著者

FERREIRA Luiz A 澤渡 信之 戸田 晃一

出版者

富山県立大学

雑誌

富山県立大学紀要 (ISSN:09167633)

巻号頁・発行日

vol.20, pp.pp15-24, 2010-03

著者

A.C. マッキンタイア 竹中 久留美

出版者

東洋大学国際哲学研究センター

雑誌

国際哲学研究 = Journal of International Philosophy (ISSN:21868581)

巻号頁・発行日

no.3, pp.165-174, 2014-03-31

著者

edited by N. Jardine J.A. Secord and E.C. Spary

出版者

Cambridge University Press

巻号頁・発行日

1996

著者

A.P. Prudnikov Yu.A. Brychkov O.I. Marichev translated from the Russian by N.M. Queen

出版者

Gordon and Breach Science Publishers

巻号頁・発行日

1986

著者

Tatsuya Umeda Ai Hayashi Akiko Harada Kotoba Okuyama Carl A. Baxter Shigeru Tokita Tamio Teramoto

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0971, (Released:2018-04-07)

参考文献数

37

被引用文献数

7

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Background:To understand the recent management status in Japan, we determined the low-density lipoprotein cholesterol (LDL-C) goal attainment (GA) rate of patients initiating statin monotherapy for dyslipidemia.Methods and Results:Dyslipidemic patients undergoing either primary prevention with high cardiovascular risk or secondary prevention (defined by 2012 Japan Atherosclerosis Society Guidelines) were retrospectively analyzed from a hospital-based claims database. In both groups, the LDL-C levels and GA rates of patients treated with intensive or standard statin monotherapy for ≥4 weeks (January 2012–August 2016) were evaluated. Among 1,501,013 dyslipidemic patients, 11,695 and 9,642 were included in the primary and secondary prevention groups, respectively. A total of 94% of patients underwent statin monotherapy as the initial lipid-lowering therapy, of which most (≥80%) took intensive statins. The proportions of patients in the primary prevention group who achieved an LDL-C goal <120 mg/dL by intensive and standard statins were 81.1% and 61.2%, respectively, and the proportions of those who achieved a goal <100 mg/dL in the secondary prevention group were 73.3% and 48.1%, respectively. The GA rates were similar regardless of disease complications.Conclusions:Most patients (>70%) in both groups achieved LDL-C management goals using intensive statin monotherapy. Further treatment approaches are required for high-risk patients not achieving LDL-C goals by initial statin monotherapy. Continuous efforts are crucial for adherence and persistence of lipid-lowering therapies.

著者

Stephen A. McCullough Michael A. Fifer Pouya Mohajer Patricia A. Lowry Caitlin O’Callaghan Reen Aaron L. Baggish Gus J. Vlahakes Yuichi J. Shimada

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0959, (Released:2018-03-09)

参考文献数

25

被引用文献数

8

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Background:The clinical characteristics associated with elevated right atrial pressure (RAP) in hypertrophic cardiomyopathy (HCM) are unknown. Few data exist as to whether elevated RAP has prognostic implications in patients with HCM. This study investigated the clinical correlates and prognostic value of elevated RAP in HCM.Methods and Results:This retrospective cohort study was performed on 180 patients with HCM who underwent right heart catheterization between 1997 and 2014. Elevated RAP was defined as >8 mmHg. Baseline characteristics, mean pulmonary artery pressure, and mean pulmonary capillary wedge pressure (PCWP) were assessed for association with elevated RAP. The predictive value of elevated RAP for all-cause mortality and the development of atrial fibrillation (AF), ventricular tachycardia/fibrillation (VT/VF), and stroke was evaluated. Elevated RAP was associated with higher New York Heart Association class, dyspnea on exertion, orthopnea, edema, jugular venous distention, larger left atrial size, right ventricular hypertrophy, higher pulmonary artery pressure, and higher PCWP. RAP independently predicted all-cause mortality (adjusted hazard ratio [aHR] 2.18 per 5-mmHg increase, 95% confidence interval [CI] 1.05–4.50, P=0.04) and incident AF (aHR 1.85 per 5-mmHg increase, 95% CI 1.20–2.85, P=0.005). Elevated RAP did not predict VT/VF (P=0.36) or stroke (P=0.28).Conclusions:Elevated RAP in patients with HCM is associated with left-sided heart failure and is an independent predictor of all-cause mortality and new-onset AF.

著者

A.K.

