著者

MARINKOVIC Slobodan STOSIC-OPINCAL Tatjana STRBAC Mile TOMIC Irina TOMIC Oliver DJORDJEVIC Drago

出版者

Tohoku University Medical Press

雑誌

Tohoku journal of experimental medicine (ISSN:00408727)

巻号頁・発行日

vol.222, no.4, pp.297-302, 2010-12-01

被引用文献数

2

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Radiology has attracted the world of art with the esthetic value of its images, and as a new medium for the artistic expression. In order to investigate the links between neuroradiology and art, we examined 12,763 artworks presented in corresponding publications and in Google images on the Internet. The selected artworks were created by 1,964 authors. To give our own contribution to this field, we produced several artful radiological images using the X-ray of 4 cerebral hemispheres, one dissected brain, serial sections of one head and brain, the vascular casts of 2 brains, the magnetic resonance imaging (MRI) scans of one volunteer, and various options in Photoshop. Among the examined artworks, neuroradiological images were used in 129 artworks (1.01%) that were created by 31 artists (1.58%). The artists applied different radiological techniques: X-ray, angiography, computed tomography (CT), multislice CT, MRI, functional MRI, positron emission tomography (PET) or single-photon emission computed tomography (SPECT), either alone or in various combinations. They used the original images, i.e. radiographs or scans, or their electronic modifications in Photoshop or three-dimensional (3D) software. Some artworks presented the skull, yet others the brain, and still others both, either with or without a head image. The neuroradiological artworks were created as paintings, photographs, digital works and sculptures. Their authors were professional artists, designers, amateurs and radiologists. In conclusion, thanks to the esthetics of some radiological images and the valuable creations of certain artists, neuroradiology has become an important field of contemporary art.

著者

Toshiaki Toyota Takeshi Morimoto Hiroki Shiomi Kenji Ando Koh Ono Satoshi Shizuta Takao Kato Naritatsu Saito Yutaka Furukawa Yoshihisa Nakagawa Minoru Horie Takeshi Kimura on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0987, (Released:2017-02-07)

参考文献数

31

被引用文献数

10

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Background:Few studies have evaluated the prevalence and clinical outcomes of ad hoc percutaneous coronary intervention (PCI), performing diagnostic coronary angiography and PCI in the same session, in stable coronary artery disease (CAD) patients.Methods and Results:From the CREDO-Kyoto PCI/CABG registry cohort-2, 6,943 patients were analyzed as having stable CAD and undergoing first PCI. Ad hoc PCI and non-ad hoc PCI were performed in 1,722 (24.8%) and 5,221 (75.1%) patients, respectively. The cumulative 5-year incidence and adjusted risk for all-cause death were not significantly different between the 2 groups (15% vs. 15%, P=0.53; hazard ratio: 1.15, 95% confidence interval: 0.98–1.35, P=0.08). Ad hoc PCI relative to non-ad hoc PCI was associated with neutral risk for myocardial infarction, any coronary revascularization, and bleeding, but was associated with a trend towards lower risk for stroke (hazard ratio: 0.78, 95% confidence interval: 0.60–1.02, P=0.06).Conclusions:Ad hoc PCI in stable CAD patients was associated with at least comparable 5-year clinical outcomes as with non-ad hoc PCI. Considering patients’ preference and the cost-saving, the ad hoc PCI strategy might be a safe and attractive option for patients with stable CAD, although the prevalence of ad hoc PCI was low in the current study population.

著者

Tae-Sik Lee Min-Young Song Yu-Jeong Kwon

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.12, pp.3407-3410, 2016 (Released:2016-12-27)

参考文献数

22

被引用文献数

10

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[Purpose] The purpose of this study was to investigate the activation of back and lower limb muscles in subjects who were performing a squat exercise at different angles of trunk flexion. [Subjects and Methods] Twenty healthy subjects (age 21.1± 1.8 years, height 168.7 ± 8.2 cm, weight 66.1 ± 12.3 kg) volunteered. The activation of the erector spinae muscle, rectus femoris muscle, gluteus maximus muscle and biceps femoris muscle was observed while the subjects performed squat exercises with a trunk flexion of 0°, 15°, and 30°. [Results] The erector spinae muscle, gluteus maximus muscle, and biceps femoris muscle were activated more during the squat exercise with the trunk flexion at 30° than the exercise with the trunk flexion at 0°. The rectus femoris muscle showed a tendency to decrease as the truck flexion increased. [Conclusion] Squat exercise be executed while maintaining an erect trunk posture if one wishes to strengthen the quadriceps muscle while reducing the load on the lower back.

