著者

木下 一彦 水野 裕和 日比 英晴

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.65, no.6, pp.424-428, 2019-06-20 (Released:2019-08-20)

参考文献数

17

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A case of multiple sialolithiasis in the submandibular gland and duct is reported. A 71-year-old man was referred to the Department of Oral and Maxillofacial Surgery in our hospital. He had no symptoms in the right submandibular region, but panoramic radiography and computed tomography showed multiple calculi in the right submandibular gland and duct. The patient underwent excision of the right submandibular gland with Wharton’s duct including multiple stones. A total of 332 sialoliths were detected, and the submandibular gland tissues were normal histopathologically. The postoperative period was uneventful, and the patient recovered without any complications. This is a rare case with the largest number of sialoliths ever reported.

著者

鹿嶋 光司 黒川 英雄 高森 晃一 井川 加織 市來 剛 迫田 隅男

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.53, no.7, pp.420-424, 2007-07-20 (Released:2011-04-22)

参考文献数

10

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We report the a successful intensive care of a 41-year-old man, who had facial and cervical cellulitis, descending necrotizing mediastinitis, and bilateral pyothorax caused by pericoronitis. Computed tomographic scans showed abscesses extending from the left temporal region and the neck to the mediastinum, with bilateral pleural effusion. Surgical drains were placed in the face, neck, and chest, and several types of antibiotics were administered intravenously. Pus cultures disclosed abundant growth ofStreptococcus constellatesandPrevotella intermedla. The patient received mechanical ventilation with a high concentration of oxygen. Our experience suggested that such severe cases require aggressive chemotherapy with a combination of antibiotics and surgical drainage by a multidisciplinary team of surgeons.

著者

豊福 明

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.55, no.4, pp.163-168, 2009-04-20 (Released:2012-08-28)

参考文献数

25

被引用文献数

1 2

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In dry mouth clinic, there are many patients who complained of subjective feelings of dry mouth despite their normal salivation. This dry mouth frequently comorbid with glossodynia or oral dysaesthesia. So far, these complaints have been thought to be ‘psychogenic’. Namely, psychosocial factors and/or individual factors have long been considered as main cause. Even if oral surgeons referred patients to psychiatry clinic, a majority of them wished to avoid consultation, or, would sometimes complain that the dry mouth got worse after medication. Therefore, it is very important and difficult problems for clinical oral surgeons to see how look at these patients and to learn how cope with them.From my own years of experience in psychosomatic studies, I think ‘distorted cognition ’ is central to these pathogenesis. These distorted cognition cause dissociations between subjective and objective findings. Moreover, I have propose a hypothesis that neurochemical dysfunction of some sort of neurotransmitter systems and distortions of information-processing in cerebral association area related to thought and memory underlie the distorted cognition.Patients with subjective dry mouth never tell a lie about their symptoms, but they have just ‘ neural network error’ in their brain. We should take up to problems of oral discomfort at the root of their complaint.If we suspect their complaints as the cause of psychogenic, it might be often unsuccessful in treatment. First of all, to listen carefully to complaints from them is very important, and then we have to do differential diagnosis. If patients are diagnosed the symptom form with distorted cognition, medication using SSRI or SNRI is necessary for reconstruction of impaired neuronal network. Of course oral surgeons have to receive advanced education and training to use psychotropic drugs. At the same time, it is needed for sensitive response to patients and family members.The distorted cognition with these patients are associated with dysfunction of neurotransmitter systems and information-processing in peripheral to higher central nervous system. Strange complaints and persistent therapeutic demand are representatives of the distorted cognition. If we regard queer complaints as neural network errors, we can see the psychogenic complaints as distorted cognition.At present, this hypothesis cannot be shown objectively, but it might be possible that some new approaches such as brain imaging make mechanisms of the distorted cognition more clear. It is very important to collect evidence-based diagnosis, therapies and pathophysiological mechanism for dry mouth as an oral psychosomatic disorder.

