depend on a wide range of IT knowledge. Appropriate planning of IT training programs is necessary to improve information security, efficiency, and quality of daily work. This article lists possible kind of IT knowledge and describe how they can be applied to working areas.
著者
Ohta Sho Nishida Eisuke Yamanaka Shinya Yamamoto Takuya
出版者
Elsevier
雑誌
Cell Reports (ISSN:22111247)
巻号頁・発行日
pp.1-10, 2013-10-17
被引用文献数
52

大規模遺伝子解析により体細胞の初期化過程でRNAスプライシングパターンが変化することを解明. 京都大学プレスリリース. 2013-10-18.
著者
Yoji Urabe Hideya Yamamoto Toshiro Kitagawa Hiroto Utsunomiya Hiroshi Tsushima Fuminari Tatsugami Kazuo Awai Yasuki Kihara
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.77, no.10, pp.2578-2585, 2013 (Released:2013-09-25)
参考文献数
38
被引用文献数
11 16

Background: Intensive lipid-lowering therapy with statins reduces cardiovascular events, but residual cardiovascular risks remain. Intake of n-3 polyunsaturated fatty acids (PUFAs) has been associated with cardiovascular events. We examined the relationships between serum n-3 PUFAs and coronary atherosclerotic findings on computed tomography angiography (CTA) in patients undergoing statin treatment. Methods and Results: We enrolled 172 subjects (mean age: 68.2 years; 64% men) prior to statin treatment for 6 months. Serum PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, were measured. When the patients were divided into 2 groups according to the median EPA level (61.3μg/ml), the low-EPA group showed higher incidences of 3-vessel plaque involvement (62% vs. 43%, P=0.015), noncalcified plaques (NCPs) (74% vs. 52%, P=0.0016), extensive NCPs (≥2 segments) (56% vs. 34%, P=0.0036), and high-risk plaques (minimum CT density <39HU and remodeling index >1.05) (43% vs. 22%, P=0.0034). Multivariate analyses revealed that low EPA levels were an independent factor for these coronary plaque findings. The DHA levels were not independently associated with these findings. Conclusions: Low serum EPA level, but not serum DHA, is associated with the presence and extent of NCPs and high-risk plaques detected by coronary CTA in patients undergoing lipid-lowering therapy with statins.  (Circ J 2013; 77: 2578–2585)
著者
Yuki YAMAMOTO Tatsuya YAMAMOTO Natsuki YUTO Thomas B. HILDEBRANDT Imke LUEDERS Gudrun WIBBELT Osamu SHIINA Yasushi MOURI Keisuke SUGIMURA Sayuri SAKAMOTO Saroch KAEWMANEE Kentaro NAGAOKA Gen WATANABE Kazuyoshi TAYA
出版者
日本繁殖生物学会
雑誌
Journal of Reproduction and Development (ISSN:09168818)
巻号頁・発行日
pp.1111070413-1111070413, (Released:2011-11-11)
被引用文献数
2 13

The objective of the present study was to define the secretion of prolactin (PRL) in pregnant African and Asian elephants. Levels of immunoreactive (ir-) PRL in serum and placental homogenates were measured by a heterologous radioimmunoassay (RIA) based on an ovine and human RIA system, and the localization of immunoreactive (ir-) PRL in the placenta was detected by immunohistochemistry using anti-human PRL. Circulating ir-prolactin clearly showed a biphasic pattern during pregnancy in African and Asian elephants. Serum levels of ir-PRL started to increase from the 4-6th month of gestation and reached the first peak level around the 11-14th month. A second peak of circulating ir-PRL levels was observed around the 18-20th month of gestation followed by an abrupt decline after parturition. In contrast, in a case of abortion of an African elephant, the second peak of ir-PRL was not observed, and the levels remained low for about four months until parturition. The weight of the fetus delivered at the 17th month of gestation was 23.5 kg, which was quite small compared with normal fetuses in previous reports. Ir-PRL was detected in placental homogenates, and immunolocalization was observed in trophoblasts in both the African and Asian elephants, indicating that the placenta is the source of ir-PRL during pregnancy in elephants. The present results clearly demonstrated that circulating ir-PRL shows a biphasic pattern during normal pregnancy and that the placenta appears to be an important source of circulating ir-PRL during pregnancy in both African and Asian elephants.
著者
Yusuke MURAHATA Asami YAMAMOTO Yuya MIKI Yoshiaki HIKASA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.13-0398, (Released:2013-10-08)
被引用文献数
1 3

