著者

Rong-Long WANG Xiao-Fan ZHOU Kozo OKAZAKI

出版者

一般社団法人 電子情報通信学会

雑誌

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E92.A, no.5, pp.1368-1372, 2009-05-01 (Released:2009-05-01)

参考文献数

15

被引用文献数

1 3 1

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Ant colony optimization (ACO) algorithms are a recently developed, population-based approach which has been successfully applied to optimization problems. However, in the ACO algorithms it is difficult to adjust the balance between intensification and diversification and thus the performance is not always very well. In this work, we propose an improved ACO algorithm in which some of ants can evolve by performing genetic operation, and the balance between intensification and diversification can be adjusted by numbers of ants which perform genetic operation. The proposed algorithm is tested by simulating the Traveling Salesman Problem (TSP). Experimental studies show that the proposed ACO algorithm with genetic operation has superior performance when compared to other existing ACO algorithms.

著者

compiled in A.H. 730 (A.D. 1330) and now abridged in English from a manuscript dated A.H. 857 (A.D. 1453) by Edward G. Browne with indices of the fac-simile text by R.A. Nicholson

出版者

Luzac

巻号頁・発行日

1910

著者

Akira Kobayashi Akiko Ohara-Takada Shogo Tsuda Chie Matsuura-Endo Norikazu Takada Yoshiki Umemura Takashi Nakao Tsutomu Yoshida Kazuya Hayashi Motoyuki Mori

出版者

日本育種学会

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.58, no.1, pp.77-82, 2008 (Released:2008-03-26)

参考文献数

6

被引用文献数

3 13

著者

Joong-Yeon Cho Heon Lee

出版者

The Society of Photopolymer Science and Technology (SPST)

雑誌

Journal of Photopolymer Science and Technology (ISSN:09149244)

巻号頁・発行日

vol.28, no.4, pp.541-545, 2015-05-25 (Released:2015-10-05)

参考文献数

11

被引用文献数

1

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In this study, a 2 inch sized a highly periodic nanometer-scaled patterned sapphire substrate (NPSS) was fabricated using nanoimprint lithography (NIL) and inductively coupled plasma etching to improve the light-extraction efficiency of GaN-based light-emitting diodes (LEDs). Both truncated cone and cone shape patterns were fabricated on the sapphire substrate to compare the enhancement effect of light extraction efficiency of LEDs according to the shape of sapphire patterns. A blue LED structure was grown on the two different NPSS, and the photoluminescence (PL) and electroluminescence (EL) were measured to confirm the effectiveness of the two different nanometer-scaled patterns on sapphire. An improvement in luminescence efficiency was observed when NPSS was applied; 2 times stronger PL intensity and 2 times stronger EL intensity than the LED structure grown on the un-patterned sapphire substrate was measured. These results show highly periodic nanometer-scaled patterns create multi-photon scattering and effectively enhance the light-extraction efficiency of LEDs.

著者

Akira OKU Kiichiro UETA KENJI ARAKAWA Tomomi KANO-ISHIHARA Mamoru MATSUMOTO Tetsuya ADACHI Koichiro YASUDA Kinsuke TSUDA Akira SAITO

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.23, no.12, pp.1434-1437, 2000-12-01 (Released:2008-04-10)

参考文献数

24

被引用文献数

17 26

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T-1095, a derivative of phlorizin, is an orally active inhibitor of Na+ -glucose cotransporter (SGLT). We investigated the acute antihyperglycemic effect of T-1095 in streptozotocin-induced diabetic rats (STZ rats). T-1095 and its metabolite T-1095A inhibited the SGLT activity in brush border membranes prepared from kidneys of both normal and STZ rats, but the latter agent was approximately 10 times more potent than the former. Single oral administration of T-1095 (30-100 mg/kg) dose-dependently induced glycosuria in normal rats. The fed glucose levels in STZ rats were dose-dependently suppressed by single oral administration of T-1095 (3-100 mg/kg), whereas there was only marginal hypoglycemic effect in normal rats. Since there was no effect on blood glucose in nephrectomized STZ rats, inhibition of renal glucose reabsorption rather than intestinal glucose absorption mainly contributes to the antihyperglycemic effect of T-1095. In conclusion, T-1095 is the first orally active agent which has an acute antihyperglycemic action in the absence of endogeneous insulin secretion with a low risk of hypoglycemia and has therapeutic potential for treatment of diabetes mellitus.