著者

河野 峰 柴田 敏之 永易 裕樹 北所 弘行 中田 大地 有末 眞

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.44, no.1, pp.16-21, 1998-01-20 (Released:2011-07-25)

参考文献数

13

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We studied whether epidermal growth factor (EGF) enhances the motility of human oral squamous cell carcinoma (SCC) cells in an autocrine manner. The motility of five SCC cell lines (SAS, Ca 9-22, HSC-2, -3, -4) was examined with the use of a phagokinetic track assay. The motility of SAS cells and HSC-2 cells was significantly increased without EGF stimulation as compared with the three other cell lines. Amounts of EGF in the culture supernatants of the five cell lines after 48h of culture were examined with the immunoblotting method. EGF was detected in the supernatants of SAS cells and HSC-2 cells (SAS, 8.65±0.45; HSC-2, 2.60±1.13ng/ml). SAS cells, showing the highest levels of motility and EGF production, was used for further study. When SAS cells were treated with anti-EGF antibody, anti-EGF receptor antibody, and erbstatin analog, the motility of SAS cells was significantly inhibited. Furthermore, the culture supernatant of SAS cells enhanced the motility of HSC-3 cells in a concentration-dependent fashion. These results suggest that EGF may stimulate the motility of human oral SCC cells in an autocrine manner.

著者

林 良夫

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.57, no.5, pp.234-237, 2011-05-20 (Released:2014-05-22)

参考文献数

8

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Primary Sjören’s syndrome (SS) is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lacrimal glands, leading to clinical symptoms of dryness of the mouth and eyes. Autoreactive T cells bearing CD4 molecule may recognize unknown self antigen, triggering autoimmunity in the salivary and lacrimal glands. Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T cells to tissue-specific self antigen including 120KD α-fodrin, and may drive the autoimmune phenomenon. Cleavage of certain autoantigens during apoptosis may reveal immunocryptic epitopes that could potentially induce autoimmune response. It is now evident that the interaction of Fas with FasL regulates a large number of pathophysiological process of apoptosis including autoimmune diseases. Our data imply that tissue-specific apoptosis and caspase-mediated α-fodrin proteolysis are involved in the progression of autoimmune lesions in SS. We found that retinoblastoma-associated protein RbAp48 overexpression induces apoptosis in the salivary glands caused by estrogen deficiency. The studies reviewed the pathology and molecular mechanisms on the development of SS.

著者

牧野 修治郎

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.61, no.5, pp.261-261, 2015-05-20 (Released:2015-10-11)

著者

田代 英雄 千野 武広 中島 和男

出版者

社団法人 日本口腔外科学会

雑誌

口腔外科学会雑誌 (ISSN:04541693)

巻号頁・発行日

vol.8, no.3, pp.334-338, 1962-12-01 (Released:2011-07-25)

参考文献数

9

著者

野間 弘康 山根 源之 松井 隆 杉崎 正志 木下 善隆

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.25, no.3, pp.672-681, 1979

著者

柴田 考典 木住野 義信 鬼谷 信美 米津 博文 高野 直久 佐藤 和則 関 泰忠 重松 知寛 高橋 庄二郎

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.34, no.4, pp.752-767, 1988

被引用文献数

4 2

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The efficacy of Amfenac Sodium (Fenazox<SUP>&reg;</SUP>), nonsteroid anti-inflammatory agent on temporomandibular joint pain was clinically evaluated in 28 temporomandibular arthrosis patients. Amfenac Sodium dosage of 200 mg was given orally in 4 times daily for two weeks.<BR>The results were as follows:<BR>1) Temporomandibular joint pain and limitation of mouth opening because of pain improved remarkedly.<BR>2) Effectiveness of Amfenac Sodium was &ldquo;Excellent&rdquo; in 5 cases (17.9%), &ldquo;Good&rdquo; in 12 cases (42.9%) and &ldquo;Fair&rdquo; in 10 cases (35.7%).<BR>3) Side effects were observed in 8 of the 28 cases. Most of those 3 cases had slight gastrointestinal disorders and only two cases were dropped.<BR>4) The usefulness of Amfenac Sodium was in 3 cases (10.7%) &ldquo;Excellent&rdquo;, 13 cases (46.4%) &ldquo;Good&rdquo; and 10 cases (35.7%) &ldquo;Fair&rdquo;.<BR>It is suggested that Amfenac Sodium is useful for relief from temporomandibular joint pain in temporomandibular arthrosis patients.

