著者

稲垣 治

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.2, pp.213-219, 2013 (Released:2013-02-01)

被引用文献数

1

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Recently many pharmaceutical industries aim at “academic-industrial alliances” to increase opportunities for new drug development. The form of the alliance is mainly a “center-based” one, but recently “open-type” alliance has also become popular. To promote effective collaboration between academia and industries, both parties should obtain clear understanding and support from society through compliance with the social requirement including accountability on the collaborative research and transparency on their relationship. In addition, clinical studies need to comply with the “Ethical Guideline for Clinical Research,” or Good Clinical Practice (GCP). Pharmaceutical industries anticipate seeing the deliverables of academic research, and are working on realization of utilizing them in actual medicinal cases.

著者

木方 正 永井 勝幸 宮本 郁夫 渡辺 利明 鵜飼 茂夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.110, no.4, pp.286-288, 1990-04-25

被引用文献数

4

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Biological activities of two galactomannans (CI-P and CI-A) isolated from the insectbody portion of Chan hua (fungus : Cordyceps cicadae) were studied. CI-P having low affinity for concanavalin A (Con A) exhibited potent carbon-clearance activity in mouse, although both polysaccharides had little antitumor activity against sarcoma 180 in mice. Furthermore, CI-P and CI-A was found to have potent hypoglycemic activity in normal mice, and CI-A having high affinity for Con A showed slightly higher activity than CI-P.

著者

吉松 嘉代 河野 徳昭 川原 信夫 穐山 浩 手島 玲子 西島 正弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.5, pp.629-674, 2012 (Released:2012-05-01)

参考文献数

412

被引用文献数

2 3 1

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Developments in the use of genetically modified plants for human and livestock health and phytoremediation were surveyed using information retrieved from Entrez PubMed, Chemical Abstracts Service, Google, congress abstracts and proceedings of related scientific societies, scientific journals, etc. Information obtained was classified into 8 categories according to the research objective and the usage of the transgenic plants as 1: nutraceuticals (functional foods), 2: oral vaccines, 3: edible curatives, 4: vaccine antigens, 5: therapeutic antibodies, 6: curatives, 7: diagnostic agents and reagents, and 8: phytoremediation. In total, 405 cases were collected from 2006 to 2010. The numbers of cases were 120 for nutraceuticals, 65 for oral vaccines, 25 for edible curatives, 36 for vaccine antigens, 36 for therapeutic antibodies, 76 for curatives, 15 for diagnostic agents and reagents, and 40 for phytoremediation (sum of each cases was 413 because some reports were related to several categories). Nutraceuticals, oral vaccines and curatives were predominant. The most frequently used edible crop was rice (51 cases), and tomato (28 cases), lettuce (22 cases), potato (18 cases), corn (15 cases) followed.

著者

小林 大高 坂巻 弘之 小松 涼 飯島 伴典 飯島 康典 大津賀 博之 斉藤 克也 関 徹也 中村 英俊 山浦 知之 横林 邦明

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.7, pp.823-828, 2014 (Released:2014-07-01)

参考文献数

4

被引用文献数

2

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This study aimed to determine how much time can be saved with the use of unit-of-use packaging for prescription drugs as compared with bulk packaging in community pharmacies as well as to determine the number of errors. In a simulation, mock prescriptions were dispensed either in unit-of-use packages or by transferring medication from a bulk container, and a time study was conducted to measure the time spent on dispensing and prescription auditing by pharmacists. Pharmacists' and patients' degree of satisfaction was also surveyed. The time saved with unit-of-use packaging was 66.25 s per prescription. The sole dispensing error that was found in the study occurred with bulk dispensing. Among both pharmacists and patients, many were of the opinion that dispensing with unit-of-use packaging was preferable to bulk dispensing. Unit-of-use packaging shortens the time that pharmacists spend on dispensing activities and increases the efficiency of their work. Unit-of-use packaging is also thought to reduce the number of counting errors.

