著者

동북아역사재단 러시아과학원 극동분소 역사고고민속학연구소 편 = Отчете об археологических раскопках Краскинского городища в российском Приморье / Фонд изчения Северо-Восточной Азии Институт Истории Археологии и Этнографии ДВО РАН

出版者

동북아역사재단

巻号頁・発行日

2010

著者

Yasuo HIRONAKA Tetsuya MORIMOTO Yasushi MOTOYAMA Young-Sue PARK Hiroyuki NAKASE

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.oa2012-0379, (Released:2013-10-21)

参考文献数

52

被引用文献数

1 13

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Surgical treatment for degenerative spinal disorders is controversial, although lumbar fusion is considered an acceptable option for disabling lower back pain. Patients underwent instrumented minimally invasive anterior lumbar interbody fusion (mini-ALIF) using a retroperitoneal approach except for requiring multilevel fusions, severe spinal canal stenosis, high-grade spondylolisthesis, and a adjacent segments disorders. We retrospectively reviewed the clinical records and radiographs of 142 patients who received mini-ALIF for L4-5 degenerative lumbar disorders between 1998 and 2010. We compared preoperative and postoperative clinical data and radiographic measurements, including the modified Japanese Orthopaedic Association (JOA) score, visual analog scale (VAS) score for back and leg pain, disc height (DH), whole lumbar lordosis (WL), and vertebral wedge angle (WA). The mean follow-up period was 76 months. The solid fusion rate was 90.1% (128/142 patients). The average length of hospital stay was 6.9 days (range, 3–21 days). The mean blood loss was 63.7 ml (range, 10–456 ml). The mean operation time was 155.5 min (range, 96–280 min). The postoperative JOA and VAS scores for back and leg pain were improved compared with the preoperative scores. Radiological analysis showed significant postoperative improvements in DH, WL, and WA, and the functional and radiographical outcomes improved significantly after 2 years. The 2.8% complication rate included cases of wound infection, liquorrhea, vertebral body fractures, and a misplaced cage that required revision. Mini-ALIF was found to be associated with improved clinical results and radiographic findings for L4-5 disorders. A retroperitoneal approach might therefore be a valuable treatment option.

著者

Yasuhiro Maejima Kiyoshi Nobori Yuichi Ono Susumu Adachi Jun-ichi Suzuki Kenzo Hirao Mitsuaki Isobe Hiroshi Ito for the Heart Failure by Coadministration of Statin and Angiotensin-II Receptor Blocker (HF-COSTAR) Trial Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.75, no.3, pp.589-595, 2011 (Released:2011-02-25)

参考文献数

38

被引用文献数

5 11

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Background: It is known that HMG-CoA reductase inhibitors (statins) may have a therapeutic benefit in patients with heart failure (HF). However, no studies have yet evaluated the possible interaction of statins and angiotensin-II receptor blockers (ARBs) on left ventricular (LV) function in patients with HF. We hypothesized that statins might alter the effect of ARBs on cardiac function in patients with HF. Methods and Results: We prospectively randomized patients with chronic HF who received the ARB, losartan (LOS group), or the statin, simvastatin (SIM), in combination with LOS (SIM+LOS group) at our hospitals and assessed before and after treatment for 6 months. Although no significant improvement of HF symptoms as evaluated by the New York Heart Association (NYHA) classification was observed in the LOS group, HF symptoms in the SIM+LOS group significantly improved. The percent increase of LV ejection fraction after treatment in the SIM+LOS group was significantly larger than in the LOS group. Furthermore, the plasma brain natriuretic peptide level was significantly lower after treatment in the SIM+LOS group than in the LOS group. Conclusions: Combined statin and ARB therapy significantly improves both symptoms and LV function over time in patients with HF. Thus, the combination of an ARB with a statin may be a useful therapeutic strategy for HF. (Circ J 2011; 75: 589-595)

著者

edited by Yu-Ying Brown sponsored by the British Library with support from the Japan Foundation ...