著者

Odeh Rashed Al-Jayyousi

出版者

Gower

巻号頁・発行日

2012

著者

松久 裕子 鷹尾 祐樹 Yuhua Huang Shin-Tson Wu 藤井 彰彦 尾崎 雅則

出版者

一般社団法人 日本液晶学会

雑誌

日本液晶学会討論会講演予稿集 2007年 日本液晶学会討論会 (ISSN:18803490)

巻号頁・発行日

pp.63, 2007 (Released:2009-04-01)

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コレステリック液晶はストップバンド端において光の群速度異常が誘起されるため、レーザーデバイスへの応用が可能となる。しかしながら、これまでのコレステリック液晶を用いたレーザー発振では、ストップバンド端における群速度異常はレーザーの出力光にのみ用いられてきた。我々はこの群速度異常を出力光のみならず、入力される励起光にも利用することによりレーザー発振の低閾値化及び高効率化を試みた。

著者

Yuko Wada Yukie Takaoka Mitsuru Nozawa Miho Goto Ken-ichi Shimokawa Fumiyoshi Ishii

出版者

バイオ&ソーシャル・サイエンス推進国際研究交流会

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

vol.10, no.6, pp.300-306, 2016 (Released:2017-01-15)

参考文献数

16

被引用文献数

6

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We measured the pH, water-vapor permeability, adhesive force, peeling-force, elongation rate, support flexibility, and peeling time of medicinal and over-the-counter (OTC) tape preparations containing felbinac. When measuring the pH of each preparation, Felnabion (pH 4.5) was weakly acidic, and EMEC and Tokuon (pH 7.0) were neutral. When measuring the water-vapor permeability of each preparation, that of a generic product, EMEC (380 g/m2/24h), was twice as high as that of a brand-name product, Seltouch (189 g/m2/24 h). The adhesive force was measured using the ball tack test. The adhesive forces of OTC drugs, Salomethyl, Homepass, and Tokuhon (1.04 g), were higher than that of Seltouch (0.06 g). Concerning peeling-force measurement, the peeling-forces of a generic product, Falzy (4.15 N), and an OTC drug, Omuneed (4.89 N), were higher than that of Seltouch (0.91 N). The elongation rates of a generic product, Sumilu (319%), and OTC drugs, Nabolin (298%) and Homepass (299%), were higher than that of Seltouch (251%), but that of Tokuhon (72%) was lower. The support flexibilities of EMEC (150 degrees) and Tokuhon (131 degrees) were higher than that of Seltouch (96 degrees). In addition, the peeling time of Seltouch was 120 min or more, whereas those of EMEC and Nabolin were 1.4 and 0.2 min, respectively. These results suggest that the differences in pharmaceutical properties, such as the pH, water-vapor permeability, adhesive force, peeling-force, elongation rate, support flexibility, and peeling time, among the preparations markedly influence patients' subjective comfortableness. The results of this study facilitated individuals’ comfortableness-matched drug selection.

著者

TAKAGI Sei-ichi

出版者

一般社団法人日本土壌肥料学会

雑誌

Soil science and plant nutrition (ISSN:00380768)

巻号頁・発行日

vol.22, no.4, pp.423-433, 1976-12

被引用文献数

29

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The root washings of water-cultured oat and rice (non-sterile) contained some sort of amphoteric, iron-solubilizing chelating (or complexing) compound(s), which could be separated into a "cationic fraction" by elution in a cation exchanger column with 1N NH_4OH. In oats, the release of the chelator into the washings greatly increased under iron-stress conditions. Under the same condition "iron-inefficient" rice plants also increased the release of the chelator, though to a much less extent than did the oats. Further examination of the "cationic fraction" revealed that this chelator may be a heat-stable, acid-hydrolyzable non-macromolecule of extraordinarily high polarity. In the absence of interfering ions, the chelator was able to solubilize hydrated Fe (III) oxide effectively within a range of pH 4 to 9. Its Fe-solubilizing action was inhibited by the presence of divalent metals, the extent being in the order, Cu>Co≧Zn>Mn>Ca (no inhibition).

