著者

edited by Vincent T. DeVita Jr. Samuel Hellman Steven A. Rosenberg 161 contributors

出版者

Lippincott

巻号頁・発行日

1989

著者

edited by Vincent T. DeVita Jr. Samuel Hellman Steven A. Rosenberg

出版者

Lippincott

巻号頁・発行日

1982

著者

editors Vincent T. DeVita Jr. Theodore S. Lawrence and Steven A. Rosenberg associate scientific advisors Robert A. Weinberg Ronald A. DePinho

出版者

Wolters Kluwer/Lippincott Williams & Wilkins

巻号頁・発行日

2011

著者

edited by Vincent T. DeVita Jr. Samuel Hellman Steven A. Rosenberg 290 contributors

出版者

Lippincott-Raven

巻号頁・発行日

1997

著者

edited and translated by B. T. A. Evetts with added notes by Alfred J. Butler

出版者

Clarendon Press

巻号頁・発行日

1895

著者

Eng Jacqueline T. Zhang Quanchao Zhu Hong

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.118, no.2, pp.107-116, 2010

被引用文献数

10

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The practice of castrating men is an ancient one. Eunuchs have served as guards to harems and as palace chamberlains for many early courts, but details about their lives are often hazy or shrouded in secrecy. Although the changes wrought to their physical appearance from castration are well-documented, little is known about the magnitude of the skeletal changes resulting from the loss of sex hormones associated with the procedure. Such a loss of hormones, especially before puberty, affects skeletal growth and development and may result in early osteoporosis as well as impacting quality of life. The burials of two eunuchs from the Ming Dynasty (1368–1644 AD) of imperial China provide an opportunity to examine the consequences of castration upon the human skeleton. These eunuchs may have been castrated at different periods in their lives. One eunuch appears to have been castrated before the development of secondary sexual characteristics; the delayed epiphyseal closure accompanying androgen deficiency may account for his long limbs. Skeletal evidence also sheds light on the lives of these eunuchs, including their oral health, history of childhood stress, and activity patterns.<br>

著者

Franken Nicolaas A.P. Van Bree Chris Veltmaat Martijn A.T. RODERMOND HANS M. HAVEMAN JAAP BARENDSEN GERRIT W.

出版者

日本放射線影響学会

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.42, no.2, pp.179-190, 2001-06

被引用文献数

3 25

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Sensitization by bromodeoxyuridine (BrdUrd) and hyperthermia (HT) on cell reproductive death induced by ionizing radiation was analyzed using the linear-quadratic [S(D)/S(0)=exp{-( αD+ βD^2 )}] model. Plateau-phase human lung tumor cells (SW-1573) and human colorectal carcinonoma cells (RKO) were treated with BrdUrd, radiation and HT. LQ-analysis was performed at iso-incubation dose and at iso-incorporation level of BrdUrd, and at iso-HT doses and iso-survival levels after HT. Clonogenic assays were performed 24 h after treatment to allow repair of potentially lethal damage (PLD). In SW cells BrdUrd, HT or the combination significantly increased the α-parameter (factor 2.0- 5.7), without altering the β-parameter. In RKO cells sensitization with BrdUrd increased both α (factor 1.4) and β(factor 1.3) while HT only influenced β (factor 2.1-4.0). The combination did not further increase the α and β The results indicate that BrdUrd has its main effect on the parameter α, dominant at clinically relevant radiation doses but that HT can affect both α and β The addition of BrdUrd and HT provides a method to enhance the efficacy of radiotherapy.

