著者

衣笠 豊 服部 安藏

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.485, pp.579-595, 1922-07-26

著者

新藤 恭司 安田 行寛 多比良 和基 三谷 鳴夫 神田 敦弘 赤沢 明

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.99, no.12, pp.1186-1200, 1979

被引用文献数

5

---

The biological fate of 4-butyl-4-(β-carboxypropionyl-oxymethyl)-1, 2-diphenyl-3, 5-pyrazolidinedione (Suxibuzone, SB) was compared with that of phenylbutazone (PB) in rats, rabbits, beagle dogs and rhesus monkeys. The results obtained were as follows ; 1) When SB was administered orally, the main metabolites in the plasma were PB, oxyphenbutazone (Oxy-PB) and γ-hydroxyphenylbutazone (γ-Hydroxy-PB) in all species, though species differences were observed in the maximum plasma levels of the respective metabolites. Only in dogs and monkeys, was a small amount of SB detected in the plasma during the early time of dosing. 2) The metabolites and their maximum levels in plasma after the administration of SB were almost identical with those observed after the administration of PB. 3) After administration of SB, the main metabolites found in urine were PB, Oxy-PB, γ-Hydroxy-PB and their conjugates in all species, while species differences were observed in the percent excreted. In the dogs and monkeys, urinary excretion as the form of SB and 4-hydroxymethylphenylbutazone (4-HM-PB) glucuronides was observed in small amount for 0-12 hours. 4) There were no significant differences in the metabolites and their excreted percent in urine between SB and PB administration. 5) Differences between male and female in maximum plasma levels of PB and γ-Hydroxy-PB and in urinary excreted percent of γ-Hydroxy-PB were observed only in rats. 6) Species differences were observed in esterase activity on SB in vitro. 7) SB was bound to the albumin fraction as in the case of PB, but its binding percent was about 1/2 lower than that of PB. 8) SB showed anti-edematous action on carrageenin-induced edema and its activity was almost similar to that of PB. Anti-edematous activity of Oxy-PB was weaker than that of SB and γ-Hydroxy-PB had no effect on its action.

著者

酒井

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.208, pp.584-585, 1899-06-26

著者

今村 孝史 野田 敦子 柴田 重信 渡辺 繁紀 野田 浩司 小野 容子 後藤 茂 井上 善文

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.113, no.5, pp.400-405, 1993-05-25

---

A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo [3,4-a] phthalazine (Tri-P) and 3-propyl derivatives of Tri-P (PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.

著者

吉富 英助 甲斐 晋

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.1926, no.530, pp.307-308, 1926-04-26 (Released:2009-10-22)

著者

南 基泰 四方 恒生 長谷川 千晃 大江 千里 芦田 馨 杉野 守

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.115, no.10, pp.832-842, 1995-10-25

被引用文献数

6

---

We studied that the morphological and histological characteristics, and the content (%DW) of saikosaponins on the root of Bupleurum falcatum cultivated in an Ebb & Flood system (E&F), a kind of soilless culture system, by both the direct sowing and the transplanting methods, and that effects of pinching on the root growth and the content (%DW) of saikosaponins in each part of root. Yield of root and content (%DW) of saikosaponins in each part of root, 8-months-old, cultivated in E&F by both methods were at the same level as that cultivated for the same period in soil conditoin by generally standard procedures. Morphological characteristics of the root cultivated by the direct sowing method were the same appearance as that by soil condition, but by the transplanting method main root branched off in all direction and the lateral root were more developed than by the direct sowing method. By pinching lignification in xylem on the main root were inhibited, but the dried weight of total root part and content (%DW) of saikosaponins in each part of the root were not shown to be significantly changed.

