著者

北島 潤一 高森 靖 田中 靖子

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.109, no.3, pp.188-191, 1989-03-25

被引用文献数

1

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In fresh leaves of Acanthopanax sciadophylloides FR. et SAV. collected in June, the following substances were identified : (-)-β-caryophyllene, trans-β-farnesene, phytol, 1-dotriacontanol, taraxerol, a mixture of stigmasterol and β-sitosterol, trans-p-coumaric acid, trans-p-coumaric acid methylester, afzerin, kaemferitrin, kaempferol 7-O-α-L-rhamnopyranoside, 3-O-β-D-galactopyranosyl kaempferol 7-O-α-L-rhamnopyranoside and quercetin 3,7-O-bis-α-L-rhamnopyranoside. On the other hand, from the fresh leaves collected in August, trans-p-coumaric acid and kaempferol were obtained as aromatic compounds, but flavonoid glycosides were not detected. It is interesting that the constituents of these leaves were quite different between June and August.

著者

上釜 兼人

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.10, pp.857-873, 1981-10-25

被引用文献数

11

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Cyclodextrins are homologous series of cyclic oligosaccharides consisting of glucose units joined by α-1,4 linkages. One of the important characteristics of cyclodextrins is the formation of inclusion complexes with various guest molecules in solid phase and in solution, in which the guest molecules are included in the relatively hydrophobic cavity of cyclodextrins. The present review is mainly concerned with the possible utilities of cyclodextrins in pharmaceutical fields. A number of examples such as improvements of solubility, chemical stability, bioavailability, etc. are presented. These informations will provide a rational basis for design of formulation and a means for improving efficacy of drug activity.

著者

鹿野 美弘 縦 青 小松 健一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.111, no.1, pp.32-35, 1991-01-25

被引用文献数

1

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A crude drug, Evodia fruit (goshuyu) was processed to detoxicate and reduce the bitter taste. Following the procedure described in Shokanron (傷寒論), Evodia fruit was washed in hot water, and then dried. The alkaloid contents of processed Evodia fruit was analyzed by high performance liquid chromatography. The result shows that the content of hydroxyevodiamine decreased to 0.55 times, while the content of rutaecarpine and evodiamine hardly change in the final processed material. However, evocarpine content increased to 1.3 times comparing with the untreated Evodia fruit. The phenomena was ascribed to the flowing-out of the water-soluble portion, and also the weight of extract and the intense of bitterness in the processed fruit were reduced to about 1/3 times.

著者

坂井 進一郎 高山 広光 岡本 敏彦

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.99, no.6, pp.647-656, 1979-06-25

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Reinvestigation of the alkaloidal constituents of Aconitum japonicum THUNB. of Mt. Takao (Tokyo) was made. In addition to the reported constituents, i.e. isohypognavine, delcosine and dehydrodelcosine, two known compounds, isotalatizidine and condelphine, were isolated. Furthermore, five new bases, i.e. 11-acetylisohypognavine, diacetylisohypognavine, 14-acetyltalatizamine, takaosamine and takaonine, were isolated and their structures were elucidated. Takaosamine was proved to be 18-O-demethyldelcosine from the spectroscopic study on the parent material and the acetyl derivatives, and from the chemical correlation with known diterpene alkaloids, gigactonine and delsoline. The structure of takaonine was deduced to be 2,3-dehydro-14-dehydrodelcosine on the basis of ^<13>C-nuclear magnetic resonance spectral evidence and the derivation to the known diterpene alkaloid, delcosine, by catalytic hydrogenation.

著者

植木 昭和

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.103, no.9, pp.909-921, 1983-09-25

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Characteristics of aggressive behavior induced in rats by olfactory bulbectomy, midbrain raphe lesions, nucleus accumbens septi lesions and an administration of Δ^9-tetrahydrocannabinol were compared and the effects of various drugs were investigated in details. Defensive aggression of these rats was readily inhibited by neuroleptics and antianxiety drugs, while muricide (mouse-killing behavior) was selectively suppressed by antidepressants, indicating that muricide of the rat would be a good animal model for depressive illness. It was also clarified that the neural mechanism for inducing muricide and the response to antidepressants differed each other depending upon the method of muricide induction. It is suggested that these various types of muricide are useful in evaluating the mechanisms of action of antidepressants.