著者

土屋 文人

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.5, pp.595-598, 2014 (Released:2014-05-01)

参考文献数

3

---

In Japan, information technology (IT) in the medical field has prevailed as a means for handling claims for health insurance reimbursement. In contrast, IT is primarily used for electronic medical records in Western countries. Originally, preparation of health insurance claims was one of the outcomes of computerized medical information in Japan. As its protocols are already well established in Japan, information from the insurance claim system is hard to integrate into the Electronic Medical Chart system. To ensure drug safety, it is necessary to determine the number of users, and to accurately tabulate the incidence of adverse events. For this purpose, three kinds of information are required: prescription information, dispensing information, and drug administration information. Prescription information and dispensing information should be consistent with each other in content. Dispensing information is essential to identify the “substance” when adverse events occur. Drug administration information is the “true drug history”. With these three kinds of information, it should be possible to enter drug safety data as evidence. To accurately capture these three kinds of information, it is necessary to utilize Standard Drug Code and Standard Usage Master, suggesting that it may be necessary to reconstruct the current system.

著者

曲淵

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.222, 1900-08-26

著者

長沢 元夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.81, no.1, pp.129-138, 1961-01-25 (Released:2010-02-19)

参考文献数

9

被引用文献数

10

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Xi-xin is a crude drug using a subterranean portion of a few plants of Asiasarum genus (Asaraceae family). The most important of its component has been reported as methyleugenol which makes up about 50% of its essential oil but this was found to vary greatly according to habitat of the plant. Some plants contained safrole, eucarvone, and 1, 8-cineol as the chief components. Xi-xin oil from Manchurian plant was proved to contain elemicin, an isomer of cis-asaron.Tu-xi-xin is the dried root of Hetehotropa genus of the same family and used as a substitute for Xi-xin. The chief component of its essential oil had been reported as safrole but elemicin was found to be present as the chief component in some of the crude drug.

著者

関根 勇一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.6, pp.769-775, 2010 (Released:2010-06-01)

参考文献数

30

被引用文献数

1 2

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Signal-transducing adaptor protein-2 (STAP-2) was recently identified as a novel adaptor protein and is a family of STAP adaptor protein and has a variety of functions in cellular signal transductions. Especially STAP-2 has a crucial role in immune systems by controlling cytokine signal transduction. STAP-2 functionally interacts with STAT3 through its YXXQ motif and enhances STAT3 transcriptional activation. In contrast, STAP-2 interacts with STAT5 through its PH and SH2-like domains and decreases STAT5 activity. Importantly, STAP-2 also binds to MyD88 and IKK-α/β and regulates LPS/TLR4 signaling. Moreover, STAP-2 interacts with Epstein-Barr virus-derived LMP1 and modulates LMP1-mediated NF-κB signaling. More importantly, experiments using STAP-2 deficient mice showed that STAP-2 modulated several T-cell functions. T-cells from STAP-2 deficient mice showed enhanced integrin-mediated cell adhesion to fibronectin. Furthermore STAP-2-deficient T-cells show reduced chemotaxis toward SDF-1α. These accumulated evidences indicate that novel adaptor protein STAP-2 plays an important modulator role in both of innate and adaptive immune systems.

著者

竹本 常松 中島 正

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.84, no.12, pp.1183-1186, 1964-12-25 (Released:2010-02-19)

参考文献数

7

被引用文献数

29

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A colorless pillar crystalline component, m.p. 207° (decomp.), [α]D+80.0°(H2O), C5H8O4N2 of good flavor without smell, and of having insecticidal property was isolated from Tricholoma muscarium KAWAMURA (Jap. name: Haetorishimeji) in the process illustrated in Fig. 1. The compound was considered to be acidic amino acid, still unknown substance, which named tricholomic acid.

著者

竹本 常松 横部 哲朗 中島 正

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.84, no.12, pp.1186-1188, 1964-12-25 (Released:2010-02-19)

参考文献数

2

被引用文献数

42

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From Amanita strobiliformis (PAUL.) QUER. (Jap. name: Ibotengutake), colorless and odorless pillar crystalline component with good flavor, providing remarkable fly-killing properties, m. p. 151-152° (decomp.), C5H8O5N2 was isolated. The compound is considered to be an unknown acidic amino acid and is called ibotenic acid, naming after the ibotengutake.