出版者

公益社団法人日本船舶海洋工学会

雑誌

造船協会雑纂 (ISSN:03861597)

巻号頁・発行日

no.107, pp.25-27, 1931-02

著者

edited by Richard J.A. Talbert in collaboration with Roger S. Bagnall ... [et al.] and map editors Mary E. Downs M. Joann McDaniel cartographic managers Janet E. Kelly Jeannine M. Schonta David F. Stong

出版者

Princeton University Press

巻号頁・発行日

2000

著者

Keith F. Otterbein with a foreword by Robert L. Carneiro

出版者

HRAF Press

巻号頁・発行日

1989

著者

Yuki TANIDA Taiji UENO Matthew A. LAMBON RALPH Satoru SAITO

出版者

プシコロギア会

雑誌

PSYCHOLOGIA (ISSN:00332852)

巻号頁・発行日

vol.58, no.3, pp.145-154, 2015 (Released:2016-09-24)

参考文献数

20

被引用文献数

1

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It is well established that the phonological system captures the quasiregularity of phoneme sequences. For example, repetition performance is better for nonwords composed of phoneme combinations that occur frequently in one’s native language. Although phoneme sequences are necessarily accompanied by suprasegmental aspects (e.g., accent patterns), the influence of suprasegmental aspects has not been investigated extensively. This study examined the influence of Japanese pitch-accent pattern on nonword repetition. Exploration of nonwords provides an opportunity to investigate phonological factors largely without lexical and semantic influences. We conducted immediate and delayed nonword repetition experiments, manipulating phonotactic frequency and pitch-accent type. Two experiments revealed that nonwords presented with atypical accent patterns showed more frequent phonemic and accent pattern errors than nonwords with more typical accent patterns. The results indicate that the phonological system captures a range of sublexical phonological characteristics found in each language through linguistic experiences and is not limited to coding phonemic sequences alone. We suggest that although there is diversity in functioning of phonological systems driven by linguistic variability, such diversity stems from universal learning mechanisms in language processing systems.

著者

ZENT A. P.

雑誌

Icarus

巻号頁・発行日

vol.108, pp.146-157, 1994

被引用文献数

1 173

著者

Takaharu ITAMI Yasuo SAITO Tomohito ISHIZUKA Jun TAMURA Mohammed A. UMAR Hiroki INOUE Kenjiro MIYOSHI Kazuto YAMASHITA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0638, (Released:2016-02-11)

被引用文献数

5

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This study aimed to compare the pharmacokinetics of tramadol between young and middle-aged dogs. Tramadol (4 mg/kg) was administered intravenously (IV) to young and middle-aged dogs (2 and 8–10 years, respectively). Plasma concentrations of tramadol were measured using high-performance liquid chromatography (HPLC), and its pharmacokinetics best fit a two-compartment model. The volume of distribution (Vd), elimination half-life (t1/2,β) and total body clearance (CLtot) of the young group were 4.77 ± 1.07 l/kg, 1.91 ± 0.26 hr and 29.9 ± 7.3 ml/min/kg, respectively, while those of the middle-aged group were 4.73 ± 1.43 l/kg, 2.39 ± 0.97 hr and 23.7 ± 5.4 ml/min/kg, respectively. Intergroup differences in the t1/2,β and CLtot were significant (P<0.05). In conclusion, tramadol excretion was significantly prolonged in middle-aged dogs.

著者

Seiji KATO Norman G. LOEB David A. RUTAN Fred G. ROSE

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.93, no.6, pp.597-612, 2015 (Released:2016-01-13)

参考文献数

107

被引用文献数

11

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NASA’s Clouds and the Earth’s Radiant Energy System (CERES) project integrates CERES, Moderate Resolution Imaging Spectroradiometer (MODIS), and geostationary satellite observations to provide top-of-atmosphere (TOA) irradiances derived from broadband radiance observations by CERES instruments. It also uses snow cover and sea ice extent retrieved from microwave instruments as well as thermodynamic variables from reanalysis. In addition, these variables are used for surface and atmospheric irradiance computations. The CERES project provides TOA, surface, and atmospheric irradiances in various spatial and temporal resolutions. These data sets are for climate research and evaluation of climate models. Long-term observations are required to understand how the Earth system responds to radiative forcing. A simple model is used to estimate the time to detect trends in TOA reflected shortwave and emitted longwave irradiances.

著者

Kenzo Tanaka Koichiro Gibo Hiroko Watase Masaki Oohashi Carlos A. Camargo Kohei Hasegawa on behalf of the Japanese Emergency Medicine Network Investigators

出版者

日本プライマリ・ケア連合学会

雑誌

Journal of General and Family Medicine (ISSN:21896577)

巻号頁・発行日

vol.16, no.4, pp.281-287, 2015-12-20 (Released:2015-12-25)

参考文献数

14

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Background: Little is known about the extent that acute asthma is inappropriately treated with antibiotics in Japanese emergency departments (EDs).Objectives: We examined the proportion and predictors of inappropriate antibiotic use for adults with acute asthma in the Japanese EDs.Methods: We conducted a chart review study in 23 Japanese EDs. Subjects were ED patients aged 18 to 54 years with acute asthma between 2009 and 2011. To examine predictors of inappropriate antibiotic use, we performed multi-level logistic regression analysis at both the patient- and ED-level modeling EDs as a random variable.Results: Among 1380 patients in the overall study, the analytic cohort comprised 1311 patients. Overall, antibiotics were inappropriately prescribed for 4.4% (95% confidence interval [CI], 3.4%–5.7%). In the multi-level logistic regression analysis, higher annual ED asthma visit volume was significantly associated with a lower proportion of inappropriate antibiotic use (odds ratio per 100-visit increase, 0.3 ; 95%CI, 0.2–0.6).Conclusions: In this large multicenter study in Japan, we found that approximately 4% of ED patients with acute asthma were inappropriately treated with antibiotics. We also demonstrated that the inappropriate use of antibiotics largely differed across the EDs and was less common in EDs with a more annual ED asthma visits. Organized knowledge translation initiatives are warranted to address this gap in emergency asthma care.