著者

Mamoru Toyofuku Tomohiko Taniguchi Takeshi Morimoto Kyohei Yamaji Yutaka Furukawa Kosuke Takahashi Takashi Tamura Hiroki Shiomi Kenji Ando Norio Kanamori Koichiro Murata Takeshi Kitai Yuichi Kawase Chisato Izumi Makoto Miyake Hirokazu Mitsuoka Masashi Kato Yutaka Hirano Shintaro Matsuda Tsukasa Inada Tomoyuki Murakami Yasuyo Takeuchi Keiichiro Yamane Mitsuru Ishii Eri Minamino-Muta Takao Kato Moriaki Inoko Tomoyuki Ikeda Akihiro Komasa Katsuhisa Ishii Kozo Hotta Nobuya Higashitani Yoshihiro Kato Yasutaka Inuzuka Chiyo Maeda Toshikazu Jinnai Yuko Morikami Naritatsu Saito Kenji Minatoya Takeshi Kimura on behalf of the CURRENT AS Registry Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-1244, (Released:2017-04-08)

参考文献数

23

被引用文献数

34

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Background:There is a paucity of data on the sex differences in the prevalence, clinical presentation, and prognosis of aortic stenosis (AS).Methods and Results:A total of 3,815 consecutive patients with severe AS were enrolled in the multicenter CURRENT AS registry between January 2003 and December 2011. The registry included 1,443 men (38%) and 2,372 women (62%). Women were much older than men (79±10 vs. 75±10 years, P<0.0001), and the ratio of women to men increased with age. The cumulative 5-year incidence of all-cause death was significantly higher in men than in women (47% vs. 41%, P=0.003), although women were more symptomatic and much older. The 5-year mortality was similar between men and women at age <65 years (16% vs. 15%, P=0.99), whereas it was significantly higher in men than in women at age ≥65 years (65–74 years, 38% vs. 19%, P<0.0001; 75–84 years, 55% vs. 34%, P<0.0001; ≥85 years: 82% vs. 72%, P=0.03).Conclusions:A large Japanese multicenter registry of consecutive patients with severe AS included a much higher proportion of women than men, with the female:male sex ratio increasing with age. The 5-year mortality rate of women was lower than that of men. Lower 5-year mortality rates in women were consistently seen across all age groups >65 years.

著者

by Joo-Yup Lee

出版者

Brill

巻号頁・発行日

2016

著者

上條 篤 増山 敬祐 E-BOAT study group

出版者

日本鼻科学会

雑誌

日本鼻科学会会誌 (ISSN:09109153)

巻号頁・発行日

vol.51, no.1, pp.70-71, 2012 (Released:2012-05-22)

参考文献数

3

著者

Chi-Wei Lee Hung Su You-Da Cai Ming-Tsang Wu Den-Chyang Wu Jentaie Shiea

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.6, no.2, pp.S0056-S0056, 2017-03-31 (Released:2017-03-28)

参考文献数

18

被引用文献数

2 20

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Psychoactive drug overdoses are life-threatening and require prompt and proper treatment in the emergency room to minimize morbidity and mortality. Prompt identification of the ingested psychoactive drugs is challenging, since witness recall is unreliable and patients’ symptoms do not necessarily explain their loss of consciousness. Gas and liquid chromatography mass spectrometric analyses have been the traditionally employed methods to detect and identify abused substances; however, these techniques are time-consuming and labor-intensive. In this study, thermal desorption electrospray ionization mass spectrometry, an ambient mass spectrometric technique, was applied to rapidly characterize flunitrazepam, lysergic acid diethylamide, and 3,4-methylenedioxy-methamphetamine in drained gastric lavage fluid, and ketamine, cocaine, amphetamine and norketamine in whole blood samples. No pretreatment of the gastric lavage fluid specimens was required and the entire analytical process took less than 30 s per specimen. Liquid–liquid extraction, followed by centrifugation, was performed on the whole blood samples. The corresponding compounds were identified through matching the obtained mass spectrometric data with those provided by commercial databases. The limits-of-detection of the tested drugs in both drained gastric lavage fluid and whole blood samples are at sub ppm levels. This is sensitive enough for emergency medical application, since the quantities of medications ingested by overdosed abusers are much higher than the amounts that were tested.