著者

高田 宏文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.8, pp.1195-1200, 2011 (Released:2011-08-01)

参考文献数

21

被引用文献数

1 1

---

The mitogen-activated protein kinase (MAPK) pathways are signal transduction mechanisms that regulate many cellular processes in eukaryotic organisms, from yeasts to mammals. Multiple MAPKs regulate eukaryotic gene expression in response to various extracellular stimuli through phosphorylation of transcription factors. We have been studying the Pmk1 MAPK, a homologue of the mammalian ERK/MAPK in fission yeast. The Pmk1 MAPK regulates cell integrity and cell morphology. We have previously demonstrated that Atf1, a transcription factor downstream of the stress-activated MAPK pathway, serves also as a target of the Pmk1 MAPK signaling in fission yeast. Here, we identified ecm33+ gene, encoding a glycosyl-phosphatidylinositol (GPI)-anchored cell surface protein as a transcriptional target of Pmk1 and Atf1. The gene expression of ecm33+ is regulated by two transcription factors Atf1 and Mbx1. We also developed an in vivo real-time monitoring system of Atf1 or Mbx1 transcriptional activity, which enables to monitor the activation of the Pmk1 MAPK pathway by various stimuli. Finally, we demonstrated that Ecm33 is involved in the negative regulation of the Pmk1 MAPK signaling through the control of Ca2+ homeostasis. The ecm33 deleted cells displayed Ca2+ sensitivity and increased phosphorylation levels of Pmk1 MAPK. In addition, the Ecm33 overproducing cells displayed phenotypes closely similar to those of the pmk1 knockout cell. Collectively, Ecm33 plays a role in the negative feedback regulation of Pmk1 cell integrity signaling.

著者

岡田 欣晃

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.9, pp.1045-1049, 2012 (Released:2012-09-01)

参考文献数

14

被引用文献数

1 3

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Roundabout4 (Robo4) is a transmembrane receptor that belongs to the Robo family of neural cell adhesion molecules. Robo4 has been shown to play a role in endothelial cell (EC) migration, proliferation, angiogenesis, and stabilizing the vasculature. Robo4 is expressed specifically in ECs in the developing embryo, placenta, tumors, and normal tissues. The goal of our study is to understand the mechanism for Robo4 gene expression. In the previous study we demonstrated that EC-specific Robo4 gene expression was regulated by the 3-kb Robo4 promoter in the 5′-flanking region of the human Robo4 gene. In vitro studies demonstrated that the Robo4 promoter is activated by the transcription factors GA-binding protein (GABP) and SP1 through the ETS binding site at −119 and the 2 SP1 binding sites at −42 and −153, respectively. The functional relevance of these sites was confirmed by in vivo reporter gene assays using Hprt locus knock in mice. In addition to the regulation mechanism by transcription factors, our recent study implicated that epigenetic modification of the promoter contributes to the Robo4 gene expression. Here I will discuss the regulation mechanism of Robo4 gene expression by transcription factors and epigenetic control.

著者

櫻井 小平太

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.52, pp.232-239, 1886-06-26

著者

相本 太刀夫 平田 巳円男 平木 優子 土手 千恵子 井上 直人 今井 公江

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.114, no.2, pp.89-93, 1994-02-25

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The antioxidative effect of the mammalian liver hydrolyzate preparation (LH) was investigated mainly in the mouse liver homogenates. At lower concentrations, LH stimulated lipid peroxidation induced by Fe^<2+> and ascorbic acid in the homogenates, but inhibited completely the oxidation at higher concentrations. LH also inhibited the peroxidation of linolenic acid and linoleic acid. LH reduced 1,1-diphenyl-2-picrylhydrazyl, a free radical model, in a concentration-dependent manner, suggesting that the radical scavenging property of LH is involved in its antioxidative action. Fe^<2+> and glutathione, contained in LH, seem to act as a stimulator and an inhibitor of peroxidation, respectively.

著者

中村 清 宇津井 雄三 二之宮 靖子

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.86, no.5, pp.404-409, 1966-04-25

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Examination were made on gas chromatographic detection of approximately sixty kinds of nitrofuran derivatives. With the exception of a few compounds, majority of these derivatives were found to be detectable without decomposition.

