著者

Eizo NAKAMURA Katsura KOBAYASHI Ryoji TANAKA Tak KUNIHIRO Hiroshi KITAGAWA Christian POTISZIL Tsutomu OTA Chie SAKAGUCHI Masahiro YAMANAKA Dilan M. RATNAYAKE Havishk TRIPATHI Rahul KUMAR Maya-Liliana AVRAMESCU Hidehisa TSUCHIDA Yusuke YACHI Hitoshi MIURA Masanao ABE Ryota FUKAI Shizuho FURUYA Kentaro HATAKEDA Tasuku HAYASHI Yuya HITOMI Kazuya KUMAGAI Akiko MIYAZAKI Aiko NAKATO Masahiro NISHIMURA Tatsuaki OKADA Hiromichi SOEJIMA Seiji SUGITA Ayako SUZUKI Tomohiro USUI Toru YADA Daiki YAMAMOTO Kasumi YOGATA Miwa YOSHITAKE Masahiko ARAKAWA Atsushi FUJII Masahiko HAYAKAWA Naoyuki HIRATA Naru HIRATA Rie HONDA Chikatoshi HONDA Satoshi HOSODA Yu-ichi IIJIMA Hitoshi IKEDA Masateru ISHIGURO Yoshiaki ISHIHARA Takahiro IWATA Kosuke KAWAHARA Shota KIKUCHI Kohei KITAZATO Koji MATSUMOTO Moe MATSUOKA Tatsuhiro MICHIKAMI Yuya MIMASU Akira MIURA Tomokatsu MOROTA Satoru NAKAZAWA Noriyuki NAMIKI Hirotomo NODA Rina NOGUCHI Naoko OGAWA Kazunori OGAWA Chisato OKAMOTO Go ONO Masanobu OZAKI Takanao SAIKI Naoya SAKATANI Hirotaka SAWADA Hiroki SENSHU Yuri SHIMAKI Kei SHIRAI Yuto TAKEI Hiroshi TAKEUCHI Satoshi TANAKA Eri TATSUMI Fuyuto TERUI Ryudo TSUKIZAKI Koji WADA Manabu YAMADA Tetsuya YAMADA Yukio YAMAMOTO Hajime YANO Yasuhiro YOKOTA Keisuke YOSHIHARA Makoto YOSHIKAWA Kent YOSHIKAWA Masaki FUJIMOTO Sei-ichiro WATANABE Yuichi TSUDA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.98, no.6, pp.227-282, 2022-06-10 (Released:2022-06-10)

参考文献数

245

被引用文献数

90

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Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate matrix, 41% porosity and 9% minor phases, including organic matter. The abundances of 70 elements from the particles are in close agreement with those of CI chondrites. Bulk Ryugu particles show higher δ18O, Δ17O, and ε54Cr values than CI chondrites. As such, Ryugu sampled the most primitive and least-thermally processed protosolar nebula reservoirs. Such a finding is consistent with multi-scale H-C-N isotopic compositions that are compatible with an origin for Ryugu organic matter within both the protosolar nebula and the interstellar medium. The analytical data obtained here, suggests that complex soluble organic matter formed during aqueous alteration on the Ryugu progenitor planetesimal (several 10’s of km), <2.6 Myr after CAI formation. Subsequently, the Ryugu progenitor planetesimal was fragmented and evolved into the current asteroid Ryugu through sublimation.

著者

Hiroshi TSUBOMURA Naoto YAMAMOTO Nobutaka MATSUO Yoshio OKADA

出版者

The Japan Academy

雑誌

Proceedings of the Japan Academy, Series B (ISSN:03862208)

巻号頁・発行日

vol.56, no.7, pp.403-407, 1980 (Released:2006-10-06)

参考文献数

14

被引用文献数

6 7

著者

Satsuki Aochi Masaaki Uehara Motohisa Yamamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.1125-22, (Released:2023-03-08)

参考文献数

22

被引用文献数

1 9

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A 78-year-old Japanese woman with no history of rheumatic disease received 2 doses of the BNT162b2 COVID-19 mRNA vaccine. Two weeks later, she noticed bilateral swelling in the submandibular region. Blood tests showed hyper-immunoglobulin (Ig)G4emia, and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) revealed the strong accumulation of FDG in the enlarged pancreas. She was diagnosed with IgG4-related disease (IgG4-RD) according to the American College of Rheumatology (ACR)/the European League Against Rheumatism (EULAR) classification criteria. Treatment was started with prednisolone at 30 mg/day, and the organ enlargement improved. We herein report a case of IgG4-RD that may have been associated with an mRNA vaccine.

