著者

一瀬 白帝

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.23, no.9, pp.533-538, 1996-04-10 (Released:2011-09-21)

参考文献数

18

著者

武永 美津子 平井 愛山 寺野 隆 田村 泰 北川 晴雄 吉田 尚

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.13, no.4, pp.825-829, 1985-10-01 (Released:2011-09-21)

参考文献数

15

被引用文献数

1

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Arachidonic acid (AA) is well known to be metabolized to thromboxane (TX) A2, 12-hydroxyheptadecatrienoic acid (HHT) and 12-hydroxyeicosatetraenoic acid (12-HETE) in platelets. Prostaglandin endoperoxides and TXA2 are known to be potent aggregating agents. On the otherr hand, the labile 12-lipoxygenase metabolite, 12-hydroperoxyeicosatetraenoic acid (12-HPETE) has been reported to have a rather anti-aggregating action.It has been reported that eicosapentaenoic acid (EPA) has a potent inhibitory effect on platelet aggregation. TXA3 produced from EPA is nonaggregating agent. Although major metabolites of EPA in platelets is said to be those of 12-lipoxygenase pathway, the effect of them has not been clearly elucidated yet. So, we examined the effect of 12-lipoxygenase metabolites of EPA on platelet function and compared them with those of AA.Both of the labile 12-lipoxygenase metabolites, 12-HPETE and 12-hydroperoxyeicosapentaenoic acid (12-HPEPE) suppressed dose-dependently platelet aggregation and release of 5-hydroxytryptamine (5-HT) induced by collagen and AA, while 12-HETE and 12-hydroxyeicosapentaenoic acid (12-HEPE) had no such effects. The inhibitory effects of these 12-hydroperoxy compounds on platelet aggregation and release reaction seem to be almost equipotent. However, 5- and 15-hydroperoxy isomers were less potent in inhibiting aggregation.These results may indicate that 12-HPETE and 12-HPEPE have a potent anti-aggregatory activity and may play a role in regulating platelet aggregability.

著者

高沢 謙二 黒須 富士夫 斎木 徳祐 安藤 寿章 奥秋 勝彦 Ranjeet S BARAL 田中 信大 伊吹山 千晴

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.26, no.11-12, pp.313-319, 1999-10-20 (Released:2011-09-21)

参考文献数

25

被引用文献数

1 2

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Second derivative of photoplethysmogram (SDPTG) or acceleration plethysmogram (APG) is the second derivative wave of the photoplethysmogram. SDPTG has been developed to allow more accurate recognition of the inflection points on the original plethysmographic wave, ie, anacrotic or dicrotic notches. It has been recognized as the independent examination tool for vascular properties.SDPTG includes 4 systolic waves and 1 diastolic wave, namely a-wave (early systolic positive wave), b-wave (early systolic negative wave), c-wave (late systolic reincreasing wave), d-wave (late systolic redecreasing wave) and e-wave (early diastolic positive wave).The ratio of the height of the each wave to that of the a-wave (b/a, c/a, d/a and e/a) are usually used for wave analyses.We previously reported characteristic age related wave changes of SDPTG in 600 subjects (each 50 men and 50 women in each decade from the 3rd to the 8th) in our health assessment center (Hypertension, 1998; 32: 365-370.).SDPTG-AI increased with augmentation index of original photoplethysmogram which is known to increase with increasing age, and is defined as the ratio of the amplitude of the late systolic component to that of the early systolic component of the original plethysmogram.The b/a increased with age and c/a, d/a and e/a decreased with age. Thus b-c-d-e/a was taken as the aging index of SDPTG (SDPTG aging index: SDPTGAI) which increased with age. SDPTG (Y) increased with age (X) as Y=0.023X-1.515, r=0.80, p<0.001).Similar distribution of vascular ages were seen in different districts group, including women in Toba city in Mie prefecture, subjects in shinjuku in Tokyo and patients in Broussias Hospital in Paris.SDPTGAI increased with vascular stiffness represented by inceased b/a and increasing reflection wave represented by decreasing d/a. Vascular age estimated by SDPTG=43.5SDPTGAI+65.9.SDPTGAI and vascular age were significantly higher in patients with a history of hypertension, diabetes mellitus, and hyperlipidemia than in subjects without any disease (p<0.01).The possibility of arteriosclerotic disease can be considered when vascular age is higher than actual age. Though cut-off value of the difference of vascular and actual ages are under examination, the tentative cut-off value is a difference of 15-20 years, which will provide us useful information for screening of arteriosclerotic diseases.A new type of apparatus (Fukuda FCP series) provides full automated detection of each indices and prints out within 30 seconds, which will be widely used for noninvasive evaluation of arteriosclerosis through vascular age.