This study aimed to investigate and compare the antagonistic effects of atipamezole, yohimbine and prazosin on medetomidine-induced diuresis in healthy cats. Five cats were repeatedly used in each of the 9 groups. One group was not medicated. Cats in the other groups received 40 µg/kg medetomidine intramuscularly and saline (as the control), 160 µg/kg prazosin, or 40, 160 or 480 µg/kg atipamezole or yohimbine intravenously 0.5 hr later. Volume, pH and specific gravity of urine; plasma arginine vasopressin (AVP) level; and creatinine, osmolality and electrolyte levels in both urine and plasma were measured. Both atipamezole and yohimbine, but not prazosin, antagonized medetomidine-induced diuresis. The antidiuretic effect of atipamezole was more potent than that of yohimbine, but was not dose dependent, in contrast to the effect of yohimbine at the tested doses. Both atipamezole and yohimbine reversed medetomidine-induced decreases in both urine specific gravity and osmolality and increases in plasma osmolality and free-water clearance. Antidiuresis of either atipamezole or yohimbine was not related to the area under the curve for AVP level, although the highest dose of both atipamezole and yohimbine initially and temporarily increased plasma AVP levels, suggesting that this may partly influence the antidiuretic effects of both agents. The diuretic effect of medetomidine in cats may be mediated by α2-adrenoceptors, but not α1-adrenoceptors. Atipamezole and yohimbine can be used as antagonistic agents against medetomidine-induced diuresis in healthy cats.
著者
Shigenobu Inami Masamichi Takano Masanori Yamamoto Daisuke Murakami Kenichiro Tajika Kenji Yodogawa Shinya Yokoyama Norihiko Ohno Takayoshi Ohba Junko Sano Chikao Ibuki Yoshihiko Seino Kyoichi Mizuno
出版者
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
vol.48, no.6, pp.725-732, 2007 (Released:2007-12-27)
参考文献数
25
被引用文献数
34 70

It has been reported that green tea consumption reduces the risk of coronary artery disease and cardiac events. Catechin is a major constituent of Japanese green tea and an antioxidant. Lipids and oxidization of low-density lipoprotein cholesterol (LDL-C) play important roles in atherosclerosis. Therefore, we evaluated the effect of catechin intake on the lipid profile and plasma oxidized LDL. The study population consisted of 40 healthy adult volunteers (10 men, 30 women). Catechin was extracted from green tea leaves. The subjects were randomly divided into two groups, a catechin group (n = 29) and a control group (n = 11). In the catechin group, catechin (500 mg: equivalent to 6 or 7 cups of green tea) was administered orally. Venous blood samples were obtained before eating a meal at the start and after 4 weeks without any lifestyle modification. Plasma oxidized LDL assay was performed with a sandwich-type enzyme immunoassay using anti-oxidized phosphatidylcholine monoclonal antibody. The baseline lipid profiles and tea consumptions were similar between the two groups. Plasma oxidized LDL was significantly decreased after catechin administration (from 9.56 ± 9.2 to 7.76 ± 7.7 U/mL, P = 0.005), while plasma LDL-C, triglyceride, and HDL-C concentrations did not change. Catechin decreased the plasma oxidized LDL concentration without significant change in plasma LDL concentration. The mechanism of the beneficial effects of green tea on coronary artery disease might result from a decrease in plasma oxidized LDL.
著者
Kei Yamamoto Yasuyuki Kato Takuma Shindo Mugen Ujiie Nozomi Takeshita Shuzo Kanagawa Junwa Kunimatsu Yuiichi Tamori Toshikazu Kano Rumi Okuno Hideyuki Takahashi Norio Ohmagari
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.66, no.5, pp.443-445, 2013 (Released:2013-09-19)
参考文献数
10
被引用文献数
1 5