著者

Long John A.

出版者

日経サイエンス

雑誌

日経サイエンス (ISSN:0917009X)

巻号頁・発行日

vol.41, no.4, pp.34-41, 2011-04

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2005 年の8月,豪メルボルンにあるビクトリア博物館の研究チームは,同国北西部の有名な化石産地ゴーゴーで太古の魚の化石を見つけ,持ち帰ります。約3億 7500万年前の古生代デボン紀の海を泳いでいた最も原始的な魚類にして,最初に顎をもった脊椎動物,板皮類(ばんぴるい)の化石です。

著者

Giulianne C. CROCIOLLI Renata N. CASSU Rafael C. BARBERO Thalita L.A ROCHA Denis R. GOMES Gabriel M. NICÁCIO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0602, (Released:2015-03-29)

被引用文献数

4 38

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This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperative pain management in dogs. Twenty dogs undergoing mastectomy were randomized to receive perioperative oral placebo or gabapentin (10 mg/kg). All dogs were premedicated with intramuscular acepromazine (0.03 mg/kg) and morphine (0.3 mg/ kg). Anesthesia was induced with propofol (4 mg/kg) intravenously and maintained with isoflurane. Intravenous meloxicam (0.2 mg/kg) was administered preoperatively. Postoperative analgesia was evaluated for 72 hr. Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Dogs in the Placebo group received significantly more morphine doses than the Gabapentin group (P=0.021) despite no significant differences in pain scores. Perioperative gabapentin reduced the postoperative morphine requirements in dogs after mastectomy.

著者

Song Qilei Cao Shuai Pritchard Robyn H Ghalei Behnam Al-Muhtaseb Shaheen A Terentjev Eugene M Cheetham Anthony K Sivaniah Easan

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-09-04

被引用文献数

255

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排ガスを膜でキャッチ -空気洗浄技術、実用化に期待-. 京都大学プレスリリース. 2014-09-10.

著者

Rebecca C. REGAN Robert M. GOGAL Jr James P. BARBER R. Cary TUCKFIELD Elizabeth W. HOWERTH Jessica A. LAWRENCE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0537, (Released:2014-09-15)

被引用文献数

9

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Loperamide is a peripheral opiate agonist that can cause apoptosis and G2/M arrest in human cancer cell lines and may sensitize cells to chemotherapy. The objectives of this study were to investigate the effects of loperamide on viability, apoptosis and cell cycle kinetics in canine cancer cells and to establish whether the drug sensitizes cells to doxorubicin. Cell viability was assessed using Alamar Blue. Cell death and cell cycle were studied using flow cytometry with 7-Aminoactinomycin-D (7-AAD) and propidium iodide (PI), respectively. Loperamide decreased cell viability in a dose-dependent fashion and was most effective against canine osteosarcoma cells. In all cell lines, it induced a dose and time dependent apoptosis and resulted in accumulation in G0/G1. When co-incubated with doxorubicin, loperamide induced a synergistic cell kill in canine carcinoma cells. Investigation is warranted into the role of loperamide in the treatment of canine cancer.

著者

A. ベーク著 安酸敏眞訳

出版者

知泉書館

巻号頁・発行日

2014

著者

Awad A.Shehata Wieland Schrödl Philipp Schledorn Monika Krüger

出版者

日本家禽学会

雑誌

The Journal of Poultry Science (ISSN:13467395)

巻号頁・発行日

vol.51, no.3, pp.333-337, 2014-07-25 (Released:2014-07-25)

参考文献数

25

被引用文献数

2 17

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Glyphosate (N-(phosphonomethyl) glycine) is a most popular herbicide in agricultural practices throughout the world. It is possible that glyphosate spread in the ecosystems can reach plants, animals. The present work was directed to investigate the glyphosate residue in different organs of broiler chickens using ELISA and to study the possibility of its neutralisation using humic acid, Chlorella vulgaris and Saccharomyces boulardii. Results showed that glyphosate residues could be detected in the animal feed and different organs as liver, spleen, lung, intestine, heart, muscles and kidney. Humic acid, Chlorella vulgaris and Saccharomyces boulardii showed neutralization of the antimicrobial effect of glyphosate in vitro. Also, feed supplementation of commercial broiler with humic acid (0.2%) leads to a significant decrease in the glyphosate content, i.e. by 53%, 28%, 44%, 50%, 56%, 16%, 63% and 0% in serum, liver, spleen, lung, gastro-intestinal tract, heart, muscles and kidney, respectively. There were no significant effects of humic acid on the production parameters. This enlightenment will help to overcome the negative effect of glyphosate residues on gastrointestinal microbiota and protect consumers from glyphosate residues in chicken meat.