著者

Sukegawa Noriyoshi Yamamoto Yoshitsugu

出版者

Springer

雑誌

Japan journal of industrial and applied mathematics (ISSN:09167005)

巻号頁・発行日

vol.29, no.3, pp.547-560, 2012-10

被引用文献数

4

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Concerning the strategic manipulability of the stable matching produced by the Gale–Shapley algorithm, Kobayashi and Matsui recently considered the existence problem of a preference profile of women, that is, given a preference profile of men, find a preference profile of women that makes the Gale–Shapley algorithm produce the prescribed complete matching of men and women. Reformulating this problem by introducing the set of proposals to be made through the execution of the algorithm, and switching the roles of men and women, we consider the existence problem of a preference profile of men and show that the problem is reduced to a problem of checking if a directed graph is a rooted tree and it is solvable in polynomial time. We also show that the existence problem of preference profiles of both sexes when a set of proposals is given is solvable in polynomial time.

著者

Leiner Johannes Saleem Sajid Fenton J. C. Yamamoto Takashi Kadowaki Kazuo Warburton P. A.

出版者

American Institute of Physics

雑誌

Applied physics letters (ISSN:00036951)

巻号頁・発行日

vol.95, no.25, pp.252505, 2009-12

被引用文献数

2 2

---

We have measured the response of an array of Bi2Sr2CaCu2O8+delta intrinsic Josephson junctions to irradiation at 3 GHz. By measuring the dependence of the switching current upon the radio-frequency current for five of the junctions in the array we show quantitatively that the junctions have identical impedances at 3 GHz, this impedance being given by the inverse of the slope of the current-voltage characteristics.

著者

Koshelev A. E. Buzdin A. I. Kakeya I. Yamamoto T. Kadowaki K.

出版者

American Physical Society

雑誌

Physical review B (ISSN:10980121)

巻号頁・発行日

vol.83, no.22, pp.224515, 2011-06

被引用文献数

9

---

In strongly anisotropic layered superconductors in tilted magnetic fields, the Josephson vortex lattice coexists with the lattice of pancake vortices. Due to the interaction between them, the dissipation of the Josephson vortex lattice is very sensitive to the presence of the pancake vortices. If the c-axis magnetic field is smaller than the corresponding lower critical field, the pancake stacks are not formed but the individual pancakes may exist in the fluctuational regime either near the surface in large-size samples or in the central region for small-size mesas. We calculate the contribution of such fluctuating pancake vortices to the c-axis conductivity of the Josephson vortex lattice and compare the theoretical results with measurements on small mesas fabricated out of Bi2Sr2CaCu2O8+δ crystals. A fingerprint of fluctuating pancakes is a characteristic exponential dependence of the c-axis conductivity observed experimentally. Our results provide strong evidence of the existence of the fluctuating pancakes and their influence on the Josephson vortex lattice dissipation.

著者

Sasaoka Kenji Yamamoto Takahiro Watanabe Satoshi Shiraishi Kenji

出版者

American Physical Society

雑誌

Physical review B (ISSN:10980121)

巻号頁・発行日

vol.84, no.12, pp.125403, 2011-09

被引用文献数

5

---

The alternating-current response of a quantum point contact (QPC) is numerically investigated using the nonequilibrium Green function method combined with an effective mass theory. We found that the susceptance of a QPC increases stepwise with increasing gate voltage, when the width of the quantization plateau in the gate voltage-conductance curve is narrower than the width of the region where the conductance changes gradually. We also show that the height of a susceptance step is proportional to the ac-bias frequency. These simulation results are in excellent qualitative agreement with recent experimental results. Moreover, we found that the transition from capacitive susceptance to inductive susceptance occurs with increasing gate voltage. The capacitive-inductive transition point is independent of the ac-bias frequency, but it does depend on the contact width.

