著者

清水 弘

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.48, no.9, pp.635-653, 1955 (Released:2011-10-14)

参考文献数

18

被引用文献数

1 2

著者

三上 慎司 上條 朋之 小泉 敏三 福田 多介彦 家根 旦有 細井 裕司

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.101, no.2, pp.147-151, 2008-02-01 (Released:2011-10-07)

参考文献数

16

---

White lesions in the larynx, pharynx, and oral regions, which are called leukoplakias clinically, show a variety of histopathological features, including hyperplasia, dysplasia and cancer. Therefore, they should be treated carefully as precancerous lesions. Eighty-one patients with leukoplakia of the larynx, pharynx and oral tissue were treated between 1996 and 2005.The majority of these patients with leukoplakia in the larynx were heavy smokers.In the 11 cases of leukoplakia in the larynx, the white lesions were resolved by conservative treatment. Based on the findings above, it is important for heavy smokers to stop smoking completely. In leukoplakia of the larynx, squamous cell carcinoma was detected in 15 cases (26.8%).In leukoplakia of the oral tissue and pharynx, squamous cell carcinoma was detected in 2 (8.0%).Among the 81 cases in this series, squamous cell carcinoma was detected in 6 laryngeal lesions and 1 oral and pharyngeal lesions. Histological findings of these lesions were all dysplasia, initially. Therefore, long term follow-up is recommended if the histologoical findings of leukoplakia initially demonstrate dysplasia.

著者

雫 俊一 牛尾 信也 多田 豊 石田 美夫

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.69, no.10special, pp.1380-1390, 1976-10-20 (Released:2011-11-04)

参考文献数

22

著者

卜部 信行

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.78, no.8special2, pp.1731-1745, 1985-08-24 (Released:2011-11-04)

参考文献数

32

---

Cases of tinnitus totaling up to 163 examined at the Oto-Rhino-Laryngological Clinic of Tottori University Hospital have been reviewed. They consisted of 78 men and 85 women aged from 15 to 84 years. Tinnitus was attempted to be expressed verbally by onomatopoeia. The most frequent expression was “geen” [d i n]. Pitch matching and loudness matching tests were carried out in 146 patients. The most frequently observed pitch and loudness of tinnitus was 8000Hz and 0dB HL., respectively. The masking curve examined by bands of noise showed 7 types, including the convergence type (42% of 77 cases). Residual inhibition (RI) was studied by 1-min delivery of bands of noise in 82 cases, in 58 of which RI was positive. Effects of i. v. injected lidocaine (60mg for males, 40mg for females) were examined in 121 cases: tinnitus disappeared entirely in 39 cases; and was reduced partially in 53. The i. v. injected agent was effective in most of the RI-positive cases. To sum up these findings and ones obtained by auditory brain-stem response examination, suppression of tinnitus by RI and i. v. injected lidocaine may result from participation in the brain stem.

著者

調所 廣之

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.85, no.1, pp.21-23, 1992-01-01 (Released:2011-11-04)

参考文献数

4

被引用文献数

1

著者

立木 孝

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.58, no.11, pp.741-751, 1965-11-01 (Released:2011-10-14)

参考文献数

31

著者

末光 喜代三

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.42, no.1-12, pp.119-129, 1949 (Released:2011-10-14)

参考文献数

26

著者

馬越 智浩 高橋 廣臣 八尾 和雄 稲木 勝英 中山 明仁 永井 浩巳 岡本 牧人

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.94, no.1, pp.65-69, 2001-01-01 (Released:2011-11-04)

参考文献数

18

---

Between June 1988 and December 1996, 57 patients with non-Hodgkin's lymphomas of the head and neck were treated at our department. The primary lesion was located in Waldeyer's ring in 31 patients and cervical lymph nodes in 26 patients. These patients, who were diagnosed as Stage I or II, were treated with chemotherapy and radiation. The chemotherapy regimen consisted of pirarubicin (45mg/m2; day 1), cyclophosphamide (750mg/m2; dayl), vindesine (1.5mg/m2; day 1) and predonisolone (100mg/body; days 1-5). The complete and partial response rates were 79% and 82% respectively. The five-year estimated overall survival rate calculated by Kaplan-Meier method was 75%. We concluded that the combination of chemotherapy regimen (THP-CVP) and radiation were useful and safe for treating non-Hodgkin's lymphomas of the head and neck.

