著者

橋口 拓勇 黒木 勝久 水光 正仁 榊原 陽一

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.93, no.3, pp.128-132, 2019-03-25 (Released:2020-03-31)

著者

森下 玲児

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.55, no.8, pp.421-422, 1981-08-25 (Released:2018-03-10)

著者

田中 清

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.93, no.8, pp.325-333, 2019-08-25 (Released:2020-08-31)

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Vitamin deficiency causes classical deficiency diseases such as beriberi and rickets. Vitamin insufficiency, which is milder than deficiency, is a risk for various chronic diseases, but its significance has not been recognized in Japan. Vitamin D insufficiency is quite common in Japan, and a serious risk for osteoporotic fracture through its unbeneficial effect on bone and muscle. Vitamin K insufficiency is also a risk for fracture. Insufficiency of water-soluble vitamins has been little studied. However, we have reported that vitamin B12 and folate insufficiency is a risk for muscle weakness in the elderly, and vitamin B 1 insufficiency is a risk for heart failure in the elderly. Although the therapeutic effect of improvement of nutritional status including vitamins is not marked than that of drug treatment, the improvement of nutritional status is far lower in cost and suited for the primary prevention of diseases. Although it is considered that randomized controlled trial is the study with most robust evidence in the evaluation of drug treatment, higher significance should be put on the well-designed cohort studies in evaluating the role of nutrients. Vitamin insufficiency is quite prevalent, and vitamin requirement is much higher for its insufficiency avoidance than for its deficiency prevention.

著者

今西 文男

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.22, no.3, pp.313-322, 1961-03-25 (Released:2017-12-18)

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The lesion of each organ of the rats administrated with 50,000 I.U. of vitamin A-acetate for 7-15 days was examined histologically. After describing the pathological changes of heart, liver, kidneys, brain, peripheral nerve fibers and end-plates in skeletal muscle, bone, endcrine glands etc., the author discussed the effect of synthetic vitamin A on the living bodies comparing with the old examination using liver oil. From the histological finding of thalamo-hypophyseal system, it was pointed out that the hypervitaminosis was regarded as a kind of stressor.

著者

林 秀行

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.87, no.12, pp.685-690, 2013

著者

吉川 祐子 小川 直樹 香川 幸大 剣持 貴弘 森 利明 渡辺 好章 吉川 研一 今中 忠行

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.88, no.5, 2014

著者

田中 隆義

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.53, no.12, pp.577-586, 1979-12-25 (Released:2018-03-07)

被引用文献数

1

著者

遠藤 寛 福地 茂穂 代田 稔

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.45, no.1, pp.47-48, 1972

著者

福地 茂穂 遠藤 寛 代田 稔

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.42, no.5, 1970

著者

鎌尾 まや 岡野 登志夫

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.82, no.11, pp.612-614, 2008-11-25 (Released:2017-10-10)

参考文献数

5

著者

二五田 公俊

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.48, no.9, pp.453-462, 1974-09-25

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A mutant strain of Escherichia coli, O8-442,requiring lipoic acid (LiA) for both aerobic and anaerobic growth in a minimal medium with glucose as a sole carbon source was isolated. The requirment for LiA could be replaceable by either acetate+succinate or acetate+lysine+methionine under aerobic conditions, but anaerobically it grew on either acetate or succinate alone. Pyruvate markedly stimu1ated.the respiration of the mutant cells grown aerobically on LiA and the addition of LiA did not cause a further stimulation. Conversely, results obtained with the cells grown aerobically on acetate+ lysine+methionine was quite different ; the degree of the pyruvate-oxidizing activity was very low but the activity was fully restored by the addition of LiA. In the same system, lipoamide (LiANH_2) was found to have no activity for the respiration of the mutant cells, while it was more active than LiA when extracts prepared from the mutant cells were used. These results suggest that the de novo synthesis of LiA is blocked in the mutant strain. A permeability barrier appears to be involved in the utilization of LiANH_2.

