著者

Mamoru Hayano Takeru Makiyama Tsukasa Kamakura Hiroshi Watanabe Kenichi Sasaki Shunsuke Funakoshi Yimin Wuriyanghai Suguru Nishiuchi Takeshi Harita Yuta Yamamoto Hirohiko Kohjitani Sayako Hirose Fumika Yokoi Jiarong Chen Osamu Baba Takahiro Horie Kazuhisa Chonabayashi Seiko Ohno Futoshi Toyoda Yoshinori Yoshida Koh Ono Minoru Horie Takeshi Kimura

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0064, (Released:2017-06-20)

参考文献数

38

被引用文献数

23

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Background:TheSCN5Agene encodes the α subunit of the cardiac voltage-gated sodium channel, NaV1.5. The missense mutation, D1275N, has been associated with a range of unusual phenotypes associated with reduced NaV1.5 function, including cardiac conduction disease and dilated cardiomyopathy. Curiously, the reported biophysical properties ofSCN5A-D1275N channels vary with experimental system.Methods and Results:First, using a human embryonic kidney (HEK) 293 cell-based heterologous expression system, theSCN5A-D1275N channels showed similar maximum sodium conductance but a significantly depolarizing shift of activation gate (+10 mV) compared to wild type. Second, we generated human-induced pluripotent stem cells (hiPSCs) from a 24-year-old female who carried heterozygousSCN5A-D1275N and analyzed the differentiated cardiomyocytes (CMs). AlthoughSCN5Atranscript levels were equivalent between D1275N and control hiPSC-CMs, both the total amount of NaV1.5 and the membrane fractions were reduced approximately half in the D1275N cells, which were rescued by the proteasome inhibitor MG132 treatment. Electrophysiological assays revealed that maximum sodium conductance was reduced to approximately half of that in control hiPSC-CMs in the D1275N cells, and maximum upstroke velocity of action potential was lower in D1275N, which was consistent with the reduced protein level of NaV1.5.Conclusions:This study successfully demonstrated diminished sodium currents resulting from lower NaV1.5 protein levels, which is dependent on proteasomal degradation, using a hiPSC-based model forSCN5A-D1275N-related sodium channelopathy.

著者

Shota Fukuda Hiroyuki Watanabe Masao Daimon Yukio Abe Akihiro Hirashiki Kumiko Hirata Hiroshi Ito Masumi Iwai-Takano Katsuomi Iwakura Chisato Izumi Takayuki Hidaka Toshinori Yuasa Kazuya Murata Satoshi Nakatani Kazuaki Negishi Kazuhiro Nishigami Tomoko Nishikage Takahiro Ota Akihiro Hayashida Konomi Sakata Nobuhiro Tanaka Satoshi Yamada Kazuhiro Yamamoto Junichi Yoshikawa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.5, pp.1177-1181, 2012 (Released:2012-04-25)

参考文献数

27

被引用文献数

27 67

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Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population. Methods and Results: This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. All subjects had no history of cardiac disease and no risk factors. The mean values in men and women were as follows: 50±12ml/m2 and 46±9ml/m2 for left ventricular (LV) end-diastolic volume index, 19±5ml/m2 and 17±4ml/m2 for end-systolic volume index, 61±4% and 63±4% for ejection fraction, 64±12g/m2 and 56±11g/m2 for mass index, 23±6ml/m2 and 24±6ml/m2 for left atrial (LA) maximum volume index, 10±3ml/m2 and 10±3ml/m2 for minimum volume index, and 58±6% and 58±6% for percent volume change. LV sizes decreased with age, whereas LV mass index did not change. LA sizes slightly increased with age. Conclusions: This multicenter investigation determined normal reference values for LV and LA sizes, and their functional parameters on RT3DE in a large, healthy Japanese population. The results of the present study support the use of RT3DE for the diagnosis and management of cardiovascular disease. (Circ J 2012; 76: 1177-1181)

著者

佐藤 慶 山本 信次 広田 純一 Kei Sato Shinji Yamamoto Jun-ichi Hirota 岩手大学大学院農学研究科 岩手大学農学部 岩手大学農学部 Graduate School of Agriculture Iwate Univ. Faculty of Agriculture Iwate Univ. Faculty of Agriculture Iwate Univ

出版者

農村計画学会

雑誌

農村計画論文集 = Transactions of rural planning (ISSN:09129731)