著者

Michio Yamamoto Dai Keino Shinichiro Sumii Tomoko Yokosuka Hiroaki Goto Ayano Inui Tsuyoshi Sogo Makio Kawakami Mio Tanaka Masakatsu Yanagimachi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.1308-22, (Released:2023-03-22)

参考文献数

17

被引用文献数

4

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We herein report a case of hepatitis-associated aplastic anemia (HAAA) that occurred after severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) vaccination. In this patient, progressive pancytopenia observed two months after acute hepatitis following the second dose of the SARS-Cov-2 vaccine indicated the development of HAAA. Although some reports have suggested that SARS-Cov-2 vaccination may be involved in the development of autoimmune diseases, no cases of HAAA developing after SARS-Cov-2 vaccination have been reported. SARS-Cov-2 vaccination in children has only started relatively recently, so the range of side effects in children has not yet been thoroughly described. Therefore, we need to strengthen surveillance for symptoms of children who are vaccinated.

著者

Satoshi Yamaori Yoshimi Okushima Kazufumi Masuda Mika Kushihara Takashi Katsu Shizuo Narimatsu Ikuo Yamamoto Kazuhito Watanabe

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.7, pp.1197-1203, 2013-07-01 (Released:2013-07-01)

参考文献数

39

被引用文献数

2 15

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Our recent work has shown that cannabidiol (CBD) exhibits the most potent direct inhibition of human cytochrome P450 1A1 (CYP1A1) among the CYP enzymes examined. However, the mechanism underlying this CBD inhibition remains to be clarified. Thus, to elucidate the structural requirements for the potent inhibition by CBD, the effects of CBD and its structurally related compounds on CYP1A1 activity were investigated with recombinant human CYP1A1. Olivetol, which corresponds to the pentylresorcinol moiety of CBD, inhibited the 7-ethoxyresorufin O-deethylase activity of CYP1A1; its inhibitory effect (IC50=13.8 µM) was less potent than that of CBD (IC50=0.355 µM). In contrast, d-limonene, which corresponds to the terpene moiety of CBD, only slightly inhibited CYP1A1 activity. CBD-2′-monomethyl ether (CBDM) and CBD-2′,6′-dimethyl ether inhibited CYP1A1 activity with IC50 values of 4.07 and 23.0 µM, respectively, indicating that their inhibitory effects attenuated depending on the level of methylation on the free phenolic hydroxyl groups in the pentylresorcinol moiety of CBD. Cannabidivarin inhibited CYP1A1 activity, although its inhibitory potency (IC50=1.85 µM) was lower than that of CBD. The inhibitory effects of Δ9-tetrahydrocannabinol and cannabielsoin (IC50s ≈10 µM), which contain a free phenolic hydroxyl group and are structurally constrained, were less potent than that of CBDM, which contains a free phenolic hydroxyl group and is rotatable between pentylresorcinol and terpene moieties. These results suggest that the pentylresorcinol structure in CBD may have structurally important roles in direct CYP1A1 inhibition, although the whole structure of CBD is required for overall inhibition.

著者

Takahiro Sanada Tomoko Honda Fumihiko Yasui Kenzaburo Yamaji Tsubasa Munakata Naoki Yamamoto Makoto Kurano Yusuke Matsumoto Risa Kohno Sakiko Toyama Yoshiro Kishi Takuro Horibe Yudai Kaneko Mayumi Kakegawa Kazushige Fukui Takeshi Kawamura Wang Daming Chungen Qian Fuzhen Xia Fan He Syudo Yamasaki Atsushi Nishida Takayuki Harada Masahiko Higa Yuko Tokunaga Asako Takagi Masanari Itokawa Tatsuhiko Kodama Michinori Kohara

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20210324, (Released:2021-11-13)

