著者
Crystal L. GRANT Jillian DORRIAN Alison M. COATES Maja PAJCIN David J. KENNAWAY Gary A. WITTERT Leonie K HEILBRONN Chris DELLA VEDOVA Charlotte C. GUPTA Siobhan BANKS
出版者
独立行政法人 労働安全衛生総合研究所
雑誌
Industrial Health (ISSN:00198366)
巻号頁・発行日
pp.2017-0047, (Released:2017-07-25)
被引用文献数
25

This study examined the impact of eating during simulated night shift on performance and subjective complaints. Subjects were randomized to eating at night (n=5; 23.2±5.5y) or not eating at night (n=5; 26.2±6.4y). All participants were given one sleep opportunity of 8h (22:00h-06:00h) before transitioning to the night shift protocol. During the four days of simulated night shift participants were awake from 16:00h-10:00h with a daytime sleep of 6h (10:00h-16:00h). In the simulated night shift protocol, meals were provided at ≈0700h, 1900h and 0130h (eating at night); or ≈0700h, 0930h, 1410h and 1900h (not eating at night). Subjects completed sleepiness, hunger and gastric complaint scales, a Digit Symbol Substitution Task and a 10-minute Psychomotor Vigilance Task. Increased sleepiness and performance impairment was evident in both conditions at 0400h (p<0.05). Performance impairment at 0400h was exacerbated when eating at night. Not eating at night was associated with elevated hunger and a small but significant elevation in stomach upset across the night (p<0.026). Eating at night was associated with elevated bloating on night one, which decreased across the protocol. Restricting food intake may limit performance impairments at night. Dietary recommendations to improve night-shift performance must also consider worker comfort.
著者
by R.A. Donkin
出版者
W. Junk
巻号頁・発行日
1980
著者
永崎 研宣 三宅 真紀 苫米地 等流 A.CharlesMuller 下田 正弘
雑誌
じんもんこん2013論文集
巻号頁・発行日
vol.2013, no.4, pp.239-246, 2013-12-05

本稿は、大正新脩大藏經テキストデータベースにおける脚注の校勘情報を通じた人文学資料としてのテクスト構造化に関する研究を扱う。これはこのデータベースを構築・運用するSAT プロジェクトの次のフェーズの方針の策定に役立てることを目指すものである。大正新脩大藏經の校勘情報は、各一次資料の歴史的な関係からある程度想定可能だが、具体的に研究されてきたわけではなかった。ここでは、デジタル化された校勘情報を用いた分析を行ったが、結果は一般的な想定を裏付けするものであった。いくつかの例外的なものがあったことが、今後の方針を策定する上で有益かもしれない。また、Linked Data という形で校勘情報を扱うことで、一次資料公開に関する権利所有者との合意形成が容易になるかもしれない。
著者
Hiromi KATO Masayuki ANZAI Tasuku MITANI Masahiro MORITA Yui NISHIYAMA Akemi NAKAO Kenji KONDO Petr A. LAZAREV Tsuyoshi OHTANI Yasuyuki SHIBATA Akira IRITANI
出版者
The Japan Academy
雑誌
Proceedings of the Japan Academy, Series B (ISSN:03862208)
巻号頁・発行日
vol.85, no.7, pp.240-247, 2009 (Released:2009-07-31)
参考文献数
27
被引用文献数
9 19