出版者

British Library

巻号頁・発行日

1990

著者

Toki-Zenmaro amu

出版者

Nippon-no-Rômazi-Sya

巻号頁・発行日

1924

著者

Hideki OHNO Shunsuke GOTO Masao OWAKI Joji OHTA Naoshi NAKAJIMA Kaori NAKATA Ken-ichiro MUTOH Toshifumi OYAMADA Kazuki YOSHIOKA

出版者

オカジマ・フォリア・アナトミカ・ヤポニカ編集部

雑誌

Okajimas Folia Anatomica Japonica (ISSN:0030154X)

巻号頁・発行日

vol.90, no.2, pp.31-39, 2013 (Released:2013-10-10)

参考文献数

18

被引用文献数

1

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Androgen is closely involved as the cause of rupture of anterior cruciate ligament (ACL) in human. In dogs, however, factors contributing to rupture of ACL remain unknown. In this study, expression of androgen receptor (AR) and histological distribution of blood vessels in ACL, and serum testosterone concentration were investigated in relation with age and sex to confirm whether canine ACL is an androgen-responsive tissue. Materials of ACL were obtained from 26 dogs: 12 young female Beagles, 2 old female mixed breeds, 9 young male Beagles, and 3 old male mixed breeds. In all canine ACL, positive AR expression was recognized in the nuclei of the fibrocytes, fibroblasts, synovial cells, and vascular endothelial cells of ACL. Expressions of AR were lesser in old males compared to the young males; however, females had no age difference in expression. Distributions of blood vessels in the synovial membrane of the ligament were fewer in old dogs both of males and females than youngs. Although distributions of vessels in the interstitium were apparently fewer in young females. Serum testosterone concentration was significantly higher in young males. Females had no age difference in the levels. From these results, it is suggested that canine ACL is an androgen-responsive tissue, and this consideration seems to closely relate to the epidemiological background that the incidence of rupture of ACL of dogs is higher in females than in males.

著者

Eun-Sun Choi Taeho Chung Jun-Sung Kim Hakmo Lee Ki Han Kwon Nam-Pyo Cho Sung-Dae Cho

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.53, no.2, pp.89-93, 2013 (Released:2013-08-31)

参考文献数

40

被引用文献数

3 12

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Mithramycin A (Mith) is an aureolic acid-type polyketide produced by various soil bacteria of the genus Streptomyces. Mith inhibits myeloid cell leukemia-1 (Mcl-1) to induce apoptosis in prostate cancer, but the molecular mechanism underlying this process has not been fully elucidated. The aim of this study was therefore to investigate the detailed molecular mechanism related to Mith-induced apoptosis in prostate cancer cells. Mith decreased the phosphorylation of mammalian target of rapamycin (mTOR) in both cell lines overexpressing phospho-mTOR compared to RWPE-1 human normal prostate epithelial cells. Mith significantly induced truncated Bid (tBid) and siRNA-mediated knock-down of Mcl-1 increased tBid protein levels. Moreover, Mith also inhibited the phosphorylation of mTOR on serine 2448 and Mcl-1, and increased tBid protein in prostate tumors in athymic nude mice bearing DU145 cells as xenografts. Thus, Mith acts as an effective tumor growth inhibitor in prostate cancer cells through the mTOR/Mcl-1/tBid signaling pathway.

著者

TRAN Nhat-Phuong LEE Myungho HONG Sugwon LEE Seung-Jae

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.96, no.8, pp.1685-1695, 2013

被引用文献数

1

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Data encryption and decryption are common operations in network-based application programs that must offer security. In order to keep pace with the high data input rate of network-based applications such as the multimedia data streaming, real-time processing of the data encryption/decryption is crucial. In this paper, we propose a new parallelization approach to improve the throughput performance for the de-facto standard data encryption and decryption algorithm, AES-CTR (Counter mode of AES). The new approach extends the size of the block encrypted at one time across the unit block boundaries, thus effectively encrypting multiple unit blocks at the same time. This reduces the associated parallelization overheads such as the number of procedure calls, the scheduling and the synchronizations compared with previous approaches. Therefore, this leads to significant throughput performance improvements on a computing platform with a general-purpose multi-core processor and a Graphic Processing Unit (GPU).