著者

福島 統 北村 聖 伴 信太郎 村田 善則 Duck-Sun Ahn 小野 輝雄 奈良 信雄 日野原 重明 田原 克志

出版者

Japan Society for Medical Education

雑誌

医学教育 (ISSN:03869644)

巻号頁・発行日

vol.44, no.3, pp.155-170, 2013

著者

Nozomu YOKOYAMA Hiroshi OHTA Yumiko KAGAWA Rommaneeya LEELA-ARPORN Angkhana DERMLIM Khoirun NISA Tomoya MORITA Tatsuyuki OSUGA Noboru SASAKI Keitaro MORISHITA Kensuke NAKAMURA Mitsuyoshi TAKIGUCHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0479, (Released:2017-01-16)

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We examine the expression of tight junction and adherence junction proteins in the colorectal mucosa of miniature dachshunds (MDs) with inflammatory colorectal polyps (ICRPs). Colorectal mucosa samples were endoscopically obtained from 8 MDs with ICRPs and 8 control dogs for immunoblotting. Paraffin-embedded tissues of surgically resected inflamed lesions from another 5 MDs with ICRPs and full-thickness colorectal specimens from 5 healthy beagles were obtained for immunohistochemistry. The expression patterns of claudin-1, -2, -3, -4, -5, -7 and -8, E-cadherin and β-catenin were analyzed in the non-inflamed mucosa and inflamed mucosa of ICRPs and colorectal mucosa of control dogs by immunoblotting. The localization of these proteins in the inflamed lesions was analyzed by immunohistochemistry. The expressions of each of claudin, E-cadherin and β-catenin were not significantly different between control dogs and non-inflamed colonic mucosa from MDs with ICRPs. In contrast, only E-cadherin and β-catenin were detected in the inflamed lesions of MDs with ICRPs. By immunohistochemistry, claudin-2, -3, -4, -5 and -7, E-cadherin and β-catenin were expressed in the colorectal epithelium within the inflamed mucosa, but not in granulation tissue. Distributions of claudin-2, -3, -4, -5 and -7, E-cadherin and β-catenin in the colonic epithelium were not different between MDs with ICRPs and control dogs. These results indicated that no significant alteration was detected in several tight junction or adherence junction proteins expression in the colorectal epithelium of ICRPs.

著者

鄭 聖汝 黒川 尚彦 Chung Sung-Yeo Kurokawa Naohiko

出版者

大阪大学大学院文学研究科

雑誌

待兼山論叢. 日本学篇 (ISSN:03874818)

巻号頁・発行日

vol.46, pp.1-22, 2012-12-25

著者

Sook Kyoung Kim Jae Hyung Park Jong Youn Kim Jong Il Choi Boyoung Joung Moon-Hyoung Lee Sung Soon Kim Young-Hoon Kim Hui-Nam Pak

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.75, no.3, pp.557-564, 2011 (Released:2011-02-25)

参考文献数

45

被引用文献数

29 42

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Background: The degree of electroanatomical remodeling of the left atrial (LA) affects the clinical outcome after rhythm control of atrial fibrillation (AF). Our hypothesis was that plasma concentrations of transforming growth factor (TGF)-β and tissue inhibitor of metalloproteinase (TIMP)-1 reflect LA voltage and structural remodeling in patients with non-valvular AF. Methods and Results: In the study, 242 patients (male 79.4%, 55.1±11.0 years old) with AF (155 paroxysmal AF, 87 persistent AF) underwent catheter ablation. Pre-ablation plasma concentrations of TGF-β and TIMP-1 and the degree of electroanatomical remodeling quantified by LA voltage map (NavX) and 3D-CT were evaluated. The mean LA voltage and volume were compared in patients with high TGF-β (≥10.0ng/ml, H-TGF) vs. low TGF-β (<10.0ng/ml, L-TGF) and high TIMP-1 (≥1.1ng/ml, H-TIMP) vs. low TIMP-1 (<1.1ng/ml, L-TIMP). Patients with H-TGF had lower mean LA voltage (P=0.014) and greater LA volume (P=0.022), particularly, posterior venous LA volume (P=0.005) than those with L-TGF. In patients with H-TIMP, the mean LA voltage (P=0.019) was lower than those with L-TIMP. LA volume was significantly higher (P<0.001) in patients with ejection fraction ≤58% than those with >58%. Conclusions: In patients with non-valvular AF, high plasma concentrations TGF-β and TIMP-1 and low ejection fraction were closely related with electroanatomical remodeling of LA. (Circ J 2011; 75: 557-564)

著者

Eunji KOH Yun Chan JUNG Heung-Myong WOO Byung-Jae KANG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0456, (Released:2017-01-06)

