著者

Shih-Lin Hsu Harumi Oda Saya Shirahata Mana Watanabe Makoto Sasaki

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.8, pp.1014-1018, 2018 (Released:2018-07-24)

参考文献数

10

被引用文献数

21

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[Purpose] To investigate the effects of core strength training on core stability with and without the Valsalva maneuver. [Participants and Methods] Twenty-four students were randomly assigned to the training and control groups. Students in the training group undertook a 4-week training program that included exercises for the transverse abdominis, multifidus, diaphragm, and pelvic floor muscles, whereas students in the control group performed their usual activities. Participants were required to perform four types of task with and without the Valsalva maneuver. Seated stabilometry was assessed according to the center of pressure (COP). [Results] In the training group, the rectus area in the quiet sitting position with the Valsalva maneuver was enlarged and the length of trajectory during a sudden perturbation task was decreased. No significant changes to the COP were seen in the control group. [Conclusion] Some parameters of core stability improved after participants completed a 4-week core strength training program.

著者

Hiroki YAMAZAKI Naoki MIURA Yu-Chang LAI Masashi TAKAHASHI Yuko GOTO-KOSHINO Momoi YASUYUKI Munekazu NAKAICHI Hajime TSUJIMOTO Asuka SETOGUCHI Yasuyuki ENDO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.7, pp.1225-1229, 2017 (Released:2017-07-19)

参考文献数

20

被引用文献数

8

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We examined whether multidrug resistant (MDR) canine lymphoma increases gene expression for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and c-KIT, and whether toceranib phosphate (TOC) has potential as a treatment for MDR canine lymphoma. The clinical data showed that PDGFRα expression was higher in canine subjects with MDR T-cell lymphoma than in those with untreated T-cell lymphoma, and that c-KIT expression was greater in subjects with T-cell lymphoma than in those with B-cell lymphoma. TOC monotherapy was well tolerated without serious adverse effects, and two of the five subjects that received TOC exhibited partial responses. The data presented here could contribute to the assessment of TOC-based therapy for dogs with MDR or T-cell lymphoma.

著者

Chia-Da HSU Yaoprapa MATHURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.2, pp.320-322, 2018 (Released:2018-02-20)

参考文献数

11

被引用文献数

2

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In January 2016, a 20-year-old female oriental small-clawed otter (Aonyx cinereus) from Night Safari in Singapore was euthanized and diagnosed with a thyroid gland carcinoma. Postmortem examination and histology also revealed metastasis to the regional lymph nodes and severe visceral pentastomiasis. Grossly, the lymph nodes were infested, and encapsulation was observed on the visceral serosal surface. Histopathologically, the lymph nodes were encysted by a thick fibrous connective capsule with minimal inflammatory response. Pentastomiasis has been previously reported in the smooth-coated otter (Lutrogale perspicillata) in Malaysia. This report is the first case of severe visceral pentastomiasis in an oriental small-clawed otter with functional thyroid carcinoma.

著者

Blanca ALGARRA Verónica MAILLO Manuel AVILÉS Alfonso GUTIÉRREZ-ADÁN Dimitrios RIZOS Maria JIMENEZ-MOVILLA

出版者

THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2018-058, (Released:2018-08-06)

被引用文献数

17

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Previously, our group demonstrated that recombinant porcine oviductin (pOVGP1) binds to the zona pellucida (ZP) of in vitro-matured (IVM) porcine oocytes with a positive effect on in vitro fertilization (IVF). The fact that pOVGP1 was detected inside IVM oocytes suggested that this protein had a biological role during embryo development. The aim of this study was to evaluate the effects of pOVGP1 on bovine in vitro embryo development. We applied 10 or 50 µg/ml of pOVGP1 during IVF, embryonic in vitro culture (IVC), or both, to evaluate cleavage and embryo development. Blastocyst quality was assessed by analyzing the expression of important developmental genes and the survival rates after vitrification/warming. pOVGP1 was detected in the ZP, perivitelline space, and plasma membrane of blastocysts. No significant differences (P > 0.05) were found in cleavage or blastocyst yield when 10 or 50 µg/ml of pOVGP1 was used during IVF or IVC. However, when 50 µg/ml pOVGP1 was used during IVF + IVC, the number of blastocysts obtained was half that obtained with the control and 10 µg/ml pOVGP1 groups. The survival rates after vitrification/warming of expanded blastocysts cultured with pOVGP1 showed no significant differences between groups (P > 0.05). The use of pOVGP1 during IVF, IVC, or both, increased the relative abundance of mRNA of DSC2, ATF4, AQP3, and DNMT3A, the marker-genes of embryo quality. In conclusion, the use of pOVGP1 during bovine embryo in vitro culture does not affect embryo developmental rates but produces embryos of better quality in terms of the relative abundance of specific genes.