著者

福井 聡 河村 正 片岡 正明 藤井 崇 山本 浩司 吉岡 真二 池添 潤平 フクイ アキラ カワムラ マサシ カタオカ マサアキ フジイ タカシ ヤマモト コウジ ヨシオカ シンジ イケゾエ ジュンペイ Fukui Akira Kawamura Masashi Kataoka Masaaki Fujii Takashi Yamamoto Koji Yoshioka Shinji Ikezoe Junpei

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.58, no.1, pp.25-33, 1998-01-25

著者

Akiyama Suguru Kurahashi Teruo Morito Ken Yamamoto Tsuyoshi Usuki Tatsuya Nomura Shintaro

出版者

Optical Society of America

雑誌

Optics Express (ISSN:10944087)

巻号頁・発行日

vol.20, no.15, pp.16321-16338, 2012-07

被引用文献数

14 2

---

A cascaded-ring-resonator-loaded Mach–Zehnder modulator (CRR-MZM) is presented in which a number of cascaded ring resonators (RRs) are loaded in the interferometer as phase modulators. The ability of the design to provide enhanced modulation efficiency at a wide optical bandwidth is demonstrated in comparison with a conventional single-RR-type modulator without an interferometer. The optimization of RRs for the CRR-MZM is investigated experimentally by measuring the transmission spectra in both intensity and group delay of RRs having various structural parameters. Using the optimized parameters, we fabricated a CRR-MZM with 10 cascaded RRs loaded on each arm of the interferometer on a silicon-on-insulate substrate. The RRs had pin-diodes along the waveguides, which were operated with forward bias voltage. Its modulation efficiency was enhanced by a factor of 4.4 at the expense of additional loss of less than 3.5 dB compared with a standard non-resonant MZM. 10 Gb/s-operations of CRR-MZM were successfully demonstrated using pre-emphasized RF signals with amplitude of 1.5 Vpp in a wavelength range of 2 nm.

著者

Momoko TANIGAWA Yukita SATO Hiroko EJIRI Takayuki IMURA Rei CHIBA Hanae YAMAMOTO Makoto KAWAGUCHI Yoshio TSUDA Koichi MURATA Masayoshi YUKAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0359, (Released:2012-10-31)

被引用文献数

3 19

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We investigated for the first time the prevalence of avian haemosporidia of genera Plasmodium, Haemoproteus, and Leucocytozoon among birds and mosquitoes on Tsushima Island of Japan, which is located between Japan and the Korean Peninsula. Of 55 wild birds belonging to 33 species, 16 (29.1%) tested positive for haemosporidia as follows: Plasmodium spp. (11/55; 20.0%); Haemoproteus spp. (2/55; 3.6%); and Leucocytozoon spp. (3/55; 5.5%). A genetic lineage isolated from the Eurasian Sparrowhawk (Accipiter nisus) was identical to that of the known avian malaria parasite P. circumflexum. Several genetic lineages were identical or closely related to the parasite lineages that were previously detected in birds and mosquitoes in Japan and Korea. Another single identical genetic lineage was also detected in both migratory and resident birds. A total of 753 mosquitoes from 12 species were collected; and one fully fed Aedes albopictus was positive for avian Plasmodium (1/753; 0.13%) which is identical to a genetic lineage detected in both mosquitoes in Japan and birds in Korea. Blood-meal identifications of blood-fed mosquitoes showed direct contact between the mosquitoes and 4 species of mammals including humans, cattle, rodents, and the endangered Tsushima leopard cat (Prionailurus bengalensis euptilura). Migratory birds use Tsushima Island as a site for wintering, breeding, and resting, and our results suggest the transmission of avian haematozoa between resident and migratory birds during their stay on Tsushima Island.

著者

Iwamoto Mitsugu Koga Hiroki Yamamoto Hirosuke

出版者

IEEE

雑誌

IEEE transactions on information theory (ISSN:00189448)

巻号頁・発行日

vol.58, no.9, pp.6194-6206, 2012-09

被引用文献数

1

---

Coding theorems on a $(2,2)$-threshold scheme with an opponent are discussed in an asymptotic setup, where the opponent tries to impersonate one of the two participants. A situation is considered where $n$ secrets $S^{n}$ from a memoryless source is blockwisely encoded to two shares and the two shares are decoded to $S^{n}$ with permitting negligible decoding error. We introduce correlation level of the two shares and characterize the minimum attainable rates of the shares and a uniform random number for realizing a $(2, 2)$-threshold scheme that is secure against the impersonation attack by the opponent. It is shown that if the correlation level between the two shares equals to $ell geq 0$, the minimum attainable rates coincide with $H(S)+ell $, where $H(S)$ denotes the entropy of the source, and the maximum attainable exponent of the success probability of the impersonation attack equals to $ell $. It is also shown that a simple scheme using an ordinary $(2,2)$-threshold scheme attains all the bounds as well.

