著者

河野 敦子 石川 秀樹 中村 富予 河野 公一

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.65, no.3, pp.422-446, 2010 (Released:2010-05-27)

参考文献数

118

被引用文献数

6 7

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Enviromental factors have been consistently associated with colon cancer risk. In particular, consumption of Western-style diet including red meat is the most widely accepted etiologic risk factor. It has been reported that dietary factors change the proportion of intestinal flora, and it also affects the composition of fecal bile acids and the intestinal activity of some mutagens. In addition, it was suggested that modulating the composition of intestinal flora may reduce the occurrence of colorectal cancer. In this review, we present the clinical studies on the association between intestinal flora and the risk of colorectal cancer that have been carried out to date. The clinical studies of intestinal bacteria related to colorectal cancer risk have not shown consistent results so far, compared with the accomplishments of some basic studies. On the other hand, it was suggested in some clinical studies that lactic acid bacteria reduce the occurrence of colorectal cancer.

著者

林田 真梨子 鎌田 由佳 大田 智子 児島 沙由梨 増見 恭子 村田 成範 木下 健司

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.70, no.2, pp.134-138, 2015 (Released:2015-05-21)

参考文献数

15

被引用文献数

2 7

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Objectives: The purpose of this study was to identify associations between ALDH2 and ADH1B genotypes and ethanol-induced cutaneous erythema and assess the accuracy of an ethanol patch test in young Japanese women. Methods: The subjects were 942 female Japanese university students. They were given an ethanol patch test and examined for ethanol-induced cutaneous erythema both immediately after removing the patch and 10 minutes after removing the patch. A saliva sample was used to determine the ALDH2 and ADH1B genotype of each subject by realtime PCR. Results: The sensitivity and specificity of erythema immediately after removing the patch as the marker for the presence of inactive ALDH2 were 69.6% and 87.7%, respectively, and the sensitivity and specificity of erythema 10 minutes after removing the patch were 85.2% and 85.1%, respectively. The sensitivity of erythema after 10 minutes was markedly lower in the ADH1B*1/*1 carriers than in the ADH1B*2 carriers (8.3% vs. 89.7%, p<0.0001), and the specificity was significantly higher in the ADH1B*1/*1 carriers than in the ADH1B*2 carriers (96.9% vs. 84.3%, p<0.05). Conclusions: Overall, both sensitivity and specificity were satisfactorily high, but having the ADH1B*1/*1 genotype prevented a positive reaction for inactive ALDH2 and caused false-negative results. The data also suggested that having the ADH1B*2/*2 genotype caused a positive reaction in subjects with the ALDH2*1/*1 genotype. Despite these exceptions, the ethanol patch test has enough accuracy and can be used easily to subjects who don’t drink alcohol. This is a valuable tool for improving the health literacy of younger generation subjects.

著者

佐田 文宏

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.71, no.1, pp.41-46, 2016 (Released:2016-01-30)

参考文献数

38

被引用文献数

5 21

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Japan has the highest proportion of low-birth-weight infants among OECD countries for over 20 years. In 2011, the proportion of low-birth-weight infants in Japan was 9.6%, whereas the mean proportion in OECD countries was only 6.8%. In particular, young Japanese women’s strong desire to be thin has been pointed out as the underlying cause. Indeed, the frequencies of unhealthy thinness among third-year female junior and senior high school Japanese students have been increasing since the start of “Healthy Parents and Children 21”, and both groups have reached about 20%. The hypothesis of the fetal origins of adult disease (Barker’s theory) was proposed by Professor David J. Barker of Southampton University, who had conducted descriptive epidemiological studies in England and Wales and birth cohort studies in Hertfordshire, for example. In early 21st century, it became the wider theory known as the “Developmental Origins of Health and Disease (DOHaD)”, which was composed of developmental plasticity and the mismatch concept. Birth cohort studies are believed to be suitable for epidemiological studies to demonstrate the DOHaD theory. These studies and their collaborations are very popular in European countries, whereas such collaborations lagged behind in Japan. Recently, a new paradigm, “preemptive medicine”, has been proposed in Japan. The importance of interdisciplinary studies focusing on fetal and childhood periods was also recommended as a political strategy. We just expect the realization of nationwide large-scale interdisciplinary research projects based on DOHaD and preemptive medicine and the establishment of a central research institute of these studies.