巻号頁・発行日

vol.3, pp.241-246, 2001-12-07

参考文献数

5

被引用文献数

3

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本研究では、地域づくりの優良事例の内容をミクロに分析し「住民主導」の内実を明らかにすることを目的とした。本事例からは、地区住民から出された要望を地域リーダーが具体化し、それを自治会役員会が承認し、地区全体の活動として実施するという、活動における地域リーダー層の役割を明らかにすることができた。こうした地域リーダー層以外の一般住民の意識と活動に対する関与の実態を明らかにすることを目的としたアンケート調査を行った。その結果、地区住民の中には「地域づくりを支持はするが、自ら積極的にかかわりたいとまでは思わない」といういわば「消極的支持層」が存在することが明らかになった。In J area in Murone village, Iwate Prefecture, several community activities have been found to contribute to revitalization of the rural community and people's exchange with visitors. This study is to analyze the involvement of local people in the development process of those activities, to discuss how the activities became possible and to analyze the consciousness of local people about those activities. The result of the questionnaire are summarized as follows : 1) a half or more local people agreed to do those activities, 2) though some of them had intention of leaving up those activities to someone else.

著者

山本 直人 Yamamoto Naoto

出版者

名古屋大学文学部

雑誌

名古屋大学文学部研究論集 (ISSN:04694716)

巻号頁・発行日

vol.42, pp.43-99, 1996-03-31 (Released:2006-02-14)

著者

"豊田 幸子/山本 寿子" "トヨダ サチコ/ヤマモト ヒサコ" "TOYODA Sachiko/YAMAMOTO Hisako"

雑誌

名古屋女子大学紀要. 家政・自然編 = Journal of Nagoya Women's University. Home economics・natural science

巻号頁・発行日

vol.43, pp.45-55, 1997-03-09

著者

山本 英司 Eiji Yamamoto 奈良産業大学経済学部

雑誌

奈良産業大学産業と経済 = Nara Sangyo University, the journal of industrial economics (ISSN:09159789)

巻号頁・発行日

vol.20, no.3, pp.123-146, 2005-09-30

著者

山本 俊樹 ヤマモト トシキ Toshiki YAMAMOTO

雑誌

恵泉女学園大学人文学部紀要 = Keisen Jogakuen College Bulletin

巻号頁・発行日

vol.5, pp.69-89, 1993-01

著者

Tomoyuki Yamamoto Kazuhiro Shimizu Mao Takahashi Ichiro Tatsuno kohji Shirai

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.38646, (Released:2017-03-22)

参考文献数

32

被引用文献数

16

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Aim: The effect of nitroglycerin on proper arterial stiffness of the arterial tree has not been fully clarified. The cardio-ankle vascular index (CAVI), which is an application of the stiffness parameter β theory on the arterial tree from the origin of the aorta to the ankle, was developed recently. Furthermore, the stiffness of the aorta (heart-thigh β (htBeta)) and of the femoral-tibial arteries (thigh to ankle β (taBeta)) could be monitored by applying the same theory. The effects of nitroglycerin on CAVI, htBeta, and taBeta were studied comparing the values of healthy people and those of arteriosclerotic patients.Methods: The subjects were healthy people (CAVI <7.5, n=25) and arteriosclerotic patients (CAVI >9, n=25). Nitroglycerin (0.3 mg) was administrated sublingually, and various arterial stiffness indices were measured at one-minute intervals for a period of 20 minutes using Vasera VS-1500 (Fukuda Denshi, Tokyo).Results: After the administration of nitroglycerin in healthy people, CAVI decreased significantly after 5 min. [from 6.76(6.32-7.27) to 5.50(4.70-6.21), P<0.05], and recovered after 15 min. htBeta [from 5.10(4.76-5.76) to 3.96(3.35-4.79), P<0.05], and taBeta [from 14.41(10.80-16.33) to 10.72 (9.19-13.01), P<0.05] also decreased significantly. In arteriosclerotic patients, CAVI decreased after 5 min. [from 10.47(9.67-11.29) to 9.71(8.74-10.57), P<0.05] and recovered after 15 min. htBeta did not significantly change [from 12.00(11.46-13.21) to 11.81(10.14-13.83), ns], but taBeta decreased significantly [from 18.55(12.93-23.42) to 12.37(9.68-16.99), P<0.05].Conclusion: These results indicate that a nitroglycerin-induced decrease of arterial stiffness is more prominent in muscular arteries than in elastic arteries, and this effect was preserved much more prominently in arteriosclerotic patients than in healthy people.