著者

Jin-Ok AHN Won-Joung JAUNG Sang-Heum WON Min-Ok RYU Woo-Jin SONG Kee-Ok JEON Jin-Young CHUNG Hwa-Young YOUN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.1, pp.152-155, 2018 (Released:2018-02-02)

参考文献数

23

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Two dogs presented to the emergency service after accidental ingestion of afloqualone tablets, a muscle relaxant used for back pain in humans. Toxic effects of the drug in these dogs included vomiting, respiratory depression, seizures, ataxia, bradycardia, and hematuria. Treatment consisted of fluid diuresis, furosemide, and propofol. Flumazenil, a gamma-amino butyric acid antagonist, was administered intravenously; however, it was not effective in stopping the seizures in these dogs. Both dogs recovered with supportive treatment. To the authors’ knowledge, this is the first documented report of afloqualone intoxication in dogs.

著者

Kanayama Tomohiko Mamiya Satoru Nishihara Tsutomu NISHIKAWA Jun-ichi

出版者

Japanese Biochemical Society

雑誌

The journal of biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.133, no.6, pp.791-797, 2003-06-01

被引用文献数

14

著者

director editor Luis Fernández-Galiano

出版者

Arquitectura Viva

巻号頁・発行日

2017

著者

小坂 喜太郎 木崎 善郎 杉本 徹 ウエン-リン ショー フウミン フウ ユアンーツオング チェン

雑誌

日本先天代謝異常学会雑誌 (ISSN:09120122)

巻号頁・発行日

vol.17, no.2, 2001-10-23

著者

Ha-Hyun KIM Dong-Kun YANG Bo-Hyun SEO In-Soo CHO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0012, (Released:2018-07-31)

被引用文献数

14

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Rabies virus (RABV), canine distemper virus (CDV), canine parvovirus type-2 (CPV-2), and canine influenza A virus (CIV) are important contagious pathogens in canine populations. To assess post-vaccination immunity against RABV, CDV and CPV-2, and serological evidence of exposure to influenza A virus in military working dogs (MWDs) in Korea, we tested blood samples of 78 MWDs by fluorescent antibody virus neutralization (FAVN) for RABV, and by commercially available enzyme-linked immunosorbent assay (ELISA) for CDV, CPV-2, and CIV. Korean MWDs had high antibody-positive rates against RABV (97.4%, ≥0.5 IU/ml), CDV (94.8%), and CPV (100%). All dogs tested seronegative (0/78; 0%) for influenza A virus. Two 1-year-old dogs stationed in known rabies outbreak areas (Gangwon and Gyeonggi) exhibited VNA titers below the protective level (0.06 and 0.29 IU/ml, respectively). The breed and sex of MWDs were not significantly associated with antibody titers for RABV, CDV, or CPV; however, age was significantly associated with CPV antibody titers, while region of residence was associated with CDV antibody titer. Taken together, the data presented here provide important insights necessary for post-vaccination management and control of infectious diseases in MWDs.

著者

Yasuyoshi Shikama Jun-ichi Kitazawa Nobuo Yagihashi Osamu Uehara Yuuji Murata Nobuhisa Yajima Ryuichi Wada Soroku Yagihashi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.49, no.5, pp.397-401, 2010 (Released:2010-03-01)

参考文献数

9

被引用文献数

43 111

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A 60-year-old woman diabetic patient presented with a subcutaneous mass in right lower abdominal quadrant where recombinant human insulin or insulin analogue had been injected for 16 years. Her diabetes has been insulin resistant with insufficient blood glucose control. The mass was extirpated under the suspicion of neoplasm but it was found to consist of diffuse deposition of eosinophilic amorphous materials mixed with inflammatory change. Congo-red staining demonstrated positive red color and yielded green birefringence by polarized microscopy. Pre-digestion with potassium permanganate was incomplete to quench positive Congo-red stains. Immunostains with insulin antibody were positive for this deposition but not so with amylin or AA or AL amyloid. Thus, the mass was considered to be localized amyloidosis composed of iatrogenic A-Ins type amyloid. Thus, the case suggested that her insulin resistance, i.e. refractoriness of insulin treatment, may be ascribed to poor penetration of injected insulin and human insulin itself or its analogue is amyloidogenic to form a local mass.