著者

Acharya BS Actis M Aghajani T Agnetta G Aguilar J Aharonian F Ajello M Akhperjanian A Alcubierre M Aleksic J Alfaro R Aliu E Allafort AJ Allan D Allekotte I Amato E Anderson J Anguner EO Antonelli LA Antoranz P Aravantinos A Arlen T Armstrong T Arnaldi H Arrabito L Asano K Ashton T Asorey HG Awane Y Baba H Babic A Baby N Bahr J Bais A Baixeras C Bajtlik S Balbo M Balis D Balkowski C Bamba A Bandiera R Barber A Barbier C Barcelo M Barnacka A Barnstedt J de Almeida UB Barrio JA Basili A Basso S Bastieri D Bauer C Baushev A Becerra J Becherini Y Bechtol KC Tjus JB Beckmann V Bednarek W Behera B Belluso M Benbow W Berdugo J Berger K Bernard F Bernardino T Bernlohr K Bhat N Bhattacharyya S Bigongiari C Biland A Billotta S Bird T Birsin E Bissaldi E Biteau J Bitossi M Blake S Bigas OB Blasi P Bobkov A Boccone V Boettcher M Bogacz L Bogart J Bogdan M Boisson C Gargallo JB Bolmont J Bonanno G Bonardi A Bonev T Bonifacio P Bonnoli G Bordas P Borgland A Borkowski J Bose R Botner O Bottani A Bouchet L Bourgeat M Boutonnet C Bouvier A Brau-Nogue S Braun I Bretz T Briggs M Bringmann T Brook P Brun P Brunetti L Buanes T Buckley J Buehler R Bugaev V Bulgarelli A Bulik T Busetto G Buson S Byrum K Cailles M Cameron R Camprecios J Canestrari R Cantu S Capalbi M Caraveo P Carmona E Carosi A Carr J Carton PH Casanova S Casiraghi M Catalano O Cavazzani S Cazaux S Cerruti M Chabanne E Chadwick P Champion C Chen A Chiang J Chiappetti L Chikawa M Chitnis VR Chollet F Chudoba J Cieslar M Cillis A Cohen-Tanugi J Colafrancesco S Colin P Calome J Colonges S Compin M Conconi P Conforti V Connaughton V Conrad J Contreras JL Coppi P Corona P Corti D Cortina J Cossio L Costantini H Cotter G Courty B Couturier S Covino S Crimi G Criswell SJ Croston J Cusumano G Dafonseca M Dale O Daniel M Darling J Davids I Dazzi F De Angelis A De Caprio V De Frondat F Dal Pino EMD de la Calle I De La Vega GA Lopez RD De Lotto B De Luca A Neto JRTD de Naurois M de Oliveira Y Wilhelmi ED de Souza V Decerprit G Decock G Deil C Delagnes E Deleglise G Delgado C Della Volpe D Demange P Depaola G Dettlaff A Di Paola A Di Pierro F Diaz C Dick J Dickherber R Dickinson H Diez-Blanco V Digel S Dimitrov D Disset G Djannati-Atai A Doert M Dohmke M Domainko W Prester DD Donat A Dorner D Doro M Dournaux JL Drake G Dravins D Drury L Dubois F Dubois R Dubus G Dufour C Dumas D Dumm J Durand D Dyks J Dyrda M Ebr J Edy E Egberts K Eger P Einecke S Eleftheriadis C Elles S Emmanoulopoulos D Engelhaupt D Enomoto R Ernenwein JP Errando M Etchegoyen A Evans P Falcone A Fantinel D Farakos K Farnier C Fasola G Favill B Fede E Federici S Fegan S Feinstein F Ferenc D Ferrando P Fesquet M Fiasson A Fillin-Martino E Fink D Finley C Finley JP Fiorini M Curcoll RF Flores H Florin D Focke W Fohr C Fokitis E Font L Fontaine G Fornasa M Forster A Fortson L Fouque N Franckowiak A Fransson C Fraser G Frei R Albuquerque IFM Fresnillo L Fruck C Fujita Y Fukazawa Y Fukui Y Funk S Gabele W Gabici S Gabriele R Gadola A Galante N Gall D Gallant Y Gamez-Garcia J Garcia B Lopez RG Gardiol D Garrido D Garrido L Gascon D Gaug M Gaweda J Gebremedhin L Geffroy N Gerard L Ghedina A Ghigo M Giannakaki E Gianotti F Giarrusso S Giavitto G Giebels B Gika V Giommi P Girard N Giro E Giuliani A Glanzman T Glicenstein JF Godinovic N Golev V Berisso