著者

小山 岩雄 山上 治夫 桑江 豊保 倉田 宗司

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.102, no.8, pp.796-799, 1982

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The contents of 6-keto-prostaglandin F<SUB>1&alpha;</SUB> (6KF<SUB>1&alpha;</SUB>) and thromboxane B<SUB>2</SUB> (TXB<SUB>2</SUB>) in mouse peritoneal macrophages were determined by radioimmunoassay. When indomethacin at a final concentration of 0.1 mM was added at each stage in the preparation of macrophage samples, i.e. (I) before incubation of peritoneal exudate cells in glass dishes to prepare macrophage monolayers, (II) before harvest of macrophages from the glass surfaces, (III) before sonication of macrophage suspensions, and (IV) before centrifugation of sonicated macrophage solutions, large differences were detected in the contents of 6KF<SUB>1&alpha;</SUB> and TXB<SUB>2</SUB> at each stage. These results suggested that physical stimulation during the preparation of samples resulted in increases of 6KF<SUB>1&alpha;</SUB> and TXB<SUB>2</SUB> production by macrophages.

著者

小森 浩二 塙 由美子 山本 淑子 古前 竜平 山崎 裕己 中野 祥子 三田村 しのぶ 宮﨑 珠美 菊田 真穂 高田 雅弘 首藤 誠

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.133, no.8, pp.905-911, 2013

被引用文献数

2

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&nbsp;&nbsp;Loxoprofen (Loxonin^&reg;), an antipyretic painkiller, was approved as an over-the-counter (OTC) drug (Loxonin^&reg;-S) in January 2011. With regard to self-medication using OTC drugs, the information that pharmacists provide to consumers is very important. Although loxoprofen is a very versatile drug and can be used during breastfeeding, information regarding its mammary gland transfer is inadequate. In this study, we established a simple method to evaluate mammary transfer of drugs, and compared loxoprofen's mammary gland transfer with that of aspirin. Loxoprofen 12 mg/kg and aspirin 132 mg/kg was orally administered to mother mice (ddY), and blood and milk samples were collected. Twenty microliters of ethanol was added to the blood and milk samples (10 &mu;L), and the mixture was centrifuged for 15 min (12000 <i>g</i>); the supernatant was analyzed by high-performance liquid chromatography. Since aspirin was immediately metabolized, we analyzed salicylic acid concentrations. Maximum concentration of loxoprofen was observed at around 15 min after its oral administration, with the concentrations in the blood and milk being 2.9 and 0.5 &mu;g/mL, respectively. The drug was metabolized promptly thereafter. In contrast, maximum concentration of salicylic acid was observed at 30 min after aspirin administration, with the concentrations in the blood and milk being 187.2 and 64.4 &mu;g/mL, respectively. These concentrations remained constant from 60 to 120 min. Salicylic acid could be detected 240 min after aspirin administration. Thus, mammary gland transfer of loxoprofen is lower than that of aspirin, suggesting that loxoprofen does not accumulate in milk.<br>

著者

瀬川 林次郎

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.1915, no.401, pp.854-868, 1915-07-26 (Released:2018-08-30)

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.194, pp.361-367, 1898-04-26

著者

栗秋 要

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌

巻号頁・発行日

vol.64, no.2, pp.128-129, 1944

著者

石津 利作

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.335, pp.1-12, 1910-01-26

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純粹度ヲ保シ難キ製品ニ就キ極メテ不確實ナル分析ヲ基礎トシテC_<16>H_<19>O_4SK+H_2Oナル化學記號ヲ設定スルハ大早計ナルヲ難シ純レスピラチン」ナルモノニ於テ喜多尾氏カ言明セルカ如キ特殊ノ形熊並ニ性状ヲ發見スルコト能ハサルヲ述へ同氏ガ「デブス氏法ニ依リテ硫黄ヲ定量シ其成績ニ甚シキ動揺アルハ偶々以テ自己技術ノ拙劣ヲ表ハスモノニシテ未タ純レスピラチン中硫黄定量ノ困難ナル證據トナスニ足ラサルヲ論シ終ニ藥學雜誌上ニ發表セラレタルカ如ク「チオヂクレオソール」ナル名稱ハ單ニ發明名稱ニシテ此名稱ニ依リ純レスピラチン」ノ分子構造ヲ表示セントスル意ニ非スシテ只其成分ノ列記ニ過キサルコトヲ齊シク他ノ雜誌並ニ新聞ニ廣古シ世人ヲ惑ハスカ如キ告白ヲ避ケ且ツ硫黄含量ノ確定スルニ至ル迄C_<16>H_<19>O_4SK+H_2Oノ如キ更ニ根據ナキ化學記號ヲ吹聽スルノ輕學ヲ戒メラレンコトヲ發明者ニ希望セリ