参考文献数

26

被引用文献数

18

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Background: Tokyo, the capital of Japan, is a densely populated city of >13 million people and thus at high risk of epidemic severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. A serologic survey of anti–SARS-CoV-2 IgG would provide valuable data for assessing the city’s SARS-CoV-2 infection status. This cross-sectional study therefore estimated the anti–SARS-CoV-2 IgG seroprevalence in Tokyo.Methods: Leftover serum of 23,234 hospital visitors was tested for antibodies against SARS-CoV-2 using an iFlash 3000 chemiluminescence immunoassay analyzer (Shenzhen YHLO Biotech) with an iFlash–SARS-CoV-2 IgG kit (YHLO) and iFlash–SARS-CoV-2 IgG-S1 kit (YHLO). Serum samples with a positive result (≥10 AU/mL) in either of these assays were considered seropositive for anti–SARS-CoV-2 IgG. Participants were randomly selected from patients visiting 14 Tokyo hospitals between September 1, 2020, and March 31, 2021. No participants were diagnosed with coronavirus disease 2019 (COVID-19), and none exhibited COVID-19–related symptoms at the time of blood collection.Results: The overall anti–SARS-CoV-2 IgG seroprevalence among all participants was 1.83% (95% confidence interval [CI]: 1.66%-2.01%). The seroprevalence in March 2021, the most recent month of this study, was 2.70% (95% CI: 2.16%-3.34%). After adjusting for population age, sex, and region, the estimated seroprevalence in Tokyo was 3.40%, indicating that 470,778 individuals had a history of SARS-CoV-2 infection.Conclusions: The estimated number of individuals in Tokyo with a history of SARS-CoV-2 infection was 3.9-fold higher than the number of confirmed cases. Our study enhances understanding of the SARS-CoV-2 epidemic in Tokyo.

著者

Akemi SAITO Masaharu YAMAMOTO

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.21, no.3, pp.195-200, 1996-08-25 (Released:2008-02-21)

参考文献数

18

被引用文献数

40 54

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The oral toxicity of capsaicin was investigated in mice and rats. Oral LD50 values were 118.8 mg/kg for male and 97.4 mg/kg for female mice, and 161.2 mg/kg for male and 148.1 mg/kg for female rats. Major toxic symptoms in mice were salivation, erythema of skin, staggering gait, bradypnea and cyanosis. Some animals showed tremor, clonic convulsion, dyspnea and lateral or prone position and then died 4 to 26 min after dosing. Survivors recovered within 6 hr in mice and 24 hr in rats. Toxic symptoms of fats were almost the same as mice, but rats showing higher incidence of cyanosis, clonic or tonic convulsion, dyspnea and lateral position, and the recovery was later than mice. The cause of death by capsaicin may be due to hypotension and respiratory paralysis in both animals, although the pathophysiology of death is not clearly understood. At pathological examination, erosion and ulcer of gastric fundus were seen in dead animals, while no pathological change was seen in surviving ones.

著者

Yuka Hamada Takuma Yanaoka Kyoko Kashiwabara Kuran Kurata Ryo Yamamoto Susumu Kanno Tomonori Ando Masashi Miyashita

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.4, pp.625-629, 2018 (Released:2018-04-20)

参考文献数

14

被引用文献数

4

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[Purpose] This study examined the effects of gum chewing while walking on physical and physiological functions. [Subjects and Methods] This study enrolled 46 male and female participants aged 21–69 years. In the experimental trial, participants walked at natural paces for 15 minutes while chewing two gum pellets after a 1-hour rest period. In the control trial, participants walked at natural paces for 15 minutes after ingesting powder containing the same ingredient, except the gum base, as the chewing gum. Heart rates, walking distances, walking speeds, steps, and energy expenditure were measured. [Results] Heart rates during walking and heart rate changes (i.e., from at rest to during walking) significantly increased during the gum trial compared with the control trial. Walking distance, walking speed, walking heart rate, and heart rate changes in male participants and walking heart rate and heart rate changes in female participants were significantly higher during the gum trial than the control trial. In middle-aged and elderly male participants aged ≥40 years, walking distance, walking speed, steps, and energy expenditure significantly increased during the gum trial than the control trial. [Conclusion] Gum chewing while walking measurably affects physical and physiological functions.

著者

Hiroaki Kawano Nobu Yamamoto Hirokazu Kurohama Shinji Okano Masaya Kurobe Tomohiro Honda Ryohei Akashi Tsuyoshi Yonekura Satoshi Ikeda Koichi Izumikawa Koji Maemura

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0680-22, (Released:2022-11-23)

参考文献数

37

被引用文献数

3

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A 19-year-old Japanese man was hospitalized for cardiogenic shock 28 days after receiving a second dose of the COVID-19 mRNA-1273 vaccine. He had had a high fever for three days with vomiting and abdominal pain before arriving at our hospital. The patient visited a local hospital and was diagnosed with heart failure and acute appendicitis. An endomyocardial biopsy specimen showed myocarditis. Thereafter, Impella CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were initiated immediately along with inotropic support and steroid pulse therapy. Given these findings, he was finally diagnosed with multiple inflammatory syndrome and fulminant myocarditis.

