著者

Ko Jae-Jung

出版者

Kyoto University

巻号頁・発行日

2009-03-23

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新制・課程博士

著者

Ken-Ichi Furukawa

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.124, no.2, pp.129-137, 2014-02-20 (Released:2014-02-19)

参考文献数

84

被引用文献数

1 12

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Aortic valve calcification can aggravate aortic stenoses, and it is a significant cause of sudden cardiac death. The increasing number of patients with age-related calcification is a problem in developed nations. However, the only treatment option currently available is highly invasive cardiac valve replacement. Therefore, clarification of the etiology of calcification is urgently needed to develop drug therapies and prevention methods. Recent studies have revealed that calcification is not a simple sedimentation of a mineral through a physicochemical phenomenon; various factors dynamically contribute to the mechanism. Further, we are finally beginning to understand the cellular origins of calcification, which had been unclear for a long time. Based on these findings that help to clarify potential drug targets, we expect to establish drug therapies that reduce the stress on patients. In this paper, I introduce the latest findings on cells that are most likely to contribute to calcification and on calcification-related factors that may lead to the development of drug therapies.

著者

Hideyuki Yamamoto Sayomi Higa-Nakamine Nobuhiro Noguchi Noriko Maeda Yutaka Kondo Seikichi Toku Ichiro Kukita Kazuhiro Sugahara

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

pp.13R11CP, (Released:2014-02-19)

参考文献数

28

被引用文献数

2 17

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Four transmembrane tyrosine kinases constitute the ErbB protein family: epidermal growth factor receptor (EGFR) or ErbB1, ErbB2, ErbB3, and ErbB4. In general, the structure and mechanism of the activation of these members are similar. However, significant differences in homologous desensitization are known between EGFR and ErbB4. Desensitization of ligand-occupied EGFR occurs by endocytosis, while that of ErbB4 occurs by selective cleavage at the cell surface. Because ErbB4 is abundantly expressed in neurons from fetal to adult brains, elucidation of the desensitization mechanism is important to understand neuronal development and synaptic functions. Recently, it has become clear that heterologous desensitization of EGFR and ErbB4 are induced by endocytosis and cleavage, respectively, similar to homologous desensitization. It has been reported that heterologous desensitization of EGFR is induced by serine phosphorylation of EGFR via the p38 mitogen-activated protein kinase (p38 MAP kinase) pathway in various cell lines, including alveolar epithelial cells. In contrast, the protein kinase C pathway is involved in ErbB4 cleavage. In this review, we will describe recent advances in the desensitization mechanisms of EGFR and ErbB4, mainly in alveolar epithelial cells and hypothalamic neurons, respectively.

著者

Rafael MORAN-MUÑOZ J. A. IBANCOVICHI Eduardo GUTIERREZ-BLANCO Carlos M. ACEVEDO-ARCIQUE J. Mauro VICTORIA MORA Francisco J. TENDILLO Martin SANTOS-GONZALEZ Kazuto YAMASHITA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0407, (Released:2014-02-27)

被引用文献数

3 21

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The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO–DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained with sevoflurane in oxygen and MAC of sevoflurane was determined after 90 min equilibration period in the dogs (SEV-MACBASAL). Then, sevoflurane MAC was determined again in the dogs after 45 min equilibration period of one of the following treatments: an intravenous loading dose of lidocaine 2 mg/kg followed by 6 mg/kg/hr CRI (SEV-MACLIDO); an intravenous loading dose of dexmedetomidine 2 µg/kg followed by 2 µg/kg/hr CRI (SEV-MACDEX); or their combination (SEV-MACLIDO-DEX). These SEV-MACs were determined in duplicate. Data were analyzed using ANOVA and post hoc Tuckey test when appropriate. The SEV-MACBASAL was 1.82 ± 0.06%, SEV-MACLIDO was 1.38 ± 0.08%, SEV-MACDEX was 1.22 ± 0.10%, and SEV-MACLIDO-DEX was 0.78 ± 0.06%. The CRI administration of lidocaine, dexmedetomidine and their combination produced a significant reduction in the MAC of sevoflurane by 26.1 ± 9.0% (P<0.0001), 43.7 ± 11.8% (P<0.0002) and 54.4 ± 9.8% (P<0.0001), respectively. The MAC reduction was significantly greater after the CRI combination of lidocaine and dexmedetomidine when compared with lidocaine CRI (P<0.0001) or dexmedetomidine CRI treatments (P<0.025).