著者

下村 伊一郎

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.23, no.7-8, pp.443-449, 1996-03-30 (Released:2011-09-21)

参考文献数

7

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We clarified, using computed tomography, that the accumulation of intra-abdominal visceral fat is more closely associated with complications of obesity, such as diabetes mellitus, hyperlipidemia, hypertension and ischemic heart disease, than the accumulation of subcutaneous fat. Recently we also revealed that the accumulation of intra-abdominal visceral fat correlates to metabolic disorders and cardiovascular disease even in normal weight subjects. From these backgrounds, we proposed the concept of “visceral fat syndrome”, a multiple risk factors-clustering syndrome for the incidence of atherosclerosis. Clinically, it was showed that the reduction of visceral fat should be important for the cure and the protection of these disorders. We have suggested that physical exercise reduced accumulated visceral fat prominently from the observations of the effect of exercise therapy on visceral fat type obesity and the analysis of fat distribution of sumo wrestlers. In order to clarify the effect of exercise on fat distribution, the mRNA levels and the activities of acyl-CoA synthetase (ACS), lipoprotein lipase (LPL), and glucose transporter (Glut 4) in some tissues were compared between exercised and sedentary rats. We observed rapid decrease of tissue weight in visceral fat through marked decrease of ACS, LPL, and Glut 4 parameters, while there were no alterations of them in subcutaneous fat. Gastrocnemius muscle was heavier in exercised rats, and ACS activity elevated in the gastrocnemius muscle of the exercised rats. By analyzing the expressed genes in human visceral fat, compared with human subcutaneous fat and various tissues, visceral fat was showed to have a higher metabolic activity at fene expression level. We suggest that intra-abdominal visceral fat may contribute to switching of distribution of plasma energy flux, including lipid and glucose, from fat tissue to muscle in physical exercise, in rapid response to exercise from transcriptional level.

著者

原納 優

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.27, no.12, pp.313-318, 2000-06-20 (Released:2011-09-21)

参考文献数

15

被引用文献数

1

著者

岩崎 勤 松下 哲 折茂 肇 白木 正孝 萬木 信人 加藤 洋一 高橋 龍太郎 蔵本 築 村上 元孝 野間 昭夫 岡部 紘明

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.9, no.1, pp.87-91, 1981-04-01 (Released:2011-09-21)

参考文献数

13

被引用文献数

1

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Effects of γ-oryzanol on the serum HDL, LDL and total cholesterol (ch) and Triglyceride were studied in 17 cases whose age was 47 years old to 82 years old (mean age was 71.2 years old). Three hundred mg/day of γ-oryzanol was given for 4 months.Serum HDL-ch was 50.0±2.3 (m±SE) mg/dl before γ-oryzanol and 53.7mg/dl 3 months later but HDL-ch which was below 50mg/dl before treatment increased significantly (p<0.01) from 43.3mg/dl to 50.4mg/dl 2 months later. HDL-ch below 45mg/dl increased significantly (p<0.01) from 41.3mg/dl (mean) to 50.0mg/dl (mean) 2 months later. LDL-ch decreased significantly (p<0.01) from 158.8mg/dl to 134.8mg/dl after γ-oryzanol. HDL-ch×10/LDL-ch showed significant changes (p<0.01) (from 3.26 to 4.14) 2 months later. Total-ch did not change and between 203mg/dl and 208mg/dl. Triglyceride did not show significant changes.It is suggested that γ-oryzanol alters the metabolism of HDL-ch and LDL-ch and increases serum low HDL-ch.