著者

Acharya BS Actis M Aghajani T Agnetta G Aguilar J Aharonian F Ajello M Akhperjanian A Alcubierre M Aleksic J Alfaro R Aliu E Allafort AJ Allan D Allekotte I Amato E Anderson J Anguner EO Antonelli LA Antoranz P Aravantinos A Arlen T Armstrong T Arnaldi H Arrabito L Asano K Ashton T Asorey HG Awane Y Baba H Babic A Baby N Bahr J Bais A Baixeras C Bajtlik S Balbo M Balis D Balkowski C Bamba A Bandiera R Barber A Barbier C Barcelo M Barnacka A Barnstedt J de Almeida UB Barrio JA Basili A Basso S Bastieri D Bauer C Baushev A Becerra J Becherini Y Bechtol KC Tjus JB Beckmann V Bednarek W Behera B Belluso M Benbow W Berdugo J Berger K Bernard F Bernardino T Bernlohr K Bhat N Bhattacharyya S Bigongiari C Biland A Billotta S Bird T Birsin E Bissaldi E Biteau J Bitossi M Blake S Bigas OB Blasi P Bobkov A Boccone V Boettcher M Bogacz L Bogart J Bogdan M Boisson C Gargallo JB Bolmont J Bonanno G Bonardi A Bonev T Bonifacio P Bonnoli G Bordas P Borgland A Borkowski J Bose R Botner O Bottani A Bouchet L Bourgeat M Boutonnet C Bouvier A Brau-Nogue S Braun I Bretz T Briggs M Bringmann T Brook P Brun P Brunetti L Buanes T Buckley J Buehler R Bugaev V Bulgarelli A Bulik T Busetto G Buson S Byrum K Cailles M Cameron R Camprecios J Canestrari R Cantu S Capalbi M Caraveo P Carmona E Carosi A Carr J Carton PH Casanova S Casiraghi M Catalano O Cavazzani S Cazaux S Cerruti M Chabanne E Chadwick P Champion C Chen A Chiang J Chiappetti L Chikawa M Chitnis VR Chollet F Chudoba J Cieslar M Cillis A Cohen-Tanugi J Colafrancesco S Colin P Calome J Colonges S Compin M Conconi P Conforti V Connaughton V Conrad J Contreras JL Coppi P Corona P Corti D Cortina J Cossio L Costantini H Cotter G Courty B Couturier S Covino S Crimi G Criswell SJ Croston J Cusumano G Dafonseca M Dale O Daniel M Darling J Davids I Dazzi F De Angelis A De Caprio V De Frondat F Dal Pino EMD de la Calle I De La Vega GA Lopez RD De Lotto B De Luca A Neto JRTD de Naurois M de Oliveira Y Wilhelmi ED de Souza V Decerprit G Decock G Deil C Delagnes E Deleglise G Delgado C Della Volpe D Demange P Depaola G Dettlaff A Di Paola A Di Pierro F Diaz C Dick J Dickherber R Dickinson H Diez-Blanco V Digel S Dimitrov D Disset G Djannati-Atai A Doert M Dohmke M Domainko W Prester DD Donat A Dorner D Doro M Dournaux JL Drake G Dravins D Drury L Dubois F Dubois R Dubus G Dufour C Dumas D Dumm J Durand D Dyks J Dyrda M Ebr J Edy E Egberts K Eger P Einecke S Eleftheriadis C Elles S Emmanoulopoulos D Engelhaupt D Enomoto R Ernenwein JP Errando M Etchegoyen A Evans P Falcone A Fantinel D Farakos K Farnier C Fasola G Favill B Fede E Federici S Fegan S Feinstein F Ferenc D Ferrando P Fesquet M Fiasson A Fillin-Martino E Fink D Finley C Finley JP Fiorini M Curcoll RF Flores H Florin D Focke W Fohr C Fokitis E Font L Fontaine G Fornasa M Forster A Fortson L Fouque N Franckowiak A Fransson C Fraser G Frei R Albuquerque IFM Fresnillo L Fruck C Fujita Y Fukazawa Y Fukui Y Funk S Gabele W Gabici S Gabriele R Gadola A Galante N Gall D Gallant Y Gamez-Garcia J Garcia B Lopez RG Gardiol D Garrido D Garrido L Gascon D Gaug M Gaweda J Gebremedhin L Geffroy N Gerard L Ghedina A Ghigo M Giannakaki E Gianotti F Giarrusso S Giavitto G Giebels B Gika V Giommi P Girard N Giro E Giuliani A Glanzman T Glicenstein JF Godinovic N Golev V Berisso