著者

吉益 光一 大賀 英史 加賀谷 亮 北林 蒔子 金谷 由希

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.67, no.1, pp.27-36, 2012 (Released:2012-03-07)

参考文献数

32

被引用文献数

1 3

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Psychological approaches such as mindfulness-based stress reduction or mindfulness-based cognitive therapy could be effective for relieving a wide range of psychosocial stresses or frictions between parents and children. Several interventional approaches based on mindfulness have been shown to be useful for improving parent-child relationships not only among healthy families but also among those with difficult psychopathologies. Particularly in the relationships of parents with their children with developmental disorders such as autism or attention-deficit/hyperactivity disorders, these approaches may play an important role in that the motivations of both parents and children could be enhanced because they can actually feel that their mental condition improves through meaningful parent-child interactions that they experience in their daily lives. These approaches are also expected to improve communications between mothers and children through the development of a finely honed sensitivity. One practical example is shown for the mental growth of children by the mindfulness-based dietary education and the secondary effects of this education on the parents. We can also apply these effective methods to the improvement of general interpersonal relationships.

著者

恒次 祐子 朴 範鎭 李 宙営 香川 隆英 宮崎 良文

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.66, no.4, pp.670-676, 2011 (Released:2011-10-12)

参考文献数

34

被引用文献数

11 23

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Objectives: In the present study, we aimed to clarify the psychological effects of shinrin-yoku (taking in the atmosphere of the forest) by conducting field experiments. Methods: The experiments were conducted in 19 forested and urban areas in Japan during the 2007–2010 period. Twelve male students participated at each of the 19 areas (a total of 228 persons). Subjective ratings of “comfortable-uncomfortable”, “soothing-stimulating”, and “natural-artificial” feelings were conducted after each of the participants had viewed the scenery for 15 min in the forested and urban areas. A postviewing questionnaire on “stressed-refreshed” feelings was also administered and the Profile of Mood State (POMS) questionnaire was employed to assess six aspects of mood before and after viewing the sceneries. Results: The forest environments were perceived as significantly more “comfortable”, “soothing”, and “natural” than the urban environments after viewing the sceneries. The score for “refreshed feeling” was also significantly higher in the forested areas. The score for the “vigor” subscale of POMS was significantly higher after viewing the scenery in the forested areas, whereas the scores for negative feelings such as “tension-anxiety”, “depression-dejection”, “anger-hostility”, “fatigue”, and “confusion” significantly decreased. Conclusion: Collectively, these results suggest that the forest environments have significant beneficial and relaxing effects on human’s moods compared with the urban environments.

著者

渡久山 朝裕 松井 利仁 平松 幸三 宮北 隆志 伊藤 昭好 山本 剛夫

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.64, no.1, pp.14-25, 2009 (Released:2009-02-26)

参考文献数

16

被引用文献数

1 1

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Objectives: To investigate the association between aircraft noise exposure as expressed by Weighted Equivalent Continuous Perceived Noise Level (WECPNL) and preschool children’s misbehaviours around the Kadena and Futenma airfields in Okinawa. Methods: A questionnaire survey on children’s misbehaviour was conducted in nursery schools and kindergartens around the Kadena and Futenma airfields. The children living around the Kadena airfield were divided into four groups according to WECPNL at their residences and those around the Futenma airfield into three groups according to WECPNL. The subjects were 1,888 male and female preschool children, 3 to 6 years of age, whose parents, caregivers, and teachers answered the questions. The answers used for the analysis were limited to those of respondents fulfilling the following conditions: parents living with their children, fathers with a daytime job, and mothers with a daytime job or no job. Thus, the number of valid answers was 1,213. The responses were analysed using logistic regression models taking the number of misbehaviours related to the items of Biological Function, Social Standard, Physical Constitution, Movement Habit, or Character as the dependent variables, and WECPNL, age, sex, size of family, birth order, mother’s age at birth, mother’s job, caregiver’s career, and category of subject as the independent variables. Results: A significant dose-response relationship was found between the odds ratio and WECPNL for the outcomes of Physical Constitution around the Kadena and Futenma airfields. Conclusions: It would be reasonable to conclude that the aircraft noise exposure is a factor that increases the number of preschool children’s misbehaviours.