著者

荻 和弘 小林 淳一 竹田 康佑 井手 隆 宮崎 晃亘 平塚 博義

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.61, no.3, pp.173-176, 2015

被引用文献数

2

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Carcinoma ex pleomorphic adenoma mainly occurs in the major salivary gland, and a tissue type of myoepithelial carcinoma is extremely rare in the minor salivary gland.<br>We report a case of myoepithelial carcinoma ex pleomorphic adenoma of the hard palate in a 65-year-old man. At presentation, a tumor measuring 23 × 16 mm, which had a painless elastic hard, smooth surface and clear border, was found in the right side of the hard palate. Computed tomographic scanning and magnetic resonance imaging indicated the suspicion of malignancy. Histological examination suggested a myoepithelial carcinoma. A partial maxillectomy combined with a supraomohyoid neck dissection was performed. The histological diagnosis of the resected specimen was a myoepithelial carcinoma ex pleomorphic adenoma. There has been no sign of recurrence as of 2 years postoperatively.

著者

冨永 和宏 松尾 長光 上野 功 森本 守 重本 康晴 空閑 祥浩 水野 明夫 佐々木 元賢

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.39, no.8, pp.879-890, 1993

被引用文献数

1 1

---

To evaluate the utility of subperiosteal tissue expansion (STE) for mandibular augmentation with hydroxylapatite (HA) particles, two experimental studies in adult mongrel dogs were performed. One was to observe histologic changes following STE and to compare the tissue response to STE with that to subcutaneous expansion. The other was to observe clinical and histologic changes following implantation of HA particles in the subperiosteal expanded bed. In the first experiment, small tissue expanders were placed and inflated subperiosteally in the mandible and subcutaneously in the breast. A fibrous connective tissue capsule was formed surrounding the implanted expanders. Periosteum was replaced by simple connective tissue during expansion. Capsule formation during STE was much more rapid than the subcutaneous expansion. In the subperiosteal group, a thick fibrous capsule consisting of coarse collagen fibers was observed one week after full inflation. Leaving the fully inflated subperiosteal expanders in place more than one month accelerated the resorption of the underlying bone. In the second experiment, one week after full expansion of the mandibular subperiosteal expander, the expander was removed and HA particles were implanted in the expanded bed. Despite marked augmentation with excessive amounts of HA particles, there was no deformity or infection of the grafts, which maintained their designed controur. The firm fibrous capsule formed by STE permitted consolida tion of HA particles easily and effectively, and prevented migration of the particles. Immobilization of the grafts was achieved within two months following implantation of the HA particles.

著者

上田 順宏 山本 伸介 髙嶌 森彦 髙橋 佑佳 黒川 聡司 桐田 忠昭

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.66, no.1, pp.25-30, 2020-01-20 (Released:2020-03-23)

参考文献数

23

被引用文献数

1

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Bisphosphonates (BPs) are widely used as effective anti-resorptive agents in the treatment of osteoporosis. Although BP-related osteonecrosis of the jaws (BRONJ) is a well-known adverse effect, BP-related oral ulcers are not common. Here we report such a case of BP-related oral ulceration probably caused by an error in how to take the drug. A 91-year-old woman was referred to our department because of oral ulcerations. Her medical history revealed articular rheumatism, dementia, dermatomyositis, and osteoporosis. Clinical examination revealed several ulcerations on the left buccal mucosa, upper lip, soft palate, and tongue. She had been receiving treatment for osteoporosis with alendronate for approximately 10 years and suffered from recurrent oral ulcerations. It was revealed that the patient was inhaling the tablet or placing it in the mouth for an extended period, rather than immediately swallowing the tablet with water. We suspected BPs-related oral ulcerations, so we contacted her prescriber to change the medication. Three weeks after alendronate treatment cessation, the ulcerations had completely epithelialized. In addition, the patient exhibited no clinical evidence of recurrence 4 months after withdrawing alendronate treatment. This outcome confirmed that other forms of treatment may be more suitable for patients who have difficulty in swallowing BP tablets.