著者

ビンセント T. デヴィータ Jr. セオドール S. ローレンス スティーブン A. ローゼンバーグ編

出版者

メディカル・サイエンス・インターナショナル

巻号頁・発行日

2012

著者

editors Vincent T. DeVita Jr. Theodore S. Lawrence Steven A. Rosenberg associate scientific advisors Robert A. Weinberg Ronald A. DePinho with 70 contributing authors

出版者

Wolters Kluwer/Lippincott Williams & Wilkins

巻号頁・発行日

2011

著者

Tsuyoshi T. SEKIYAMA Masaru KUNII Mizuo KAJINO Toshiki SHIMBORI

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.93, no.1, pp.49-64, 2015 (Released:2015-03-18)

参考文献数

55

被引用文献数

1 34

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We investigated the horizontal resolution dependence of atmospheric radionuclide (Cs-137) simulations of the Fukushima nuclear accident on March 15, 2011. We used Eulerian and Lagrangian transport models with low- (15-km), medium- (3-km), and high- (500-m) resolutions; both models were driven by the same meteorological analysis that was prepared by our data assimilation system (NHM-LETKF) for each horizontal resolution. This preparation was necessary for the resolution-dependent investigation, excluding any interpolation or averaging of meteorological fields. In the results, the 15-km grid analysis could not reproduce Fukushima’s mountainous topography in detail, and consequently failed to depict a complex wind structure over mountains and valleys. In reality, the Cs-137 plume emitted from the Fukushima Daiichi Nuclear Power Plant (FDNPP) was mostly blocked by Mt. Azuma and other mountains along the Naka-dori valley after crossing over Abukuma Mountains on March 15, 2011. However, the 15-km grid simulations could not represent the blockage of the Cs-137 plume, which unnaturally spread through the Naka-dori valley. In contrast, the 3-km and 500-m grid simulations produced very similar Cs-137 concentrations and depositions, and successfully produced the plume blockage and deposition along the Naka-dori valley. In conclusion, low-resolution (15-km grid or greater) atmospheric models should be avoided for assessing the Fukushima nuclear accident when a regional analysis is needed. Meanwhile, it is reasonable to use 3-km grid models instead of 500-m grid models due to their similarities and the high computational burden of 500-m grid model simulations.

著者

Dwi Hilda Putri T Mirawati Sudiro Rina Yunita Ungke Anton Jaya Beti Ernawati Dewi Fithriyah Sjatha Eiji Konishi Hak Hotta Pratiwi Sudarmono

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2014.313, (Released:2015-03-13)

参考文献数

31

被引用文献数

2 8

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The development of a dengue vaccine is a major priority. Several researchers are using Asian 1 and Asian 2 genotypes as vaccine candidates to develop a vaccine for dengue type 2 virus (DENV-2). However, in this study, we constructed a recombinant plasmid-based prM-E gene from the DENV-2 Cosmopolitan genotype as a dengue DNA vaccine candidate. The protein expression levels of recombinant plasmids in CHO cell lines were analyzed using an enzyme-linked immunosorbent assay, western blotting, and sucrose gradients. After immunizing ddY mice three times, DNA vaccine doses of 25 and 100 µg induced humoral immune responses. There was no difference in the neutralizing antibody titer (focus reduction neutralization test 50%) of mice immunized with 25 and 100 µg DNA vaccine doses. A challenge test using 3 × 105 FFU DENV-2 showed that immunized mice could raise anamnestic neutralizing antibody responses at day 4 and 8 post-challenge. An immunogenicity test with BALB/c mice showed that their antibody neutralization titers were lower than those of ddY mice. In addition, the antibodies produced after immunization and challenge test could also neutralize DENV-2 Asian 2 genotype (NGC strain). Thus, the DENV-2 Cosmopolitan genotype may be a DENV-2 vaccine candidate.