著者

Hans Kelsen herausgegeben von Matthias Jestaedt in Kooperation mit dem Hans Kelsen-Institut

出版者

Mohr Siebeck

巻号頁・発行日

2007

著者

Murakami Katsuhisa Kadowaki Takuya Fujita Jun-ichi

出版者

American Institute of Physics

雑誌

Applied physics letters (ISSN:00036951)

巻号頁・発行日

vol.102, no.4, pp.043111, 2013-01

被引用文献数

29 2

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From the analysis of the ratio of D peak intensity to G peak intensity in Raman spectroscopy, electron beam irradiation with energies of 100 eV was found to induce damage in single-layer graphene. The damage becomes larger with decreasing electron beam energy. Internal strain in graphene induced by damage under irradiation is further evaluated based on G peak shifts. The dose-dependent internal strain was approximately 2.22% cm2/mC at 100 eV and 2.65 × 10−2% cm2/mC at 500 eV. The strain induced by the irradiation showed strong dependence on electron energy.

著者

Fujita Jun-ichi Tachi Masashi Murakami Katsuhisa Sakurai Hidehiro Morita Yuki Higashibayashi Shuhei Takeguchi Masaki

出版者

American Institute of Physics

雑誌

Applied physics letters (ISSN:00036951)

巻号頁・発行日

vol.104, no.4, pp.043107, 2014-01

被引用文献数

4

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We found that electron-beam irradiation of sumanene aggregates strongly enhanced their transformation into a graphitic carbon cage, having a diameter of about 20 nm. The threshold electron dose was about 32 mC/cm2 at 200 keV, but the transformation is still induced at 20 keV. The transformation sequence suggested that the cage was constructed accompanied by the dynamical movement of the transiently linked sumanene molecules in order to pile up inside the shell. Thus, bond excitation in the sumanene molecules rather than a knock-on of carbon atoms seems to be the main cause of the cage transformation.

著者

水本旭洋 KhaledEl-Fakih 安本慶一

出版者

一般社団法人情報処理学会

雑誌

研究報告数理モデル化と問題解決(MPS) (ISSN:09196072)

巻号頁・発行日

vol.2013, no.25, pp.1-6, 2013-12-04

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本論文では,スマートハウスにおいて省エネルギーに様々なデバイスをコンテキストアウェア制御することを目的に,任意の 2 つのコンテキスト間を最小コストで遷移させるデバイス操作シーケンスを導出するツール PathSim を提案する.PathSim は,スマートスペースにおけるコンテキストの各構成要素の値域を有限個の範囲に分割することで,コンテキストを有限個の要素からなる空間として扱う.そして,各コンテキストにおいて任意のデバイスの操作イベントを実行した時に遷移するコンテキストをシミュレーションにより求めていくことで,最小コストで目的のコンテキストに遷移するデバイスの操作シーケンスを A* アルゴリズムに基づいて導出する.スマートスペースにおける典型的な要求仕様を想定したケーススタディを通して評価実験を行った結果,PathSim によって導出された操作シーケンスが,人が直感的な方法でデバイスを操作する場合と比べ,デバイスの合計消費電力量を 72% 削減できることを確認した.

著者

Ibayashi Ken-ichi Takahashi Tadashi

出版者

京都大学数理解析研究所

雑誌

数理解析研究所講究録 (ISSN:18802818)

巻号頁・発行日

vol.920, pp.236-246, 1995-08

著者

Po-Chao Hsu Tsung-Hsien Lin Wen-Hsien Lee Chun-Yuan Chu Cheng-An Chiu Hung-Hao Lee Ho-Ming Su Wen-Chol Voon Wen-Ter Lai Sheng-Hsiung Sheu

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.21212, (Released:2013-11-27)

参考文献数

29

被引用文献数

5 11

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Aim: The ankle-brachial index(ABI) is an easy-to-use, non-invasive and reliable diagnostic tool for assessing peripheral arterial occlusive disease(PAOD). The CHADS2(congestive heart failure, hypertension, age ≧75 years, diabetes, prior stroke) score is a simple and popular clinical parameter that is used to assess the risk of stroke in patients with atrial fibrillation(AF). Because all five components of the CHADS2 score are risk factors for PAOD, the score should have a strong correlation with the presence of PAOD. However, there are limited studies regarding the association between the CHADS2 score and PAOD in patients without AF. Therefore, the aim of the present study was to investigate whether the CHADS2 score is positively associated with PAOD in patients without AF. Methods: A total of 1,320 patients without AF were included in this study. The ABI was measured using an ABI-form device. PAOD was defined as an ABI of <0.9 in either leg. Results: Among the 1,320 subjects(mean age: 60.3±13.4 years), the prevalence of an ABI of <0.9 was 5.7%. A multivariate analysis showed that an increased age(odds ratio [OR], 1.054; p<0.001), decreased estimated glomerular filtration rate (OR, 0.971; p<0.001) and increased CHADS2 score(OR, 1.861; p<0.001) were independently associated with an ABI of <0.9. Conclusions: Our study demonstrated that the CHADS2 score is significantly associated with an ABI of <0.9 in non-AF patients. Further prospective studies are needed to examine the ability of the CHADS2 score to predict the incidence of PAOD.