著者

Rong-Long WANG Li-Qing ZHAO Xiao-Fan ZHOU

出版者

一般社団法人 電子情報通信学会

雑誌

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E95.A, no.3, pp.639-645, 2012-03-01 (Released:2012-03-01)

参考文献数

24

被引用文献数

1 3

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Ant Colony Optimization (ACO) is one of the most recent techniques for solving combinatorial optimization problems, and has been unexpectedly successful. Therefore, many improvements have been proposed to improve the performance of the ACO algorithm. In this paper an ant colony optimization with memory is proposed, which is applied to the classical traveling salesman problem (TSP). In the proposed algorithm, each ant searches the solution not only according to the pheromone and heuristic information but also based on the memory which is from the solution of the last iteration. A large number of simulation runs are performed, and simulation results illustrate that the proposed algorithm performs better than the compared algorithms.

著者

Hiroshi Mabuchi Toru Kita Masunori Matsuzaki Yuji Matsuzawa Noriaki Nakaya Shinichi Oikawa Yasushi Saito Jun Sasaki Kazuaki Shimamoto Hiroshige Itakura the J-LIT Study Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.66, no.12, pp.1096-1100, 2002 (Released:2002-11-25)

参考文献数

26

被引用文献数

84 103

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Hyperlipidemia is primarily implicated in the progression of coronary heart disease (CHD) and its treatment is essential for patients with a history of CHD. Statins such as simvastatin, the lipid-lowering agents, are well-known for their ability to normalize patient's serum lipid levels. The Japan Lipid Intervention Trial study of simvastatin is the first nationwide investigation of the relationship between serum lipid levels and the development of CHD in Japanese patients with hypercholesterolemia. Of 5,127 patients, exclusively with a history of documented CHD at enrollment, 4,673 were treated with open-labeled simvastatin at an initial dose of 5-10 mg/day and were monitored for 6 years. The risk of coronary events tended to be higher in patients with a serum total cholesterol (TC) ≥240 mg/dl compared with total cholesterol <240 mg/dl. The concentration of low-density lipoprotein cholesterol (LDL-C) positively correlated and that of high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of CHD. Each 10 mg/dl decrease in LDL-C and each 10 mg/dl increase in HDL-C concentration reduced the risk of CHD by 8.0% (95% confidence interval 3.8-12.0) and 28.3% (95% CI 13.9-40.3), respectively. A reasonable therapeutic strategy to reduce CHD progression in patients with prior CHD under low-dose statin treatment might be regulating the serum LDL-C concentration to at least <120 mg/dl and HDL-C >40 mg/dl, respectively. (Circ J 2002; 66: 1096 - 1100)

著者

Masahiro NISHII Yasuko FUJIHARA Jin-ichiro INAGAKI Kazuo OGAWA Fujio NOHARA Makoto UBUKATA Kiyoshi ISONO

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.50, no.10, pp.2697-2699, 1986 (Released:2006-04-05)

参考文献数

5

被引用文献数

1

著者

Hawley John F. De Villiers Jean-Pierre

出版者

Published for the Yukawa Institute for Theoretical Physics and the Physical Society of Japan

雑誌

Progress of theoretical physics. Supplement (ISSN:03759687)

巻号頁・発行日

no.155, pp.132-139, 2004-11-15

参考文献数

21

被引用文献数

4

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Observations are providing increasingly detailed quantitative information about the accretion flows that power such high energy systems as X-ray binaries and active galactic nuclei. Analytic models of such systems must rely on assumptions such as regular flow geometry and a simple, parameterized stress. Global numerical simulations offer a way to investigate the basic physical dynamics of accretion flows without these assumptions. For black hole accretion studies one solves the equations of general relativistic magnetohydro-dynamics. Magnetic fields are of fundamental importance to the structure and evolution of accretion disks because magnetic turbulence is the source of the anomalous stress that drives accretion. We have developed a three-dimensional general relativistic magnetohydrodynamic simulation code to evolve time-dependent accretion systems self-consistently. Recent global simulations of black hole accretion disks suggest that the generic structure of the accretion flow is usefully divided into five regimes : the main disk, the inner disk, the corona, the evacuated funnel, and the funnel wall jet. The properties of each of these regions are summarized.