MG Gomez-Ortega J Gonzalez MM Gonzalez A Gonzalez F Munoz AG Gothe KS Gougerot M Graciani R Grandi P Granena F Granot J Grasseau G Gredig R Green A Greenshaw T Gregoire T Grimm O Grube J Grudzinska M Gruev V Grunewald S Grygorczuk J Guarino V Gunji S Gyuk G Hadasch D Hagiwara R Hahn J Hakansson N Hallgren A Heras NH Hara S Hardcastle MJ Harris J Hassan T Hatanaka K Haubold T Haupt A Hayakawa T Hayashida M Heller R Henault F Henri G Hermann G Hermel R Herrero A Hidaka N Hinton J Hoffmann D Hofmann W Hofverberg P Holder J Horns D Horville D Houles J Hrabovsky M Hrupec D Huan H Huber B Huet JM Hughes G Humensky TB Huovelin J Ibarra A Illa JM Impiombato D Incorvaia S Inoue S Inoue Y Ioka K Ismailova E Jablonski C Jacholkowska A Jamrozy M Janiak M Jean P Jeanney C Jimenez JJ Jogler T Johnson T Journet L Juffroy C Jung I Kaaret P Kabuki S Kagaya M Kakuwa J Kalkuhl C Kankanyan R Karastergiou A Karcher K Karczewski M Karkar S Kasperek A Kastana D Katagiri H Kataoka J Katarzynski K Katz U Kawanaka N Kellner-Leidel B Kelly H Kendziorra E Khelifi B Kieda DB Kifune T Kihm T Kishimoto T Kitamoto K Kluzniak W Knapic C Knapp J Knodlseder J Kock F Kocot J Kodani K Kohne JH Kohri K Kokkotas K Kolitzus D Komin N Kominis I Konno Y Koppel H Korohoda P Kosack K Koss G Kossakowski R Kostka P Koul R Kowal G Koyama S Koziol J Krahenbuhl T Krause J Krawzcynski H Krennrich F Krepps A Kretzschmann A Krobot R Krueger P Kubo H Kudryavtsev VA Kushida J Kuznetsov A La Barbera A La Palombara N La Parola V La Rosa G Lacombe K Lamanna G Lande J Languignon D Lapington J Laporte P Lavalley C Le Flour T Le Padellec A Lee SH Lee WH de Oliveira MAL Lelas D Lenain JP Leopold DJ Lerch T Lessio L Lieunard B Lindfors E Liolios A Lipniacka A Lockart H Lohse T Lombardi S Lopatin A Lopez M Lopez-Coto R Lopez-Oramas A Lorca A Lorenz E Lubinski P Lucarelli F Ludecke H Ludwin J Luque-Escamilla PL Lustermann W Luz O Lyard E Maccarone MC Maccarone TJ Madejski GM Madhavan A Mahabir M Maier G Majumdar P Malaguti G Maltezos S Manalaysay A Mancilla A Mandat D Maneva G Mangano A Manigot P Mannheim K Manthos I Maragos N Marcowith A Mariotti M Marisaldi M Markoff S Marszalek A Martens C Marti J Martin JM Martin P Martinez G Martinez F Martinez M Masserot A Mastichiadis A Mathieu A Matsumoto H Mattana F Mattiazzo S Maurin G Maxfield S Maya J Mazin D Mc Comb L McCubbin N McHardy I McKay R Medina C Melioli C Melkumyan D Mereghetti S Mertsch P Meucci M Michalowski J Micolon P Mihailidis A Mineo T Minuti M Mirabal N Mirabel F Miranda JM Mirzoyan R Mizuno T Moal B Moderski R Mognet I Molinari E Molinaro M Montaruli T Monteiro I Moore P Olaizola AM Mordalska M Morello C Mori K Mottez F Moudden Y Moulin E Mrusek I Mukherjee R Munar-Adrover P Muraishi H Murase K Murphy A Nagataki S Naito T Nakajima D Nakamori T Nakayama K Naumann C Naumann D Naumann-Godo M Nayman P Nedbal D Neise D Nellen L Neustroev V Neyroud N Nicastro L Nicolau-Kuklinski J Niedzwiecki A Niemiec J Nieto D Nikolaidis A Nishijima K Nolan S Northrop R Nosek D Nowak N Nozato A O'Brien P Ohira Y Ohishi M Ohm S Ohoka H Okuda T Okumura A Olive JF Ong RA Orito R Orr M Osborne J Ostrowski M Otero LA Otte N Ovcharov E Oya I Ozieblo A Padilla L Paiano S Paillot D Paizis A Palanque S Palatka M Pallota J Panagiotidis K Panazol JL Paneque D Panter M Paoletti