著者

Ángel López-Cuenca Sergio Manzano-Fernández Francisco Marín Soledad Parra-Pallares Marina Navarro-Peñalver Salvador Montalban-Larrea Jose M. Andreu-Cayuelas Ana I. Romero-Aniorte Francisco Avilés-Plaza Mariano Valdés-Chavarri James L. Januzzi Jr

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.8, pp.2088-2096, 2013 (Released:2013-07-25)

参考文献数

24

被引用文献数

4 5

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Background: Beta-trace protein (BTP) and cystatin C (CysC) are novel biomarkers of renal function. We assessed the ability of both to predict major bleeding (MB) in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), compared to other renal function parameters and clinical risk scores. Methods and Results: We included 273 patients. Blood samples were obtained within 24h of admission. The endpoint was MB. During a follow-up of 760 days (411–1,098 days), 25 patients (9.2%) had MB. Patients with MB had higher concentrations of BTP (0.98mg/L; 0.71–1.16mg/L vs. 0.72mg/L, 0.60–0.91mg/L, P=0.002), CysC (1.05mg/L; 0.91–1.30mg/L vs. 0.90mg/L, 0.75–1.08mg/L, P=0.003), higher CRUSADE score (39±16 points vs. 29±15 points, P=0.002) and lower estimated glomerular filtration rate (eGFR; 66±27 vs. 80±30ml·min–1·1.73m–2, P=0.02) than patients without MB; there was no difference in creatinine level between the groups (P=0.14). After multivariable adjustment, both were predictors of MB, while eGFR and creatinine did not achieve statistical significance. Among subjects with eGFR >60ml·min–1·1.73m–2, those with elevated concentrations of both biomarkers had a significantly higher risk for MB. Net reclassification indexes from the addition of BTP and CysC to CRUSADE risk score were 38% and 21% respectively, while the relative integrated discrimination indexes were 12.5% and 3.8%. Conclusions: Among NSTE-ACS patients, BTP and CysC were superior to conventional renal parameters for predicting MB, and improved clinical stratification for hemorrhagic risk.  (Circ J 2013; 77: 2088–2096)

著者

Miguel Ruiz-Canela Miguel A. Martínez-González

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-14-0062, (Released:2014-02-01)

参考文献数

101

被引用文献数

9 36

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Peripheral artery disease (PAD) usually refers to ischemia of the lower limb vessels. Currently, the estimated number of cases in the world is 202 million. PAD is the third leading cause of atherosclerotic cardiovascular morbidity. The measurement of the ankle-brachial index (ABI) is recommended as a first-line noninvasive test for screening and diagnosis of PAD. An ABI <0.90 is an independent predictor of cardiovascular events and this measurement is useful to identify patients at moderate to high risk of cardiovascular disease. However, there is insufficient evidence to assess the benefits and harms of screening for PAD with the ABI in asymptomatic adults. Lifestyle modifications, including smoking cessation, dietary changes and physical activity, are currently the most cost-effective interventions. Inverse associations with PAD have been reported for some subtypes of dietary fats, fiber, antioxidants (vitamins E and C), folate, vitamins B6, B12 and D, flavonoids, and fruits and vegetables. A possible inverse association between better adherence to the Mediterranean diet and the risk of symptomatic PAD has also been reported in a large randomized clinical trial. Therefore, a Mediterranean-style diet could be effective in the primary and secondary prevention of PAD, although further experimental studies are needed to better clarify this association.