MG Gomez-Ortega J Gonzalez MM Gonzalez A Gonzalez F Munoz AG Gothe KS Gougerot M Graciani R Grandi P Granena F Granot J Grasseau G Gredig R Green A Greenshaw T Gregoire T Grimm O Grube J Grudzinska M Gruev V Grunewald S Grygorczuk J Guarino V Gunji S Gyuk G Hadasch D Hagiwara R Hahn J Hakansson N Hallgren A Heras NH Hara S Hardcastle MJ Harris J Hassan T Hatanaka K Haubold T Haupt A Hayakawa T Hayashida M Heller R Henault F Henri G Hermann G Hermel R Herrero A Hidaka N Hinton J Hoffmann D Hofmann W Hofverberg P Holder J Horns D Horville D Houles J Hrabovsky M Hrupec D Huan H Huber B Huet JM Hughes G Humensky TB Huovelin J Ibarra A Illa JM Impiombato D Incorvaia S Inoue S Inoue Y Ioka K Ismailova E Jablonski C Jacholkowska A Jamrozy M Janiak M Jean P Jeanney C Jimenez JJ Jogler T Johnson T Journet L Juffroy C Jung I Kaaret P Kabuki S Kagaya M Kakuwa J Kalkuhl C Kankanyan R Karastergiou A Karcher K Karczewski M Karkar S Kasperek A Kastana D Katagiri H Kataoka J Katarzynski K Katz U Kawanaka N Kellner-Leidel B Kelly H Kendziorra E Khelifi B Kieda DB Kifune T Kihm T Kishimoto T Kitamoto K Kluzniak W Knapic C Knapp J Knodlseder J Kock F Kocot J Kodani K Kohne JH Kohri K Kokkotas K Kolitzus D Komin N Kominis I Konno Y Koppel H Korohoda P Kosack K Koss G Kossakowski R Kostka P Koul R Kowal G Koyama S Koziol J Krahenbuhl T Krause J Krawzcynski H Krennrich F Krepps A Kretzschmann A Krobot R Krueger P Kubo H Kudryavtsev VA Kushida J Kuznetsov A La Barbera A La Palombara N La Parola V La Rosa G Lacombe K Lamanna G Lande J Languignon D Lapington J Laporte P Lavalley C Le Flour T Le Padellec A Lee SH Lee WH de Oliveira MAL Lelas D Lenain JP Leopold DJ Lerch T Lessio L Lieunard B Lindfors E Liolios A Lipniacka A Lockart H Lohse T Lombardi S Lopatin A Lopez M Lopez-Coto R Lopez-Oramas A Lorca A Lorenz E Lubinski P Lucarelli F Ludecke H Ludwin J Luque-Escamilla PL Lustermann W Luz O Lyard E Maccarone MC Maccarone TJ Madejski GM Madhavan A Mahabir M Maier G Majumdar P Malaguti G Maltezos S Manalaysay A Mancilla A Mandat D Maneva G Mangano A Manigot P Mannheim K Manthos I Maragos N Marcowith A Mariotti M Marisaldi M Markoff S Marszalek A Martens C Marti J Martin JM Martin P Martinez G Martinez F Martinez M Masserot A Mastichiadis A Mathieu A Matsumoto H Mattana F Mattiazzo S Maurin G Maxfield S Maya J Mazin D Mc Comb L McCubbin N McHardy I McKay R Medina C Melioli C Melkumyan D Mereghetti S Mertsch P Meucci M Michalowski J Micolon P Mihailidis A Mineo T Minuti M Mirabal N Mirabel F Miranda JM Mirzoyan R Mizuno T Moal B Moderski R Mognet I Molinari E Molinaro M Montaruli T Monteiro I Moore P Olaizola AM Mordalska M Morello C Mori K Mottez F Moudden Y Moulin E Mrusek I Mukherjee R Munar-Adrover P Muraishi H Murase K Murphy A Nagataki S Naito T Nakajima D Nakamori T Nakayama K Naumann C Naumann D Naumann-Godo M Nayman P Nedbal D Neise D Nellen L Neustroev V Neyroud N Nicastro L Nicolau-Kuklinski J Niedzwiecki A Niemiec J Nieto D Nikolaidis A Nishijima K Nolan S Northrop R Nosek D Nowak N Nozato A O'Brien P Ohira Y Ohishi M Ohm S Ohoka H Okuda T Okumura A Olive JF Ong RA Orito R Orr M Osborne J Ostrowski M Otero LA Otte N Ovcharov E Oya I Ozieblo A Padilla L Paiano S Paillot D Paizis A Palanque S Palatka M Pallota J Panagiotidis K Panazol JL Paneque D Panter M Paoletti