著者

古賀 理恵 古賀 信康

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.6, pp.325-330, 2020 (Released:2020-11-28)

参考文献数

26

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Protein design holds promise for applications such as control of cells, therapeutics, new enzymes and protein-based materials. Recently, rational design of protein molecules has made a great progress, guided by the consistency principle proposed by Nobuhiro Gō in 1983: local and non-local interactions consistently favor the same folded conformation. We discovered a set of rules for designing ideal protein structures stabilized by consistent local and non-local interactions. The rules enabled the de novo design of amino acid sequences having the funnel-shaped energy landscapes toward the desired target structures. Various ideal protein structures have been created using the rules.

著者

織田 昌幸

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.6, pp.342-345, 2020 (Released:2020-11-28)

参考文献数

14

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A cutinase-like enzyme from a thermophilic isolate, Saccharomonospora viridis AHK190, Cut190, has the ability to depolymerize polyethylene terephthalate (PET). The catalytic activity and thermal stability of Cut190 are increased by Ca2+ binding. The structural analysis of Cut190 mutants in complex with metal ions and substrates elucidated the reaction mechanism regulated by Ca2+. The metal ion-binding properties, analyzed using isothermal titration calorimetry were correlated with the effects on Cut190 activity and stability, which could be improved using protein engineering. The Cut190 mutant will be used for PET chemical recycling.

著者

難波 啓一

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.6, pp.357-358, 2020 (Released:2020-11-28)

参考文献数

4

著者

李 聖林 小林 亮

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.58, no.4, pp.216-219, 2018 (Released:2018-07-28)

参考文献数

8

著者

渡部 輝明 岸野 洋久

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.52, no.3, pp.146-147, 2012 (Released:2012-05-30)

参考文献数

7

著者

Yano Midori Yura Kei

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.53, no.1, 2013

著者

橋本 博 菱木 麻美 原 幸大 菊池 壮太郎

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.57, no.1, pp.015-019, 2017 (Released:2017-01-26)

参考文献数

20

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DNA damage tolerance (DTT) is a cell function to avoid replication arrest by DNA damage during DNA replication. DTT includes two pathways, translesion DNA synthesis (TLS) and template-switched DNA synthesis (TS), regulated by various molecular interactions. TLS is transient DNA synthesis using a damaged template by error-prone DNA polymerases specialized for DNA damage (TLS polymerases). TS, in which one newly synthesized strand is utilized as an undamaged template for replication by replicative polymerases, is error-free process. This review article describes recent progress in structural studies of proteins involved in TLS and TS.

著者

橋本 秀春

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.53, no.4, pp.206-207, 2013 (Released:2013-07-25)

参考文献数

9

著者

井出 博 松原 真由美 片渕 淳

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.46, no.5, pp.263-269, 2006 (Released:2006-09-25)

参考文献数

28

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DNA that carries vital genetic information constantly suffers from oxidative damage. Oxidative DNA damage is generally repaired by the base excision repair (BER) pathway initiated by damage-specific DNA glycosylases. Although the basic mechanism of BER is conserved from bacteria to mammals, recent studies indicate that mammalian cells use an elaborate and efficient repair network to cope with oxidative DNA damage. It remains elusive how BER enzymes gain access to and repair DNA lesions in the condensed nucleosome organization of the eukaryotic genome.

著者

井上 敬 竹内 郁夫

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.18, no.1, pp.22-34, 1978-01-25 (Released:2009-05-25)

参考文献数

27

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Several models for pattern formation by cell differentiation were critically described. They were classified into the two main types. The first type of models is based on the concept of positional information formulated by Wolpert from the generally observed fact that cells differentiate according to their relative positions in a developing system. The two models were illustrated as those which materialize the concept: a diffusion model of Laurence, Crick and Munro for pattern formation in insect epidermis and the phase-shift model devised by Goodwin and Cohen. In contrast, the second type of models is based on the idea that pattern formation can be explained by considering interactions among cells in a developing system without resorting to a mechanism specifying positions of individual cells. Two examples of this sort were presented: a model of Gierer and Meinhardt for pattern formation in hydra and a diffusion-reaction model of Turing. An attempt was made to formulate the process of specification of cell state which leads to differentiation of a cell. Finally, the significance and te interpretation of a model were discussed.

著者

肥後 順一 中迫 雅由

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.46, no.4, pp.220-223, 2006 (Released:2006-07-25)

参考文献数

7

著者

堤 研太

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.3, pp.174-175, 2020 (Released:2020-05-27)

参考文献数

7

著者

篠原 彰

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.47, no.2, pp.100-106, 2007 (Released:2007-03-31)

参考文献数

14

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Homologous recombination promotes faithful segregation of homologous chromosomes during meiosis. Two RecA homologues, Rad51 and Dmc1, work together to catalyze homology search and strand exchange process in the recombination. We recently identified a protein complex containing two meiosis-specific proteins, Mei5 and Sae3, which promotes the assembly of Dmc1 on the Rad51 ensembles. In this review, I will discuss the function of Dmc1-containing protein machinery in meiotic-recombination and possible asymmetric distribution of the two RecA homologues on chromosomes.

著者

北畑 裕之 田中 正信

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.57, no.4, pp.191-195, 2017 (Released:2017-07-28)

参考文献数

12

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Spiral waves are often observed in wide variety of reaction-diffusion systems. Those in cardiac tissues are important since they are related to serious disease that threatens human lives, such as atrial and ventricular fibrillation. We consider the unpinning of spiral waves around two types of defects using high-frequency pacing. The defects are classified into two kinds, i.e, that without any diffusive interaction with the environment, and that with diffusive interaction. We found that the threshold frequency is lower for the defect with diffusive interaction than for the one without it.

著者

野中 茂紀

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.54, no.1, 2014

著者

小川 誠二

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.40, 2000

著者

小川 誠二

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.14, no.5, pp.183-199, 1974

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Nuclear magnetic resonance studies on the cooperative oxygen binding in hemoglobin are reviewed. First brief descriptions of NMR methods of variousl nuclei are made by typical examples found in hemoglobin studies. Then the recent interests in hemoglobin are categorized in four chapters, the allosteric transition between the two states with different functional properties, the presence of hemoglobin molecules with intermediate structure, α-β nonequivalency and the location of the interaction energy. Those topics are discussed mainly with NMR results in order to show the merit and limitation of the technique.

著者

岩本 裕之

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.50, no.4, pp.168-173, 2010 (Released:2010-07-25)

参考文献数

27

被引用文献数

2 3

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Insects, the largest group of animals on the earth, owe their prosperity to their ability of flight and small body sizes. The ability of flight provided means for rapid translocation. The small body size allowed access to unutilized new niches. By acquiring both features, however, insects faced a new problem: They were forced to beat their wings at enormous frequencies. Insects have overcome this problem by inventing asynchronous flight muscle, a highly specialized form of striated muscle capable of oscillating at >1,000 Hz. This article reviews the structure, mechanism, and molecular evolution of this unique invention of nature.

著者

前田 豊 溝田 学

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.24, no.4, pp.209-214, 1984

著者

品川 嘉也 瀬野 裕美

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.31, no.6, pp.38-42, 1991-11-25 (Released:2009-07-09)

参考文献数

35