著者
吉田 光二 榑谷 和男 星 昭夫
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.26, no.2, pp.429-434, 1978-02-25 (Released:2008-03-31)
被引用文献数
2

5-Fluorouridine and 1-β-D-arabinofuranosylcytosine are active against various tumors as antimetabolites. Antitumor activity and mode of action of their nucleotides, 5-fluorouridine 5'-phosphate and 1-β-D-arabinofuranosylcytosine 5'-phosphate, were examined. 5-Fluorouridine 5'-phosphate was active similar to the nucleoside against L1210 leukemia, but the nucleotide showed higher therapeutic ratio than 5-fluorouracil and 5-fluorouridine. The mode of action of these nucleotides was examined by the incorporation of labeled precursors into acid-insoluble fraction of the cells for 30 min. Inhibition patterns of these nucleotides were the same as those of the nucleosides, but the potency of the nucleotides was very weak, and increased with time. Analysis showed that these nucleotides were dephosphorylated on the cell surface and the dephosphorylation was greater than that of phenolphthalein monophosphate. 5-Fluorouridine 5'-phosphate was considered to be a good candidate for an antitumor agent.

1 1 1 1 OA 資料編 統計

出版者
北海道大学
雑誌
北大百二十五年史
巻号頁・発行日
vol.論文・資料編, pp.939-642, 2003-02-21

1 1 1 1 OA 詩仙堂志 4巻

著者
石川丈山 原輯
出版者
巻号頁・発行日
vol.[3],
著者
法学セミナ-編集部
出版者
日本評論社
雑誌
法学セミナ- (ISSN:04393295)
巻号頁・発行日
no.279, pp.p138-142, 1978-06
著者
池内 紀
出版者
新書館
雑誌
大航海
巻号頁・発行日
no.42, pp.221-231, 2002