R Papayannis A Papyan G Paredes JM Pareschi G Parks G Parraud JM Parsons D Arribas MP Pech M Pedaletti G Pelassa V Pelat D Perez MDC Persic M Petrucci PO Peyaud B Pichel A Pita S Pizzolato F Platos L Platzer R Pogosyan L Pohl M Pojmanski G Ponz JD Potter W Poutanen J Prandini E Prast J Preece R Profeti F Prokoph H Prouza M Proyetti M Puerto-Gimenez I Puhlhofer G Puljak I Punch M Pyziol R Quel EJ Quinn J Quirrenbach A Racero E Rajda PJ Ramon P Rando R Rannot RC Rataj M Raue M Reardon P Reimann O Reimer A Reimer O Reitberger K Renaud M Renner S Reville B Rhode W Ribo M Ribordy M Richer MG Rico J Ridky J Rieger F Ringegni P Ripken J Ristori PR Riviere A Rivoire S Rob L Roeser U Rohlfs R Rojas G Romano P Romaszkan W Romero GE Rosen S Lees SR Ross D Rouaix G Rousselle J Rousselle S Rovero AC Roy F Royer S Rudak B Rulten C Rupinski M Russo F Ryde F Sacco B Saemann EO Saggion A Safiakian V Saito K Saito T Saito Y Sakaki N Sakonaka R Salini A Sanchez F Sanchez-Conde M Sandoval A Sandaker H Sant'Ambrogio E Santangelo A Santos EM Sanuy A Sapozhnikov L Sarkar S Sartore N Sasaki H Satalecka K Sawada M Scalzotto V Scapin V Scarcioffolo M Schafer J Schanz T Schlenstedt S Schlickeiser R Schmidt T Schmoll J Schovanek P Schroedter M Schultz C Schultze J Schulz A Schure K Schwab T Schwanke U Schwarz J Schwarzburg S Schweizer T Schwemmer S Segreto A Seiradakis JH Sembroski GH Seweryn K Sharma M Shayduk M Shellard RC Shi J Shibata T Shibuya A Shum E Sidoli L Sidz M Sieiro J Sikora M Silk J Sillanpaa A Singh BB Sitarek J Skole C Smareglia R Smith A Smith D Smith J Smith N Sobczynska D Sol H Sottile G Sowinski M Spanier F Spiga D Spyrou S Stamatescu V Stamerra A Starling R Stawarz L Steenkamp R Stegmann C Steiner S Stergioulas N Sternberger R Sterzel M Stinzing F Stodulski M Straumann U Strazzeri E Stringhetti L Suarez A Suchenek M Sugawara R Sulanke KH Sun S Supanitsky AD Suric T Sutcliffe P Sykes J Szanecki M Szepieniec T Szostek A Tagliaferri G Tajima H Takahashi H Takahashi K Takalo L Takami H Talbot C Tammi J Tanaka M Tanaka S Tasan J Tavani M Tavernet JP Tejedor LA Telezhinsky I Temnikov P Tenzer C Terada Y Terrier R Teshima M Testa V Tezier D Thuermann D Tibaldo L Tibolla O Tiengo A Tluczykont M Peixoto CJT Tokanai F Tokarz M Toma K Torii K Tornikoski M Torres DF Torres M Tosti G Totani T Toussenel C Tovmassian G Travnicek P Trifoglio M Troyano I Tsinganos K Ueno H Umehara K Upadhya SS Usher T Uslenghi M Valdes-Galicia JF Vallania P Vallejo G van Driel W van Eldik C Vandenbrouke J Vanderwalt J Vankov H Vasileiadis G Vassiliev V Veberic D Vegas I Vercellone S Vergani S Veyssiere C Vialle JP Viana A Videla M Vincent P Vincent S Vink J Vlahakis N Vlahos L Vogler P Vollhardt A von Gunten HP Vorobiov S Vuerli C Waegebaert V Wagner R Wagner RG Wagner S Wakely SP Walter R Walther T Warda K Warwick R Wawer P Wawrzaszek R Webb N Wegner P Weinstein A Weitzel Q Welsing R Werner M Wetteskind H White R Wierzcholska A Wiesand S Wilkinson M Williams DA Willingale R Winiarski K Wischnewski R Wisniewski L Wood M Wornlein A Xiong Q Yadav KK Yamamoto H Yamamoto T Yamazaki R Yanagita S Yebras JM Yelos D Yoshida A Yoshida T Yoshikoshi T Zabalza V Zacharias M Zajczyk A Zanin R Zdziarski A Zech A Zhao A Zhou X Zietara K Ziolkowski J Ziolkowski P Zitelli V Zurbach C Zychowski P