著者

森 昌彦 住友 伸一郎 太田 貴久 式守 道夫

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.58, no.6, pp.350-356, 2012-06-20 (Released:2014-11-05)

参考文献数

6

被引用文献数

1

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The present paper analyzed Chinese medical staff (including stomatologists, pharmacists, and nurses), comprising a total 1782 persons who visited Japan from 1987 through 2006 and were sponsored by the Sasagawa Medical Fellowship. Chinese stomatologists accounted for 88 persons among the total of 1782. Among the 88 stomatologists, 15 were from the 4th Military Medical University, 9 from Jilin University, 8 from Beijing University, and 6 from China Medical University; a total of 25 were from North East China. The departments of Japanese universities attended by Chinese stomatologists included 17 departments of in periodontology and conservative dentistry, 16 departments of oral surgery, 12 departments of prosthetics, 11 departments of orthodontics, and 8 departments of pedodontics at dental and medical schools. Stomatologists who had learned major specialties in Chinese stomatological colleges also majored in similar specialties at the Japanese universities or hospitals.Chinese administrators have been investigating Japanese health science systems, including not only medical technology and clinical medicine, but also several administrative specialties such as medical law, public health, provention of infection diseases, cancer, population research, and budgets from both research and clinical perspectives.Medical staff from central administration in the Government of China have also learned considerably from his or her experience during investigations in Japan. No administration staff of stomatologists were supported by the Sasagawa Fund.

著者

坂本 一郎 依田 哲也 塚原 宏泰 森田 伸 小幡 宏一 榎本 昭二

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.41, no.3, pp.224-232, 1995-03-20

参考文献数

21

被引用文献数

2

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The efficacy of combined treatment with amfenac sodium (150 mg/day for 14 days) and ethyl loflazepate (2 mg/day for 14 days) was clinically evaluated in 44 patients with temporomandibular disorders in comparison with 77 patients with temporomandibular disorders who were given amfenac sodium (150 mg/day for 14 days) alone.<BR>The 121 temporomandibular disorder patients were classified into four types (I-IV) according to the criteria proposed by the Japanese Society for the Temporomandibular Joint.<BR>The usefulness of combined treatment with amfenac sodium and ethyl loflazepate was excellent in 14 cases (31.8%), good in 14 cases (31.8%), and fair in 12 cases (27.3%).<BR>The usefulness of amfenac sodium alone was excellent in 6 cases (7.8%), good in 34 cases (44.1%), and fair in 31 cases (40.3%).

著者

早瀬 智広 冨田 陽二 木下 靖朗

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.41, no.4, pp.339-341, 1995-04-20

参考文献数

10

被引用文献数

1

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We report a case of chronic sclerosing sialadenitis in the sublingual gland.<BR>A 34-year-old woman was referred to our hospital for an indolent mass in the sublingual region. No salivary stone nor foreign matter were found. The histpathological diagnosis was chronic sclerosing sialadenitis. Immunological variable, (RA, IgA, IgG, IgM) were within normal limits postoperatively.

著者

有馬 実咲 桑島 精一 福田 雅幸 福地 峰世 五十嵐 秀光 高野 裕史

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.67, no.5, pp.281-285, 2021-05-20 (Released:2021-07-20)

参考文献数

26

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Ectopic impacted teeth are considered to be caused by congenital malposition of tooth germs, increased internal pressure from cysts, tumor growth, periodontal ligament traction, and rupture of the gubernacular cord. It often progresses asymptomatic, but has been reported to cause pain and infection. Here, we report a case of ectopic impacted tooth in which the mandibular horizontal impacted wisdom tooth migrated to the vicinity of the mandibular notch over 9 years. A 42-year-old woman visited our department with the chief complaint of pain in the left mandible. Upon comparison with past radiographs, the left impacted mandibular wisdom tooth was found to have migrated to the mandibular notch over 9 years. We performed an ectopic impacted wisdom tooth extraction to improve thepain. Fragile soft tissue was found forward the tooth. Histopathological specimens showed no epithelial structure and numerous plasma cell infiltrates. Immunohistochemical staining was negative for cytokeratin. The cause of the migration was considered to be the gubernacular cord thickened by inflammation. After the operation, the pain disappeared, no relapse was observed, and the patient has shown good progress.