著者

Atsushi Mizuno Takuya Kishi Chisa Matsumoto Mari Ishida Shoji Sanada Memori Fukuda Yuki Sahashi Tadafumi Sugimoto Miki Hirano Yusuke Yoshikawa Erika Yamamoto Takeshi Kimura Koichi Node

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-20-0093, (Released:2020-09-25)

参考文献数

10

被引用文献数

1 3

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Background:Twitter has become increasingly popular at annual medical congresses as a platform to communicate to attendees. The aim of this study is to reveal the twitter usage in the annual congress of the Japanese Cirsulation Society.Methods and Results:We compared the total number of tweets during the Japanese Circulation Society’s annual meetings in 2019 and 2020. The total number of tweets increased from 7,587 in 2019 to 23,867 in 2020. Most tweets were retweets (>70%), and approximately half of Twitter users tweeted only once.Conclusions:Twitter usage during the Japanese Circulation Society’s annual meeting increased from 2019 to 2020, and a large number of tweets were from Twitter ambassadors of the Japanese Circulation Society. However, further evaluation is needed, with future studies investigating the usefulness of this platform.

著者

Naruhiko Sunada Hiroyuki Honda Yasuhiro Nakano Koichiro Yamamoto Kazuki Tokumasu Yasue Sakurada Yui Matsuda Toru Hasegawa Yuki Otsuka Mikako Obika Yoshihisa Hanayama Hideharu Hagiya Keigo Ueda Hitomi Kataoka Fumio Otsuka

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ22-0093, (Released:2022-04-28)

被引用文献数

26

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Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms. In this study, to clarify the hormonal characteristics of long COVID patients, laboratory data for patients who visited the outpatient clinic for long COVID were evaluated. A retrospective analysis was performed for patients who visited Okayama University Hospital during the period from Feb 2021 to Dec 2021 with focus on the interrelationships between major symptoms and endocrine data. Information and laboratory data were obtained from medical records for 186 patients. The patients had various symptoms, and the most frequent symptoms were general malaise, dysosmia/dysgeusia, hair loss, headache, dyspnea, and sleeplessness. Patients who were suffering from fatigue and dysosmia/dysgeusia were younger, while hair loss was more frequent in older and female patients. As for the characteristics of patients suffering from general fatigue, the scores of depression and fatigue were positively correlated with serum levels of cortisol and free thyroxin (FT4), respectively. Also, patients suffering from general fatigue had lower levels of serum growth hormone and higher levels of serum FT4, while patients with dysosmia/dysgeusia had a significantly lower level of serum cortisol. Serum thyrotropin (TSH) levels were higher and the ratios of FT4/TSH were lower in the initially severe cases, suggesting occult hypothyroidism. In addition, the ratios of plasma adrenocorticotropin to serum cortisol were decreased in patients with relatively high titers of serum SARS-CoV-2 antibody. Thus, hormonal changes seem to be, at least in part, involved in the persistent symptoms of long COVID.

著者

山本 すみ子 Yamamoto Sumiko

出版者

法政大学大原社会問題研究所

雑誌

大原社会問題研究所雑誌 (ISSN:09129421)

巻号頁・発行日

vol.668, pp.38-56, 2014-06-25

著者

Rei YAMASHITA Nagako HIKI Fumika KASHIWADA Hideshige TAKADA Kaoruko MIZUKAWA Britta Denise HARDESTY Lauren ROMAN David HYRENBACH Peter G. RYAN Ben J. DILLEY Juan Pablo MUÑOZ-PÉREZ Carlos A. VALLE Christopher K. PHAM João FRIAS Bungo NISHIZAWA Akinori TAKAHASHI Jean-Baptiste THIEBOT Alexis WILL Nobuo KOKUBUN Yuuki Y. WATANABE Takashi YAMAMOTO Kozue SHIOMI Ui SHIMABUKURO Yutaka WATANUKI

出版者

Japan Society for Environmental Chemistry

雑誌

Environmental Monitoring and Contaminants Research (ISSN:24357685)