雑誌

ASTROPARTICLE PHYSICS (ISSN:09276505)

巻号頁・発行日

vol.43, pp.3-18, 2013

著者

山本 俊樹 津田 博史 ヤマモト トシキ ツダ ヒロシ Yamamoto Toshiki Tsuda Hiroshi

出版者

同志社大学ハリス理化学研究所

雑誌

同志社大学ハリス理化学研究報告 = The Harris science review of Doshisha University (ISSN:00368172)

巻号頁・発行日

vol.56, no.1, pp.29-40, 2015-04

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観光産業は、日本の主要産業であるが、平成18年度に旅行消費額が30兆円に至ったものの、平成22年度は、約24兆円へと低下した。そのため、日本政府は、観光産業の活性化を図るため「平成28年度までに国内における旅行消費額を30兆円に拡大する。」という観光立国推進計画を平成24年3月30日に発表した。一方、昨今、ネット社会が急速に広がる中、cyber worldを利用したビジネスが急速に拡大してきており、観光産業においても例外ではない。ここ最近では、各旅行会社が企画・運営している旅行プランに満足できず、旅行会社に企画してもらうのではなく、自分で旅行プランを立てる人の数が増加してきている。このような人々は個人旅行者と呼ばれ、個人旅行者の多くはインターネットを利用して宿泊場所や宿泊プランの予約を行いつつある。今後のIT産業の発展を考慮に入れると、このようにインターネットを通して宿泊予約をする個人旅行者の数が増加することが予想される。そこで、本研究では、世界的な観光都市である京都の宿泊施設に焦点を当てた。京都を訪問する観光客は個人旅行者の割合が多いのが特徴である。Webサイトから収集した京都市内の宿泊施設の宿泊プランの空室数と価格のデータを用いて、京都市内の宿泊施設の客室稼働率と経済規模を日次で推定することを試みた。推定した客室稼働率と経済規模から季節変動や曜日効果などを見出したと共に、京都駅からの距離や宿泊施設の規模などで宿泊施設を分類することにより、新しい知見が得られた。Tourism is a key industry in Japan. However, although domestic travel expenditure reached 30 trillion yen in fiscal 2006, it subsequently declined to approximately 24 trillion yen in fiscal 2010. For this reason, on March 30, 2012, the Japanese government announced a tourism nation promotion plan to stimulate the tourism industry with the objective of increasing domestic travel expenditure to 30 trillion yen by fiscal 2016. At the same time, the rapid spread of the Internet in society has brought a rapid expansion of business conducted utilizing the cyber world, with the tourism industry being no exception. In recent years, the number of people who are not satisfied with tours planned and operated by travel agencies and who construct their own travel plans instead of relying on travel agencies has been increasing. Many of these people, called free independent travelers, are using the Internet to book lodgings. Taking into account future developments in the IT industry, an increase in the number of such individual travelers is expected. Accordingly, the present study focuses on lodging facilities in Kyoto City, a global tourism destination. A large proportion of the tourists who visit Kyoto are individual travelers. Using data on the number of room vacancies and prices for accommodation packages at lodging facilities in Kyoto City collected from websites, we estimated the daily occupancy rates of lodging facilities and the economic scale of Kyoto City. From these estimates, we could also gain such information as seasonal variations and day-of-the-week effects. Additional information was obtained by classifying lodging facilities according to factors such as their distance from Kyoto Station and the number of rooms of lodging facility.