著者

山浦 克典 吉原 正義

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.123, no.10, pp.887-891, 2003-10-01

被引用文献数

3 11

---

インフルエンザは毎年日本国内において12月から3月の間に大流行し,小児ではインフルエンザ脳炎・脳症を,高齢者では肺炎などの重篤な合併症を引き起こす危険性のある呼吸器系感染症である.近年,インフルエンザウイルスの特効薬となるノイラミニダーゼ阻害剤が開発され,インフルエンザ治療においても特異的な薬物治療が行われるようになり,治療効果も格段に向上した.現在日本国内で臨床使用されているノイラミニダーゼ阻害剤は内服薬のオセルタミビルと吸入薬のザナミビルの2剤である.2002年度のインフルエンザ流行シーズンにおいては,オセルタミビル製造供給メーカーによる供給計画の狂いと,前年より1ヵ月早いインフルエンザの流行により,オセルタミビルの供給滞り問題が発生したことから出荷調整が行われ,全国的にノイラミニダーゼ阻害剤の在庫不足に陥った.いずれの薬剤も保険適応は5日間処方であるが,全国各地の医療機関において,2日又は3日間処方により在庫不足に対応せざるを得ない状況が多くみられた.そこで,本研究においては,オセルタミビル供給滞りに伴い,短縮処方された患者の医療費及び治療効果について,適応の5日間処方患者と比較検討した.

著者

近藤

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.253, pp.250-251, 1903-03-26

著者

朝比奈

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.319, pp.934-935, 1908-09-26

著者

木村 雄四郎 滝戸 道夫 中野 紘一 滝下 満之

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.86, no.12, pp.1184-1186, 1966-12-25

被引用文献数

1

---

From the petroleum ether extracts of rhizomate of Alpinia speciosa K. SCHUMANN and A. kumatake MAKINO (A. formosana K. SCHUMANN), dihydro-5,6-dehydrokawain (I) and 5,6-dehydrokawain (II) were isolated. The latter was isolated for the first time from Zingiberaceae plants and the former, from a natural source.

著者

平塚 祥子 熊野 宏昭 片山 潤 岸川 幸生 菱沼 隆則 山内 祐一 水柿 道直

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.120, no.2, pp.224-229, 2000-02-01

被引用文献数

1

---

The failure of patients to comply with treatment regimens recommended by their physicians is a significant clinical problem. Researches on the assessment of compliance have, however, been precluded by methodological difficulties such as lack of adequate measures. The purpose of this study was to develop a self-administered questionnaire to evaluate drug compliance. First, questionnaire containing a 52-items complied by two doctors, a pharmacist and a nurse, was tested on 81 outpatients, all volunteers, attending the departments of psychosomatic medicine and internal medicine. Four items were temporarily removed for later analysis because they directly inquired about drug compliance (drug compliance items). The other 48 items were analyzed and three factors consisting of 26 items were further studied : expectation on taking medicine, rejection to taking medicine and seeking knowledge of drugs. Chronback's alpha coefficients representing internal consistency of the three factors were sufficiently high (ranging from .75 to .84). Furthermore, we preformed a simplified pill count to validate the 4 drug compliance items. There was a weak to moderate correlation between the result of pill count and each of 4 drug compliance items. A new self-administered questionnaire of 30 items was thus developed and named the Drug Compliance Scale.

著者

山口 秀夫 有本 正生 田之口 真理子 沼田 敦

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.5, pp.485-488, 1981

被引用文献数

7

---

Two kinds of reactions were carried out on the components of the seeds of Hernandia ovigera L. The reaction of lead tetraacetate on desoxypodophyllotoxin (I) and its analogous compounds caused the cleavage of methylenedioxyl group, affording the corresponding diphenols. In the case of 3, 4-methylenedioxypropylbenzene (XII), an intermediate acetoxyl compound (XIII) was isolated. The reactions of 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) on I and its analogous compounds afforded smoothly aromatized compounds. By the same reaction on bursehernin (III), cyclization and aromatization occurred simultaneously affording chinensin (XVIII) which was confirmed by direct comparison with authentic speciemen. The results of the cleavage reaction on I and XII by use of borontrichloride were also described.