著者

千葉 雅俊 高橋 哲

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.66, no.11, pp.540-552, 2020-11-20 (Released:2021-01-20)

参考文献数

20

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Trigeminal neuropathy is characterized by numbness in the skin or mucosa in the distribution of the trigeminal nerves, sometimes in association with pain. Sensory deficits in the lower lip and tongue frequently causes difficulties with speech and eating. Thus, numbness in the trigeminal distribution is more distressin than numbness involving spinal dermatomes. The differential diagnosis of the causative diseases underlying the trigeminal neuropathy is difficult, because a spectrum of pathophysiological conditions may affect the trigeminal nerves, including traumatic, vascular, inflammatory, demyelinating, infectious, and neoplastic disorders. Moreover, trigeminal neuropathy develops in isolation or in combination with other neurological deficits of nearby cranial nerves or extremity. Trigeminal neuropathy may also be the presenting manifestation of malignancy, autoimmune disease, or vascular hemorrhage or ischemia of the brainstem. Thus, the findings of orofacial numbness necessitate a comprehensive assessment of all aspects of the trigeminal pathways, which may include neurophysiological, radiographic, and laboratory evaluation in addition to the careful medical interview. In this review, we illustrated some of the principal pathological conditions causing trigeminal neuropathy.

著者

山岸 眞弓美 北村 豊 矢ケ崎 崇 中嶌 哲 千野 武廣 安東 基善 枝 重夫

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.35, no.7, pp.1886-1889, 1989

被引用文献数

1

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A pigmented nevus is defined as a harnartomatous proliferation of the melaninproducing cells (nevus cells). It is a relatively rare disease, especially in the oral mucosa. In this report, the authors present a case of a pigmented nevus of the gingiva, and review 18 cases of pigmented nevus in the region of mucous membrane or lip as previously reported in Japanese medical literature.<BR>The patient, a 63-year-old woman, was referred by her dentist complaining of denture instability due to swelling of the gingiva. About six months ago, she first noted the swelling on the left mandibular gingiva, in the area of the cuspid. The swelling gradually enlarged. At the time of oral examination, a well-defined pigmented swelling about the size of a red bean was noticed.<BR>Having been clinically diagnosed as fibroma, the lesion was surgically excised with little difficulty.<BR>A histopathological study revealed it to be an intramucosal pigmented nevus.<BR>Postoperative healing was uneventful and there has been no evidence of recurrence after a lapse of 1 year and 8 months.

著者

篠原 治征 杉浦 正

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.62, no.2, pp.100-104, 2016-02-20 (Released:2016-04-20)

参考文献数

17

---

A 34-year-old woman was referred to our department because of trismus. Physical examination showed severe trismus and stiffness of the masseter muscles. She had a miscarriage in the Philippines a few days ago, received treatment, and went back to Japan. Maternal tetanus( MT) was diagnosed on the basis of the clinical course and symptoms. The patient was immediately admitted to the intensive care unit. She was given anti-tetanus human immunoglobulin and antibiotics. The patient recovered without undergoing a tracheotomy or tracheal intubation. The World Health Organization( WHO) has reported that maternal and neonatal tetanus( MNT) has decreased in developing countries. However, delivery and miscarriage in an insanitary environment remain a problem. Tetanus is a fatal infectious disease if early treatment is not appropriately performed. An early warning symptom of tetanus is trismus. Patients with this disease may therefore initially consult a dentist or an oral surgeon. We should consider the possibility of tetanus when examining patients with trismus and observe them carefully.

著者

牧志 祥子 又吉 亮 宮本 昇 平野 惣大 仲宗根 敏幸 中村 博幸

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.67, no.3, pp.194-199, 2021

被引用文献数

1

---

<p>Malignant peripheral nerve sheath tumors (MPNSTs) are very rare malignant neoplasia that arise from the peripheral nervous system and show nerve sheath differentiation. We report a case of primary malignant peripheral nerve sheath tumor of the mandibular gingiva.</p><p> A 53-year-old male was referred to our hospital presenting with a mass and pain in the mandibular gingiva. He had no appreciable disease and paralysis of the lower lip.</p><p> Computed tomography showed resorption of the mandible but no obvious lymph node metastasis.</p><p> Biopsy revealed a possible invasive unusual neuroectodermal tumor. Surgical resection was performed and the frozen section showed negative margins.</p><p> Histology revealed atypical spindle cells with clear chromatin and clear nucleolus which had proliferated and loosely infiltrated, but the cell boundaries were unclear. Immunohistochemical staining showed positive results for S-100 protein, p53, and vimentin, but negative results for pan-cytokeratin (AE1 / AE3), Melan A, and desmin. The Ki-67 labeling index was 10%. Accordingly, we diagnosed a low-grade peripheral nerve sheath tumor of the mandibular gingiva.</p><p> There were no signs of recurrence or metastasis at two years postoperatively. MPNSTs have poor prognoses and require careful follow-up.</p>