著者

後藤 祐児 萩原 義久

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.10, no.6, pp.457-462, 1999-12-01 (Released:2010-08-05)

参考文献数

9

被引用文献数

1 1 1

著者

中村 晴臣 嘉本 崇也

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.4, pp.261-267, 1976-04-25 (Released:2010-08-05)

参考文献数

11

被引用文献数

1

著者

山本 信二郎 埴生 知則 林 実

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.6, no.7, pp.543-550, 1975-07-25 (Released:2010-08-05)

参考文献数

24

著者

村嶋 正幸 成田 有吾 岩崎 英一 橋爪 永子 出口 晃 西川 政勝 出口 克巳 白川 茂

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.3, no.6, pp.392-398, 1992-08-01 (Released:2010-08-05)

参考文献数

13

被引用文献数

2 2

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The effect of a novel compound, 3-isobutyryl-2-isopropylpyrazolo [1, 5-a] pyridine (ibudilast, KC-404), on human platelet aggregation and its mechanism of action were investigated.In vitro, KC-404 inhibited human platelet aggregation induced by ADP, collagen, adrenalin, platelet activating factor and arachidonic acid but not by ristocetin. Together, KC-404 and agents which increased cAMP (prostaglandin I2, prostaglandin E1 (PGE1), forskolin) or cGMP (3-morpholinosydnonimine (SIN-1)) produced synergistic inhibitory effects on platelet aggregation.KC-404 inhibited human platelet cAMP phosphodiesterase (PDE) (IC50: 50μM) and cGMP-PDE (IC50: 5.2μM) activities. cAMP and cGMP concentration of human platelets were not increased by KC-404 itself. PGE1, an adenylate cyclase stimulator, increased cAMP content; KC-404 enhanced the effect of PGE1 on cAMP accumulation. SIN-1, which stimulates guanylate cyclase, increased cGMP content; KC-404 enhanced the effect of SIN-1 on cGMP accumulation.These results suggest that effects of KC-404 on accumulation of cyclic nucleotides and inhibition of platelet aggregation are mediated via inhibition of platelet cyclic nucleotide phosphodiesterase activities.

著者

工藤 龍彦 首藤 裕

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.7, no.3, pp.239-243, 1996-06-01 (Released:2010-08-05)

参考文献数

10

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Patients on oral anticoagulant therapy present a clinical problem when they take large amounts of natto, because immoderate ingestion of natto results in reduction of the effect of warfarin so that thrombotest and PT-INR are adversely affected.We previously demonstrated an undesirable effect of immoderate ingestion of natto in a trial in patients given 100g of natto each. In the present study changes in blood levels of vitamins K were determined after the administration of reduced doses of 10 and 30g of natto.There was no change in blood levels of MK-4. Howevere, the blood levels of vitamin K1 increased from 0.53±0.26ng/ml to 0.72±0.25ng/ml at 4 hours after the administration of 10g of natto (p<0.001). After the administration of 30g of natto the blood level of vitamin K1 increased from 0.46±0.28ng/ml to 0.70±0.21ng/ml at 4 hours (p<0.001). The blood level of MK-7 increased from 0.58±0.15ng/ml to 2.43±0.77ng/ml at 4 hours, 1.66±0.69ng/ml at 24 hours, and 1.28±0.46ng/ml at 48 hours after the administration of 10g of natto (p<0.001).After the administration of 30g of natto the blood level of MK-7 increased from 0.57±0.18ng/ml to 7.24±2.92, 4.53±1.82, and 3.00±1.09ng/ml at the same time points as mentioned above, respectively (p<0.001).The results of this study suggest the wisdom of discouraging patients on anticoagulant therapy from taking natto, since it may reduce the effect of warfarin, be the amount ingested 30g or 10g insted of 100g.

著者

松尾 博司

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.5, pp.363-366, 1976-05-25 (Released:2010-08-05)

参考文献数

3

著者

金子 弘真 高塚 純 柴 忠明 竹内 節夫 斉藤 徹 五十嵐 紀子 浅田 敏雄

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.15, no.3, pp.274-276, 1984-06-01 (Released:2010-08-05)

参考文献数

7

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(Multiple organ failure) MOF or (Disseminated intravascular coagulation) DIC often becomes a fatal complication for the patients suffering from endotoxin shock. And it is also pointed out that MOF and DIC share many common or simiar clinical features. To clarify the relationship between these two, we surveyed the changes in haematological indices of organ failure patient.DIC was complicated in 10 of 14 patients with endotoxin shock and 9 of these were victimized. In the latter 9 cases, failure of more than three organs occured concomitantly. DIC observed in patients with organ failure is as follows: 10 in 13 cases of lung failure, 3 in 5 cases of heart failure, 10 in 12 cases of renal failure, 3 in 5 cases of liver failure and 3 in 4 cases of gastro-intestinal bleeding. Both organ failure and DIC usually began at the lung in endotoxin shock patients. From the viewpoint of haematology, hypercoagulable tendency preceded the lung failure. For example, decrease in antithrombin III and plasminogen level was observed prior to that in platelet.In endotoxin shock patients, MOF and DIC have close relationship, which suggests that hypercoagulable state induced by endotoxin triggers an organ failure and results in MOF through chain reactions.