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.27, no.Supplement1, pp.101-135, 1999-10-25 (Released:2011-09-21)

著者

Sy Rody G Cutiongco Eva Maria C Punzalan1 Felix Eduardo R Santos Ronald S Geronimo Francis Ruel B Tangco Rogelio V

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.14, no.3, pp.116-121, 2007

被引用文献数

9

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Aim: Background: HDL-C has emerged as an important independent predictor of cardiovascular disease. The FNRI-HDL and NNHes Study Group in the Philippines reported that there was a high prevalence of low HDL among Filipinos. Most cases of low HDL-C are associated with secondary causes like Metabolic Syndrome. A primary cause of reduced HDL-C such as increase Cholesteryl Ester Transfer Protein activity has been identified. Objectives: 1. To determine the phenotype and frequency of Cholesteryl Ester Transfer Protein (TaqIB) polymorphism among Filipinos with cardiovascular risk factors. 2. To determine the association of TaqIB polymorphism with HDL-C levels among Filipinos with cardiovascular risk factors. Design: Cross-sectional Study. Setting: University of the Philippines-Philippine General Hospital. Statistical Analysis: Descriptive statistics, Chi square test and Fisher's correlation test using Stata version 6.<BR>Methods: Fifty patients were included in this pilot study and were examined with respect to genotype, lipid profiles, blood sugar and other cardiovascular risk factors. Polymerase Chain Reaction (PCR), Restriction Fragment Length Polymorphism (RFLP) and Agarose Gel Electrophoresis techniques were used to determine the CETP TaqIB Polymorphism.<BR>Results: Out of 50 patients, 66% were females and 34% were males with a mean age of 55 y/o and a BMI of 27 kg/m&sup2;. The following risk factors were identified: hypertension (92%), dyslipidemia (88%), obesity (68%), smoking (50%), diabetes mellitus type 2 (18%) and family history of premature CAD (14%). The genotype frequencies of B1B1; B1B2; B2B2 were 40%; 50% 10% respectively. The B1B1 homozygote was associated with lower HDL-C levels (45.35 &plusmn; 8.82 mg/dL) compared to B1B2 (48.96 &plusmn; 10.10 mg/dL) and B2B2 (48.99 &plusmn; 10.13 mg/dL)). <BR>Conclusions: Cholesteryl Ester Transfer Protein (TaqIB) Polymorphisms exist among Filipinos with cardiovascular risk factors. The frequency of TaqIB polymorphism among Filipinos with cardiovascular risk factors were B1B1 (40%), B1B2 (50%) and B2B2 (10%). B1B1 polymorphism is more common than B2B2 and associated with low HDL-C.

著者

内藤 周幸 川村 光信 橋本 佳明

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.11, no.2, pp.239-250, 1983-06-01 (Released:2011-09-21)

参考文献数

15

被引用文献数

5

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We have studied the effects of polyunsaturated fatty acids on platelet aggregation, mainly by means of the in vitro experiments. The results of the studies are as follows.1) It seemed that arachidonic acid aggregated platelets as well irrespective of prostaglandin pathways.2) Eicosapentaenoic acid (EPA) inhibited platelet aggregation caused by various aggregating agents, such as ADP, collagen, and arachidonic acid, when platelet-rich plasma was used. However, EPA itself aggregated platelets when washed platelets were used.3) On the other hand, such a low concentration of EPA as not to induce platelet aggregation by itself, inhibited platelet aggregation caused by arachidonic acid, even when washed platelets were used.4) From these results it was thought that the inhibitory effect of EPA on platelet aggregation was not active and direct one but indirect due to reducing the use of arachidonic acid in the platelets.5) It was suggested that the ratio of EPA to arachidonic acid in phospholipid fatty acids of platelets needed to be more than 0.14, in order that EPA had an inhibitory effect on platelet aggregation.6) It is considered that the optimum balance between ω-3 species of fatty acids and ω-6 ones in phosphlipid fatty acids of platelets is necessary for platelets to function normally.