著者

DECENZO MAUREEN KURANDA MIKE COHEN SETH BABIAK JOHN JIANG ZHI-DONG SUN DONGYU HICKEY MARK SANCHETI PRAVEEN BRADFORD PATRICIA A. YOUNGMAN PHIL PROJAN STEVE ROTHSTEIN DAVID M.

出版者

公益財団法人 日本感染症医薬品協会

雑誌

The Journal of Antibiotics

巻号頁・発行日

vol.55, no.3, pp.288-295, 2002

被引用文献数

25

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A screening system is described that can detect and confirm inhibitors of the late steps of cell wall biosynthesis. The primary high through-put screen monitors induction of &beta;-lactamase following exposure to samples, in an <i>Escherichia coli envA</i>- strain that carries the &beta;-lactamase gene from <i>Citrobacter freundii</i> on a plasmid. Positive samples were detected from compound libraries, from natural products libraries, and from fractions of natural products crude preparations. These samples were then subjected to <i>in vitro</i> assays that could detect the incorporation of soluble cell wall precursor into Lipid I, Lipid II, and polymerized cell wall, using a TLC system that was very accurate and unambiguous in detecting known cell wall inhibitors. One partially purified sample containing a novel antibacterial agent derived from natural products was found to inhibit the formation of Lipid I (50% inhibition at &le;62.5ng/ml), whereas another partially purified sample also derived from natural products inhibited transglycosylation into cell wall polymer (50% inhibition at &le;10&mu;g/ml). This screening system proved to be especially useful because it was sufficiently sensitive and robust to detect inhibitors among samples of crude preparations or varying states of purity.

著者

Lopes Murilo Baena Consani Simonides Gonini-Júnior Alcides Moura Sandra Kiss McCabe John Francis

出版者

東京歯科大学

雑誌

The Bulletin of Tokyo Dental College

巻号頁・発行日

vol.50, no.3, pp.111-116, 2009

被引用文献数

10

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Microleakage in human and bovine teeth was compared. Cavities were prepared on the buccal surface in 20 human and 20 bovine teeth (3mm&times;2mm in depth). The teeth were divided into 4 groups (n=10) according to the substrate and adhesive (CLEARFIL SE Bond-CF or Scotchbond 1-SB1). Resin composite (Wave) was applied in two increments, each cured for 30 sec. Specimens were stored in 100% relative humidity at 37&deg;C for 24 hr and submitted to 1,000 thermal cycles, followed by immersion in 0.6% aqueous rhodamine for 48 hr. Specimens were rinsed and sectioned at the center. Microleakage length was measured and the score recorded using the following scale: 0-none, 1-up to enamel junction, 2-up to pulp wall, 3-in pulp wall, 4-beneath pulp wall. Percentage of leakage penetration into the cavity was submitted to an ANOVA and Tukey's test (5%) and the scores submitted to the Kruskal-Wallis and Dunn's multiple comparison tests (5%). When bovine teeth were used, SB1 (87.76%) showed a statistically higher penetration mean than CF (66.22%). When human teeth were used, no difference was found between SB1 (47.35%) and CF (36.01%). When scores were analyzed, SB1 showed no difference to CF. The differences found should be taken into consideration when evaluating adhesive microleakage using bovine teeth.

著者

Park Byung-Joon Kim Joong-Hwi Kim Jang-Hwan Choi Byeong-Ho

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science

巻号頁・発行日

vol.27, no.10, pp.3137-3139, 2015

被引用文献数

4

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[Purpose] This study was performed to provide evidence for the therapeutic exercise approach through a compative analysis of muscle activities according to climbing wall inclination. [Subjects and Methods] Twentyfour healthy adult subjects without climbing experience performed static exercises at a therapeutic climbing at with various inclination angles (0°, 10°, 20°), and the activities of the trunk muscles (rectus abdominis, obliquus externus abdominis, obliquus internus abdominis, erector spinae) were measured using surface electromyography (EMG) for 7 seconds. [Results] Significant differences were found between the inclination angles of 10° and 0°, as well as 20° in the rectus abdominis, obliquus internus abdominis, right obliquus externus abdominis, and right erector spinae. [Conclusion] Based on measurements of trunk muscle activity in a static climbing standing position at different angles, significant changes in muscle activity appear to be induced at 10 degrees. Therefore, the results appear to provide clinically relevant evidence.