著者

水田 啓介 伊藤 八次 西田 基 秋田 茂樹 加藤 雅也 小塩 勝博 海田 健宏 古田 充哉 宮田 英雄 柳田 正巳 柴田 康成 横山 壽一 松原 茂規 小泉 光 森 芳郎 大野 通敏 近藤 由香 藤宮 大 山田 匡彦 渡辺 英彦 加藤 洋治

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.12, pp.1399-1407, 1997-12-01 (Released:2011-11-04)

参考文献数

14

---

IPD® (supratast tosilate) was investigated for its prophylactic efficacy and therapeutic efficacy in the treatment of cedar pollinosis during the 1996 cedar pollen season. The subjects investigated were patients at the Gifu University School of Medicine and its affiliated hospitals, who had a history of cedar pollinosis. The patients were classified into two treatment groups: the prophylaxis group (70 patients), in whom IPD® administration began before the start of cedar pollen dispersion, and the treatment group (49 patients), who underwent IPD® treatment only after cedar pollen dispersion had begun and symptoms of pollinosis had manifested.Results were as follows: (1) The nasal symptoms (sneezing, runny nose, nasal congestion) were milder in the prophylaxis group than in the treatment group throughout the cedar pollen season, with the difference being significant during the season's first 2 weeks. (2) In the prophylaxis group, IPD®'s inhibitory effect was rated as excellent in 18.6% of the patients, good in 45.7% and fair in 20.0%. In the treatment group, the improvement in the symptoms was rated as disappearance in 4.2%, excellent in 20.8% and good in 43.8%. (3) When symptom inhibition in the prophylaxis group was investigated as a function of the duration of IPD® administration prior to the start of pollen dispersion, the good + excellent inhibition rate was 57.7% in the subpopulation pretreated for <2 weeks (26 cases), 64.9% with 2 to <4 weeks' pretreatment (37 cases) and 85.7% with 4 to <6 weeks' pretreatment (7 cases). Thus, IPD®'s prophylactic inhibitory rate increased with the length of the pretreatment period. (4) In the prophylaxis groups, the CAP-RAST value was significantly reduced at the time of peak pollen level and at the end of the pollen season compared with the value before IPD® administration.

著者

栗橋 克昭 柳原 尚明 西村 宏子 末広 進 近藤 武久

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.68, no.4, pp.533-541, 1975 (Released:2011-11-04)

参考文献数

53

被引用文献数

4 5

著者

寺薗 富朗 大島 渉 中尾 美穂 紀平 晋也 河田 了 大川 和春 高田 憲

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.84, no.2, pp.203-207, 1991-02-01 (Released:2011-11-04)

参考文献数

20

被引用文献数

2 1

---

An unusual case of pleomorphic adenoma of the epiglottis is described. A 71-year-old female complained of dysphagia. Laryngoscopy revealed a tumor located on the laryngeal side of the epiglottis. The tumor was excised successfully by laser treatment under laryngomicroscopy. The extirpated tumor was 1.5cm in diameter, the cut surface was solid and light yellow, and the microscopic diagnosis was pleomorphic adenoma. This is one of three cases of pleomorphic adenoma of the epiglottis to have been reported in Japan.

著者

菱村 祐介 清水 啓成 篠原 宏 中野 光花

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.112, no.8, pp.505-510, 2019

---

<p>Herein, we report a case of isolated oculomotor nerve paralysis caused by a sphenoid sinus cyst. An 80-year-old man presented with right-sided ptosis, diplopia and occipital headache. He had unilateral ptosis and disturbance of the upward, downward and inward ocular movements, however, ophthalmologic examination showed neither visual impairment, nor pupillary dilatation. The symptoms were clearly caused by isolated right oculomotor nerve paralysis. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a lateral sphenoid sinus lesion with a smooth margin compressing the right cavernous sinus and shaving down the surface of the clivus. Based on a diagnosis of sphenoid sinus cyst, we performed endoscopic surgery under general anesthesia. The ocular movements became normal approximately 2 months after the operation and the right-sided ptosis disappeared within 6 months of the sugery. Since oculomotor nerve paralysis due to sphenoid sinus cyst is highly amenable to cure by endoscopic surgery, operation should be aggressively pursued for its treatment.</p>

著者

金丸 眞一 福島 英行 中村 一 木村 裕毅 玉木 久信

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.87, no.2, pp.171-176, 1994-02-01 (Released:2011-11-04)

参考文献数

18

被引用文献数

1

---

The severe type of idiopathic sudden sensorineural hearing loss (ISSHL) was treated with genetic recombination interferon alpha-2a (alpha-IFN) (3 million IU/day for 10 days) plus cortico-steroid, and the results were significantly better than those obtained by conventional treatment with cortico-steroid, vitamins, and vasodilators. Assays for 2'-5' oligoadenylate synthetase (2-5 AS), one of the indices of circulating anti-viral activity were performed patients before and on the third day of IFN therapy, and the levels were found to correlate well with the degree of their hearing improvement. These results suggest that viral infections may be related to the etiology of the severe type of ISSHL and that alpha-Interferon is useful in its treatment.