著者

上野

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.142, pp.1201-1207, 1893-12-26

著者

世取山 守 伊藤 功 高島 大典 正山 征洋 西岡 五夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.100, no.6, pp.611-614, 1980-06-25

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Cannabinoids (CN) of CBDA stock, Tochishi No. 1 stock and crossed stock were determined on a high-pressure liquid chromatograph equipped with a LiChrosorb RP-18 column (25 cm×4 mm) by elution with a mixture of methanol and 0.02 N sulphuric acid (4 : 1). The CBDA stock was found to contain cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA). Tochishi No. 1 stock was detected to have thtrahydrocannabinolic acid (THCA), CBCA and a small amount of CBDA. F_1 was obtained by crossing CBDA stock (female) and Tochishi No. 1 stock (male). All 79 F_1 specimens were found to contain CBDA, THCA and CBCA. Therefore F_1 was designated the median type. F_2 was then obtained by crossing F_1 and out of 199 F_2 specimens, 58,40 and 101 stocks were designated as CBDA stock type, Tochishi No. 1 stock type and the median type by CN analysis, respectively. F_3 was also gained by crossing CBDA stock type of F_2 and all 166 F_3 specimens were CBDA stock type. F_4,which was obtained by crossing F_3,was also CBDA stock type. In addition, the fibers of F_4 were found to be better than those of the original CBDA stock, and F_4 contained a negligible amount of THCA.

著者

今村 主税 金納 明宏 光岡 ちほみ 北島 俊一 井上 秀顕 岩原 正宜 松本 陽子 上岡 龍一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.116, no.12, pp.942-950, 1996-12-25

被引用文献数

12

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Remarkably high inhibitory effects of the hybrid liposomes composed of L-α-dimyristoyl-phosphatidylcholine (DMPC) and polyoxyethylenealkyl ether (C_<14> (EO)_n, n=6-8 and C_<12> (EO)_n, n=8-12)) on the growth of human lymphoma-human B-lymphocyte hybridoma (HF) cells in vitro were obtained. The hybrid liposomes composed of 90 mol% DMPC/10mol% C_<14> (EO)_n (n=6-8) or C_<12> (EO)_n (n=8-12) were more fluid as compared with 90mol% DMPC/10 mol% C_<14> (EO)_4 or C_<12> (EO)_n (n=4,23) hybrid liposomes on the basis of fluorescence polarization measurements. These results suggest that the inhibitory effects of the hybrid liposomes on the growth of HF cells should be related to the membrane fluidity. No toxicity to normal rats in vivo was observed in the experiment using 90mol% DMPC/10mol% C_<14> (EO)_7 or 90mol% DMPC/10mol% C_<12> (EO)_<12> hybrid liposomes.

著者

刈米 達夫 渥美 嶮次郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.462, pp.747-758, 1920-08-26

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.109, pp.205-209, 1891-03-26

著者

安本

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.482, 1922-04-26

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.52, pp.228-232, 1886-06-26

著者

K. K.

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.122, 1892-04-26

著者

高木 誠司

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.508, pp.457-460, 1924-06-26

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Beim Einleiten eines Gases in eine Flussigkeit je inniger die beiden in Beruhrung kommen, desto schneller, erfolgt die Absorption. Wie aus der Figur ersichtlich, erfullen die vom Verfasser konstruirten Kolben mit Seiten-rohr, welches wie eine Peligotsches Rohr funktionirt, diese Erfordernisse ganz vortrefflich. Beim Gebrauch giesst man in die Flasche so viel Fluissigkeit, als das Niveau etwas hoher als die seitliche Mundung des Kolbens liegt. Wenn das Gas von der Flussigkeit zu begierig absorbiert wird, so steckt man das Ende des Leitungsrohres nicht in die Flussigkeit hinein, wo durch das Zurucksteigen der letzteren vermeiden wird. Im Vergleich mit einem offenen Gefasse verkurzen diese Kolben die Opetationsdauer einer Reaktion ausserordentlich.