著者

Wang Sheng Ken Ishikawa Hiromi T. Tanaka Akihiro Tsukamoto Satoshi Tanaka

出版者

一般社団法人 日本シミュレーション学会

雑誌

日本シミュレーション学会英文誌 (ISSN:21885303)

巻号頁・発行日

vol.1, no.1, pp.188-204, 2015 (Released:2015-02-17)

参考文献数

17

被引用文献数

5

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Virtual reality (VR) technology can be used to simulate environments of historical sites in virtual spaces. In fact, many VR reproductions of historical sites have already been studied and developed. For users, the quality of the visual experience largely determines the authenticity of a VR space. However, when developing a VR space, it is difficult and time-consuming to significantly improve visual quality while maintaining real-time rendering speed, which is the primary requirement of an effective user interface. For this reason, there have been few genuinely photorealistic VR spaces created for historical sites. However, this has begun to change due to the arrival of next-generation three-dimensional (3D) game engines. In this paper, we report on our recent development of photorealistic VR spaces for historical Kyoto sites created using the UDK 3D Game Engine. Specifically, we describe our VR reproduction of Reizei-ke, which consists of the Japanese court noble residence (kuge-yashiki), and Funehoko-cho, which is an important site for Japan's Gion Festival. Through the fabrication of these VR spaces, we could also extract a workflow that allows us to realize photorealistic and read-time VR contents of other cultural assets based on the abovementioned next-generation 3D game engine.

著者

N. TAYLES S.E. HALCROW T. SAYAVONGKHAMDY V. SOUKSAVATDY

出版者

日本人類学会

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

pp.141013, (Released:2015-01-29)

被引用文献数

9

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This paper describes a human skeleton from a rock-shelter in northeast Laos, dated to ~7000 BP. It was excavated in 2004 and moved en bloc to the Laos National Museum in Vientiane. Here we report observations made from the in situ skeleton. The burial is the largely complete but slightly damaged remains of a tall, middle-aged, probable male buried on his side in a flexed position. His teeth were heavily worn and one was infected but otherwise there is no evidence of poor health. We were not able to make an assessment of biological affiliation. In comparison with the very small samples of approximately contemporary skeletal remains from the wider region around the middle Mekong, it is clear that the burial position and dental health were not unusual, but that he was very tall for that period of prehistory.

著者

T.J.Aoba 陳明裕 JCO誌編集・協力

出版者

東京臨床出版

巻号頁・発行日

2010

著者

Lin Chang Hamblin Milton Daniel T. Eitzman Y. Eugene Chen

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.1, pp.11-18, 2013 (Released:2012-12-25)

参考文献数

74

被引用文献数

17 63

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Perivascular adipose tissue (PVAT) is the fat tissue surrounding most of the vasculature and it has long been considered solely as vessel-supporting connective tissue. There are 2 major types of adipose tissue widely distributed throughout the body: white (WAT) and brown (BAT). PVAT is similar to BAT in rodents, but it was believed that only WAT existed in adult humans and BAT was present only in infants. However, the presence of functional BAT in adult humans is now accepted. The main function of BAT is to generate heat, and it is essential for adaptive thermogenesis and energy expenditure, whereas the main function of WAT is to store lipids. Besides the different functions of WAT and BAT, growing evidence suggests that different depots of adipose tissue have different functions. Similar to other fat depots, PVAT produces various adipokines, growth factors and inhibitors that affect functions of adjacent layers of the vasculature. Pathophysiological conditions such as obesity, vascular injury, aging and infection could cause PVAT dysfunction, leading to vascular endothelial and smooth muscle cell dysfunctions. In this review, we discuss the function and dysfunction of PVAT on atherosclerosis and hypertension.  (Circ J 2013; 77: 11–18)

著者

R. Zhang T. Hamada S. Inagi Y. Kitamoto

出版者

(公社)日本磁気学会

雑誌

Journal of the Magnetics Society of Japan (ISSN:18822924)

巻号頁・発行日

vol.37, no.3-2, pp.303-306, 2013-05-01 (Released:2013-05-23)

参考文献数

20

被引用文献数

3

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Novel multifunctional superparamagnetic and optical nanohybrids are fabricated for biomedical applications. This architecture involves a silica core surrounded by a thin shell of FePt that is further covered with an outer shell of gold. Polyethyleneimine was utilized as a linker to bridge the FePt shell with the gold shell, which allowed 3-nm gold nanoparticle seeds to be loaded and a uniform gold shell to be formed. These gold and FePt doubly coated silica nanoparticles take advantage of the tunable resonance absorption in the visible and near-infrared (NIR) ranges and can be controlled by using an external magnetic field, which makes them very promising candidates for future biomedical applications.