著者

『中之島百年-大阪府立図書館のあゆみ』編集委員会編集

出版者

大阪府立中之島図書館百周年記念事業実行委員会

巻号頁・発行日

2004

著者

Makoto NARUSE Masashi AONO Song-Ju KIM

出版者

一般社団法人 電子情報通信学会

雑誌

IEICE Transactions on Communications (ISSN:09168516)

巻号頁・発行日

vol.E96.B, no.11, pp.2724-2732, 2013-11-01 (Released:2013-11-01)

参考文献数

34

被引用文献数

1 5

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Nature-inspired devices and architectures are attracting considerable attention for various purposes, including the development of novel computing techniques based on spatiotemporal dynamics, exploiting stochastic processes for computing, and reducing energy dissipation. This paper demonstrates that networks of optical energy transfers between quantum nanostructures mediated by optical near-field interactions occurring at scales far below the wavelength of light could be utilized for solving a constraint satisfaction problem (CSP), the satisfiability problem (SAT), and a decision making problem. The optical energy transfer from smaller quantum dots to larger ones, which is a quantum stochastic process, depends on the existence of resonant energy levels between the quantum dots or a state-filling effect occurring at the larger quantum dots. Such a spatiotemporal mechanism yields different evolutions of energy transfer patterns in multi-quantum-dot systems. We numerically demonstrate that networks of optical energy transfers can be used for solution searching and decision making. We consider that such an approach paves the way to a novel physical informatics in which both coherent and dissipative processes are exploited, with low energy consumption.

著者

Heather D. Edginton Jeanine Peters-Kennedy Danny W. Scott

出版者

日本獣医皮膚科学会

雑誌

獣医臨床皮膚科 (ISSN:13476416)

巻号頁・発行日

vol.19, no.3, pp.149-153, 2013 (Released:2013-10-31)

参考文献数

21

被引用文献数

2

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ヒト,マウス,ウシ,ヒツジおよびアルパカでは,少数の常在T細胞が健常な表皮に存在する。加えてヒト,ウシおよびヒツジでは,少数の常在T細胞が真皮にも存在する。本研究の目的はリンパ球,CD3陽性細胞(Tリンパ球)ならびにPax5陽性細胞(Bリンパ球)が,健常犬の皮膚の真皮浅層および深層に存在するかを解析することであった。26頭の犬から採取された正常な皮膚の生検組織を対象として,真皮浅層および深層にCD3陽性細胞 ならびにPax5陽性細胞が存在するかを組織学的ならびに免疫組織化学的手法を用いて解析した。その結果,全ての検体において前述の細胞は認められなかった。この結果から,正常犬皮膚の真皮浅層および深層ではリンパ球がほとんど存在しないか,存在してもごく少数であることが示唆された。

著者

Huseyin Aydin Elhachmi Essadiqi In-Ho Jung Stephen Yue

出版者

一般社団法人 日本鉄鋼協会

雑誌

ISIJ International (ISSN:09151559)

巻号頁・発行日

vol.53, no.10, pp.1871-1880, 2013-10-15 (Released:2013-10-30)

参考文献数

22

被引用文献数

1 5

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In the present work, the effects of intercritical annealing parameters on the microstructure and cold rollability (deformation rate and ratio) of “3rd Generation Advanced High Strength Steels (AHSS)” were studied. Hence, this paper discusses the formation of microstructures with different volume fractions of ferrite, martensite, bainite and retained austenite (RA). Two novel microstructures have been created, based on two levels of manganese (Mn): (i) ferrite plus martensite nucleated in austenite microstructure (FMNA structures), using Mn levels of 5 to 7 wt% and (ii) ferrite plus retained austenite duplex structure (FADP steels) for a Mn level of 10 wt%. In general, the ductility is a function of the amount of retained austenite and the strength is highly dependent on the martensite level.

著者

Tanaka Shinsuke Kawaguchi Shin-Ya Shioi Go Hirano Tomoo

出版者

The Society for Neuroscience

雑誌

The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:02706474)

巻号頁・発行日

vol.33, no.43, pp.17209-17220, 2013-10-23

被引用文献数

41

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運動学習の新メカニズム解明に成功. 京都大学プレスリリース. 2013-10-23.