著者

Seiko Toyozawa Chikako Kaminaka Fukumi Furukawa Yasushi Nakamura Hiroshi Matsunaka Yuki Yamamoto

出版者

日本組織細胞化学会

雑誌

ACTA HISTOCHEMICA ET CYTOCHEMICA (ISSN:00445991)

巻号頁・発行日

vol.45, no.5, pp.293-299, 2012 (Released:2012-10-31)

参考文献数

22

被引用文献数

11 19

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The CXCR4/CXCL12 pathway has recently been reported to be involved in stimulating the metastasis of many different neoplasms, in which CXCR4 activates various phenomena such as chemotaxis, invasion, angiogenesis and proliferation. The purpose of this study was to analyze a possible association between the expression of chemokine receptors CXCR4, CCR6 and CCR7 with the clinicopathological features of cutaneous malignant melanoma, and to assess the usefulness of these chemokine receptors for diagnosis and prognosis. In our study, a percentage of immunoexpression of both CXCR4 and its ligands CXCL12 was associated with high clinical risk. In contrast, the patients with a low immunoexpression of CXCR4 and CXCL12 had low clinical risk. CCR6 and CCR7 immunoexpressions were also correlated with some clinical parameters, but seemed no more useful than CXCR4. These data suggest that the assessment of CXCR4 immunoexpression is a novel tool for predicting tumor aggressiveness in malignant melanomas, and in particular, a high immunoexpression percentage of CXCR4 and CXCL12 might be a sign of a poor prognosis.

著者

Hideo Sasai Nobuyuki Shimozawa Takahiko Asano Norio Kawamoto Takahiro Yamamoto Takeshi Kimura Minako Kawamoto Eiko Matsui Toshiyuki Fukao

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.237, no.4, pp.323-327, 2015 (Released:2015-12-04)

参考文献数

11

被引用文献数

2 9

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Cystathionine β-synthase (CBS) deficiency, well known as classical homocystinuria, is a rare autosomal recessive inborn error of homocysteine and sulfur metabolism. CBS converts homocysteine to cystathionine. The clinical features of untreated CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Cerebral white matter lesions (CWMLs), identified in magnetic resonance imaging (MRI), are related to various clinical conditions including ischemia, inflammation, demyelination, infection, a tumor, and metabolic disorders such as phenylketonuria. The presence of CWMLs is, however, believed to be a very rare condition in CBS-deficient patients. Herein, we report reversible CWMLs associated with hypermethioninemia caused by poor protein restriction and betaine therapy in a 21-year-old male with pyridoxine-nonresponsive CBS deficiency. T2-weighted images (T2WI) and fluid-attenuated inversion-recovery (FLAIR) images showed diffuse high signal intensity in subcortical areas extending to the deep white matter. Diffusion-weighted images (DWI) showed high signal intensity, while apparent diffusion coefficient (ADC) map demonstrated decreased ADC value in the lesions. The course of improvement after correct methionine restriction was successively followed by brain MRI. The CWMLs had regressed at 1 month after restriction, and disappeared after 5 months. ADC values were very low before proper methionine restriction, but normalized after 2 months. Use of betaine in the presence of elevated plasma methionine may increase the risk of reversible CWMLs in some CBS-deficient patients.

著者

Shinji TANIMURA Hiroyuki HAYASHI Terumi YAMAMOTO Koji MIMURA

出版者

The Japan Society of Mechanical Engineers

雑誌

Journal of Solid Mechanics and Materials Engineering (ISSN:18809871)

巻号頁・発行日

vol.3, no.12, pp.1263-1273, 2009 (Released:2009-12-25)

参考文献数

19

被引用文献数

11 18

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Through intensive analysis of the tensile stress-strain curves of a variety of steel sheets over a wide range of strain rates on the order of 10-2 ∼103 s-1 obtained by using the Sensing Block Type High Speed Material Testing System, it was confirmed that the newly-partially extended constitutive model (Tanimura-Mimura Model) is useful to simulate the dynamic stress-strain curves for the entire range of deformation reaching as far as fracture over the wide strain rate range, as long as the quasi-static stress-strain curve of the material concerned is only known in advance. Dynamic tensile properties, over the wide strain rate range and the entire strain region reaching the true fracture strain, of ten kinds of aluminum alloys, which compose of a wide strength level from a commercial pure aluminum to the extra super duralumin are systematically studied. It was cleared that the aluminum alloys belonging to the one group exhibit the positive strain rate sensitivity and the aluminum alloys belonging to another group exhibit the negative sensitivity or almost non sensitivity. It was found that the values of the true fracture strain εf are substantially not affected by the strain rates, for all the tested aluminum alloys, and are closely related to the values of the tensile strength σB whose values are obtained by the quasi-static nominal tensile stress-strain curves.

