著者

王 宝禮

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.33, no.1, pp.32-44, 2014-04-01 (Released:2014-09-05)

参考文献数

32

被引用文献数

3

著者

前田 伸子

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.35, no.3, pp.115-122, 2016 (Released:2017-01-14)

参考文献数

35

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Candida is the most significant species among fungi, because it is not only a member of the normal microbiota of oral cavity, skin, gastrointestinal tract and vagina, but also one of the pathogens for opportunistic infections(candidiasis). Recently incidence and prevalence of candidiasis have increased in large populations of compromised hosts. Studies of poly-microbial Candida biofilms suggest that the hyphae of Candida provides the scaffold for oral bacteria in biofilms and show the interactions with many oral infections such as dental caries, periodontal disease, endodontic infection, and denture stomatitis. Candida has a number of virulence factors, the most important is aspartic proteinase (Sap). Sap plays a central role in the pathogenicity of Candida destroying human proteins and invading tissues. The gold standard of diagnosis for candidiasis is based on clinical findings and confirmed by identification of colonies cultured on the media for Candida. However, microscopic examinations of staining smear samples are faster and simpler methods than culture methods, if the staining is sufficiently accurate. We compared staining methods of candidiasis smear samples, and suggest that Fungiflora Y staining is useful for the diagnosis of oral erythematous candidiasis. Right now, we are doing both, basic and clinical research to reduce Candida colonization in the oral cavity. Basic research includes the development of probiotics with lactobacilli as well as biogenic products of lactobacilli for controlling Candida colonization in the oral cavity. Clinical research comprises of reducing the number of Candida in the oral cavity by gargling with a diluted antifungal drug(amphotericin B). The goal of our studies is to improve QOL, not restricted to the oral cavity, but for the entire body by eliminating Candida from the oral cavity.

著者

王 宝禮

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.31, no.2, pp.67-82, 2012-08-01 (Released:2012-09-06)

被引用文献数

2

著者

八木沢 就真 栗林 伸行 川又 均

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.38, no.3, pp.195-199, 2019 (Released:2020-03-31)

参考文献数

12

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In this study, we examined the effectiveness and adverse events of pilocarpine hydrochloride (pilocarpine) gargle in the treatment of xerostomia in Sjogren's syndrome (SS). Dryness of the mouth, salivary flow rate, adverse events associated with oral administration or gargle method were compared before and after 4 weeks of administration in the eight SS patients enrolled in this study. Dryness of the mouth in seven patients was significantly improved by oral administration. Gargling also improved dryness of mouth but did not reach statistical significance. The salivary flow rate based on the gum test was significantly increased with the gargle method as well as with oral administration. The salivary flow rate by the Saxon test also increased with both oral administration and gargling but did not reach statistical significance. Increased rate of salivary flow was equally observed in both methods. An adverse event associated with oral administration was sweating, and one patient could not continue the study due to uncomfortable sweating and palpitation. In contrast, the gargle method induced slight sweating alone in six of seven patients. These results indicate that the gargle method, compared with oral administration improves xerostomia with equivalent efficacy without inducing excessive sweating.

著者

佐藤 真理子 石田 孝文 岩渕 絵美 岩渕 博史

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.39, no.1, pp.9-15, 2020 (Released:2020-05-16)

参考文献数

19

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Patient`s with Sjögren’s syndrome(SS)are prone to the development of dental caries as a result of reduced salivary flow. As no studies to date have reported on the association between improved salivary flow in patients with SS and caries prevention, we conducted a retrospective study on the influence of salivary secretion on the number of decayed/missing/filled(DMF)teeth. This study involved a total of 165 patients with a mean observation period of 57.7±8.62 months. The results showed a significant negative correlation between the change in the number of missing teeth from baseline to end point and the mean stimulated whole salivary flow(SWSF), which was based on the mean baseline and end point SWSF(r=−0.155, P=0.047). In addition, an increase in the number of missing teeth in patients with a mean SWSF not exceeding 6 mL/10min was observed compared to patients with a mean SWSF of more than 6 mL/10min. Logistic regression analysis showed SWSF to be a risk factor for increased number of missing teeth(OR=0.905, 95 % CI=0.832–0.985, P=0.021). During the observation period, although SWSF increased between baseline and end point, increase in SWSF did not prevent an increase of DMF. As this study showed that SS patients were susceptible to missing teeth with no clear evidence of reduced number of DMF teeth associated with increased salivation, the results suggest that SS patients require all available caries prevention interventions, including not only salivary secretagogue, but also topical measures such as fluoride, antimicrobials and non-fluoride re-mineralizing agents.

著者

半場 道子

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.18, no.3, pp.156-164, 1999-12-01 (Released:2010-06-08)

参考文献数

29

著者

黒木 祐吾 岡本 喜之 石橋 真乃介 川田 賢介 石川 好美

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.1, pp.9-15, 2015-04-01 (Released:2015-06-01)

参考文献数

15

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Hunter glossitis is a relatively rare disease caused by vitaminB12 deficiency. We clinically studied six cases of Hunter glossitis caused by vitamin B12 deficiency. All cases complained tongue pain and dysgeusia, and they showed atrophy of lingual papillae and vitamin B12 deficiency in blood examination. Macrocytic anemia was found out in five cases but one case was not anemia. Two cases were under treatment of chronic gastritis and three cases were total gastric resection in past. Untreated atrophic gastritis was found out in one case by upper gastrointestinal endoscopy. We treated all cases by oral administered vitamin B12 therapy 1500 µg/day. After this therapy, red smooth tongue, oral pain, dysgeusia and level of vitamin B12 in blood were improved in all cases. It is popular that the treatment of vitamin B12 deficiency is based on parenteral vitamin B12 administered intramuscular injection. But recently, a few reports documented positive results following oral vitamin B12 therapy. As the result of these cases, oral administered vitamin B12 therapy was effective to Hunter glossitis.