著者

Mohammad Mahbubur RAHMAN Akira YABUKI Moeko KOHYAMA Sawane MITANI Keijiro MIZUKAMI Mohammad Mejbah UDDIN Hye-Sook CHANG Kazuya KUSHIDA Miori KISHIMOTO Remi YAMABE Osamu YAMATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0443, (Released:2013-10-25)

被引用文献数

1 7

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GM2 gangliosidosis variant 0 (Sandhoff disease, SD) is a fatal, progressive neurodegenerative lysosomal storage disease caused by mutations of the HEXB gene. In canine SD, a pathogenic mutation (c.283delG) of the canine HEXB gene has been identified in toy poodles. In the present study, a TaqMan probe-based real-time PCR genotyping assay was developed and evaluated for rapid and large-scale genotyping and screening for this mutation. Furthermore, a genotyping survey was carried out in a population of toy poodles in Japan to determine the current mutant allele frequency. The real-time PCR assay clearly showed all genotypes of canine SD. The assay was suitable for large-scale survey as well as diagnosis, because of its high throughput and rapidity. The genotyping survey demonstrated a carrier frequency of 0.2%, suggesting that the current mutant allele frequency is low in Japan. However, there may be population stratification in different places, because of the founder effect by some carriers. Therefore, this new assay will be useful for the prevention and control of SD in toy poodles.

著者

Sungjin CHOI I-Li LIU Kenichi YAMAMOTO Muneki HONNAMI Takamasa SAKAI Shinsuke OHBA Ryosuke ECHIGO Shigeki SUZUKI Ryouhei NISHIMURA Ung-Il CHUNG Nobuo SASAKI Manabu MOCHIZUKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0054, (Released:2013-10-25)

被引用文献数

3 8

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We investigated biodegradability and new bone formation after implantation of tetrapod-shaped granular artificial bone (Tetrabone®) or β-tricalcium phosphate granules (β-TCP) in experimental critical-size defects in dogs, which were created through medial and lateral femoral condyles. The defect was packed with Tetrabone® (Tetrabone group) or β-TCP (β-TCP group) or received no implant (control group). Computed tomography (CT) was performed at 0, 4 and 8 weeks after implantation. Micro-CT and histological analysis were conducted to measure the non-osseous tissue rate and the area and distribution of new bone tissue in the defect at 8 weeks after implantation. On CT, β-TCP was gradually resorbed, while Tetrabone® showed minimal resorption at 8 weeks after implantation. On micro-CT, non-osseous tissue rate of the control group was significantly higher compared with the β-TCP and Tetrabone groups (P<0.01), and that of the β-TCP group was significantly higher compared with the Tetrabone group (P<0.05). On histology, area of new bone tissue of the β-TCP group was significantly greater than those of the Tetrabone and control groups (P<0.05), and new bone distribution of the Tetrabone group was significantly greater than those of the β-TCP and control groups (P<0.05). These results indicate differences in biodegradability and connectivity of intergranule pore structure between study samples. In conclusion, Tetrabone® may be superior for the repair of large bone defects in dogs.

著者

郡司 ペギオ-幸夫 澤 宏司

出版者

日本認知科学会

雑誌

認知科学 = Cognitive studies : bulletin of the Japanese Cognitive Science Society (ISSN:13417924)

巻号頁・発行日

vol.15, no.3, pp.442-456, 2008-09-01

被引用文献数

3

著者

HUANG Min Li LEE Jin SETIAWAN Hendra OCHI Hiroshi PARK Sin-Chong

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE transactions on communications (ISSN:09168516)