著者

Hiroshi Fujii Yu Ikeuchi Yasutaka Kurata Nobuhito Ikeda Udin Bahrudin Peili Li Yuji Nakayama Ryo Endo Akira Hasegawa Kumi Morikawa Junichiro Miake Akio Yoshida Kyoko Hidaka Takayuki Morisaki Haruaki Ninomiya Yasuaki Shirayoshi Kazuhiro Yamamoto Ichiro Hisatome

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-12-0126, (Released:2012-09-04)

参考文献数

27

被引用文献数

3 2

---

Background: The prion protein (PrP) has been reported to serve as a surface maker for isolation of cardiomyogenic progenitors from murine embryonic stem (ES) cells. Although PrP-positive cells exhibited automaticity, their electrophysiological characteristics remain unresolved. The aim of the present study was therefore to investigate the electrophysiological properties of PrP-positive cells in comparison with those of HCN4p-or Nkx2.5-positive cells. Methods and Results: Differentiation of AB1, HCN5p-EGFP and hcgp7 ES cells into cardiac progenitors was induced by embryoid body (EB) formation. EBs were dissociated and cells expressing PrP, HCN4-EGFP and/or Nkx2.5-GFP were collected via flow cytometry. Sorted cells were subjected to reverse transcriptase-polymerase chain reaction, immunostaining and patch-clamp experiments. PrP-positive cells expressed mRNA of undifferentiation markers, first and second heart field markers, and cardiac-specific genes and ion channels, indicating their commitment to cardiomyogenic progenitors. PrP-positive cells with automaticity showed positive and negative chronotropic responses to isoproterenol and carbamylcholine, respectively. Hyperpolarization-activated cation current (If) was barely detectable, whereas Na+ and L-type Ca2+ channel currents were frequently observed. Their spontaneous activity was slowed by inhibition of sarcoplasmic reticulum Ca2+ uptake and release but not by blocking If. The maximum diastolic potential of their spontaneous firings was more depolarized than that of Nkx2.5-GFP-positive cells. Conclusions: PrP-positive cells contained cardiac progenitors that separated from the lineage of sinoatrial node cells. PrP can be used as a marker to enrich nascent cardiac progenitors.

著者

Yasuhiro YOSHIKAWA Motohiro HORIUCHI Naotaka ISHIGURO Mutsuyo KADOHIRA Satoshi KAI Hidehiro MIZUSAWA Chisato NAGATA Takashi ONODERA Tetsutaro SATA Toshiyuki TSUTSUI Masahito YAMADA Shigeki YAMAMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.8, pp.959-968, 2012 (Released:2012-09-03)

参考文献数

13

---

The Food Safety Commission (FSC) of Japan, established in July 2003, has its own initiative to conduct risk assessments on food stuffs known as “self-tasking assessment”. Within this framework, the FSC decided to conduct a risk assessment of beef and beef offal imported into Japan from countries with no previous BSE reports; thus, a methodology was formed to suit to this purpose. This methodology was partly based on the previous assessments of Japanese domestic beef and beef imported from U.S.A./Canada, but some modifications were made. Other organizations’ assessment methods, such as those used for BSE status assessment in live cattle by the OIE and EFSA’s GBR, were also consulted. In this review, the authors introduce this alternative methodology, which reflects (1) the risk of live cattle in the assessed country including temporal risks of BSE invasion and domestic propagation, with the assessment results verified by surveillance data, and (2) the risk of beef and beef offal consisting of cumulative BSE risk by types of slaughtering and meat production processes implemented and the status of mechanically recovered meat production. Other possible influencing factors such as atypical BSE cases were also reviewed. The key characteristic of the current assessment is a combination of the time-sequential risk level of live cattle and qualitative risk level of meat production at present in an assessed country.