被引用文献数

14

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The purpose of this study was to establish an optimized protocol for the production of alginate-encapsulated canine adipose-derived mesenchymal stem cells (cASCs) and evaluate their suitability for clinical use, including viability, proliferation and in vivo cell retention. Alginate microbeads were formed by vibrational technology and the production of injectable microbeads was performed using various parameters with standard methodology. Microbead toxicity was tested in an animal model. Encapsulated cASCs were evaluated for viability and proliferation in vitro. HEK-293 cells, with or without microencapsulation, were injected into the subcutaneous tissue of mice and were tracked using in vivo bioluminescent imaging to evaluate the retention of transplanted cells. The optimized injectable microbeads were of uniform size and approximately 250 μm in diameter. There was no strong evidence of in vivo toxicity for the alginate beads. The cells remained viable after encapsulation, and there was evidence of in vitro proliferation within the microcapsules. In vivo bioluminescent imaging showed that alginate encapsulation improved the retention of transplanted cells and the encapsulated cells remained viable in vivo for 7 days. Encapsulation enhances the retention of viable cells in vivo and might represent a potential strategy to increase the therapeutic potency and efficacy of stem cells.

著者

Yong LI Man-Li ZHANG Bin CONG Si-Ming WANG Mei DONG Françoise SAURIOL Chang-Hong HUO Qing-Wen SHI Yu-Cheng GU Hiromasa KIYOTA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.75, no.8, pp.1554-1556, 2011-08-23 (Released:2011-08-23)

参考文献数

27

被引用文献数

27 13

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Achillinin A (2β,3β-epoxy-1α,4β,10α-trihydroxyguai-11(13)-en-12,6α-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC50) values of 5.8, 10 and 0.31 μM, respectively.

著者

上田 修功 NTTコミュニケ-ション科学研究所

出版者

物性研究刊行会

雑誌

物性研究 (ISSN:05252997)

巻号頁・発行日

vol.70, no.3, pp.387-392, 1998-06-20

著者

Gideon Shelach-Lavi

出版者

Cambridge University Press

巻号頁・発行日

2015

著者

Yasuhiro TAKASHIMA Isako ONODA Shin-Pin CHIOU Katsuya KITOH

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0461, (Released:2016-12-30)

被引用文献数

2

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Platelet function hyper-activity has been reported in Dirofilaria immitis (heartworm, HW)-infected dogs. Although the mechanism of increased platelet hyper-activity has not yet been elucidated, it is suggested to be mediated by unknown factors, which may be related to adult HW components. This study aims to determine whether adult male HW whole body extract induces canine platelet aggregation in vitro. The results indicate that HW extract caused an aggregation of canine platelets in a concentration-dependent manner. This aggregation ability of the HW extract was not mediated by the adenosine diphosphate receptor. In addition, the mechanisms of aggregation did not require cyclooxygenase-dependent pathways, and the aggregating activity of substances contained in the HW extract was heat stable; therefore, the active substances may be different from collagen. Furthermore, the platelet aggregating activity remained within the molecular weight (MW)≥100,000 fraction obtained by ultrafiltrating the HW extract. In contrast, the MW<100,000 fraction also had a platelet aggregation ability, but the aggregation pattern was reversible and the maximum extent decreased, compared with the MW≥100,000 fraction response. Our experiments have been conducted using a whole body extract from adult HWs to determine with certainty the aggregating activity of HW elements on canine platelets. More studies are necessary to evaluate the effects of the metabolic products released from live adult worms in pulmonary arteries and the symbiont bacterium Wolbachia-derived antigens on canine platelet aggregation.

著者

CHE-MPONDA Aleck Humphrey

出版者

The Research Committee for African Area Studies, Kyoto University

雑誌

African Study Monographs (ISSN:02851601)

巻号頁・発行日

vol.5, pp.63-74, 1984-12

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Plato and Aristotle described a society's leader as naturally selected by Divine Providence. They call him a "Prince" or the "Philosopher King." These characterizations remotely size-up Tanzania's Julius Kambarage Nyerere whose rise to prominence is quite fascinating. A "King" he was not. A "Prince" that he was. His own people rendered him great respect and called him "Mwalimu, " the "philosopher, " the "thinker." The term "Mwalimu" ordinarily means "teacher" but when reverence is injected into it, it means "thinker" or "philosopher." Nyerere schooled in adulthood and became the first Tanganyikan to earn a Master of Arts degree. He accomplished the feat in 1952 at Edinburgh, Scotland. The five years he spent in colonial Britain were years of genuine universal nationalism. Pan-Africanism was in full swing since 1945 calling for self-determination for African peoples then under European imperialism and colonialism. And, following World War II and the formation of the United Nations in 1945, the flame of Tanganyika's nationalism was lit and Nyerere was its bearer. He led Tanganyika to independence by 1961 and to union with distabilized Zanzibar in 1964 to form the current Tanzania. Nyerere was at the helm in Tanzania for over two decades earning for himself and for his country international respectability and domestic tranquility.