著者

寺本 民生 木下 誠 桂川 敬太 岡崎 聡子 山中 正己 永好 昭 大濱 知子 松木 則夫 斎藤 洋

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.22, no.6-7, pp.465-470, 1994-10-25 (Released:2011-09-21)

参考文献数

6

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We found that fatty liver is easily induced in a novel experimental animal, Suncus murinus (suncus) by withholding food. Hepatic triglyceride content increased linearly for up to 24 hours after fasting in these animals, while the glycogen content decreased. Although the glycogen contents returned to the level before fasting at 12 hours after refeeding, the triglyceride contents decreased gradually but did not reach to the level before fasting even at 24 hours after refeeding in suncus. Plasma lipids, glucose and insulin levels decreased by fasting and returned to the levels before fasting between 8 and 24 hours after refeeding. On the other hand, the plasma levels of free fatty acid and ketone bodies were elevated significantly by fasting and decreased rapidly by refeeding. These responses to fasting and refeeding except for the change in hepatic triglyceride are in common with other experimental animals, suggesting that there are no abnormalities not only in glucose metabolism but also in fatty acid metabolism.The study of lipoproteins from this animal revealed that small amounts of lipoproteins with apolipoprotein (apo) E but without apoB were observed in the fraction of density less than 1.08g/ml. In order to learn whether apoB is synthesized by the liver or not, isolated suncus livers were perfused with an addition of [35S] methionine. Small amounts of radioactivity were observed in apoE of VLDL, and fairly large amounts in apoE and A-I in the fraction of LDL+HDL, suggesting that VLDL was secreted with apoE but not with apoB from the liver. Northern blot analysis with use of rat apoB cDNA revealed a weak signal of hybridized rat apoB cDNA between 15Kb and 9Kb in the suncus liver and intestinal mucosa; this is almost the same size as rat apoB mRNA. This finding suggests the presence of apoB mRNA in the suncus.In conclusion, apoB is not secreted from the suncus liver, owing to a defect in intracellular posttranscriptional processing or to ineffective transcription. This might be one of the reasons for fatty deposits in the suncus liver. Suncus may be a candidate for an animal model of abetalipoproteinemia as well as fatty liver due to a defect of apoB synthesis.

著者

秦 葭哉 及川 眞一 山田 信博 山下 静也 佐久間 長彦 佐々木 淳 横山 信次 馬 渕宏 齋藤 康 板倉 弘重 江草 玄士 井藤 英喜 寺本 民夫 都島 基夫 多田 紀夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.26, no.9, pp.217-218, 1999

著者

佐野 隆一 藤井 豊 義江 和子 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.13, no.2, pp.349-353, 1985

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Three dysbetalipoproteinemic subjects with the E 2/2 homozygous phenotype were analysed serum lipoproteins and serum apolipoprotein E and B levels. Two subjects were normocholesterolemic and one was hypercholesterolemic (type III hyperlipoproteinemia). A patient with type III phenotype had cholesterol-rich VLDL, although the other two normocholesterolemic subjects didn't have it. Both normo- and hypercholesterolemic subjects had elevated levels of serum apo E and a reduction in serum apo B. Therefore, serum apo E/apo B ratio of a patient with type III phenotype was extremely high as compared with other lipoprotein disorders. These ratio of normocholesterolemic dysbetalipoproteinemia was also high as compared with those except for type V hyperlipoproteinemia. It is suggested that dysbetalipoproteinemia might be easily caught in general population by screening examination of serum apo E/apo B ratio.

著者

藤井 豊 鈴木 教敬 堀 三郎 佐野 隆一 及川 真一 阿部 隆三 豊田 隆謙 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化

巻号頁・発行日

vol.13, no.6, pp.1385-1387, 1986

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Diabetes mellitus is frequently complicated with atherosclerosis. PWV (pulse wave velocity) is an indicator for the sclerotic change of thoratic and abdominal aorta. We studied the relation between PWV and lipid metabolism in diabetics.<br>The subjects who took part in this study were 54 diabetics who were aged from 50 to 59 years old and had a duration of illness over 5 years. Fasting blood sugar level and the concentration of glycosylated hemoglobin (HbA₁) were measured. Serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), apo B and apo A-I were measured by enzymatic methods and SRID, respectively. PWV was measured by the methods of Hasegawa, et al.<br>We concluded that (1) PWV increased in poorly controlled diabetics (FBS 180mg/dl) more than in well controlled diabetics (FBS 119mg/dl), and (2) PWV had significant positive-relation to serum TC, TG, apo B, apo A-I and apo B/A-I ratio, and had significant negative-relation to HDL-C.<br>According to these data we should improve not only glucose metabolism but also derangement of lipid metabolism.