著者

金川 昭啓

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.32, no.3, pp.167-171, 2013-12-01 (Released:2014-09-05)

参考文献数

10

被引用文献数

1

著者

山根 伸夫

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.3, pp.121-124, 2017 (Released:2017-12-27)

著者

岸本 裕充

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.33, no.3, pp.143-148, 2014-12-01 (Released:2015-01-28)

参考文献数

8

著者

鴨井 美帆 今村 武浩 山本 健 岡本 真理子 高橋 実里 園田 華子 西岡 千賀子 門松 伸一 山近 重生 斎藤 一郎 中川 洋一

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.30, no.3, pp.85-91, 2011-12-01 (Released:2012-02-07)

参考文献数

18

被引用文献数

1

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Purpose: The purpose of this study was to investigate the effects of sulpiride, an antidepressant, on xerostomia.Method: Fifty-five patients who visited the Dry Mouth Clinic, Tsurumi Dental Hospital with subjective oral dryness were enrolled in this study. The cause of the xerostomia in the patients was unknown. The patients did not meet Sjögren's syndrome criteria, and their condition was not congruent with xerostomia caused by radiation therapy to the head and neck, HIV infection, chronic graft-vs-host disease, or diabetes mellitus. The patients were divided into two groups: the dry group, with the chief complaint of dry mouth, and the pain group, with the chief complaint of pain. The patients received oral administration of sulpiride, and the clinical efficacy was evaluated by doctors' subjective judgment and by visual analogue scale (VAS).Results: Sulpiride was effective in both groups, but the response rate was higher in the pain group than in the dry group according to the doctors' subjective judgment. In the evaluation by VAS, improvements were not obtained in other items such as thirstiness and dysgeusia, although a significant decrease of VAS value was found in "dry mouth" in the dry group. In contrast, in the pain group, significant improvements were found in all items as well as pain.Conclusions: The results suggested that the dry and pain groups possessed completely different pathophysiologies. The results also suggested that subjective dry mouth may be a partial symptom of burning mouth syndrome (BMS), and that depression was one of the causative factors of xerostomia.

著者

関谷 亮 唐木田 一成 新井 俊弘 佐藤 佑介 坂本 由紀 金井 直樹 丸山 亮 金子 明寛

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.2, pp.69-76, 2010-08-01 (Released:2010-09-11)

参考文献数

13

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口腔感染症患者より分離した各種細菌およびCandida属菌株のbiofilm形成能をクリスタルバイオレット染色法で評価した結果,Prevotella intermedia,Porphyromonas gingivalis,Actinomyces odontolyticus,Streptococcus mitis,Candida albicansおよびCandida glabrataにおいてbiofilm形成能の高い菌株が見出された.これらの菌株を対象に各種抗菌薬または抗真菌薬のsub-MICにおけるbiofilm形成抑制作用を検討した.P. intermediaおよびP. gingivalisに対してlinezolid,azithromycinおよびclarithromycinのsub-MICでの作用によりbiofilm形成抑制効果が認められたが,検討した他の菌種のbiofilm形成に対する抑制効果は認められなかった.一方,C. albicansおよびC. glabrataに対しては,測定した抗真菌薬のうちmicafunginのみがsub-MICにおけるbiofilm形成抑制作用を示した.

著者

平藤 彰 酒井 麻里 小出 洋子 日山 邦枝 池田 幸 村山 純一郎

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.30, no.1, pp.16-19, 2011-04-01 (Released:2011-06-21)

参考文献数

5

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After implementation of the new GCP, our hospital was staffed by clinical research coordinators (CRC) to smoothly conduct clinical trials of higher quality. At present, two pharmacists, two dental hygienists, and one nurse are working concurrently as CRCs in our hospital. An unique feature of CRC work at our hospital include 1) dental hygienists working as CRCs, and 2) CRCs of different specialities are coordinated on the same trial and contributing according to their specialties, participation of each clinical trial, one by one. Previously, in our hospital, clinical trials for medications had been allocated to nurse CRCs, while dental hygienist CRCs support for clinical trial of medical devices. However, a dental hygienist have participated as a CRC for the first time in a clinical trial for a medication in 2009, a pharmacist CRC cooperated the clinical trial with the dental hygienist CRC, and this trial was successfully completed. We anticipate that dental hygienist CRCs supporting clinical trials in dental practice will play an indispensable role in smoothly conducting clinical trials with high quality. In this report, we will present the current status of CRC work, which has been accomplished by cooperation with pharmacists and dental hygienists.

著者

郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.1, pp.1-8, 2010-04-01 (Released:2010-08-20)

参考文献数

39

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Many epidemiological studies have shown that the prevention of dental caries by fluoride is a basic and indispensable method to maintain and improve dental health. However, the countermeasures for maintenance of dental health and implementation of preventive programs for caries are still not satisfactory in Japan. In developed countries, it is thought that the prevalence of water fluoridation and use of fluoride-containing dentifrices are the primary factors responsible for the remarkable decrease in the prevalence of dental caries in children. Topical application of fluorides, especially fluoride mouth rinsing, has an extremely important role in Japan as compared with various other countries, because systemic application of fluorides, such as water fluoridation and use of fluoride tablets are not yet available in Japan. However, fluoride mouth rinsing has not become prevalent on a nationwide scale. Therefore, it is hoped that fluoride mouth rinsing will be enforced in more kindergartens, elementary schools, and junior high schools to contribute to the improvement of dental health in the future.