著者

CHEN Yaodeng WANG Jia GAO Yufang CHEN Xiaomeng WANG Hongli HUANG Xiang-Yu

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2018-048, (Released:2018-06-22)

被引用文献数

3

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Background error covariance (BEC) is one of the key components in the data assimilation systems for numerical weather prediction. Recently, a scheme of using an inhomogeneous and anisotropic BEC estimated from historical forecast error samples has been tested by employing the extended alpha control variable approach (BEC-CVA) in the framework of the Variational Data Assimilation system for the Weather Research and Forecasting model (WRFDA). In this paper, the BEC-CVA approach is further examined by conducting single observation assimilation experiments and continuously cycling data assimilation and forecasting experiments covering a 3-weeks period. Moreover, additional benefits of using a blending approach (BEC-BLD), which combines a static, homogeneous BEC with an inhomogeneous and anisotropic BEC, are also assessed. Single observation experiments indicate that the noises in the increments in BEC-CVA can be somehow reduced by using BEC-BLD, while the inhomogeneous and multivariable correlations from the BEC-CVA are still taken into account. The impact of BEC-CVA and BEC-BLD on short-term weather forecasts is compared with three-dimensional variational data assimilation scheme (3DVar), and compared with the hybrid ensemble transform Kalman filter and 3DVar (ETKF-3DVar) in WRFDA also. Results show that the BEC-CVA and BEC-BLD outperform the use of 3DVar. It is shown that BEC-CVA and BEC-BLD underperform ETKF-3DVar as expected, however the computational cost of BEC-CVA and BEC-BLD is considerably less expensive since no ensemble forecasts are required.

著者

Chika Okada Hironori Imano Kazumasa Yamagishi Renzhe Cui Mitsumasa Umesawa Koutatsu Maruyama Isao Muraki Mina Hayama-Terada Yuji Shimizu Tomoko Sankai Takeo Okada Masahiko Kiyama Akihiko Kitamura Hiroyasu Iso for the CIRCS Investigators

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.44438, (Released:2018-06-13)

参考文献数

25

被引用文献数

7

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Aims: The frequency of breakfast intake has been reported to be inversely associated with the risk of cardiovascular events; however, it is uncertain what the impact of the energy and nutrient intakes from breakfast are. We assessed the association between these intakes from breakfast and the risk of stroke prospectively.Methods: In a baseline survey of four Japanese communities between 1981 and 1990, we enrolled 3 248 residents (1 662 men and 1 586 women) aged 40–59 years who were free from stroke and heart disease and who responded to the 24-hour dietary recall survey. We assessed the dietary intake at breakfast, lunch, dinner, and other times separately.Results: During the median 25-year follow-up, 230 individuals (147 men and 83 women) developed stroke. After adjustment for age, community, other dietary intakes, and lifestyle and physiological factors, the multivariable-adjusted hazard ratios (95% confidence intervals) of intracerebral hemorrhage for the highest versus lowest quartiles of energy intake from breakfast were 0.38 (0.15–0.99) in men and 1.36 (0.36–5.10) in women. For the major nutrients, a higher saturated or monounsaturated fat intake at breakfast was associated with a reduced risk of intracerebral hemorrhage in men, and remained statistically significant after further adjustment for intake of other major nutrients from breakfast.Conclusions: A higher intake of energy from breakfast, primarily saturated or monounsaturated fat, was associated with a reduced risk of intracerebral hemorrhage in Japanese men.

著者

Yoshihisa UENOYAMA Naoko INOUE Kei-ichiro MAEDA Hiroko TSUKAMURA

出版者

THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2018-110, (Released:2018-10-08)

被引用文献数

32

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Kisspeptin, identified as a natural ligand of GPR54 in 2001, is now considered as a master regulator of puberty and subsequent reproductive functions in mammals. Our previous studies using Kiss1 knockout (KO) rats clearly demonstrated the indispensable role of kisspeptin in gonadotropin-releasing hormone (GnRH)/gonadotropin secretion. In addition, behavioral analyses of Kiss1 KO rats revealed an organizational effect of kisspeptin on neural circuits controlling sexual behaviors. Our studies using transgenic mice carrying a region-specific Kiss1 enhancer-driven reporter gene provided a clue as to the mechanism by which estrogen regulates Kiss1 expression in hypothalamic kisspeptin neurons. Analyses of Kiss1 expression and gonadotropin secretion during the pubertal transition shed light on the mechanism triggering GnRH/gonadotropin secretion at the onset of puberty in rats. Here, we summarize data obtained from the aforementioned studies and revisit the physiological roles of kisspeptin in the mechanism underlying reproductive functions in mammals.