著者

保井 孝太郎 竹上 勉 小島 朝人 松浦 善治 宮本 道子 木村 純子 KIMURA-KURODA Junko 荻本 真美

出版者

(財)東京都神経科学総合研究所

雑誌

試験研究

巻号頁・発行日

1989

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日本脳炎ウイルス(JEV)が属するフラビウイルスは、世界中に70種にのぼるウイルス種が存在しており、総合的で有効な対策が待たれている。現在黄熱病ウイルス、JEV、ダニ媒介脳炎ウイルスに対する生および不活化ワクチンが使用されているが、それぞれに問題点を含んでおり新しい形のワクチンの開発が要請されている。そこで、組換えDNA技術を用いてJEVに対する新しいワクチンの開発をはかり、他のフラビウイルスに対するワクチンの開発の基盤となる技術的・方法論的知見を提供することを目的として、研究を行なった。組換えバキュロウイルスおよびワクチニアウイルスを用いた研究によって、以下のことが明らかになった。1,ウイルス粒子エンベロ-プに存在する構造蛋白E,preM,Mは、ポリプロテインとして合成された後、細胞の酵素によって切断プロセシングされて完成する。2,これらの蛋白の上流にはシグナル配列があり、正常な抗原構造を持った構造蛋白を発現させるためには、正常にプロセシングされることが必要である。3,ウイルス粒子上のE蛋白は、E蛋白単独またはpreM,M蛋白とともにオリゴマ-を形成しており、モノマ-状態のE蛋白に比べて抗原的に安定であり免疫原性も高い。4,E蛋白をオリゴマ-粒子として細胞外に大量に産生・放出させ得る、組換えウイルス発現系を開発することができた。5,蛋白上の中和抗体エピト-プの位置を明らかにできた。6,E蛋白の一部分と融合し、中和などの特定にエピト-プのみを含むHBsAg粒子を産生する系を、開発することができた。以上の成果から、JEVを初めとするフラビウイルスの新しい人工コンポ-ネントワクチンを開発するための基本的な方法を提示することができたと言える。

著者

Teruaki TOZAKI Mio KIKUCHI Hironaga KAKOI Kei-ichi HIROTA Kazutaka MUKAI Hiroko AIDA Seiji NAKAMURA Shun-ichi NAGATA

出版者

日本ウマ科学会

雑誌

Journal of Equine Science (ISSN:13403516)

巻号頁・発行日

vol.27, no.4, pp.157-164, 2016 (Released:2016-12-15)

参考文献数

39

被引用文献数

5

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Transcriptome analyses based on DNA microarray technology have been used to investigate gene expression profiles in horses. In this study, we aimed to identify exercise-induced changes in the expression profiles of genes in the peripheral blood of Thoroughbred horses using DNA microarray technology (15,429 genes on 43,603 probes). Blood samples from the jugular vein were collected from six horses before and 1 min, 4 hr, and 24 hr after all-out running on a treadmill. After the normalization of microarray data, a total of 26,830 probes were clustered into four groups and 11 subgroups showing similar expression changes based on k-mean clustering. The expression level of inflammation-related genes, including interleukin-1 receptor type II (IL-1R2), matrix metallopeptidase 8 (MMP8), protein S100-A8 (S100-A8), and serum amyloid A (SAA), increased at 4 hr after exercise, whereas that of c-Fos (FOS) increased at 1 min after exercise. These results indicated that the inflammatory response increased in the peripheral blood cells after exercise. Our study also revealed the presence of genes that may not be affected by all-out exercise. In conclusion, transcriptome analysis of peripheral blood cells could be used to monitor physiological changes induced by various external stress factors, including exercise, in Thoroughbred racehorses.

著者

Nagai Yuji Kikuchi Erika Lerchner Walter Inoue Ken-Ichi Ji Bin Eldridge Mark A G Kaneko Hiroyuki Kimura Yasuyuki Oh-Nishi Arata Hori Yukiko Kato Yoko Hirabayashi Toshiyuki Fujimoto Atsushi Kumata Katsushi Zhang Ming-Rong Aoki Ichio Suhara Tetsuya Higuchi Makoto Takada Masahiko Richmond Barry J Minamimoto Takafumi

出版者

Springer Nature

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.7, 2016-12-06

被引用文献数

88

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脳内に「やる気」のスイッチ、目で見て操作 : 霊長類の生体脳で人工受容体を画像化する技術を確立、高次脳機能研究の飛躍的な進展に期待. 京都大学プレスリリース. 2016-12-16.