著者

IWAMOTO YUKIHIDE TANAKA KAZUHIRO ISU KAZUO KAWAI AKIRA TATEZAKI SHIN-ICHIRO ISHII TAKESHI KUSHIDA KAZUYOSHI BEPPU YASUO USUI MASAMICHI TATEISHI AKIO FURUSE KIYOO MINAMIZAKI TAKESHI KAWAGUCHI NORIYOSHI YAMAWAKI SHINYA

雑誌

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (ISSN:09492658)

巻号頁・発行日

vol.14, no.4, pp.397-404, 2009-07-01

参考文献数

22

被引用文献数

5

著者

Yoon Byung-Il Jung Su-Youn Hur Kwon LEE Jae-Hyun JOO Kyung-Hwan LEE Yong-Soon KIM Dae-Yong

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.62, no.12, pp.1303-1310, 2000-12-25

参考文献数

27

被引用文献数

12

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卵円形細胞ovall cellは肝障害後に現れ, 肝細胞と胆管細胞の母細胞と考えられている.ジエチルニトロサミンと2-アセチルアミノフルオレンを投与して肝吸虫(Clonorchis sinensis; CS)を感染させたハムスターから分離した卵円形細胞を2週間培養し, その分化と可塑性について電顕と免疫染色で調べることによって評価した.CSを感染させていない細胞の2週間培養で, グリコーゲン顆粒とぺルオキシソームがみられた.免疫組織化学的に培養1週間後からのサイトケラチン19に対する明瞭な反応が増加し, アルファフェト蛋白に対しては徐々に減少した.このことはCSに感染していないハムスターより分離した卵円形細胞は肝細胞系に分化したことを意味した.しかし, CS感染グループからの培養細胞は, 多くの粗面小胞体を有し, CS感染細胞からのものと相対的に逆の反応を示した.このことはCS感染からの分離細胞はCSに最初に刺激されて胆管系の方向へ分化したことを意味した.この研究の結果, 卵円形細胞は実際には肝細胞と胆管細胞の両極性の母細胞で, 最初に刺激する要素によってどちらかの方向へ分化可能であることを示唆している.

著者

Hiroyuki Tsutsui Shin-ichi Momomura Yoshihiko Saito Hiroshi Ito Kazuhiro Yamamoto Tomomi Ohishi Naoko Okino Toshihito Kitamura Weinong Guo

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-1424, (Released:2018-07-26)

参考文献数

17

被引用文献数

15

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Background:The objective of the present analyses was to describe the baseline characteristics and treatment of the Japanese patients with HFrEF in THE PARALLEL-HF study.Methods and Results:Key demographic, clinical and laboratory findings, along with treatment, were reported and compared with patients enrolled in the PARADIGM-HF trial and other contemporary randomized clinical trials and registries of Japanese patients with HFrEF. In addition, the MAGGIC and EMPHASIS-HF risk scores were calculated. A total of 225 Japanese patients were randomized in PARALLEL-HF with a mean age of 67.9 years and the majority of the patients being male (85.8%) and in NYHA Class II (93.8%). Key baseline characteristics in PARALLEL-HF were generally comparable with PARADIGM-HF, and other contemporary clinical trials and registries of Japanese HFrEF patients. Patients enrolled in PARALLEL-HF were well treated with conventional evidence-based therapy at baseline (angiotensin-converting enzyme inhibitor inhibitor/angiotensin receptor blocker, 62.7%/37.3%; β-blockers, 94.7%; mineralocorticoid receptor antagonist, 59.1%). Despite the evidence-based treatment and most patients being in NYHA Class II, these patients had a low LVEF (mean 28.1%) and were at high risk of cardiovascular mortality and morbidity as assessed by the MAGGIC and EMPHASIS-HF risk scores.Conclusions:Overall, the patients in PARALLEL-HF were largely representative of contemporary ambulatory patients with HFrEF who are well treated with evidence-based therapies. PARALLEL-HF will determine whether sacubitril/valsartan provides similar improvements in clinical outcomes in Japanese HFrEF patients as observed in the PARADIGM-HF study.