著者

Miho TANAKA Akiko INOUE Kei YAMAMOTO Satoshi TAMAHARA Naoaki MATSUKI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.733-737, 2012 (Released:2012-07-04)

参考文献数

29

被引用文献数

2 5

---

Necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE) and granulomatous meningoencephalomyelitis (GME) are common idiopathic inflammatory central nervous system (CNS) diseases with unknown etiology in dogs. We previously showed that IgG autoantibodies in the cerebrospinal fluid (CSF) of NME cases reacted to unknown brain proteins as well as to glial fibrillary acidic protein (GFAP). In the present report, we evaluated the autoantibodies against transglutaminase2 (TG2) in the canine CNS diseases. CSF samples obtained from dogs with NME (n=19), NLE (n=7), GME (n=11) and miscellaneous CNS diseases (n=12) were subjected. CSFs from 20 healthy dogs were used as controls. Indirect fluorescent antibody test on the canine cerebrum revealed astrocyte-binding IgG in the CSF of NME. After absorption of the CSF with bovine GFAP, the CSF still possessed the reactivity to astrocytes. Double-color staining showed clear colocalization of the autoantibodies and anti-human TG2 rabbit polyclonal IgG. An immunoblot assay against human recombinant TG2 revealed anti-TG2 IgG in the CSF from dogs with NME, NLE and GME. The CSF of canine idiopathic encephalitis cases, notably of NME, tended to show high ELISA OD values against human recombinant TG2 compared to healthy controls. The presence of anti-TG2 autoantibodies in the CSF may contribute to the elucidation of the etiology of canine NME, NLE and GME.

著者

Masao Iwagami Kanae Kubo Ryoichi Tanaka Kimito Kawahata Akiko Okamoto Noboru Hagino Kazuhiko Yamamoto

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.50, no.20, pp.2413-2416, 2011 (Released:2011-10-15)

参考文献数

14

被引用文献数

3 8

---

We present the first documented case of thrombotic thrombocytopenic purpura (TTP) with severe hypertension complicated by polymyositis and systemic sclerosis sine scleroderma. TTP developed in the progressive phase of visceral fibrosis in the absence of skin thickening. ADAMTS13 activity was not useful for the diagnosis of TTP. Although TTP and scleroderma renal crisis (SRC) share similar findings of thrombotic microangiopathy, severe thrombocytopenia with multiple organ injuries and hemorrhagic manifestations suggested TTP rather than SRC. The patient's condition improved dramatically with plasmapheresis.

著者

Satoru OSUKA Shingo TAKANO Shinya WATANABE Eiichi ISHIKAWA Tetsuya YAMAMOTO Akira MATSUMURA

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.52, no.4, pp.186-193, 2012 (Released:2012-04-23)

参考文献数

31

被引用文献数

14 52

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Antiangiogenic strategy is promising for malignant glioma. Histone deacetylase inhibitors (HDACIs) are unique anticancer agents that exhibit antiangiogenic effects. The in vitro and in vivo antiangiogenic effects of HDACIs, valproic acid (VPA), were investigated in malignant glioma in the brain. In vitro, VPA preferentially inhibited endothelial cell proliferation compared to glioma cell proliferation at the optimum concentration in a dose-dependent manner. VPA reduced vascular endothelial growth factor (VEGF) secretion of glioma cells in a dose-dependent manner under both normoxic and hypoxic conditions. VPA was also found to inhibit tube formation in the angiogenesis assay. In vivo, treatment with VPA combined with irinotecan reduced the number of vessels expressing factor VIII in the brain tumor model. VPA inhibits glioma angiogenesis by direct (inhibition of endothelial cell proliferation and tube formation) and indirect (decreased secretion of VEGF by glioma cells) mechanisms. These data suggest a potential role for VPA as an adjuvant therapy for patients with malignant glioma.

著者

Ryoji TAKATA Reiko YAMAMOTO Takaaki YANAI Tomonori KONNO Toshiyuki OKUBO

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.69, no.11, pp.2042-2050, 2005 (Released:2005-11-23)

参考文献数

39

被引用文献数

36 45

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The fruit juice of black currant was found to contain a polysaccharide-rich substance, which was designated cassis polysaccharide (CAPS), with macrophage-stimulating activity. Especially, its interleukin (IL)-1β-inducing activity was remarkably high, compared with other fruit juice preparations. CAPS was found to consist of rhamnose, mannose, arabinose, galactose, xylose, and glucose in a molar ratio of 11.3:0.9:54.1:29.8:2.0:1.9. CAPS turned out to be partitioned into a soluble component (CAPS-l.m.) and a precipitable component (CAPS-h.m.) with mean MWs of 80,000 and 600,000 respectively in 45% (v/v) ethanol solution. At least in vitro, CAPS-l.m. rather than CAPS-h.m. appeared to play an important role in macrophage activation. Oral administration of black currant juice and CAPS to Ehrlich carcinoma-bearing mice retarded the growth of the solid tumor by 45% and 51% respectively. CAPS administration had a stimulatory effect on the release of IL-2, IL-10, interferon-γ, and IL-4 from splenocytes in comparison with PBS treatment in tumor-bearing mice. The IL-4 level was, however, still lower than that exhibited by a group of normal mice. CAPS showed a certain cytotoxicity directly against tumor cells.