We present the first reported case of systemic infection with Neisseria meningitidis serogroup W-135 sequence type (ST)-11 in Japan. A 44-year-old woman presented with high fever, sore throat, and fatigue and was diagnosed with N. meningitidis bacteremia. The causative strain was identified as serogroup W-135 ST-11 by polymerase chain reaction and multilocus sequence typing. Approximately 1 month after treatment, she developed high fever, dyspnea, chest pain, and shoulder pain due to pericarditis, polyarthritis, and tenosynovitis, which are all relatively common immunoreactive complications of W-135 ST-11 meningococcal infections. This causative strain was the same as that responsible for an outbreak of meningitis among Hajj pilgrims in 2000. The strain is now found worldwide because it can attain a high carriage rate and has a long duration of carriage. We suspect that our patient's infection was acquired from an imported chronic carrier.
著者
Yoshimasa Funakawa Tsuyoshi Shiozaki Kunikazu Tomita Tetsuo Yamamoto Eiji Maeda
出版者
一般社団法人 日本鉄鋼協会
雑誌
ISIJ International (ISSN:09151559)
巻号頁・発行日
vol.44, no.11, pp.1945-1951, 2004-11-15 (Released:2007-05-31)
参考文献数
24
被引用文献数
132 446

A ferritic steel precipitation-strengthened by nanometer-sized carbides was developed to obtain a high strength hot-rolled sheet steel having tensile strength of 780 MPa grade with excellent stretch flange formability. Manganese in a content of 1.5% and molybdenum in a content of 0.2% were added to 0.04% carbon Ti-bearing steel in order to lower austenite-ferrite transformation temperature for fine carbides and to retard generating of pearlite and large cementites, respectively. Tensile strength of hot-rolled sheet steel increased with titanium content and it was achieved to 800 MPa in a 0.09% Ti steel. Microstructure of the 0.09%Ti steel was ferrite without pearlite and large cementites. Fine carbides of 3 nm in diameter were observed in rows in the ferrite matrix of the 0.09% Ti steel with transmission electron microscope. The characteristic arrangement of the nanometer-sized carbides indicates that the carbides were formed at austenite-ferrite interfaces during transformation. By energy dispersive X-ray spectroscopy, the carbides were found to contain molybdenum in the same atomic concentration as titanium. Crystal structure of the nanometer-sized carbides was determined to be NaCl-type by X-ray diffractometry. The calculated amount of precipitation-strengthening by the carbides was approximately 300 MPa. This is two or three times higher than that of conventional Ti-bearing high strength hot-rolled sheet steels.Based on the results obtained in the laboratory investigation, mill trial was carried out. The developed hot-rolled high strength sheet steel exhibited excellent stretch flange formability.
著者
Hiroto Kinoshita Reiko Kunisaki Hisae Yamamoto Reikei Matsuda Tomohiko Sasaki Hideaki Kimura Katsuaki Tanaka Makoto Naganuma Shin Maeda
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.52, no.17, pp.1855-1862, 2013 (Released:2013-09-01)
参考文献数
23
被引用文献数
8 39

Objective To investigate the short- and long-term efficacy and safety of infliximab (IFX) in intestinal Behçet's disease (BD) patients in a retrospective cohort study. Methods Among 43 consecutive patients with intestinal BD presenting at the same clinic, 15 with active disease and receiving standard treatment were given IFX infusions (5 mg/kg body weight) every eight weeks. The patients were clinically and endoscopically evaluated before treatment, then assessed after 10 weeks, 12 months and 24 months for a clinical response, defined as a significant improvement in intestinal symptoms and a reduced C-reactive protein (CRP) level. Results At week 10, 12 patients (80%) exhibited a response to IFX, with eight (53%) in remission with no intestinal symptoms and normal CRP levels. A response to IFX was maintained in seven of the 11 patients (64%) available at 12 months and in four of the eight patients (50%) available at 24 months. Of the seven patients receiving prednisolone at entry, five responders had their steroid doses reduced. Fulminant intestinal BD was predictive of an absence of response to IFX. The adverse effects comprised one infusion reaction and one case of fever, most likely related to IFX. Conclusion IFX is effective and safe in patients with refractory intestinal BD.
著者
YAMAMOTO Yoshitsugu ZHOU You
出版者
University of Tsukuba. Graduate School of Systems and Information Engineering. Doctoral Program in Social Systems & Management
巻号頁・発行日
2013-08

This paper is concerned about the aggregation function which plays a centralrole in the majority judgement that was recently proposed by Balinski and Laraki as anew voting mechanism. We raise two issues about their aggregation function, named orderfunction, and show that they are resolved by relaxing the strong monotonicity conditionimposed on the aggregation function, and that the anonymous, weakly monotonic andstrategy-proof aggregation function is completely determined by the set of final grades when the judges split deeply.