巻号頁・発行日

vol.93, no.4, pp.948-960, 2010-04-01

参考文献数

15

被引用文献数

1 2

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With the growing demand for high-performance multimedia applications over wireless channels, we need to develop a Medium Access Control (MAC) system that supports high throughput and quality of service enhancements. This paper presents the standard analysis, design architecture and design issues leading to the implementation of an IEEE 802.11e based MAC system that supports MAC throughput of over 100Mbps. In order to meet the MAC layer timing constraints, a hardware/software co-design approach is adopted. The proposed MAC architecture is implemented on the Xilinx Virtex-II Pro Field-Programmable Gate Array (FPGA) (XC2VP70-5FF1704C) prototype, and connected to a host computer through an external Universal Serial Bus (USB) interface. The total FPGA resource utilization is 11, 508 out of 33, 088 (34%) available slices. The measured MAC throughput is 100.7Mbps and 109.2Mbps for voice and video access categories, transmitted at a data rate of 260Mbps based on IEEE 802.11n Physical Layer (PHY), using the contention-based hybrid coordination function channel access mechanism.

著者

高久 晃 福井 仁士 JUNG Hee-Won HAN Dae Hee O-Ki Kwon CHO Byung-Kyu CHOI Kil Soo 森田 明夫 若井 晋 島 健 端 和夫 早川 徹 桐野 高明

出版者

日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.38, no.5, pp.305-321, 1998-05-15

著者

Katada Shun Mito Takayuki Ogasawara Emi Hayashi Jun-Ichi Nakada Kazuto

出版者

Genetics Society of America

雑誌

G3: Genes, Genomes, Genetics (ISSN:21601836)

巻号頁・発行日

vol.3, no.9, pp.1545-1552, 2013-09

被引用文献数

15

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Studies in patients have suggested that the clinical phenotypes of some mitochondrial diseases might transit from one disease to another (e.g., Pearson syndrome [PS] to Kearns-Sayre syndrome) in single individuals carrying mitochondrial (mt) DNA with a common deletion (∆mtDNA), but there is no direct experimental evidence for this. To determine whether ∆mtDNA has the pathologic potential to induce multiple mitochondrial disease phenotypes, we used trans-mitochondrial mice with a heteroplasmic state of wild-type mtDNA and ∆mtDNA (mito-mice∆). Late-stage embryos carrying ≥50% ∆mtDNA showed abnormal hematopoiesis and iron metabolism in livers that were partly similar to PS (PS-like phenotypes), although they did not express sideroblastic anemia that is a typical symptom of PS. More than half of the neonates with PS-like phenotypes died by 1 month after birth, whereas the rest showed a decrease of ∆mtDNA load in the affected tissues, peripheral blood and liver, and they recovered from PS-like phenotypes. The proportion of ∆mtDNA in various tissues of the surviving mito-mice∆ increased with time, and Kearns-Sayre syndrome−like phenotypes were expressed when the proportion of ∆mtDNA in various tissues reached >70–80%. Our model mouse study clearly showed that a single ∆mtDNA was responsible for at least two distinct disease phenotypes at different ages and suggested that the level and dynamics of ∆mtDNA load in affected tissues would be important for the onset and transition of mitochondrial disease phenotypes in mice.

著者

Hisamitsu Akiba Y-h. Taguchi

出版者

一般社団法人 情報処理学会

雑誌

IPSJ Transactions on Bioinformatics (ISSN:18826679)

巻号頁・発行日

vol.1, pp.35-41, 2008 (Released:2008-11-28)

参考文献数

12

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The Barcode of Life (BOL) project aims to identify species with no other information than DNA sequence. We assume that BOL includes information on higher taxa. In the present study, we compute nonmetric distance from BOL barcodes by using rank order of pairwise distance for 3 distinct examples, namely, Ant Diversity in Northern Madagascar, Survey of Chelicerates, and Birds of North America. This enables us to recognize higher taxa, i.e., genus, family, and order, more easily. For example, the ratio of mean inner taxa nonmetric distance to the intertaxa distance is smaller than that for raw (metric) distance. Furthermore, for most pairs of higher taxa, the mean intertaxa distance is more than twice larger than intrataxa distances. The nonmetric multidimensional scaling method enables to discriminate higher taxa compared to tree construction by the neighbor-joining method or the maximum parsimony method with raw distance measure, when each species is embedded into more than 40 dimensional space with an accuracy of 90% even after leave-one-out-cross-validation.