Here, we report the recovery of cell nuclei from 14,000-15,000 years old mammoth tissues and the injection of those nuclei into mouse enucleated matured oocytes by somatic cell nuclear transfer (SCNT). From both skin and muscle tissues, cell nucleus-like structures were successfully recovered. Those nuclei were then injected into enucleated oocytes and more than half of the oocytes were able to survive. Injected nuclei were not taken apart and remained its nuclear structure. Those oocytes did not show disappearance of nuclear membrane or premature chromosome condensation (PCC) at 1 hour after injection and did not form pronuclear-like structures at 7 hours after injection. As half of the oocytes injected with nuclei derived from frozen-thawed mouse bone marrow cells were able to form pronuclear-like structures, it might be possible to promote the cell cycle of nuclei from ancient animal tissues by suitable pre-treatment in SCNT. This is the first report of SCNT with nuclei derived from mammoth tissues.(Contributed by Akira IRITANI, M.J.A.)
著者
Martel A Blooi M Adriaensen C Van Rooij P Beukema W Fisher M C Farrer R A Schmidt B R Tobler U Goka K Lips K R Muletz C Zamudio K R Bosch J Lötters S Wombwell E Garner T W J Cunningham A A Spitzen-van der Sluijs A Salvidio S Ducatelle R Nishikawa K Nguyen T T Kolby J E Van Bocxlaer I Bossuyt F Pasmans F
出版者
American Association for the Advancement of Science
雑誌
Science (ISSN:00368075)
巻号頁・発行日
vol.346, no.6209, pp.630-631, 2014-10-31
被引用文献数
383

両生類の新興感染症イモリツボカビがアジア起源であることを解明 -グローバル化がもたらす生物多様性への脅威-. 京都大学プレスリリース. 2014-11-05.
著者
Endurance A. Ophori Musa Y. Tula Azuka V. Azih Rachel Okojie Precious E. Ikpo
出版者
日本熱帯医学会
雑誌
Tropical Medicine and Health (ISSN:13488945)
巻号頁・発行日
pp.2013-13, (Released:2014-04-23)
被引用文献数
2 82

Immunization is aimed at the prevention of infectious diseases. In Nigeria, the National Programme on Immunization (NPI) suffers recurrent setbacks due to many factors including ethnicity and religious beliefs. Nigeria is made up of 36 states with its federal capital in Abuja. The country is divided into six geo-political zones; north central, north west, north east, south east, south west and south south. The population is unevenly distributed across the country. The average population density in 2006 was estimated at 150 people per square kilometres with Lagos, Anambra, Imo, Abia, and Akwa Ibom being the most densely populated states. Most of the densely populated states are found in the south east. Kano with an average density of 442 persons per square kilometre, is the most densely populated state in the northern part of the country. This study presents a review on the current immunization programme and the many challenges affecting its success in the eradication of childhood diseases in Nigeria.
著者
Maria D. Perez-Carceles Maria D. Medina Domingo Perez-Flores Jose A. Noguera Juan E. Pereniguez Manuel Madrigal Aurelio Luna
出版者
(公社)日本産業衛生学会
雑誌
Journal of Occupational Health (ISSN:13419145)
巻号頁・発行日
pp.13-0119-OA, (Released:2014-01-16)
被引用文献数
1 8

Objectives: Despite the great impact the migration has had in economic, social and health-related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem by means of a self-reported questionnaire (Alcohol Use Disorders Identification Test-AUDIT) and a biomarker (carbohydrate-deficient transferrin-CDT) and to ascertain associated risk factors. Methods: A cross-sectional survey was conducted using a random sample of 385 migrant workers, undergoing a routine health examination as part of occupational health services. Results: The results showed that 13.8% (n=53) of the workers were screened as positive with the AUDIT (≥ 8) and/or CDT (> 2.6) and identified as hazardous drinkers and that 53.8% (n=207) were teetotallers. Being a man (OR: 2.0), working in the construction industry (OR: 2.8) or agriculture (OR: 2.2), being resident in Spain for more than 7 years (OR: 2.3) and sharing a house with friends were the factors most closely associated with hazardous drinking. Conclusions: Prevention-orientated programs, adjusted to the characteristics of each country and the origin of the migrants themselves, should be instituted to modify the drinking habits of migrant workers considered at risk.
著者
SMITH A. R.
雑誌
Computers Graphics
巻号頁・発行日
vol.12, pp.12-19, 1978
被引用文献数
40 614
著者
Hajime Yoshifuji Yoshikazu Nakaoka Haruhito A. Uchida Takahiko Sugihara Yoshiko Watanabe Sohei Funakoshi Mitsuaki Isobe Masayoshi Harigai Japan Research Committee of the Ministry of Health Labour and Welfare for Intractable Vasculitis (JPVAS)
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-23-0656, (Released:2023-12-19)
参考文献数
34
被引用文献数
1

Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan’s Intractable Disease Registry.Methods and Results: After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity symptoms, a higher prevalence of organ damage, and a higher proportion of patients requiring nursing care. Compared with men, women tended to have an earlier onset age, exhibiting longer disease duration. A higher proportion of women had aortic regurgitation and required nursing care. The proportion of female patients in employment was lower than that of the general female population, whereas no difference was observed between male patients and the general male population. Logistic regression analysis revealed that age at surveillance, brain ischemia, visual impairment/loss, and ischemic heart disease were significant factors associated with high nursing care needs (Level ≥2, with daily activity limitations).Conclusions: Early diagnosis and effective treatment, particularly to prevent brain ischemia, visual impairment, and ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women.
著者
古川 智恵子 中田 明美 フルカワ ナカタ C. FURUKAWA A. NAKATA
雑誌
名古屋女子大学紀要 = Journal of the Nagoya Women's College
巻号頁・発行日
vol.31, pp.1-12, 1985-03-01

"現代のように,上に衣服を着ける社会では,褌は下着として軽視されやすいが,本来は前布によって紐衣を飾るハレの衣装であった.従って,わが国においても,昭和初期頃まで漁山村を問わず,仕事着として用いられていた事は,納得のいく事である.人間は権力を現わす手段の一つとして衣を用いてその形を変え,幾多の装飾を施してきた.しかし,褌は表着のめまぐるしい変化に対して,簡略化される事はあっても,大きく変化する事はなかった.それは,褌が人間工学的な機能美を最も追求した「衣」だったからである.シンプルな衣によってアピールするには,素材が一番重要なポイントである.従って,長い歴史の中で木綿だけでなく,絹羽二重や縮緬等の高価な素材も用いられるようになったのである.褌は,現在のファッションの動向である,最小限度という「ミニマル」の真髄を何千年もの間保ち続け,生きた日本文化を今日に伝える貴重な文化財である.伝統ある褌の形態や機能性は,時代の新しい息吹きを吹きこまれながら,若者の下着やビキニに,今後も脈々と生き続けていくであろう.褌のルーツを探る事によって日本文化の一端にふれ,愛着やいとおしさを覚えるものである."
著者
冨菜 雄介 Daniel A. WAGENAAR
出版者
日本比較生理生化学会
雑誌
比較生理生化学 (ISSN:09163786)
巻号頁・発行日
vol.35, no.3, pp.168-177, 2018-12-25 (Released:2019-01-21)
参考文献数
16

本技術ノートでは,2台の蛍光顕微鏡を上下に組み合わせて作製した両側型顕微鏡を利用することで可能となった網羅的膜電位イメージング法を紹介する。材料はチスイビル類(医用ビル; Hirudo verbana)の体節神経節である。ヒルの体節神経節はその背腹表面の2層に総計約400個のニューロンの細胞体が分布する。単離した神経節の背側と腹側に分布するニューロン群を膜電位感受性色素で染色し,この2層から同時に膜電位イメージングする手法(両側膜電位イメージング法)を適用した。また,新規な膜電位感受性色素VoltageFluorを用いることで,カルシウムイメージングでは検出の困難な閾値下脱分極性シグナルや過分極性シグナルを良好なS/N比で記録することが可能となった。今後の課題は,褪色を避けながら長時間イメージングを行うこと,セミインタクト標本において膜電位イメージングを行うこと等である。
著者
Masaki Ishida Jérôme Yerly Haruno Ito Masafumi Takafuji Shiro Nakamori Shinichi Takase Yoshito Ichiba Yoshiaki Komori Kaoru Dohi Davide Piccini Jessica A.M. Bastiaansen Matthias Stuber Hajime Sakuma
出版者
Japanese Society for Magnetic Resonance in Medicine
雑誌
Magnetic Resonance in Medical Sciences (ISSN:13473182)
巻号頁・発行日
pp.tn.2022-0086, (Released:2023-01-20)
参考文献数
17
被引用文献数
2