著者

Sato Jun Yamamoto Yasuhito Nakamura Tsuneaki ISHIDA Shigeru TAKAGI Yutaka

出版者

日本毒性学会

雑誌

Journal of toxicological sciences (ISSN:03881350)

巻号頁・発行日

vol.30, no.4, pp.339-347, 2005-12-21

被引用文献数

2 3

---

We evaluated the toxicity of tetradecanoic acid methyl ester sodium salt (C14-MES), a major component of fabric detergents, following the test guidelines of the Organization for Economic Cooperation and Development. The rat acute oral LD_<50> was 1,000 mg/kg in males and 500 mg/kg in females. Applying the combined repeated dose and reproductive/developmental toxicity screening test (ReproTox), we exposed groups of Crj:CD (SD) IGS rats to C14-MES in the diet at concentrations of 0, 0.3, 0.6, or 1.2%. We observed decreases in fibrinogen levels and longer prothrombin time at the 1.2% treated level in females and decreases in serum triglyceride levels in both sexes at the 0.6% and 1.2% treatment levels, but the effects were not clinically significant. The no-observed-effect-level (NOEL) for repeated dose toxicity was 0.3% (175 mg/kg body weight/day for males, 249 for females). The NOEL for reproduction/developmental toxicity was 1.2% (740 mg/kg for males, 1039 for females). C14-MES was negative in the reverse gene mutation assay and the chromosomal aberration test and did not induce skin sensitization in the guinea pig maximization test. These data confirm that C14-MES is of low hazard potential.

著者

Tsugunobu Andoh Qun Zhang Takumi Yamamoto Manabu Tayama Masao Hattori Ken Tanaka Yasushi Kuraishi

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.114, no.3, pp.292-297, 2010 (Released:2010-11-16)

参考文献数

30

被引用文献数

7 17

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Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G. lucidum extract would inhibit allergic itch. In mice sensitized with an extract of salivary gland of mosquito (ESGM), an intradermal injection of ESGM elicited scratching, which was suppressed by oral administration of G. lucidum extract (100 and 300 mg/kg). The scratching was inhibited by the H1 histamine–receptor antagonist azelastine, but not by the peripherally acting H1-antagonist terfenadine, at the oral dose of 30 mg/kg. In sensitized mice, ESGM increased the activity of cutaneous nerve, which was suppressed by G. lucidum extract (300 mg/kg). Although terfenadine (30 mg/kg) inhibited plasma extravasation induced by ESGM in the sensitized mice, G. lucidum extract (300 mg/kg) was without effect. These results suggest that G. lucidum extract relieves allergic itch through a peripheral action. The results support the idea that mast cells and H1 histamine receptors are not the primary sites of the antipruritic action of G. lucidum extract.

著者

Kazuo GOTO Mikachi YAMAMOTO Miwa ASAHARA Takashi TAMURA Mitsuru MATSUMURA Nobuhito HAYASHIMOTO Koichi MAKIMURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1204080808, (Released:2012-04-13)

被引用文献数

3 12

---

Mycoplasma species identification is based on biochemical, immunological, and molecular methods that require several days for accurate identification. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a novel method for identification of bacteria and has recently been introduced into the clinical microbiology laboratory as a rapid and accurate technique. This method allows a characteristic mass spectral fingerprint to be obtained from whole inactivated mycoplasmal cells. In this study, we evaluated the performance of the MALDI-TOF MS for the identification of Mycoplasma by comparison with standard sequence analysis of 16S rRNA. We developed the first database of MALDI-TOF MS profiles of Mycoplasma species, containing Mycoplasma pulmonis, M. arthritidis, and M. neurolyticum, which are the most common pathogens in mice and/or rats, and species-specific spectra were recorded. Using the database, 6 clinical isolates were identified. Six tracheal swabs from 4 mice and 2 rats were cultured on PPLO agar for 4 to 7 days, and the colonies were directly applied to analyze the protein profiles. Five strains were identified as M. pulmonis, and 1 strain from a mouse was identified as M. neurolyticum (spectral scores were >2.00); the results were consistent with the results of the 16S rRNA gene sequence analysis (homologies>97.0%). These data indicate that MALDI-TOF MS can be used as a clearly rapid, accurate, and cost-effective method for the identification of M. pulmonis isolates, and this system may represent a serious alternative for clinical laboratories to identify Mycoplasma species.