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.17, pp.677-678, 1883-06-26

著者

白井 義啓 篠島 俊史 内山 周 竹腰 昌広 津島 永吉 田端 俊英

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.3, pp.439-445, 2014 (Released:2014-03-01)

参考文献数

26

被引用文献数

1 1

---

The cerebellar cortex, the brain region responsible for motor coordination and learning expresses a high density of B-type γ-aminobutyric acid receptor (GABAbR). Previous in vitro and in situ studies indicated that cerebellar GABAbR may mediate multiple forms of inhibitory and excitatory modulation of cerebellar circuits. Nevertheless, the in vivo influence of cerebellar GABAbR activation is unclear. As the first step in addressing this issue, we examined how pharmacological activation of cerebellar GABAbR modulates optokinetic reflex (OKR), an involuntary cerebellum-dependent eye movement for stabilizing the retinal image against the drift of the visual scene. We injected baclofen, a GABAbR-selective agonist, or control saline into the cerebellar flocculi of adult mice and then performed 1-h OKR measurement sessions on two consecutive days. In the day 1 session, the baclofen (5 nM)-injected mice and control mice showed similar initial OKR gains and similar training-induced increases in the OKR gain (OKR adaptation). This result suggests that GABAbR activation does not affect cerebellar computation for executing OKR and formation of short-term memory for OKR adaptation. At the beginning of the day 2 session, the baclofen (5 nM or 50 μM)-injected mice showed an OKR gain higher than that achieved in the day 1 session while the control mice did not. This result suggests that GABAbR activation may facilitate the formation of OKR adaptation-related long-term memory. These findings provide a new insight into the functional architecture of the cerebellar circuits and indicate GABAbR to be a new target of pharmacological therapy against diseases with cerebellar dysfunction.

著者

佐藤 卓 池田 英男 古川 一 村田 雄司 供田 真由子

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.124, no.10, pp.705-709, 2004-10-01

被引用文献数

1 3

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カンゾウ(Glycyrrhiza glabra Linn.)は甘味剤, 胃腸薬などとして用いられる重要な生薬で, 日本における消費量は増加傾向にあるが, その大部分を海外, 特に中国からの輸入に頼っている. 2000年の日本のカンゾウ総輸入量は4151tで, このうち中国産は3250tを占め, 中国からの輸入は過去10年で最高となっている(厚生労働省, 2002). その一方で, カンゾウの乱獲による環境破壊が中国西北地域一帯で進行しつつあり, 中国政府は現在まで実施していたカンゾウの輸出許可制度を活用した輸出総量規制, 輸出港の限定による無許可輸出の防止, 輸出許可取得料の値上げ, 生産地に対する管理, 規制などを進めている. そこで, 中国では野生カンゾウの採集に代わり, 栽培によるカンゾウの生産を実施しているが, かならずしも日本薬局方の定めるグリチルリチン酸含有量を満たしていない. 一方, 個人輸入業者が主として販売する未承認医薬品による健康被害があとを絶たないことから, 既存の漢方や生薬においてもより厳密な品質管理が求められる可能性が考えられる.

著者

高木 修造 山木 正枝 弓岡 栄三郎 西村 正 先名 淳

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.102, no.4, pp.313-317, 1982-04-25

被引用文献数

1

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A new bitter principle, centauroside was obtained from the whole plant of Erythraea centaurium (LINNE) PERSOON. with two glucosides. On the basis of chemical and spectral evidence, the structure of centauroside was confirmed to be a novel bis-secoiridoidal structure (III), and the others were established to be 6'-(m-hydroxybenzoyl) loganin, and secologanin dimethyl acetal arising from secologanin during the extraction process.

著者

増永 卓司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.1, pp.39-43, 2014 (Released:2014-01-01)

参考文献数

12

被引用文献数

1 7

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Cosmetics are consumer products intended to contribute to increasing quality of life and designed for long-term daily use. Due to such features of cosmetics, they are required to ensure quality and safety at a high level, as well as to perform well, in response to consumers' demands. Recently, the technology associated with nanomaterials has progressed rapidly and has been applied to various products, including cosmetics. For example, nano-sized titanium dioxide has been formulated in sunscreen products in pursuit of improving its performance. As some researchers and media have expressed concerns about the safety of nanomaterials, a vague feeling of anxiety has been raised in society. In response to this concern, the Japan Cosmetic Industry Association (JCIA) has begun original research related to the safety assurance of nanomaterials formulated in cosmetics, to allow consumers to use cosmetics without such concerns. This paper describes the activities of the JCIA regarding safety research on nanomaterials, including a survey of the actual usage of nanomaterials in cosmetics, analysis of the existence of nanomaterials on the skin, and assessment of skin carcinogenicity of nano-sized titanium dioxide. It also describes the international status of safety assurance and regulation regarding nanomaterials in cosmetics.