著者

高橋 昭

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.75, no.1special, pp.266-273, 1982 (Released:2011-11-04)

参考文献数

23

---

Fisher's syndrome comprises ophthalmoplegia, ataxia and areflexia. The clinicoanatomical correlation and the nosological situation have been disputed since the first description by Fisher in 1956. The accumulated data indicate that the syndrome is a demyelinative process of peripheral nerves and is to be linked with the Guillain-Barré-Strohl syndrome.Eight patients with Fisher's syndrome were examined in order to study the site of lesion responsible for ataxia. The nature of ataxia was considered to be not segmental incoordination but static or locomotor ataxia, because of the lack of ataxia in the extremities and in speech even when the patients were unable to stand or sit. Vibratory sensation was severely impaired in the majority of the cases. Some patients had unique distribution of proximal dominancy. Both the severity and clinical course of dysequilibrium had intimate relations to those of the vibratory disorder. No clinical or laboratory findings were obtained which suggested vestibulocerebellar dysfunction.Morin's spino-cerevico-thalamic tract has been recently proposed as a possible pathway of vibratory sensation and equilibrium. A sole autospied case was reported by Richter (1962) who demonstrated the restricted degeneration of Flechsig's middle root zone in the posterior column of the spinal cord which relays vibratory and proprioceptive sensations via Morin's tract to the cerebrum and cerebellum.It is concluded that the events of vibratory sensory loss connected with dysequilibrium seem to be important in these respects.

著者

高橋 昭

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.76, no.9special, pp.2354-2362, 1983-09-15 (Released:2011-11-04)

参考文献数

16

---

Multiple cranial nerve palsy can occur in various intracranial or juxtacranial diseases including neoplasm, granuloma, angiopathy and meningeal diseases, or in acute or chronic relapsing polyneuropathy of demyelinating nature. The latter condition is characterized by symmetrical or bilateral, and predominantly motor nerve involvement.In 1967, the author described a peculiar, multiple, cranial nerve palsy and proposed the descriptive designation of migrating, disseminated, multiple, cranial neuropathy. Since then, 9 cases have been reported from Japan and 3 case series have been known from Thailand, Sri-Lanka and Finland.The cranial nerve palsy in this disease is acute in onset, usually self-limited in course, and migrates with latent interval. All of the sensori-motor cranial nerves II-XII may be involved. Repeated and careful examination and long-term follow-up study failed to disclose any evidence of systemic or local underlying disease processes.In this report, 10 of our own cases are described. Paralysis of the vestibulo-Cochlear nerve was found in 5 patients. Neurological and neuro-otological studies disclosed that hearing loss was of sensori-neural type and the vestibular dysfunction was due to peripheral origin. One of these was found to have benign paroxysmal positional vertigo.Attention should be given to those presenting with vestibulo-cochlear symptoms and signs, especially with a tendency to relapse, in relation to migrating, disseminated, multiple, cranial neuropathy.

著者

高橋 昭

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.75, no.11special, pp.2383-2391, 1982 (Released:2011-11-04)