Free-running 5D whole-heart coronary MR angiography (MRA) is gaining in popularity because it reduces scanning complexity by removing the need for specific slice orientations, respiratory gating, or cardiac triggering. At 3T, a gradient echo (GRE) sequence is preferred in combination with contrast injection. However, neither the injection scheme of the gadolinium (Gd) contrast medium, the choice of the RF excitation angle, nor the dedicated image reconstruction parameters have been established for 3T GRE free-running 5D whole-heart coronary MRA. In this study, a Gd injection scheme, RF excitation angles of lipid-insensitive binominal off-resonance RF excitation (LIBRE) pulse for valid fat suppression and continuous data acquisition, and compressed-sensing reconstruction regularization parameters were optimized for contrast-enhanced free-running 5D whole-heart coronary MRA using a GRE sequence at 3T. Using this optimized protocol, contrast-enhanced free-running 5D whole-heart coronary MRA using a GRE sequence is feasible with good image quality at 3T.
著者
Gertraud Maskarinec Phyllis Raquinio Bruce S. Kristal Adrian A. Franke Steven D. Buchthal Thomas M. Ernst Kristine R. Monroe John A. Shepherd Yurii B. Shvetsov Loïc Le Marchand Unhee Lim
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.32, no.7, pp.314-322, 2022-07-05 (Released:2022-07-05)
参考文献数
39
被引用文献数
1 7

Background: As the proportion of visceral (VAT) to subcutaneous adipose tissue (SAT) may contribute to type 2 diabetes (T2D) development, we examined this relation in a cross-sectional design within the Multiethnic Cohort that includes Japanese Americans known to have high VAT. The aim was to understand how ectopic fat accumulation differs by glycemic status across ethnic groups with disparate rates of obesity, T2D, and propensity to accumulate VAT.Methods: In 2013–2016, 1,746 participants aged 69.2 (standard deviation, 2.7) years from five ethnic groups completed questionnaires, blood collections, and whole-body dual X-ray absorptiometry and abdominal magnetic resonance imaging scans. Participants with self-reported T2D and/or medication were classified as T2D, those with fasting glucose >125 and 100–125 mg/dL as undiagnosed cases (UT2D) and prediabetes (PT2D), respectively. Using linear regression, we estimated adjusted means of adiposity measures by T2D status.Results: Overall, 315 (18%) participants were classified as T2D, 158 (9%) as UT2D, 518 (30%) as PT2D, and 755 (43%) as normoglycemic (NG), with significant ethnic differences (P < 0.0001). In fully adjusted models, VAT, VAT/SAT, and percent liver fat increased significantly from NG, PT2D, UT2D, to T2D (P < 0.001). Across ethnic groups, the VAT/SAT ratio was lowest for NG participants and highest for T2D cases. Positive trends were observed in all groups except African Americans, with highest VAT/SAT in Japanese Americans.Conclusion: These findings indicate that VAT plays an important role in T2D etiology, in particular among Japanese Americans with high levels of ectopic adipose tissue, which drives the development of T2D to a greater degree than in other ethnic groups.
著者
A. J. Patitsas
出版者
ACOUSTICAL SOCIETY OF JAPAN
雑誌
Acoustical Science and Technology (ISSN:13463969)
巻号頁・発行日
vol.43, no.6, pp.297-305, 2022-11-01 (Released:2022-11-01)
参考文献数
27

It is verified that the source of the acoustic emissions when beach sand or other squeaky grains are stepped on or impacted by a pestle lies in a thin shear band directly under the pestle. The grain layers in this band slide one over another at a slow creepy pace giving rise to energy transfer, via the stick-slip effect, from the impacting pestle to the elastic vibrations in the shear bands at the grain contact areas. In turn, this vibration energy feeds the elastic modes of vibration along the vertical grain columns or equivalently, the elastic modes of vibration in the shear band under the pestle comprising the vibrating columns, with dominant frequency in the range of 1,000 Hz. In search of an explanation of the acoustic emissions when booming dune sand is pushed by a blade or is freely avalanching, we adopt the concept of the collision shear band, where, due to the high degree of fluidity of the sand mass, the grain layers slide one over another at a brisk pace so that the average collision frequency between grains in two adjacent grain layers defines the dominant frequency of the acoustic emission in the range of 100 Hz.