著者

中島 茂 東松 豊彦 服部 浩明 岡野 幸雄 野沢 義則

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.17, no.1, pp.59-61, 1986-02-01 (Released:2010-08-05)

参考文献数

10

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In many secretory cells, cyclic nucleotides and Ca2+ cooperatively or antagonistically control cell responses. Activation of platelets with thrombin caused a rapid breakdown of phosphoinositides and an increase of cytoplasmic free Ca2+ concentration, which resulted in shape change, secretion and aggregation. The hypothetical concept has recently been proposed that inositol trisphosphate, a degradation product of phosphatidylinositol 4, 5-bisphosphate (PIP2), serves as a second messenger for mobilizing intracellular Ca2+. The effects of cAMP and cGMP on thrombin-induced human pletelet responses were investigated. Thrombin-induced serotonin secretion and aggregation were inhibited by pretreatment with dibutyryl cAMP (dbcAMP) or 8-bromo cGMP (8bcGMP) in a dose-dependent manner. However, shape change was not affected by 8bcGMP. Preincubation of platelets with dbcAMP or 8bcGMP was without effect on the basal level of inositol trisphosphate and free cytosolic Ca2+, measured by fluorescent indicator quin 2, but suppressed their thrombin-induced enhancements. Enhanced [32P] incorporation into phosphatidylinositol 4-phosphate (PIP) and PIP2 was observed with dbcAMP or 8bcGMP treatment, suggesting activation of PI- and PIP-kinases. These results indicate that cGMP as well as cAMP acts as a negative messenger to prevent platelet activation. The inhibitory effect can be explained at least in part by the repression of phospholipase activation, resulting in reduced formation of inositol trisphosphate.

著者

内藤 篤彦

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.26, no.3, pp.297-301, 2015

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要約:個体老化とは「加齢に伴い死亡率が増加する原因となる様々な臓器の機能低下」と定義される生命現象である.加齢に伴って免疫系が老化する結果,免疫系本来の非自己を排除する機構と炎症反応を制御する機構が低下し,高齢者で認められる易感染性や慢性炎症が引き起こされる.補体分子C1q は自然免疫系において重要な役割を果たす因子であり,免疫系の老化が引き起こす慢性炎症に伴って血中濃度が増加することが知られているが,われわれはC1q が補体経路非依存性に加齢に伴う骨格筋の再生能低下という老化現象の原因になっていることを報告している.本稿では前半に加齢に伴う免疫系の老化現象について概説し,後半では補体分子C1q による老化誘導のメカニズムについて述べる.

著者

辻 肇

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.3, no.1, pp.63-65, 1992-02-01 (Released:2010-08-05)

参考文献数

12

著者

伊藤 要子 水谷 洋子 山田 学 宮田 伸樹 山田 高路 小栗 隆

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.1, no.2, pp.134-140, 1990-04-01 (Released:2010-08-05)

参考文献数

23

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Activities of clotting and fibrinolytic factors in golden hamsters under acute alcohol consumption were measured with fluorogenic peptide substrate. The obtained data were as follows;1) Concentration of blood alcohol reached to the maximum values on 1hr after administration of alcohol.2) Prothrombin and factor X activities began to decrease on 1hr after administration. But their activated form, thrombin like and factor Xa like activities significantly increased on 1hr, then returned to initial value on 4hrs after administration.3) Although plasminogen activity began to decrease on 1hr, activated form of it, plasmin like, and t-PA like activities increased on 1hr and returned to the initial values or decreased on 4hrs. Both prekallikrein and kallikrein like activities significantly increased from 1hr.Under acute alcohol consumption, activities of clotting and fibrinolytic factors (prothrombin, factor X, plasminogen) in golden hamster were changed into their activated form (thrombin, factor Xa, plasmin) at the corresponding time that concentration of blood alcohol reached to the maximum values.

著者

木下 明美 堀江 登

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.4, no.6, pp.417-422, 1993-12-01 (Released:2010-08-05)

参考文献数

14

被引用文献数

9 10

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Effects of green tea catechins on thrombin activity were investigated. The major part of catechins in green tea are epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECg) and epigallocatechin gallate (EGCg). ECg and EGCg except others were found to be more potent inhibitors for thrombin by mode of noncompetitive inhibition. These 50% inhibition of thrombin amidolysis by ECg and EGCg were 1.2×10-6M and 1.1×10-6M, and fibrin formation were 2.5×10-5M and 8.8×10-6M.These facts suggested that thrombosis may be prevented by ECg and EGCg in green tea.