著者

Yamamoto Wataro

出版者

札幌博物學會

雑誌

札幌博物学会会報

巻号頁・発行日

vol.13, no.3, pp.139-143, 1934-06-20

著者

Sakai Harumi Yamamoto Chikara Iwata Akihisa

出版者

Ichthyological Society of Japan

雑誌

Ichthyological research formerly Japanese Journal of Ichthyology (ISSN:13418998)

巻号頁・発行日

vol.45, no.4, pp.363-376, 1998-11-26

被引用文献数

4

著者

Yamamoto Satoshi Masuda Reiji Sato Yukuto Sado Tetsuya Araki Hitoshi Kondoh Michio Minamoto Toshifumi Miya Masaki

出版者

Springer Nature

雑誌

Scientific Reports

巻号頁・発行日

vol.7, 2017-01-12

被引用文献数

310

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わずか1日の調査で魚種の8割を検出 : 海水からのDNA解析法で. 京都大学プレスリリース. 2017-01-13.

著者

Hasegawa Kazuya Yamashita Keitaro Murai Tomohiro Nuemket Nipawan Hirata Kunio Ueno Go Ago Hideo Nakatsu Toru Kumasaka Takashi Yamamoto Masaki

出版者

International Union of Crystallography

雑誌

Journal of synchrotron radiation (ISSN:16005775)

巻号頁・発行日

vol.24, no.Pt. 1, pp.29-41, 2017-01

被引用文献数

38

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微小タンパク質結晶からの効率的な構造解析法 : 凍結した試料を回転させる「SS-ROX法」を確立、汎用化へ. 京都大学プレスリリース. 2017-01-12.

著者

松本 満臣 堀越 浩幸 茂木 孝夫 羽鳥 昇 舘野 之男 飯沼 武 松本 徹 山本 真司 馬場 孝 マツモト ミツオミ ホリコシ ヒロユキ モテキ タカオ ハトリ ノボル タテノ ユキオ イイヌマ タケシ マツモト トオル ヤマモト シンジ ババ タカシ Matsumoto Mitsuomi Horikoshi Hiroyuki Moteki Takao Hatori Noboru Tateno Yukio Iinuma Takeshi Matsumoto Tohru Yamamoto Shinji Baba Takashi

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.55, no.3, pp.172-179, 1995-02-25

被引用文献数

10

著者

栗井 和夫 山根 浩介 西岡 康二 山本 和生 辻 修一 福岡 浩仁 東 和義 広川 裕 伊藤 勝陽 市木 敏夫 藤川 光一 西田 修実 アワイ カズオ ヤマネ コウスケ ニシオカ ヤスジ ヤマモト カズオ ツジイ シュウイチ フクオカ ハルヒト アズマ カズヨシ ヒロカワ ユタカ イトウ カツヒデ イチキ チシオ フジカワ コウイチ ニシダ オサム Awai Kazuo Yamane Kosuke Nishioka Yasuji Yamamoto Kazuo Tsujii Shyuichi Fukuoka Haruhito Azuma Kazuyoshi Hirokawa Yutaka Ito Katsuhide Ichiki Toshio Fujikawa Koichi Nishida Osami

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.51, no.6, pp.656-662, 1991-06-25

著者

Xianda Kong Hisashi Yamamoto Jing Sun Masayuki MATSUI

出版者

Japan Management Training Center

雑誌

Innovation and Supply Chain Management (ISSN:21870969)

巻号頁・発行日

vol.10, no.2, pp.61-67, 2016-06-30 (Released:2016-12-21)

参考文献数

32

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In uncertain cases, the result and efficiency of a current period (or production cycle) are in?uenced not only by the risks which exist in current period but also by the risks which exist in the previous ones. What is more, the risk itself is also affected greatly by the risks which exist in the earlier periods. This kind of problem is called a limited-cycle problem with multiple periods. Normally, workers ’efficiency is different on different tasks. How can we get an optimal assignment to minimize the total expected costs? In this paper, we consider the optimal worker assignment considering two kinds of efficiency, clever or poor efficiency on tasks. The regularity will be described that n-1 workers have two clever tasks of all, 1 worker has no clever task by contrast. Also, some numerical experiments will be done to check out the regularity of the optimal assignment that each worker has two or three clever tasks.