巻号頁・発行日

vol.1, pp.97-112, 2021 (Released:2021-10-11)

参考文献数

90

被引用文献数

17

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Plastic pollution, and its associated impacts on marine fauna due to chemical contamination, is an area of growing global concern. We analyzed 145 preen gland oil samples from 32 seabird species belonging to 8 families with different foraging habits and life history strategies from around the world for plastic additives and legacy persistent organic pollutants. The additives included two brominated flame retardants (decabromodiphenyl ether, BDE209; decabromo diphenyl ethane, DBDPE) and six benzotriazole UV stabilizers (BUVSs; UVP, UV326, UV329, UV328, UV327, and UV234). Polychlorinated biphenyls (PCBs) and organochlorine pesticides (Dichlorodiphenyltrichloroethane and its metabolites: DDTs and hexachlorocyclohexane: HCHs) were detected ubiquitously. High concentrations of PCBs (up to 20,000 ng/g-lipid) were observed in the seabirds from higher-trophic level taxa. These patterns can be attributed to PCB exposure via their diet and associated biomagnification. DDT concentrations showed strong positive correlations with PCB concentrations, suggesting that DDTs in seabirds are also a result of diet and biomagnification. Plastic additives were detected sporadically as BDE209 and DBDPE were detected in 16 seabirds from 10 species (range: 3–379 ng/g-lipid) and BUVSs were detected in 46% (67) of the examined individuals (range: 2–7,055 ng/g-lipid). UV stabilizers were more frequently detected than flame retardants because UV stabilizers are more widely applied to plastic products. None of the plastic additives were correlated to the presence of PCBs, nor were they explained by the foraging area or trophic level. High concentrations of additives were detected in the species with high levels of plastic in their digestive tracts. In some of these species, such as Hawaiian petrels (Pterodroma sandwichensis) from Hawaii and flesh-footed shearwaters (Ardenna carneipes) from Western Australia, plastics were directly observed in the stomach. For other species, including great shearwaters (Ardenna gravis) from Gough Island, blue petrels (Halobaena caerulea) from Marion Island, and black-footed and Laysan albatrosses (Phoebastria nigripes and P. immutabilis) from Hawaii, plastic ingestion has been documented in literature. These patterns can be explained if the additives are mainly from ingested plastics rather than diet. The detection of BFRs and BUVSs demonstrated that a significant proportion of the examined seabirds accumulated chemicals from ingested plastics.

著者

Atsushi Mizuno Takuya Kishi Chisa Matsumoto Mari Ishida Shoji Sanada Memori Fukuda Yuki Sahashi Tadafumi Sugimoto Miki Hirano Yusuke Yoshikawa Erika Yamamoto Takeshi Kimura Koichi Node

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.2, no.11, pp.691-694, 2020-11-10 (Released:2020-11-10)

参考文献数

10

被引用文献数

3

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Background:Twitter has become increasingly popular at annual medical congresses as a platform to communicate to attendees. The aim of this study is to reveal the twitter usage in the annual congress of the Japanese Cirsulation Society.Methods and Results:We compared the total number of tweets during the Japanese Circulation Society’s annual meetings in 2019 and 2020. The total number of tweets increased from 7,587 in 2019 to 23,867 in 2020. Most tweets were retweets (>70%), and approximately half of Twitter users tweeted only once.Conclusions:Twitter usage during the Japanese Circulation Society’s annual meeting increased from 2019 to 2020, and a large number of tweets were from Twitter ambassadors of the Japanese Circulation Society. However, further evaluation is needed, with future studies investigating the usefulness of this platform.

著者

Satsuki Aochi Masaaki Uehara Motohisa Yamamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.62, no.10, pp.1547-1551, 2023-05-15 (Released:2023-05-15)

参考文献数

22

被引用文献数

1 9

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A 78-year-old Japanese woman with no history of rheumatic disease received 2 doses of the BNT162b2 COVID-19 mRNA vaccine. Two weeks later, she noticed bilateral swelling in the submandibular region. Blood tests showed hyper-immunoglobulin (Ig)G4emia, and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) revealed the strong accumulation of FDG in the enlarged pancreas. She was diagnosed with IgG4-related disease (IgG4-RD) according to the American College of Rheumatology (ACR)/the European League Against Rheumatism (EULAR) classification criteria. Treatment was started with prednisolone at 30 mg/day, and the organ enlargement improved. We herein report a case of IgG4-RD that may have been associated with an mRNA vaccine.