著者

山村 研一

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.9, no.5, pp.335-343, 1998-10-01 (Released:2010-08-05)

参考文献数

15

著者

桜川 信男 湯浅 和典 近藤 信一 丹羽 正弘 横田 力

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.14, no.2, pp.228-230, 1983-06-01 (Released:2010-08-05)

参考文献数

5

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Crude drugs of Wakan-Yakus (traditional herbal drugs) such as Gaiyoh (Artemisiae folium), Sanshishi (Gardeniae fructus), Taiso (Zizyphi fructus), Kizutsu (Aurantii fructus immaturus) and Akyoh (Glutinum) were investigated to analyse the effects on blood coagulation system.(1) Gaiyoh (Artemisiae folium) showed the effects of anticoagulant, antifibrinolytic and anti-platelet aggregation, and the anticoagulant effect was strong prominently. When the crude drug of Gaiyoh was purified by the Sephadex G-100 column chromatography, four peaks were found. The strong antocoagulant effect was found to the third peak. We settled “Inhibition unit” of Gaiyoh from statistic studies, and 2.5mg/ml of Gaiyoh in the final concentration was evaluated to be 10 inhibition units.(2) Sanshishi (Gardeniae fructus) showed strong fibrinolytic effect characteristically.

著者

佐藤 敬 高松 滋 作田 茂 水野 成徳 高松 むつ 武田 俊平

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.13, no.3, pp.410-413, 1982-09-01 (Released:2010-08-05)

参考文献数

3

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The effects of mefenamic acid on in vitro platelet functions, namely thrombininduced production of thiobarbituric acid-reactive substances (TBARS) and ADP-induced platelet aggregation, were investigated and compared with those of aspirin and flurbiprofen.Mefenamic acid inhibited platelet TBARS production almost comparatively to aspirin and flurbiprofen. The inhibitory effects of these three drugs on platelets from patients with atherosclerotic vascular diseases were smaller than the effects on platelet from normal subjects. Percent inhibition, by mefenamic acid, on platelet TBARS production correlated positively with maximal aggregation in these subjects.Mefenamic acid also strongly suppressed platelet aggregation. In contrast to aspirin and flurbiprofen, of which effects were limited solely on secondary aggregation, mefenamic acid abolished primary aggergation, as well. Therefore, besides being a strong inhibitor of platelet thromboxane generation, mefenamic acid may exert its anti-platelet action through unknown mechanism (s). Antiplatelet action of this drug can be also characterized by the result suggesting that the inhibition tends to be large on platelets with higher aggregatory activity.

著者

八木 高秀 小橋 紀之 香取 瞭

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.18, no.3, pp.250-253, 1987-06-01 (Released:2010-08-05)

参考文献数

8

被引用文献数

1

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The purpose of the present study is to clarify the inhibitory mechanism of taurine on platelet aggregation in myocardial infarction. In vitro, platelet aggregations induced by 4.6μM ADP and calcium ionophore in the dose range of 1.7 to 10.0μM A23187 were measured by Born's method with and without 10mM taurine in normal subjects and in cases with old myocardial infarction. Platelet malondialdehyde formation induced by 125μM arachidonic acid was measured by TBA method. In order to estimate the effect of taurine on the change of cytoplasmic Ca2+ in platelet activated by 0.4U/ml thrombin, the intensity of quin 2 fluorescence was measured by Rink's method with and without 10mM taurine.Platelet aggregations induced by 4.6μM ADP and by 2.5 and 5.0μM 23187 were significantly inhibited with 10mM taurine in cases with old myocardial infarction, and also the increase of cytoplasmic Ca2+ in platelet activated by thrombin was significant. In normal subjects, on the other hand, taurine did not inhibit them. In both of cases with old myocardial infarction and normal subjects, platelet malondialdehyde formation was not significantly affected by incubation with 10mM taurine. These results suggest that the inhibitory mechanism of taurine on platelet aggregation is not due to the effect of taurine on arachidonic metabolism, but the inhibition of cytoplasmic Ca2+ change in platelets of the cases with old myocardial infarction.

著者

池田 宇一

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.9, no.1, pp.38-44, 1998-02-01 (Released:2010-08-05)

参考文献数

31

著者

福田 雅俊

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.6, no.7, pp.557-562, 1975-07-25 (Released:2010-08-05)

参考文献数

8

著者

長谷川 淳

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.1, no.1, pp.36-40, 1990-02-01 (Released:2010-08-05)

参考文献数

1

著者

吉原 博幸 美原 恒

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.15, no.2, pp.163-166, 1984-04-01 (Released:2010-08-05)

参考文献数

5

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The plasma coagulation system was converted to a mathematical model which was described using differential equations. The calculated output patterns of the mathematical model against various input stimulations were compared with results of in vitro assay.The simulated results of (1) Hemophilia A, (2) anticoagulation effect of antithrombin III and (3) anticoagulation effect of heparin corresponded to the results of in vitro assay and clinical reports. However, the simulated result of (4) anticoagulation effect of synthesized arginine derivative No. 805 (MD-805) did not correspond to the results of in vitro assay. Therefore, a new series simulation of MD-805 was done, supposing that MD-805 had an inhibitory activity not only on coagulation factor ha but also VIIa. The new simulation pattern closely resembled the results of in vitro assay. From these facts, it was theoretically indicated that MD-805 also has an inhibitory activity on VIIa.