参考文献数

23

被引用文献数

2 1

---

In 1916 three French neurologists, Guillain, Barré and Strohl, presented their important paper describing 2 patients with polyneuritis. They emphasized the predominant motor weakness of the limbs with minimal sensory loss, hyporeflexia, elevated protein level in cerebrospinal fluid without cellular reaction and favourable prognosis. Since that time, the syndrome has been referred the Guillain-Barré syndrome, but the diagnostic limits of the disorder had been disputed because of inclusion of many types of acute and chronic polyneuritis under this title. In 1960, Osler and Sidell published a paper and set down diagnostic criteria which severely restricted the definition of the disorder. A new diagnostic criteria for the disorder was clearly proposed for field studies by an ad hoc NINCDS committee (1978) and Asbury (1981). These clinical study yields pathological and experimental evidences suggesting that GBS is an acute immune-mediated polyneuropathy (AIMP) and a distinctive entity. GBS is now one of the most frequent forms of acute polyneuritis.Vestibular neuronitis is the term applied originally by Dix and Hallpike (1952) to a distinctive disturbance of vestibular function, characterized clinically by an abrupt and usually a single and severe attack of vertigo and by an absence of cochlear abnormality. The pathological site of the vestibular pathway and the nature of the affection have not been established. Consequently, there is confusion regarding its nosological situation.In this article, the diagnostic criteria of the Guillain-Barré syndrome are reviewed and vestibular neuronitis is compared with it in order to refine the definition. In considering the clinical characteristics, there is some similarlity between vestibular neuronitis and Guillain-Barré syndrome. The only significant difference is that vestibular neuronitis is confined primarily to the vestibular nerve. Thus, it is suggested that vestibular neuronitis should be investigated in future with relation to AIMP as well as from the viewpoint of directly infectious or vascular etiology.

著者

鈴木 安恒

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.58, no.3, pp.115-120, 1965-03-01 (Released:2011-10-14)

著者

伊藤 壽一

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.100, no.1, pp.1-5, 2007-01-01 (Released:2011-10-07)

参考文献数

8

---

Recently, regeneration medicine has received considerable attention in various fields and clinical applications have been attempted. There are approaches to regeneration medicine. The first approach is to transplant cells, especially various kinds of stem cells into the organs and tissues. The other approach is to promote the self-regenerative ability of cells. In many cases, however, cellular self-regenerative ability is limited. Growth factors are thought to play an important role in cellular proliferation, differentiation and regeneration, while the loss of growth factors contritutes to various diseases. In this report, the discovery of growth factors, examples of various growth factors and the application of growth factors to regeneration medicine are discussed.

著者

福島 典之

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.83, no.6, pp.953-966, 1990-06-01 (Released:2011-11-04)

参考文献数

29

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This study was designed to investigate the effects of acoustic deprivation and stimulation following acoustic trauma.Symmetrical bilateral cochlear lesions were produced in 33 chinchillas by exposure to a high intensity pure tone (117dBSPL, 2kHz) for 15 minutes. Cochlear thresholds were derived from the cochlear action potentials (CAP) taken prior to and one day after exposure. Then the incudo-malleolar complex of one side was removed so that one cochlea was normally stimulated during the recovery period, while the other was deprived of sound. After a period of one to twelve weeks the OAP's on the non-deprived (nonoperated) side were measured. Hair cell damage in the acoustically deprived cochlea was assessed with scanning electron microscopy. In order to quantify the degree of damage to the sensory epithelium, a hair cell damage scale was implemented based on stereociliary integrity.The control group consisted of six chinchillas with unilateral ossiculectomy but no sound exposure, and four which received sound exposure only. The cochleas of these animals also were analyzed by scanning electron microscopy.The most significant result of this study was that the cochleas with acoustic deprivation during the recovery period sustained a higher degree of damage than the acoustically stimulated cochleas.Another result was that symmetrical cochlear lesions could be produced by strict monitoring of sound pressure balance in both middle ear cavities. Finally, careful ossiculectomy did not affect cochlear morphology.

著者

山際 幹和 福生 治城 坂倉 康夫 三吉 康郎

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.76, no.4, pp.1307-1319, 1983-04-01 (Released:2011-11-04)

参考文献数

18

被引用文献数

1

---

咽喉頭異常感症女性例50例を東洋医学的診断を行うことなく, 西洋医薬と同様の概念でツムラ半夏厚朴湯 (7.5g/日, 14日間連日経口投与) を用いて治療した. 自覚症状の改善率が80%以上を著効, 50%以上を有効, 30%以上をやや有効, それ未満を不変として効果を判定した. その結果, 著効, 有効およびやや有効率は, 1週目で各々26%, 26%, 8%, 2週目で各々42%, 16%, 12%, 又, 3週目 (休薬後1週目) で各48%, 18%, 6%であった. 1例に副作用らしき症状 (嘔気) がみられた. 種々の点から治療成績の分析を行ったところ, 発症より本剤による治療開始までの期間が短い例ほど有効率が有意に高いことが判明したが, 本剤の作用機序を類推するには至らなかった. 西洋医学的診療に加え, 東洋医学的診療を行うことにより, 本症の治療成績は明らかに向上するものと考えた.