著者

山下 英俊 戸張 幾生 澤 充 堀 貞夫 宮園 浩平 HELDIN C-H HELDIN P DIJKE P ten SAMPATH T Kuber 水流 忠彦 江口 秀一郎 北野 滋彦 鈴木 水音 一條 秀憲 加藤 光保 山本 禎子 船津 英陽 鈴木 雅信 池上 靖子 加藤 聡 小幡 博人 堀江 公仁子 茂木 豊 征矢 耕一 田中 義和 清水 顕 加治 優一 出田 隆一 三田 知直 山田 秀之 石田 耕一 東 マルシア 羽生 亜紀 三浦 雅一 白澤 榮一 酒井 宏之

雑誌

日本眼科學会雜誌 (ISSN:00290203)

巻号頁・発行日

vol.101, no.12, pp.927-947, 1997-12-10

被引用文献数

6

著者

Linda T. Darling

出版者

Routledge

巻号頁・発行日

2013

著者

J. D. Lee Nagatomi T. (Translator) Mizutania G. (Translator) Endo K. (Translation Supervisor)

出版者

表面分析研究会

雑誌

Journal of Surface Analysis (ISSN:13411756)

巻号頁・発行日

vol.16, no.3, pp.196-213, 2010

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Photoemission process leaves the target system in several final states that are lacking one electron with respect to the initial state. Except for the trivial noninteracting case, the final state effect leads to nontrivial features in the photoemission electron spectroscopy (PES). They are distinguished as the main feature and its satellites. In this issue, we discuss the satellite features in PES when the final state is reached by the extended excitations, that is, corresponding to the collective excitations of charges, spins, or vibrations. In particular, we focus on the basic PES problems of the metallic system with the Fermi sea of conduction electrons. : 光電子放出過程によって,試料構成系は始状態に比べて電子が一つ少ないいくつかの終状態に至る.相互作用のない場合を除いて,この終状態の効果によって光電子分光(PES)に顕著な構造が見られることになる.これらの構造は主ピークとは別にサテライトとして区別される.本稿では,拡張励起,すなわち電荷やスピン,あるいは格子振動の集団励起を経て終状態に至った場合にPE スペクトルに見られるサテライト構造について議論する.特に,伝導電子によるフェルミの海をもつ金属系の基本的なPES 問題に焦点を絞って議論する.

著者

Lee J. D. Nagatomi T. (Translator) Mizutani G. (Translator) Endo K. (Translation Supervisor)

出版者

Surface Analysis Society of Japan

雑誌

Journal of Surface Analysis (ISSN:13411756)

巻号頁・発行日

vol.17, no.2, pp.64-86, 2010-12

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The angle-resolved photoemission spectroscopy (ARPES) is a powerful experimental tool to probe themomentum-resolved electronic structure, i.e., the electronic band dispersion ε(k), of solids and their surfaces. ARPES is also an ideal tool to address the question concerning the electron correlation effect on quasiparticle excitations in the low-dimensional (one- or two-dimensional) correlated electron systems. In this issue, we briefly introduce representative studies of ARPES and their fruitfulness from the free-electron-like three-dimensional systems to the low-dimensional strongly correlated electron systems. : 角度分解光電子分光法(ARPES)は,固体とその表面の電子構造の運動量依存性,すなわち電子構造のバンド分散 ε(k)を測定する有力な実験手法である.ARPES は低次元(一次元あるいは二次元)相関電子系における準粒子励起における電子相関の影響を調べるための理想的な手法でもある.本稿では,自由電子的な三次元系から低次元強相関電子系までの系に対するARPES の代表的な研究とその有効性について概説する.