著者

山本 純ノ介 ヤマモト ジュンノスケ Yamamoto Junnosuke

出版者

千葉大学教育学部

雑誌

千葉大学教育学部研究紀要 (ISSN:13482084)

巻号頁・発行日

vol.58, pp.397-412, 2010-03

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現在日本の音楽創作状況は良くも悪くも多様化しすぎている。音楽特性の絶対性を追求した作品は極端に少なくなり,標題やコンセプト中心作品がほとんどである。後者は世界的に現代音楽の流れもあり,否定するものではないがいずれもその音楽作品としての質の追求が疎かになっていないだろうか。珍しさを追求するあまりに音そのものを「紡ぐ」作業が軽視されていないだろうか。興味本位のコンセプト音楽からはあらたな創作や表現の発見はあるかもしないが,過去の歴史的作品を陵駕する価値を伴った作品が生まれる土壌はない。今後さらに質の高い「音楽」とはかけ離れた方向へ流されてしまう懸念が拭えない。音楽家の基本は歌う事であり,その延長線上に和声や対位法,作曲技法(十二音技法も含めて)等が展開され,同時にピアノなどの楽器の演奏技法の開発や楽器そのものの発達に繋がりながら,合奏へと発展し管弦楽法や電子音楽といった分野が興隆,発展してきた。今一度音楽の根本である音楽を見つめる姿勢,作り手の姿勢も含めた「作曲,歌う,聴く」つまり創作,演奏,鑑賞の根本に戻った作品の創作を実践したいと考え声楽のアンサンブルであり,ルネッサンス,バロック,古典,ロマン,近現代いずれの時代にも一貫して作曲されている a cappella の作品創作に着目し,その実践作品についての考察と分析を論じる。

著者

Hikaru OOKURA Hiroshi YAMAMOTO Katsuyuki YAMAZAKI

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E95-D, no.2, pp.546-548, 2012-02-01

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In this paper, we have proposed a new method of observing walking traces, which can observe people's indoor movement for life-logging. Particularly emphasized new techniques in this paper are methods to detect locations, where walking directions are changed, by analyzing azimuth orientations measured by an orientation sensor of an Android mobile device, and to decide walking traces by a map matching with a vector map. The experimental evaluation has shown that the proposed method can determine the correct paths of walking traces.

著者

Miho TANAKA Akiko INOUE Kei YAMAMOTO Satoshi TAMAHARA Naoaki MATSUKI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1201050751, (Released:2012-01-10)

被引用文献数

3 5

---

Necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE) and granulomatous meningoencephalomyelitis (GME) are common idiopathic inflammatory central nervous system (CNS) diseases with unknown etiology in dogs. We previously showed that IgG autoantibodies in the cerebrospinal fluid (CSF) of NME cases reacted to unknown brain proteins as well as to glial fibrillary acidic protein (GFAP). In the present report, we evaluated the autoantibodies against transglutaminase2 (TG2) in the canine CNS diseases. CSF samples obtained from dogs with NME (n=19), NLE (n=7), GME (n=11) and miscellaneous CNS diseases (n=12) were subjected. CSFs from 20 healthy dogs were used as controls. Indirect fluorescent antibody test on the canine cerebrum revealed astrocyte-binding IgG in the CSF of NME. After absorption of the CSF with bovine GFAP, the CSF still possessed the reactivity to astrocytes. Double-color staining showed clear colocalization of the autoantibodies and anti-human TG2 rabbit polyclonal IgG. An immunoblot assay against human recombinant TG2 revealed anti-TG2 IgG in the CSF from dogs with NME, NLE and GME. The CSF of canine idiopathic encephalitis cases, notably of NME, tended to show high ELISA OD values against human recombinant TG2 compared to healthy controls. The presence of anti-TG2 autoantibodies in the CSF may contribute to the elucidation of the etiology of canine NME, NLE and GME.