R Papayannis A Papyan G Paredes JM Pareschi G Parks G Parraud JM Parsons D Arribas MP Pech M Pedaletti G Pelassa V Pelat D Perez MDC Persic M Petrucci PO Peyaud B Pichel A Pita S Pizzolato F Platos L Platzer R Pogosyan L Pohl M Pojmanski G Ponz JD Potter W Poutanen J Prandini E Prast J Preece R Profeti F Prokoph H Prouza M Proyetti M Puerto-Gimenez I Puhlhofer G Puljak I Punch M Pyziol R Quel EJ Quinn J Quirrenbach A Racero E Rajda PJ Ramon P Rando R Rannot RC Rataj M Raue M Reardon P Reimann O Reimer A Reimer O Reitberger K Renaud M Renner S Reville B Rhode W Ribo M Ribordy M Richer MG Rico J Ridky J Rieger F Ringegni P Ripken J Ristori PR Riviere A Rivoire S Rob L Roeser U Rohlfs R Rojas G Romano P Romaszkan W Romero GE Rosen S Lees SR Ross D Rouaix G Rousselle J Rousselle S Rovero AC Roy F Royer S Rudak B Rulten C Rupinski M Russo F Ryde F Sacco B Saemann EO Saggion A Safiakian V Saito K Saito T Saito Y Sakaki N Sakonaka R Salini A Sanchez F Sanchez-Conde M Sandoval A Sandaker H Sant'Ambrogio E Santangelo A Santos EM Sanuy A Sapozhnikov L Sarkar S Sartore N Sasaki H Satalecka K Sawada M Scalzotto V Scapin V Scarcioffolo M Schafer J Schanz T Schlenstedt S Schlickeiser R Schmidt T Schmoll J Schovanek P Schroedter M Schultz C Schultze J Schulz A Schure K Schwab T Schwanke U Schwarz J Schwarzburg S Schweizer T Schwemmer S Segreto A Seiradakis JH Sembroski GH Seweryn K Sharma M Shayduk M Shellard RC Shi J Shibata T Shibuya A Shum E Sidoli L Sidz M Sieiro J Sikora M Silk J Sillanpaa A Singh BB Sitarek J Skole C Smareglia R Smith A Smith D Smith J Smith N Sobczynska D Sol H Sottile G Sowinski M Spanier F Spiga D Spyrou S Stamatescu V Stamerra A Starling R Stawarz L Steenkamp R Stegmann C Steiner S Stergioulas N Sternberger R Sterzel M Stinzing F Stodulski M Straumann U Strazzeri E Stringhetti L Suarez A Suchenek M Sugawara R Sulanke KH Sun S Supanitsky AD Suric T Sutcliffe P Sykes J Szanecki M Szepieniec T Szostek A Tagliaferri G Tajima H Takahashi H Takahashi K Takalo L Takami H Talbot C Tammi J Tanaka M Tanaka S Tasan J Tavani M Tavernet JP Tejedor LA Telezhinsky I Temnikov P Tenzer C Terada Y Terrier R Teshima M Testa V Tezier D Thuermann D Tibaldo L Tibolla O Tiengo A Tluczykont M Peixoto CJT Tokanai F Tokarz M Toma K Torii K Tornikoski M Torres DF Torres M Tosti G Totani T Toussenel C Tovmassian G Travnicek P Trifoglio M Troyano I Tsinganos K Ueno H Umehara K Upadhya SS Usher T Uslenghi M Valdes-Galicia JF Vallania P Vallejo G van Driel W van Eldik C Vandenbrouke J Vanderwalt J Vankov H Vasileiadis G Vassiliev V Veberic D Vegas I Vercellone S Vergani S Veyssiere C Vialle JP Viana A Videla M Vincent P Vincent S Vink J Vlahakis N Vlahos L Vogler P Vollhardt A von Gunten HP Vorobiov S Vuerli C Waegebaert V Wagner R Wagner RG Wagner S Wakely SP Walter R Walther T Warda K Warwick R Wawer P Wawrzaszek R Webb N Wegner P Weinstein A Weitzel Q Welsing R Werner M Wetteskind H White R Wierzcholska A Wiesand S Wilkinson M Williams DA Willingale R Winiarski K Wischnewski R Wisniewski L Wood M Wornlein A Xiong Q Yadav KK Yamamoto H Yamamoto T Yamazaki R Yanagita S Yebras JM Yelos D Yoshida A Yoshida T Yoshikoshi T Zabalza V Zacharias M Zajczyk A Zanin R Zdziarski A Zech A Zhao A Zhou X Zietara K Ziolkowski J Ziolkowski P Zitelli V Zurbach C Zychowski P

