著者

Yoshito Nishimura Asami Nishikori Haruki Sawada Torrey Czech Yuki Otsuka Midori Filiz Nishimura Hiroki Mizuno Naoki Sawa Shuji Momose Kumiko Ohsawa Fumio Otsuka Yasuharu Sato

出版者

The Japanese Society for Lymphoreticular Tissue Research

雑誌

Journal of Clinical and Experimental Hematopathology (ISSN:13464280)

巻号頁・発行日

pp.21038, (Released:2022-03-05)

参考文献数

38

被引用文献数

4

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Idiopathic multicentric Castleman disease (iMCD) is a systemic disorder characterized by systemic inflammation and organ dysfunction associated with an increase in pro-inflammatory cytokines. Some patients with iMCD are positive for autoantibodies, although their significance and relationship with specific associated autoimmune diseases are unclear. This study retrospectively analyzed the clinicopathological features of iMCD patients focusing on autoantibodies. Among 63 iMCD patients in our database, 19 were positive for at least one autoantibody. Among the 19, we identified five with plasma cell type (PC)-iMCD lymph node histopathology and positive anti-phospholipid antibodies. These patients were likely to have thrombocytopenia, anasarca, fever, reticulin fibrosis or renal insufficiency, organomegaly (TAFRO) symptoms, and thrombotic events. The present study suggests that patients with undiagnosed or atypical autoimmune diseases, including anti-phospholipid syndrome (APS), were treated for iMCD. APS may present with thrombocytopenia or even multi-organ failure, which overlap with clinical presentations of iMCD. Due to differences in the treatment regimen and follow-up, recognition of the undiagnosed autoimmune disease process in those suspected of iMCD is essential. Our study highlights the importance of complete exclusion of differential diagnoses in patients with iMCD in their diagnostic workup.

著者

edited by Sukanta Chaudhuri

出版者

Oxford University Press

巻号頁・発行日

1990

著者

我妻栄 著

出版者

有斐閣

巻号頁・発行日

1953

著者

毎日新聞社 編

出版者

毎日新聞社

巻号頁・発行日

vol.タイ・仏印篇, 1943

著者

文部科学省初等中等教育局初等中等教育企画課 [編]

出版者

第一法規

巻号頁・発行日

vol.51(9), no.599, 1999-12

著者

村上 加代子

出版者

神戸山手短期大学

雑誌

神戸山手短期大学紀要 (ISSN:13496808)

巻号頁・発行日

no.55, pp.67-76, 2012-12-20

著者

日本ビクター合唱団[合唱]

出版者

ビクター

巻号頁・発行日

1939-02

著者

入江 啓四郎

出版者

一般財団法人 アジア政経学会

雑誌

アジア研究 (ISSN:00449237)

巻号頁・発行日

vol.1, no.1, pp.30-51, 1954 (Released:2014-09-15)

著者

大河内常平, 柴田光男 共著

出版者

雄山閣出版

巻号頁・発行日

1963

著者

和田 崇文 上久保 毅 中島 真人 阿部 俊昭

出版者

Japanese Association for Acute Medicine

雑誌

日本救急医学会雑誌 (ISSN:0915924X)

巻号頁・発行日

vol.12, no.12, pp.755-759, 2001-12-15 (Released:2009-03-27)

参考文献数

20

被引用文献数

3 2

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A 15-year-old boy with a neck injury transferred to our emergency room was alert and cooperative. During surgical closure of the wound, he vomited and became somnolent. A piece of brain tissue was found in vomit. Computed tomography (CT) showed pneumocephalus and a small hemorrhage in the left frontal lobe. Surgery undertaken found an irregular bone defect in the plamun sphenoidale and a dural laceration in the frontal base. The dura of the left frontal convexity was also lacerated. These findings suggested that an unknown foreign body penetrated the right lateral neck and the skull base through the nasopharynx, then reached up to the frontal bone. Postoperative course was uneventful. He witnessed later that he hit his neck on to an iron rod protruding from concrete blocks when he fell. He had known that this rod had penetrated his neck. Orbitocranial stab wounds may associate penetrating brain injuries, but it seems quite rare that a cervical stab wound complicated a penetrating brain injury. It should be stressed that physicians and paramedics must glean information about the modality of penetrating injuries.

出版者

東寶

巻号頁・発行日

1947

出版者

青年社

巻号頁・発行日

vol.第10年, no.4, 1903-04

出版者

チャネル

巻号頁・発行日

vol.10(9), no.110, 1984-09

著者

C.コードウェル 著

出版者

ダヴィッド社

巻号頁・発行日

vol.第1 (廿世紀作家の没落), 1954

出版者

南満州鉄道東亜経済調査局

巻号頁・発行日

vol.(10月號), 1940-10

著者

ハーバート・リード 著

出版者

みすず書房

巻号頁・発行日

1957

著者

上原専禄 等編

出版者

河出書房

巻号頁・発行日

vol.第6, 1956

著者

前嶋信次 著

出版者

修道社

巻号頁・発行日

1958

著者

佐久間貞次郎 著

出版者

春日書房

巻号頁・発行日

1938

著者

牧勝彦 著

出版者

刀江書院

巻号頁・発行日

1940