著者

古川

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.98, 1890-04-26

著者

田原

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.176, pp.1015-1016, 1896-10-26

著者

上野 金太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.170, pp.363-373, 1896-04-26

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.51, no.4, pp.302-335, 1931-04-26 (Released:2009-11-13)

著者

須田 勝三郎 米城 善右衛門

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.1902, no.242, pp.321-326, 1902-04-26 (Released:2008-04-11)

著者

朝比 奈泰彦 上野 周

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.408, pp.146-159, 1916-02-26

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著者等は甘茶の甘味成分たる結晶性物質の化學的研究を行ひ之をフヰロヅルチンと命名し各種誘導體及分解成績物の檢査によりて一種の構造式を提出せり

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.74, pp.183-186, 1888-04-07

著者

太田 邦史 瀬尾 秀宗

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.127, no.1, pp.81-89, 2007-01-01

被引用文献数

1 2

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Monoclonal antibodies (MAbs) have been utilized as research tools, as diagnostic reagents, and for antibody medicine. The preparation of MAbs involves laborious processes and normally takes months. Here we describe an ex vivo B cell-based antibody display system called the ADLib (Autonomously Diversifying Library) system, which enables us to select chicken B cell clones producing antibody against antigens of interest in a couple of weeks. The ADLib system is applicable to self- or highly conserved antigens, polysaccharide chains, peptides, and haptens.

著者

二宮 忠八

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.254, pp.328-332, 1903-04-26

著者

上野

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.160, pp.509-510, 1895-06-26

著者

辻岡

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.101, 1890-07-26

著者

山田

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.178, pp.1206-1208, 1896-12-26

著者

安宅 弘司 伊藤 雅文 柴田 高

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.125, no.12, pp.937-950, 2005-12-01

被引用文献数

2 5

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Wood creosote, the principal ingredient in Seirogan, has a long history as a known gastrointestinal microbicidal agent. When administered orally, the intraluminal concentration of wood creosote is not sufficiently high to achieve this microbicidal effect. Through further animal tests, we have shown that antimotility and antisecretory actions are the principal antidiarrheal effects of wood creosote. Wood creosote inhibits intestinal secretion induced by enterotoxins by blocking the Cl^- channel on the intestinal epithelium. Wood creosote also decreases intestinal motility accelerated by mechanical, chemical, or electrical stimulus by the inhibition of the Ca^<2+> influx into the smooth muscle cells. In this overview, the antimotility and antisecretory effects of wood creosote are compared with those of loperamide. Wood creosote was observed to inhibit stimulated colonic motility, but not normal jejunal motility. Loperamide inhibits normal jejunal motility, but not stimulated colonic motility. Both wood creosote and loperamide inhibit intestinal secretion accelerated by acetylcholine. Wood creosote was found to have greater antisecretory effects in the colon than loperamide. Based upon these findings, we conclude that the antidiarrheal effects of wood creosote are due to both antisecretory activity in the intestine and antimotility in the colon, but not due to the microbicidal activity as previously thought. Wood creosote was found to have no effects on normal intestinal activity. These conclusions are supported by the results of a recent clinical study comparing wood creosote and loperamide, which concluded that wood creosote was more efficacious in relieving abdominal pain and comparable to loperamide in relieving diarrhea.

著者

川口 安郎 中村 芳正 佐藤 俊幸 武田 節夫 丸中 照義 藤井 節郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.98, no.4, pp.525-536, 1978

被引用文献数

8

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After oral administration of 5-fluoro-1, 3-bis (tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FD-1), the level of 5-fluoro-2, 4-pyrimidinedione (5-FU) was 5 to 7 times higher in the plasma and normal tissues and 8 to 12 times in tumor tissue than after administration of 5-fluoro-1-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (FT). Moreover, these levels were maintained longer than after administration of FT. In tumor tissue, the concentration of 5-FU was still as high as 1.42 &mu;g/g 12 hr after administration of FD-1. FD-1 was degraded to 5-fluoro-3-(tetrahydro-2-furanyl)-2, 4-pyrimidinedione (3-FT) by liver microsomal drug-metabolizing enzymes in vitro and to FT spontaneously. Subsequently, FT was converted enzymically to the active substance, 5-FU, and 3-FT changed to 5-FU spontaneously. Conversion of FD-1 to 5-FU via 3-FT was greater than via FT. It is concluded that a large amount of 5-FU formed after administration of FD-1 is formed via 3-FT. &gamma;-Hydroxybutyric acid was found to be formed in vivo and in vitro from the tetrahydrofuranyl group of FD-1.