雑誌

ASTROPARTICLE PHYSICS (ISSN:09276505)

巻号頁・発行日

vol.43, pp.3-18, 2013

著者

辻 誠一郎 Tsuji Sei-ichiro

出版者

名古屋大学年代測定資料研究センター 天然放射性元素測定小委員会

雑誌

名古屋大学加速器質量分析計業績報告書

巻号頁・発行日

vol.10, pp.56-59, 1999-03 (Released:2010-05-25)

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第11回名古屋大学タンデトロン加速器質量分析計シンポジウム(平成10 (1998)年度)報告 名古屋大学タンデトロン加速器質量分析計第1号機の研究実績と1号機,2号磯の利用計画

著者

黒田 洋一郎 木村-黒田 純子

出版者

岩波書店

雑誌

科学 (ISSN:00227625)

巻号頁・発行日

vol.83, no.6, pp.693-708, 2013-06

著者

大長 勇太 合田 憲人 ABDUL-RAHMAN Omar

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告. CPSY, コンピュータシステム (ISSN:09135685)

巻号頁・発行日

vol.114, no.155, pp.19-24, 2014-07-21

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アプリケーションの可用性や実行性能向上を目的として,利用者の拠点の計算資源と遠隔のクラウドの計算資源を併用するハイブリッドクラウドが注目されている.ハイブリッドクラウドを効率よく活用するためには,ローカル資源とクラウド資源に対して処理を適切に割り当てることが重要な課題である.本橋では,ハイブリッドクラウド上でのHadoop処理の性能評価結果について報告する.本性能評価では,Amazon EC2の2つのリージョン(ap-northeast-1およびus-east-1)および国立情報学研究所の研究クラウドを用いて,3種類のハイブリッドクラウドを構築し,Hadoopベンチマークプログラムの実行時間を測定した.またハイブリッドクラウド上での実行時間予測モデルを作成し,実測結果との比較を行った.本性能評価の結果,2つのことが明らかになった.1点目は,ローカル資源に加えて遠隔のクラウド資源を利用することにより,アプリケーションプログラムの実行時間削減が期待できる.2点目は,ベンチマークプログラム実行中の通信時間の大きい場合では,実行時間予測結果と実測結果の誤差が大きいことである.後者については,実行時間予測モデルの通信時間の予測に改良の余地があることがわかった.