著者

福原 武 福田 博之

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.31, no.6, pp.494-499, 1965-06-25 (Released:2018-02-09)

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Utilizing Trendelenburg's as well as Magnus' method the influence of TTFD upon the movement of the isolated small intestine of guinea pigs, rabbits, cats and dogs were studied. The results were summarized as follows : (1) At the concentration of 5 × 10^<-5> g/ml TTFD produced, on the one hand, a lowering of the tone, prolongation of the period of rhythmic contraction waves and on the other hand, a remarkable increase of the amplitude of the waves. (2) After the administration of atropine, the excitatory effect of TTFD was reversed to the inhibitory. (3) After successive administrations of atropine and hexamethonium, no action of TTFD was remarked. (4) TTFD had no effect on the small intestine isolated from cats treated with reserpine and atropine. (5) From the results described above, it may be concluded that TTFD exerts an exciting action upon both the excitatory and inhibitory neurones residing in Auerbach's plexus, whereas it exerts no action upon the intestinal muscle. It could be considered that the effects described in (1) were the results of a mutual coordination of the function of two kinds of neurones described above.

著者

阿部 皓一

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.94, no.3, pp.166-173, 2020-03-25 (Released:2021-03-31)

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Vitamin E is a physiologically essential nutrient and its deficiencies in animals are known as rat fecal resorption, rat hemolysis, chicken muscle dystrophy, chicken dystrophy, and chicken encephalomalacia. Each vitamin E deficiency in animals may connect with vitamin E insufficiencies and disorders in humans as follows: fecal resorption vs. infertility, hemolysis vs. vasodilation, muscle dystrophy vs. sarcopenia, and encephalomalacia vs. dementia. This review pursues the history of vitamin E clinical studies based on the following parts; (1) infertility, (2) vasodilation, (3) brain function, (4) physical activity, (5) liver function, (6) periodontal function, (7) immune response, and (8) non-α-tocopherol function.

著者

箕浦 久兵衛

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.6, pp.914-918, 1953

著者

阿部 正和 井川 幸雄 広瀬 正義 井上 礼子

出版者

日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.6, pp.470-473, 1953

著者

天ケ瀬 晴信

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.90, no.4, pp.234-236, 2016

著者

笠井 佐夫

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.63, no.12, pp.650-652, 1989-12-25 (Released:2018-03-16)

著者

木村 美恵子

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.80, no.1, pp.7-9, 2006-01-25 (Released:2017-10-10)

参考文献数

12

被引用文献数

1

著者

松井 敏史 櫻井 秀樹 遠山 朋海 吉村 淳 松下 幸生 樋口 進

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.86, no.11, pp.630-635, 2012

参考文献数

20

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Wernicke's encephalopathy (WE) is the best known acute neurologic complication of vitamin B_1 (B_1) deficiency and often occurs in chronic alcoholism. The plausible causes of B_1 deficiency in alcoholics depend on the underlying mechanisms, such as a low dietary intake of B_1, inadequate absorption of B_1 from the intestine due to the gastrointestinal tract damage, and coexistent alcoholic liver disease altering the capacity of B_1 storage and the metabolism of biologically important nutrients. Because the use of the classic triad of WE may overlook a mild form of WE that can be detected as inactive WE pathology, Caine and colleagues have proposed the clinical criteria for diagnosis of WE in chronic alcoholics based on the clinical-neuropathological correction. The Caine criteria include dietary deficiency, oculomotor abnormalities, cerebellar dysfunction and either altered mental status or mild memory impairment, two of which are required for diagnosis of clinical WE. In our cohort, 13 alcoholic patients who fulfilled the Caine criteria were followed up and CSF-tau levels increased at the acute stage of the disease and then decreased at the chronic stage, suggesting that the patients have a transient neuronal damage. The Caine criteria enabled an immediate intravenous administration of B_1 and provided a favorable prognosis. For the therapy of WE, parenteral treatment with a high dose of B_1 is now recommended. A typical regimen is that 500 mg of B_1 is intravenously administered three times daily for two consecutive days and 500 mg of B_1 is intravenously administered once daily for additional five days, in combination with other B vitamins. After establishment of a sufficiently low threshold for parenteral B_1 treatment, the B_1 treatment should be conducted in all alcoholic patients with altered mental status, oculomotor disorders or ataxia.

著者

萩原 真 神山 伸 曽根 英行

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.90, no.12, pp.600-602, 2016 (Released:2017-12-26)