著者

窪田 正彦 新井 清 頼光 彰子 島岡 真佐子 星野 響 林 一之 伊田 泰康 南 典昭 山本 博文 田中 恵一 高田 三千人 西原 正勝 藤谷 幸治 神田 博史

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.113, no.11, pp.810-817, 1993-11-25

---

The cultivation of Papaver bracteatum, having thebaine as a major alkaloid, needs permission by the law of the narcotic regulation in Japan. Therefore, the flowergrowing of P. bracteatum as garden plants is prohibited by law. Chemical, morphological and cytological analyses of gardening 18 plants of the section Oxytona of the genus Papaver collected in western Hiroshima prefecture were carried out as a preliminary study. On inquiry, thebaine was identified as an only alkaloid from one of the gardening plants. The amounts of thebaine contained in this sample was 0.68%. Petals of this plant are scarlet with black spots at their bases which are surrounded by bracts. These results indicated that one of the investigated plants was identified to be P. bracteatum.

著者

山田

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.99, pp.326-327, 1890-05-26

著者

酒井 一夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.126, no.10, pp.827-831, 2006-10-01

被引用文献数

2 18

---

"Hormesis" is defined, originally in the field of toxicology, as a phenomenon in which a harmful substance gives stimulating effects to living organisms when the quantity is small. The concept was extended and applied to ionizing radiation, high doses of which are harmful. Although radiation has been thought to be, based on findings in high dose ranges, harmful no matter low the dose is, recent investigation revealed that living organisms possess the ability to respond to low-dose radiation in very sophisticated ways. A good example of such responses is the so-called radiation adaptive response, a process in which acquired radioresistance is induced by low-dose radiation given in advance. The stimulation of certain bioprotective functions, including antioxidative capacity, DNA repair functions, apoptosis, and immune functions are thought to underly the adaptive response. The adaptive response is effective for chromosome induction, acute death, and tumorigenesis induced by high doses of radiation. Radiation hormesis and adaptive response provide a new scope in the risk assessment and medical application of ionizing radiation.

著者

大野 勝行

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.192, pp.95-118, 1898-02-26

被引用文献数

1

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.306, pp.928-929, 1907-08-26

著者

兒島

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.155, pp.21-22, 1895-01-26

著者

久田 末雄 安野 爽子 稲垣 勲

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.91, no.6, pp.687-689, 1971-06-25

被引用文献数

1

---

Rhizomes of Dryopteris bissetiana C. CHR. (Aspidiaceae) were examined for phloroglucinol derivatives and margaspidin was isolated. This is the first time that margaspidin was isolated from Japanese ferns. Margaspidin was also detected by thin-layer chromatography from the rhizomes of D. pacifica TAGAWA, D. saxifraga H. ITO, and D. sacrosancta KOIDZ.

著者

狐塚 寛

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.115, no.3, pp.157-169, 1995-03-25

被引用文献数

8

---

"Toxicology"includes a broad range of application such as environmental, clinical and forensic toxicology. These several kinds of applied toxicology forms a mutually connected ring. This ring is supported by a column called as deductive and detective analysis by the author."Deductive toxicology"is a way of thinking to solve toxicological problems more multidimensionally. In this paper, an application of this way to the study of bone lesions observed in Itai-itai diseased patients is described. In cultured embryonic chick bone, both cadmium and copper induced an atrophic change of the osseous tissue. However, zinc induced an osteomalacic change as a result of strong inhibition of calcification. These histological changes were supported by investigation using a culture system of osteoblastic MC3T3-E1 cells. Cadmium stimulated bone resorption in a neonatal parietal bone. In addition, cadmium stimulated the formation of osteoclast-like cells in bone marrow cell culture. It is thus suggested that cadmium and copper are factors of osteoporosis whereas zinc is a factor of osteomalacia when they directly act on bone tissues. A simultaneous exposure of cadmium and zinc to cultured bones resulted in an osteomalacic change with or without inhibition of bone matrix formation. Copper caused an atrophic change in the absence or the presence of zinc. A combination of cadmium and copper induced a severe damage of osteoblasts and osteogenic mesenchymal cells. These results suggested that an interactive exhibition of heavy metal toxicity can cause various bone lesions such as osteomalacia, osteoporosis and osteoporomalacia. The idea that heavy metals can directly act on bone tissues and their interaction can induce various histological changes in the tissue will help an understanding of bone lesions in Itai-itai disease.