著者

María Asunción Esteve-Pastor Amaya García-Fernández Manuel Macías Francisco Sogorb Mariano Valdés Vanessa Roldán Javier Muñiz Lina Badimon Inmaculada Roldán Vicente Bertomeu-Martínez Ángel Cequier Gregory Y.H. Lip Manuel Anguita Francisco Marín on behalf of FANTASIIA Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.10, pp.2102-2108, 2016-09-23 (Released:2016-09-23)

参考文献数

39

被引用文献数

6 19

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Background:Several bleeding risk scores have been validated in patients with atrial fibrillation (AF). The ORBIT score has been recently proposed as a simple score with the best ability to predict major bleeding. The present study aimed to test the hypothesis that the ORBIT score was superior to the HAS-BLED score for predicting major bleeding and death in “real world” anticoagulated AF patients.Methods and Results:We analyzed the predictive performance for bleeding and death of 406 AF patients who underwent 571 electrical cardioversion procedures and 1,276 patients with permanent/persistent AF from the FANTASIIA registry. In the cardioversion population, 21 patients had major bleeding events and 26 patients died. The predictive performance for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.77 (95% CI 0.66–0.88) and 0.82 (95% CI 0.77–0.93), respectively; P=0.080). For the FANTASIIA population, 46 patients had major bleeding events and 50 patients died. The predictive performances for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.63 (95% CI 0.56–0.71) and 0.70 (95% CI 0.62–0.77), respectively; P=0.116). For death, the predictive performances of HAS-BLED and ORBIT were not significantly different in both populations. The ORBIT score categorized most patients as “low risk”.Conclusions:Despite the original claims in its derivation paper, the ORBIT score was not superior to HAS-BLED for predicting major bleeding and death in a “real world” oral anticoagulated AF population. (Circ J 2016; 80: 2102–2108)

著者

Garcia-Caro Alfonso

出版者

Sophia University Faculty of Liberal Arts

雑誌

Sophia International Review (ISSN:02884607)

巻号頁・発行日

no.29, pp.15-20, 2007

著者

Lee Hu-ung Lee Seongjing Kim Jae-woon Won Youjip

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Electronics Express (ISSN:13492543)

巻号頁・発行日

vol.12, no.12, pp.20150371-20150371, 2015

被引用文献数

3

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In this paper, we propose the parallel architecture for high speed calculations of SHA-1, a widely used cryptographic hash function. Parallel SHA-1 consists of a number of base modules which process the message digest in parallel manner. The base module uses state of art SHA-1 acceleration techniques: loop unfolding, pre-processing, and pipelining. We achieved the performance improvement of 5.8% over the pipeline architecture that is known to have nearly achieved the theoretical performance limit. We implemented our system on the Xilinx Virtex-6 FPGA and verified the operations by interfacing it with MicroBlaze soft processor core.

著者

Yuki Sato Hiroki Kato Risa Ebina-Shibuya Ari Itoh-Nakadai Ryuhei Okuyama Kazuhiko Igarashi

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.241, no.3, pp.175-182, 2017 (Released:2017-02-18)

参考文献数

37

被引用文献数

4

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Bach2 is a transcription factor which represses its target genes and plays important roles in the differentiation of B and T lymphoid cells. Bach2-deficient (KO) mice develop severe pulmonary alveolar proteinosis, which is associated with increased numbers of granulocytes and T cells. Bach2 is essential for the regulation of T cells, but its role in the regulation of granulocytes is not clear. Here, we observed increased numbers of eosinophils but not neutrophils in the bone marrow, spleen, peripheral blood, and bronchoalveolar lavage fluids of Bach2 KO mice compared with those of wild-type (WT) mice. Upon co-transplantation of the bone marrow cells from CD45.2 Bach2 KO and CD45.1/CD45.2 double-positive WT mice to irradiated WT CD45.1/CD45.2 mice, the reconstituted numbers of eosinophils were similar between Bach2 KO and WT cells. These results showed that the deficiency of Bach2 in eosinophils did not directly drive the differentiation of eosinophils. To investigate the effect of Bach2 KO CD4+ T cells upon eosinophils, we analyzed Rag2/Bach2-double deficient (dKO) mice which lack lymphocytes including CD4+ T cells. Rag2/Bach2 dKO mice did not show any increase in the numbers of eosinophils. Importantly, Bach2 KO mice showed an increase of interleukin-5 (Il-5) in the sera compared with WT mice. These results suggest that up-regulated functions of CD4+ T cells including secretion of Il-5 resulted in proliferation and/or migration to peripheral tissues of eosinophils in Bach2 KO mice. We propose that Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 in CD4+ T cells.