著者

Pawel Szulc Ez Zoubir Amri Annie Varennes Patricia Panaia-Ferrari Eric Fontas Joëlle Goudable Roland Chapurlat Véronique Breuil

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0517, (Released:2018-10-03)

参考文献数

42

被引用文献数

7

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Background: Severe abdominal aortic calcification (AAC) points to high cardiovascular risk and leptin stimulates arterial calcification; however, clinical data on their association are scarce. We studied the link between serum leptin and AAC severity and progression, and the effect of smoking and lipid levels, on this association in men. Methods and Results: At baseline, 548 community-dwelling men aged 50–85 years underwent blood collection and lateral lumbar spine radiography. In 448 men, X-ray was repeated after 3 and 7.5 years. AAC was assessed using Kauppila’s semiquantitative score. In multivariable models, high leptin was associated with higher odds of severe AAC (odds ratio [OR]=1.71 per SD, 95% confidence interval [CI]: 1.22–2.40). The odds of severe AAC were the highest in men who had elevated leptin levels and either were ever-smokers (OR=9.22, 95% CI: 3.43–24.78) or had hypertriglyceridemia (vs. men without these characteristics). Higher leptin was associated with greater AAC progression (OR=1.34 per SD, 95% CI: 1.04–1.74). The risk of AAC progression was the highest in men who had elevated leptin levels and either were current smokers or had high low-density lipoprotein-cholesterol levels (OR=5.91, 95% CI: 2.46–14.16 vs. men without these characteristics). These links remained significant after adjustment for baseline AAC and in subgroups defined according to smoking and low-density lipoprotein-cholesterol levels. Conclusions: In older men, high leptin levels are associated with greater severity and rapid progression of AAC independent of smoking, low-density lipoprotein-cholesterol or triglycerides.

著者

Song Min Yeong Seo Yujeong Kim Yeon Soo Kim Hee Dong An Ho-Myoung Park Bae Ho Sung Yun Mo Kim Tae Geun

出版者

The Japan Society of Applied Physics

雑誌

Applied Physics Express (ISSN:18820778)

巻号頁・発行日

vol.5, no.9, pp.91202-091202-3, 2012-09-25

被引用文献数

20

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The authors report a silicon-based one-diode--type resistive-switching memory (RRAM) device with self-rectifying properties and high electrical properties. The RRAM cell consisted of Al/Cr--SrTiO3/Si and revealed intrinsic diode properties, so that unwanted sneaky currents could be removed from an RRAM crossbar array without extra switching devices. The insulator--metal transition property of the proposed device was explained using the space-charge--limited conduction mechanism. The memory device showed good characteristics including high ON/OFF ratio ({\sim}10^{6}), low reset current ({\sim}10^{-11} A), high speed at low voltage (200 ns, 2 V), and reasonable endurance ({>}10^{4} cycles) and retention characteristics ({>}10^{4} s).

著者

Alvarez-Taladriz J. S.

出版者

聖トマス大学

雑誌

サピエンチア : 英知大学論叢 (ISSN:02862204)

巻号頁・発行日

vol.36, pp.75-95, 2002-02

著者

Kenji Sakata Tadatsugu Gamou Hayato Tada Kenshi Hayashi Hidekazu Ino Masakazu Yamagishi Masa-aki Kawashiri behalf of the MILLION Study Group

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.44255, (Released:2018-09-21)

参考文献数

25

被引用文献数

3

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Aim: The prospective, randomized, multicenter Myocardial Ischemia Treated with Percutaneous Coronary Intervention and Plaque Regression by Lipid Lowering & Blood Pressure Controlling assessed by Intravascular Ultrasonography (MILLION) study demonstrated that combined treatment with atorvastatin and amlodipine enhanced coronary artery plaque regression. Although the baseline high-sensitive C-reactive protein (hs-CRP) reportedly plays an important role in atherogenesis, few data exist regarding the relationship between hs-CRP and plaque regression in patients receiving a combined atorvastatin and amlodipine therapy.Methods: A total of 68 patients (male, 55; mean age, 64.2 years) with baseline and follow-up 3-dimensional intravascular ultrasound examinations in the MILLION study were stratified by baseline hs-CRP level quartiles. The serial measurements of lipid, blood pressure, and percentage changes in the plaque volume were compared between the groups, and the factors associated with the percentage change in the plaque volume were assessed.Results: There were no significant between-group differences in the extent of change in low-density lipoprotein cholesterol (LDL-C) or systolic and diastolic blood pressure after 18–24 months of treatment. The percentage change in the plaque volume showed a linear association with the baseline hs-CRP (p for trend <0.05); however, there was no correlation with changes in LDL-C or systolic and diastolic blood pressure. In the multiple regression analysis, the baseline hs-CRP level was independently associated with the percentage change in the plaque volume (β=0.29, p=0.022).Conclusions: Coronary plaque regression was associated with the baseline hs-CRP level in patients treated with a combined lipid- and blood pressure-lowering therapy.