著者

Etsuji Suzuki Tomohiro Shinozaki Eiji Yamamoto

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20190192, (Released:2020-02-01)

参考文献数

70

被引用文献数

9 37

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Graphical models are useful tools in causal inference, and causal directed acyclic graphs (DAGs) are used extensively to determine the variables for which it is sufficient to control for confounding to estimate causal effects. We discuss the following ten pitfalls and tips that are easily overlooked when using DAGs: 1) Each node on DAGs corresponds to a random variable and not its realized values; 2) The presence or absence of arrows in DAGs corresponds to the presence or absence of individual causal effect in the population; 3) “Non-manipulable” variables and their arrows should be drawn with care; 4) It is preferable to draw DAGs for the total population, rather than for the exposed or unexposed groups; 5) DAGs are primarily useful to examine the presence of confounding in distribution in the notion of confounding in expectation; 6) Although DAGs provide qualitative differences of causal structures, they cannot describe details of how to adjust for confounding; 7) DAGs can be used to illustrate the consequences of matching and the appropriate handling of matched variables in cohort and case-control studies; 8) When explicitly accounting for temporal order in DAGs, it is necessary to use separate nodes for each timing; 9) In certain cases, DAGs with signed edges can be used in drawing conclusions about the direction of bias; and 10) DAGs can be (and should be) used to describe not only confounding bias but also other forms of bias. We also discuss recent developments of graphical models and their future directions.

著者

山本 裕之 小寺 香奈 YAMAMOTO Hiroyuki KOTERA Kana

出版者

岩手大学教育学部附属教育実践総合センター

雑誌

岩手大学教育学部附属教育実践総合センター研究紀要 (ISSN:13472216)

巻号頁・発行日

no.8, pp.67-80, 2009

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1920年代にC.アイヴズ、A.ハーバらによって実践された4分音などの微分音は、その後のヨーロッパ音楽において現代的奏法の中でも重要項目として扱われてきた。彼らが微分音に挑戦した当時のヨーロッパは平均律(12等分平均律)の概念が席巻して既に久しい。かつてのヨーロッパで長期にわたって繰り広げられてきた音律論争において、それぞれの音律の間に存在した非常に小さなどツチ(音高)の差は、19世紀という様々な調性を用いた時代の要請に応えて12等分平均律という画期的な妥協案に収れんした。西洋音楽文化の外にある各民族音楽の音律を除外して考えれば、微分音とはいったん世界標準として目盛りが敷かれた平均律からあらためて外れたピッチ、または音程のことを指す。 とはいえ、オルガンのように一度調律したらそうたやすくは調律が崩れないような楽器はわずかであり、それどころか多くの楽器では奏者がその場で随時楽器のピッチをコントロールしながら演奏する。19世紀に作られたキーをたくさん持つ木管楽器や、H.シュトルツェルなどが発明したヴアルヴをもつ金管楽器群は、それ以前の楽器に比べて格段に多くのピッチを安定させながら自在に鳴らせるように設計されている。が、その中で奏者はさらに楽器の精度と共に自らの耳と発音テクニックによって出来るだけ「正しい」ピッチを作り出そうと技術を磨いた。しかし実際の演奏では厳格に正しく、19世紀以降の「半音階の分かりやすい知的モデル」である平均律に即した音律で演奏されるわけではない。音楽のイントネーションに合わせて、あるいは奏者や楽器自体のコンディションに即して、平均律から大きく外れないピッチを作りながら演奏されるのが常である。したがって、例えばある音が僅かに数セントの単位で平均律からずれたからといってもそれは「ある音」の範囲を越えず、微分音の概念で語られるわけではない。 つまりこれらのような木・金管楽器は、音楽的内容に即して随時平均律から逸脱して演奏されることを前提としながらも、平均律を原則として作られている。したがって、そのような楽器であえて微分音を作り出すことは矛盾であるが、楽器の構造上は不可能ではない。すなわち、楽器はそのように作られてはいないが不可能ではないのである。 20世紀後半になって微分音が作品の中で頻繁に使われ始めると、各楽器の現代奏法を解説する書物には必ずといってよいほど微分音の運指表が掲載されるようになった。特に木管楽器の書物では多くのキーの組み合わせによって膨大な微分音の可能性が提示されている。金管楽器においては、楽器の機構上木管楽器のように膨大な微分音が作り出せるわけではないが、それでも実用的な量は作り出せる。しかしそのための資料が木管楽器ほど多いわけではない。そこで本稿では、金管楽器の中でも特に現代奏法に関する資料がほとんど書かれていないユーフォニアムにおいて、これまで存在しなかったこの楽器のための汎用的な微分音スケールを提示することを目的とした。