著者

Maekawa Yumiko Ramos-Cejudo Juan Kanai Atsuko

出版者

公益社団法人 日本産業衛生学会

雑誌

journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.58, no.6, pp.632-639, 2016

被引用文献数

6

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<p><b>Objectives: </b>Although using mental health services is an effective way to cope with work-related stressors and diseases, many employees do not utilize these services despite service improvements in recent years. The present study aimed to investigate the interaction effects of workplace climate and distress on help-seeking attitudes, and elucidate the reasons for mental health service underutilization in Japan. <b>Methods: </b>A questionnaire was distributed to 650 full-time male Japanese employees. Hierarchical multiple regression analysis was used to investigate interaction effects of workplace climate and distress on help-seeking. <b>Results: </b>Results showed that the association between workplace climate and help-seeking attitudes differed depending on employee distress level. For employees experiencing low levels of distress, openness to seeking treatment increased with a higher evaluation of the mental health services available at the workplace. However, the same did not hold true for employees experiencing high levels of distress. Instead, openness to seeking treatment decreased with perceived risk for career disadvantage for high distress employees. Additionally, negative values for seeking treatment in highly distressed employees decreased only when services were perceived as valuable, and the risk to their career was perceived as low. <b>Conclusions: </b>Overall, these findings indicate that distress distorts the perception of social support, which may lead to underutilization of available services. Assessing employees' distress levels and tailoring adequate interventions could facilitate help-seeking in male employees.</p>

著者

Maekawa Yumiko Ramos-Cejudo Juan Kanai Atsuko

出版者

公益社団法人 日本産業衛生学会

雑誌

journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.58, no.6, pp.632-639, 2016

被引用文献数

6

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<p><b>Objectives: </b>Although using mental health services is an effective way to cope with work-related stressors and diseases, many employees do not utilize these services despite service improvements in recent years. The present study aimed to investigate the interaction effects of workplace climate and distress on help-seeking attitudes, and elucidate the reasons for mental health service underutilization in Japan. <b>Methods: </b>A questionnaire was distributed to 650 full-time male Japanese employees. Hierarchical multiple regression analysis was used to investigate interaction effects of workplace climate and distress on help-seeking. <b>Results: </b>Results showed that the association between workplace climate and help-seeking attitudes differed depending on employee distress level. For employees experiencing low levels of distress, openness to seeking treatment increased with a higher evaluation of the mental health services available at the workplace. However, the same did not hold true for employees experiencing high levels of distress. Instead, openness to seeking treatment decreased with perceived risk for career disadvantage for high distress employees. Additionally, negative values for seeking treatment in highly distressed employees decreased only when services were perceived as valuable, and the risk to their career was perceived as low. <b>Conclusions: </b>Overall, these findings indicate that distress distorts the perception of social support, which may lead to underutilization of available services. Assessing employees' distress levels and tailoring adequate interventions could facilitate help-seeking in male employees.</p>

著者

Ken-ichi WATANABE James K. CHAMBERS Kazuyuki UCHIDA Kazumi NIBE Nanako USHIO Noriyuki HORIUCHI Yoshiyasu KOBAYASHI Hiroyuki NAKAYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0610, (Released:2017-01-28)

被引用文献数

5

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The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neoplastic cells in trichoblastic area were also positive for cytokeratin 15 and CD34. Neoplastic cells in apocrine glandular area were positive for pan-cytokeratin and cytokeratin 7, 18 and 19. Myoepithelial cell proliferation with osteocartilaginous metaplasia was observed in this area. Since neoplastic cells showed multiphenotypic differentiation for hair follicles and apocrine glands, the present case was diagnosed as a cutaneous mixed tumor.