著者

三善 清房

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.246, pp.771-775, 1902-08-26

著者

シュナイデル アルフレード

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.7, pp.234-239, 1882-06

著者

斎藤 慎一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.125, no.10, pp.771-784, 2005-10-01

被引用文献数

3

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In this review we report our development and applications of the highly selective cycloaddition reactions of unsaturated hydrocarbons such as conjugated enynes, electron-deficient allenes, and electron-deficient methylenecyclopropanes in the presence of nickel and palladium catalysts. Homocoupling reactions as well as co-cyclization reactions proceed with high atom economy, which is an attractive feature of these reactions. The efficient synthesis of 4-7 membered carbocycles was achieved.

著者

今井 孝司 貴志 豊和 井上 博之 西山 信好 斎藤 洋

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.108, no.6, pp.572-585, 1988

被引用文献数

11 6

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Effects of iridoid glycosides on sex- and learning-behaviours induced by chronic"hanging stress"in mice, were studied. Drugs at a dose of 50 mg/kg were given orally every day after the exposure to stress. Geniposide and geniposidic acid showed a protective effect against decrease in sex behaviours, acceleration of extinction of memory, increase in failure of retrieval of memory, decrease of rectal temperature and enlargement of adrenal gland induced by the exposure to stress. Genipin showed a protective effect against decrease in licking, acceleration of extinction of memory, increase in failure of retrieval of memory and enlargement of adrenal gland, but promoted decrease in rectal temperature. Monotropein and gardenoside showed a weak protective effect against decrease in sex behaviours and acceleration of extinction of memory. Catalpol, aucubin and mussaenoside showed a weak protective effect against acceleration of extinction of memory, and mussaenoside showed an additional protective effect against increase in failure of retrieval of memory and decrease in rectal temperature.

著者

飯田 耕太郎 LEUENBERGER Hans FUEG Lise-Marie Muller-WALZ Rudi 檀上 和美

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.119, no.10, pp.752-762, 1999-10-01

被引用文献数

5

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Most often dry powder for inhalation are formulated as ordered mixtures of a carrier excipient and a micronized drug substance. In the present study, model powder blends were prepared from a mixture of lactose α-monohydrate, microcrystalline cellulose pellets or synthesized sugar as carrier particles, and micronized salbutamol sulfate (SS). These ordered mixtures were aerosolized by the multidose JAGO dry powder inhaler (DPI) and their in vitro deposition properties were evaluated by a twin impinger (TI). The separation force between SS particles and carrier particles was investigated by the centrifuge method. In addition, the use of the air jet sieve (AJS) method was investigated to assess the separation behavior of drug particles from carrier excipient. Powder blends were sieved through a 325 mesh wire screen of an air jet sieve at an air pressure of 1500 Pa. The amount of drug deposited at the carrier surface was analysed before and after the sieving to calculate the percentage of the drug retained. A relationship was found between in vitro deposition properties (fine particle fraction, FPF) and the separation characteristics obtained by the centrifuge method and by the AJS method. The AJS method might be a suitable alternative for evaluating separation of a drug particle from carrier particles and hence can be used for the formulation screening of the dry powder inhalation.

著者

佐藤 捨三郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.361, pp.217-241, 1912-03-26

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曩ニ内務省東京衛生試驗所ニ奉職中東京市内ノ混砂米及之カ淘洗米ニ就テ試驗セシ結果假令混砂米ト雖トモ水洗宜シキヲ得レハ砂粉ヲ附着スルノ虞ナク從テ衛生上何等障害ナキヲ報告セリ當時精米業者ハ玄米搗精ノ目的ヲ以テ珪酸及其當時ヨリナレル早搗粉(俗ニ荒粉ト云フ)ノ少量ヲ加フルノミニテ他ニ何物ヲモ混セサルモノト信セシガ其後京都府ニ轉任シ當市ニ於ケル精米業者ヲ觀ルニ彼等ノ多クハ搗精ノ目的ヲ以テ使用スル荒粉ハ極メテ少量ナルニ反シ増量若クハ化装用トシテ土粉(俗ニ青本粉ト云フ)又ハ石粉ト稱スル粉末ノ多量ヲ混シ以テ不正ノ利ヲ貪リツ、アルヲ知レリ故ニ當府ニ於テハ昨年市内販賣店ヨリ收去セル混砂米百九十六種ニ就キ試驗ヲ遂ケシ結果灰分ノ量無水物レシテ一プロセント」以上ノモノハ混砂ノ量多キモノト認メ警察犯處罰令ニ據リ相當取締ヲ加フルコト、ナセリ