著者

Makoto Takeyama Sen Yachi Yuji Nishimoto Ichizo Tsujino Junichi Nakamura Naoto Yamamoto Hiroko Nakata Satoshi Ikeda Michihisa Umetsu Shizu Aikawa Hiroya Hayashi Hirono Satokawa Yoshinori Okuno Eriko Iwata Yoshito Ogihara Nobutaka Ikeda Akane Kondo Takehisa Iwai Norikazu Yamada Tomohiro Ogawa Takao Kobayashi Makoto Mo Yugo Yamashita

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20220201, (Released:2022-11-12)

参考文献数

53

被引用文献数

2 2

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Background: Reports of mortality-associated risk factors in patients with the novel coronavirus disease 2019 (COVID-19) are limited.Methods: We evaluated the clinical features that were associated with mortality among patients who died during hospitalization (n = 158) and those who were alive at discharge (n = 2,736) from the large-scale, multicenter, retrospective, observational cohort CLOT-COVID study, which enrolled consecutively hospitalized COVID-19 patients from 16 centers in Japan from April to September 2021. Data from 2,894 hospitalized COVID-19 participants of the CLOT-COVID study were analyzed in this study.Results: Patients who died were older (71.1 years vs 51.6 years, P < 0.001), had higher median D-dimer values on admission (1.7 µg/mL vs 0.8 µg/mL, P < 0.001), and had more comorbidities. On admission, the patients who died had more severe COVID-19 than did those who survived (mild: 16% vs 63%, moderate: 47% vs 31%, and severe: 37% vs 6.2%, P < 0.001). In patients who died, the incidence of thrombosis and major bleeding during hospitalization was significantly higher than that in those who survived (thrombosis: 8.2% vs 1.5%, P < 0.001; major bleeding: 12.7% vs 1.4%, P < 0.001). Multivariable logistic regression analysis revealed that age >70 years, high D-dimer values on admission, heart disease, active cancer, higher COVID-19 severity on admission, and development of major bleeding during hospitalization were independently associated with a higher mortality risk.Conclusion: This large-scale observational study in Japan identified several independent risk factors for mortality in hospitalized patients with COVID-19 that could facilitate appropriate risk stratification of patients with COVID-19.

著者

Hidetomo Yokoo Eiichi Yamamoto Sayaka Masada Nahoko Uchiyama Genichiro Tsuji Takashi Hakamatsuka Yosuke Demizu Ken-ichi Izutsu Yukihiro Goda

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.69, no.9, pp.872-876, 2021-09-01 (Released:2021-09-01)

参考文献数

23

被引用文献数

13

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N-Nitrosodimethylamine (NDMA) is a probable human carcinogen. This study investigated the root cause of the presence of NDMA in ranitidine hydrochloride. Forced thermal degradation studies of ranitidine hydrochloride and its inherent impurities (Imps. A, B, C, D, E, F, G, H, I, J, and K) listed in the European and United States Pharmacopeias revealed that in addition to ranitidine, Imps. A, C, D, E, H, and I produce NDMA at different rates in a solid or an oily liquid state. The rate of NDMA formation from amorphous Imps. A, C, and E was 100 times higher than that from crystalline ranitidine hydrochloride under forced degradation at 110 °C for 1 h. Surprisingly, crystalline Imp. H, bearing neither the N,N-dialkyl-2-nitroethene-1,1-diamine moiety nor a dimethylamino group, also generated NDMA in the solid state, while Imp. I, as an oily liquid, favorably produced NDMA at moderate temperatures (e.g., 50 °C). Therefore, strict control of the aforementioned specific impurities in ranitidine hydrochloride during manufacturing and storage allows appropriate control of NDMA in ranitidine and its pharmaceutical products. Understanding the pathways of the stability related NDMA formation enables improved control of the pharmaceuticals to mitigate this risk.

著者

山本 俊正 Toshimasa Yamamoto

雑誌

関西学院大学キリスト教と文化研究 = Kwansei Gakuin University journal of studies on Christianity and culture (ISSN:13454382)

巻号頁・発行日

no.13, pp.123-143, 2012-03-31