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(111)-oriented Ge thin films on insulators are essential for advanced electronics and photovoltaic applications. We investigate Al-induced crystallization of amorphous-Ge films (50-nm thickness) on insulators focusing on the annealing temperature and the diffusion controlling process between Ge and Al. The (111)-orientation fraction of the grown Ge layer reaches as high as 99% by combining the low-temperature annealing (325 °C) and the native-oxidized Al (AlOx) diffusion-control layer. Moreover, the transmission electron microscopy reveals the absence of defects on the Ge surface. This (111)-oriented Ge on insulators promises to be the high-quality epitaxial template for various functional materials to achieve next-generation devices.

2012-10-30 08:30:51
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1 0 0 0 OA Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

著者: Yamada Parida Ono Takako Shigemori Hideyuki Han Junkyu Isoda Hiroko
出版者: Springer Science+Business Media B.V.
雑誌: Cytotechnology (ISSN:09209069)
巻号頁・発行日: vol.64, no.3, pp.349-356, 2012-05
被引用文献数: 10

In this study, the anti-allergy potency of thirteen tannins isolated from the galls on buds of Carpinus tschonoskii (including two tannin derivatives) was investigated. RBL-2H3 (rat basophilic leukemia) cells were incubated with these compounds, and the release of β-hexosaminidase and cytotoxicity were measured. Of the thirteen tannins, tetragalloylglucose (2), pentagalloylglucose (3), casuarictin (4), and casuarinin (9) were the most potent inhibitors, and all the tannins showed no cytotoxic effect after 24 h of incubation. The results obtained suggest that tannins from C. tschonoskii are capable of inhibiting allergic reactions and may be useful for the treatment or prevention of type I allergic diseases.

2012-10-30 08:30:35
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1 0 0 0 OA Assessment of wastewater-irrigated soil containing heavy metals and establishment of specific biomarkers

著者: Fredj F. Ben Han J. Irie M. Funamizu N. Ghrabi A. Isoda H.
出版者: Elsevier
雑誌: Ecotoxicology and environmental safety (ISSN:01476513)
巻号頁・発行日: vol.84, pp.54-62, 2012-10
被引用文献数: 6 5

Irrigation with treated wastewater (TWW) is a vital alternative for arid and semi-arid lands but it poses pollution-risk to soil, vegetation and groundwater. Therefore, in the present study, in vitro bioassays were used to evaluate the adverse effects of TWW and irrigated-soil extract sample, on mammalian cells, with respect to heavy metal—Ni, Cd, Pb, Fe, Al-content. The heat shock protein (HSP) 47, E-screen, and transepithelial electrical resistance (TEER) assays served to investigate the stress response of treated-HSP47-transfected Chinese hamster ovary (CHO) cells, the estrogenic activity of the samples in MCF-7 breast cancer cells, and the barrier function (BF) of Caco-2 cells. Furthermore, proteomics analyses were performed to shed light on involved mechanisms and to establish pollution biomarkers. Results showed that the TWW elicited a stress response on HSP cells from 0.1% concentration while soil extract samples exhibited a stress at 1%. TWW induced an estrogenic activity at 10%; up-regulating cell proliferation and tumor-related proteins. Soil extract triggered the enhanced expression of HSP70 family proteins as survival mechanisms against their cytotoxicity toward MCF-7 cells. Moreover, depending on the concentration, 1% of soil extract from 20 cm depth (T20) resulted in a disruption of BF in Caco-2 cells involving cell metabolism, protein synthesis and tumor marker proteins, whereas, 5% of T20 induced the expression of BF-related proteins associated to heat shock, oxidative stress, cell proliferation and glycolytic metabolic pathway. These biological techniques were found to be extremely useful to evaluate the impact of wastewater reuse and to establish specific biomarkers that are common proteins for humans, other mammals and plants. Future studies should focus on exposure quantifications.

2012-10-30 08:30:19
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1 0 0 0 OA Capsaicin-enhanced Ribosomal Protein P2 Expression in Human Intestinal Caco-2 Cells

著者: Han Jun Kyu Akutsu Mitsuaki Talorete Terence P. N. Maekawa Takaaki Tanaka Toshiyuki Isoda Hiroko
出版者: Springer
雑誌: Cytotechnology (ISSN:09209069)
巻号頁・発行日: vol.47, no.1-3, pp.89-96, 2005-01
被引用文献数: 11 10

On the basis of transepithelial electrical resistance (TER) measurements, we found that capsaicin (100 μM)-treated human intestinal Caco-2 cells show a momentary increase in tight-junction (TJ) permeability (decrease in TER) followed by a complete recovery. We used proteome analysis to search for proteins that are associated with the recovery of TJ permeability in capsaicin-treated Caco-2 cells. A protein with a relative molecular mass of 14 kDa was found to be expressed more highly in capsaicin-treated cells than in nontreated cells. Mass spectrometry and sequence analyses revealed that the protein that is expressed significantly upon capsaicin treatment is the ribosomal protein P2; its cDNA sequence was identical to that found in the human genome database. An increase in the amount of cellular filamentous actin (F-actin) was shown after 8 h of incubation with capsaicin. It has been reported that P2 activates elongation factor 2, which stabilizes F-actin filaments, and that the depolymerization of F-actin is associated with the increase in TJ permeability (decrease in TER). Consequently, these results suggest that P2 plays an important role in the recovery of the TJ permeability in capsaicin-treated human intestinal cells.

2012-10-30 08:30:13
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1 0 0 0 OA 人文第59号

出版者: 京都大学人文科学研究所
雑誌: 人文 (ISSN:0389147X)
巻号頁・発行日: vol.59, pp.1-53, 2012-06-30

[随想] 記憶媒体 / 森時彦 [1]

2012-10-29 15:44:02
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http://hdl.handle.net/2433/160490

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1 0 0 0 OA Highly (111)-oriented Ge thin films on insulators formed by Al-induced crystallization

1 0 0 0 OA Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

1 0 0 0 OA Assessment of wastewater-irrigated soil containing heavy metals and establishment of specific biomarkers

1 0 0 0 OA Capsaicin-enhanced Ribosomal Protein P2 Expression in Human Intestinal Caco-2 Cells

1 0 0 0 OA 人文 第59号

1 0 0 0 OA 人文第59号