著者

Chun-Ho PARK Nozomi SHIWA Kazunori KIMITSUKI Takehito KAKIZAKI Daisaku WATANABE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.5, pp.755-759, 2018 (Released:2018-05-18)

参考文献数

18

被引用文献数

1

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This case report describes a congenital ganglioneuroblastoma in a 38-day-old male Japanese Black calf. The cervical multinodular mass was present at birth and grew rapidly. The cut surface was pale gray-to-yellow and had a gelatinous appearance. Hemorrhagic cysts of various sizes were observed in the nodule. Histologically, the mass contained clusters of neuroblastic cells, ganglionic cells, and Schwann-like cells. Immunohistochemically, the ganglionic cells showed strong positivity for neuron-specific enolase, neurofilament, synaptophysin, and chromogranin A, whereas the Schwann-like cells strongly expressed S-100, glial fibrillary acidic protein, and vimentin. Ultrastructurally, neurosecretory granules resembling catecholamine were observed in the neuroblastic and Schwann-like cells. Based on the pathology, the diagnosis was congenital cervical nodular ganglioneuroblastoma.

著者

Kazuhiro SHIN-IKE Hitoshi IIMA

出版者

The Society of Instrument and Control Engineers

雑誌

SICE Journal of Control, Measurement, and System Integration (ISSN:18824889)

巻号頁・発行日

vol.9, no.3, pp.144-150, 2016 (Released:2016-06-25)

参考文献数

11

被引用文献数

1

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In this study, we propose a method for determining the classroom seating arrangements considering relationships between one student and the other students sitting around him or her. The method for determining the classroom seating arrangements is constructed based on our proposed genetic algorithm. In order to determine the optimal classroom seating arrangements, the genetic algorithm is applied on the basis of the questionnaire result of how students feel when they take a class on the seats assigned to them and the analysis of each student's personality. Experiments are carried out in order to verify the effectiveness of the proposed method.

著者

小山 信也 コヤマ シンヤ Shin-ya KOYAMA

出版者

東洋大学工業技術研究所

雑誌

工業技術 (ISSN:13499955)

巻号頁・発行日

no.32, pp.44-48, 2010

著者

Shu-Hua Qi Si Zhang Cheng-Hai Gao Qin-Xing Li

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.58, no.6, pp.884, 2010-06-01 (Released:2010-06-02)

被引用文献数

2 3

著者

Her-Hsiung HUANG Mau-Chin LIN Chien-Chan LIN Sheng-Chieh LIN Chii-Chih HSU Fang-Lung CHEN Shyh-Yuan LEE Chun-Cheng HUNG

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.32, no.1, pp.195, 2013-01-31 (Released:2013-02-01)

著者

Sradhanjali Singh Bansi Dar Nayak Rama Chandra Mohanty Swaranjit S. Cameotra Lala Beheri Sukla Dong-Jin Kim

出版者

The Japan Institute of Metals and Materials

雑誌

MATERIALS TRANSACTIONS (ISSN:13459678)

巻号頁・発行日

vol.53, no.11, pp.2004-2010, 2012-11-01 (Released:2012-10-25)

参考文献数

21

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Malanjkhand copper project, Madhya Pradesh, India, generates a lot of lean sulphidic ores containing chalcopyrite (∼0.3% of copper) with traces of oxidized, semi-oxidized and secondary sulfides. EPMA analysis shows that the granitic rock samples have plagioclase feldspar, orthoclase feldspar and quartz as major constituents within which the ore minerals are sparsely distributed. Due to the complex structure and low solubility of the sulphide-bearing granitic rock, the dissolution of copper from the hard matrix is difficult. The present study deals with change in crystallographic and chemical nature of the mineral system present in the host rock. In an attempt to increase copper recovery, the ore was subjected to heating at 600°C under normal atmospheric conditions. This heat treatment resulted in enhanced copper recovery, up to 98% within 60 days of progressive leaching.