著者

[edited by] Beatrice M. Bodart-Bailey Derek Massarella

出版者

Japan Library

巻号頁・発行日

1995

著者

by Arthur Zich and the editors of Time-Life Books

出版者

Time-Life Books

巻号頁・発行日

1977

著者

Maria Nieves Franco Teresa Galeano-Díaz Jacinto Sánchez Concha De Miguel Daniel Martín-Vertedor

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.63, no.2, pp.115-125, 2014 (Released:2014-02-05)

参考文献数

65

被引用文献数

6 30

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This article reports about the presence of some of the components of minor fraction of virgin olive oils, polyphenols and tocopherols, in several of the VOO varieties from Extremadura. The relationship between both classes of compounds and the oxidative stability of the oils is also examined. The levels of total phenols, α, β, and γ tocopherols showed significant differences (p<0.05) among the different varieties. The concentration of total phenolic compounds varied from 130 to 1203 mg/kg. The α-tocopherol was the most representative in the seven varieties (95.97 %) and ranged from (288 - 170) to (485 - 244) mg/kg in the Morisca and Carrasqueña varieties respectively. On the other hand, a positive high lineal correlation was observed between oxidative stability and studied along the maturity of the fruit and the total phenolic compounds (natural antioxidants) (r2>0.90; p<0.05), α-tocopherol (r2>0.85; p<0.05), β-tocopherol (r2>0.70; p<0.05) and total-tocopherols (r2>0.87; p<0.05), in all the olive oils obtained from the seven varieties of olive from Extremadura. It is noticeable that α-tocopherol fraction contributed equally to the oxidative stability of all the VOO whereas the largest contribution was provided by the oil phenolic fraction, as it was the case of the Carrasqueña variety.

著者

ARIMURA Mitsuharu KOGA Hiroki IWATA Ken-ichi

出版者

電子情報通信学会

雑誌

IEICE transactions on fundamentals of electronics, communications and computer sciences (ISSN:09168508)

巻号頁・発行日

vol.E96.A, no.12, pp.2443-2446, 2013-12

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In this letter, we first introduce a stronger notion of the optimistic achievable coding rate and discuss a coding theorem. Next, we give a necessary and sufficient condition under which the coding rates of all the optimal FF codes asymptotically converge to a constant.

著者

ARIMURA Mitsuharu KOGA Hiroki IWATA Ken-ichi

出版者

電子情報通信学会

雑誌

IEICE transactions on fundamentals of electronics, communications and computer sciences (ISSN:09168508)

巻号頁・発行日

vol.E96.A, no.12, pp.2332-2342, 2013-12

被引用文献数

1

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In this paper we consider fixed-to-fixed length (FF) coding of a general source X with vanishing error probability and define two kinds of optimalities with respect to the coding rate and the redundancy, where the redundancy is defined as the difference between the coding rate and the symbolwise ideal codeword length. We first show that the infimum achievable redundancy coincides with the asymptotic width W(X) of the entropy spectrum. Next, we consider the two sets $\mCH(\bX)$ and $\mCW(\bX)$ and investigate relationships between them, where $\mCH(\bX)$ and $\mCW(\bX)$ denote the sets of all the optimal FF codes with respect to the coding rate and the redundancy, respectively. We give two necessary and sufficient conditions corresponding to $\mCH(\bX) \subseteq \mCW(\bX)$ and $\mCW(\bX) \subseteq \mCH(\bX)$, respectively. We can also show the existence of an FF code that is optimal with respect to both the redundancy and the coding rate.

著者

Hiraoka Yoshinori Matsuoka Tatsuhiko Ohno Mikiko Nakamura Kazuhiro Saijo Sayaka Matsumura Shigenobu Nishi Kiyoto Sakamoto Jiro Chen Po-Min Inoue Kazuo Fushiki Tohru Kita Toru Kimura Takeshi Nishi Eiichiro

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-02-04

被引用文献数

33

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「体温恒常性維持のメカニズムの解明」に成功. 京都大学プレスリリース. 2014-02-04.

著者

Cui Guangwei Hara Takahiro Simmons Szandor Wagatsuma Keisuke Abe Akifumi Miyachi Hitoshi Kitano Satsuki Ishii Masaru Tani-Ichi Shizue Ikuta Koichi

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)

巻号頁・発行日

vol.111, no.5, pp.1915-1920, 2014-01-21

被引用文献数

141

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サイトカインIL-15を産生する細胞の可視化に成功 -免疫系の微小環境の解明に期待-. 京都大学プレスリリース. 2014-01-21.

著者

Yoshizawa Yuichi Honda Shin-ichiro Shibuya Akira

出版者

Elsevier

雑誌

Molecular immunology (ISSN:01615890)

巻号頁・発行日

vol.57, no.2, pp.216-219, 2014-02

被引用文献数

4

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Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr (Fcamr−/−Faslpr/lpr) mice. Fcamr−/−Faslpr/lpr mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr+/+Faslpr/lpr mice. Moreover, Fcamr−/−Faslpr/lpr mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr+/+Faslpr/lpr mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.