著者

Kanitsak BOONANANTANASARN Kajohnkiart JANEBODIN Prapan SUPPAKPATANA Tawepong ARAYAPISIT Jit-aree RODSUTTHI Panjit CHUNHABUNDIT Surintorn BOONANUNTANASARN Wanida SRIPAIROJTHIKOON

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.33, no.1, pp.149, 2014-01-30 (Released:2014-02-01)

著者

Dimitrios DIONYSOPOULOS Eugenia KOLINIOTOU-KOUMPIA Maria HELVATZOGLOU-ANTONIADES Nikolaos KOTSANOS

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.34, no.3, pp.410, 2015-05-28 (Released:2015-06-03)

著者

Muhammad Anjum Zia Khalil-ur-Rahman Muhammad K. Saeed Fozia Andaleeb Muhammad I. Rajoka Munir A. Sheikh Iftikhar A. Khan Azeem I. Khan

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.47, no.3, pp.268, 2010 (Released:2010-10-29)

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The article published in J. Clin. Biochem. Nutr. 2007, 41(2), 132–138 was withdrawn by the Editors on August 9, 2010, because it was not original work and constituted a breach of journal’s ethical policy

著者

Marie Yeo Tae Young Oh Yong Seok Kim Young Mi Won Sung Whan Ahn Jin Kim Soon Ki Chung Myung Hee Chung Sung Uk Han Ki-Baik Hahm

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.39, no.3, pp.R1, 2006 (Released:2006-10-27)

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RETRACTED PUBLICATIONRetracted publication: Marie Yeo, Tae Young Oh, Yong Seok Kim, Young Mi Won, Sung Whan Ahn, Jin Kim, Soon Ki Chung, Myung Hee Chung, Sung Uk Han and Ki-Baik Hahm: Journal of Clinical Biochemistry and Nutrition, 38(2), 77-93(2006). "Identification of Molecular Targets Associated with Augmented Gastric Mucosal Damages after Stress in the Presence of Helicobacter Pylori Using High Throughput Analysis of cDNA Microarray and Proteomics" (Received 11 October 2005, Accepted 22 November 2006)This article was withdrawn by the request of the authors on September 22, 2006.

著者

Marie Yeo Tae Young Oh Yong Seok Kim Young Mi Won Sung Whan Ahn Jin Kim Soon Ki Chung Myung Hee Chung Sung Uk Han Ki-Baik Hahm

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.38, no.2, pp.77-93, 2006 (Released:2006-02-23)

参考文献数

41

被引用文献数

1 1

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This article was withdrawn by the request of the authors on September 22,2006.

著者

Yukiko SHOUJI Chika HASEGAWA Xiao-Pen LEE Masaya FUJISHIRO Takaaki MATSUYAMA Miho YAMADA Ayako KURIKI Yuka KATO Noriko NEMOTO Takeshi KUMAZAWA Shinichi SUZUKI Keizo SATO

出版者

The Showa University Society

雑誌

The Showa University Journal of Medical Sciences (ISSN:09156380)

巻号頁・発行日

vol.30, no.2, pp.175-187, 2018 (Released:2018-08-31)

参考文献数

33

被引用文献数

1

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A high-throughput method was developed to analyze five barbiturates (phenobarbital, cyclobarbital, amobarbital, secobarbital, and thiopental) and a metabolite in human body samples using a new Monolithic C18 gel-packed Spin Tip and ultra-performance liquid chromatography (UPLC)-quadrupole-time-of-flight (Q-ToF) mass spectrometry (MS). Plasma (20µl) or urine (100µl) samples spiked with the five barbiturates and 5-(4-methylphenyl)-5-phenylhydantoin (internal standard, IS) were mixed with distilled water. The mixture was extracted using the Monolithic C18 Spin Tip, and the analytes retained on the C18 phase were then eluted with methanol. The eluate was injected directly into an analytical column (Waters Acquity BEH C18, 50mm×2.1mm i.d., particle size 1.7µm), and quantified by Q-ToF-MS with negative-ion electrospray ionization (ESI). Good separation and clear peak shapes of the five drugs were achieved within an analysis time of 6min, including the extraction time. All drugs spiked in the plasma showed recoveries of 86-98%. The regression equations for the five drugs showed excellent linearities in the range of 5-500ng/20µl of plasma, with limits of detection and i-Fit of 1ng/20µl. The method was also successfully applied to determine the level of amobarbital and its metabolite in human plasma and urine, respectively, after oral administration to a volunteer. This new method could be applied widely in the clinical and forensic fields for the quantitative determination of drugs and metabolites.

著者

Irmela HIJIYA-KIRSCHNEREIT

出版者

公益財団法人 日本学術協力財団

雑誌

学術の動向 (ISSN:13423363)

巻号頁・発行日

vol.23, no.2, pp.2_78-2_81, 2018-02-01 (Released:2018-07-07)

参考文献数

12