著者

及川 眞一 阿部 隆三 後藤 由夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.9, no.6, pp.1035-1039, 1982

被引用文献数

2

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It is thought that multi-factors may relate to the occurence and exaggeration of arterial sclerosis in diabetes mellitus. We pointed out the calcification of peripheral arteries in the legs on X-ray photographs as a sign of arteriosclerosis, and studied its prevalence in diabetics and nondiabetics. Furthermore, in order to clarify what correlates with the arteriosclerosis, we analysed the laboratory data and studied the differences between the diabetics with or without the peripheral arterial calcification.<br>We concluded that the incidence of the peripheral arterial calcification in diabetics (32%) was twofold higher than that in non-diabetics (16%).<br>It was clarified that the incidence of the calcification increased significantly in diabetics who had insulin treatment as compared with those who had oral agents or only diet therapy. Similarly, it was significantly higher in diabetics who were complicated with proliferative retinopathy than those who had simple or no retinopathy. And also, diabetics with longer duration of illness had significantly high incidence of the calcification as compared with those with shorter duration.<br>It was relatively higher frequency in diabetics who had hypertention and were controled poorly than those who had normotention and were controled well, respectively, but there was no significance between them.<br>There were no relationships between the peripheral arterial calcification and obesity, serum concentration of lipids, ischemic changes on ECG and aortic arch-calcification in diabetics.<br>These results suggested that the peripheral arterial calcification might relate to the metabolic derangement in diabetes mellitus.

著者

室田 誠逸 森田 育男

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.16, no.7, pp.925-928, 1988-12-01 (Released:2011-09-21)

参考文献数

2

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For the simple examination of the change in vascular permeability response of endothelial cells to various stimuli, we attempted to establish an in vitro experimental model using Boyden's chamber. This chamber has both upper and lower compartments with a partition filter between them. We succeeded in obtaining a monolayer of vascular endothelial cells on the surface of the filter by using a gelatin coated nucleopore filter. Both upper and lower compartments were filled with culture medium. When bovine serum albumin was added only to the upper compartment, the albumin was time-dependently leaked from the upper compartment to the lower compartment though the pores of the filter. The leakage was inhibited greatly when the surface of the filter was covered with entothelial cells.By monitoring the amount of albumin leaked into the lower compartment after the addition of various stimuli, such as histamine, serotonin, bradykinin, PAF (Platelet activating factor) etc., to the upper compartment, we could judge which stimulus could better influence vascular permeability. PAF was found to be the most active stimulus in increasing vascular permeability.During the course of the investigation, we found that such substances as having cytotoxic activity, i.e., lipid peroxides, antiserum in the presence of the complement etc., could also increase vascular permeability. Therefore, by measuring cell viability at the same time, this model can be used as an in vitro assay system for measuring vascular endothelial cell injury. This model may also be a useful in vitro assay system for the evaluation of cytoprotective drugs. By using this system we found that 15-HPETE (15-hydroxyeicosatetraenoic acid), one of the lipoxygenase metabolites of arachidonic acid, has a strong cytolitic activity on vascular endothelial cells and that MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) could prevent the cells from such injury.

著者

張 念中 河合 祥雄 岡田 了三

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.15, no.5, pp.1185-1191, 1987-10-01 (Released:2011-09-21)

参考文献数

25

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Mental stress from one's occupational circumstances is considered an important risk factor in the occurrence of myocardial infarction. However, because of difficulty in quantitative evaluation of such stress, this issue has not been fully studied. In the present work, we investigated the relationship between deaths from acute myocardial infarction (AMI) and occupation using data from the series of the Annual of the Pathological Autopsy Cases in Japan, in which autopsy cases throughout Japan are described. With regard to the 56, 268 persons who died at the age of 15 or older in 1973, 1974 and 1975, i. e., the year of economic depression due to the first oil shock and the years before and after the oil shock, we compared (I) the mortalities from AMI and frequencies of such deaths among all autopsy cases in Japan in relation to the occupational group in the three years and (II) the mortalities from AMI according to the occupation among 3, 241 randomly selected deaths in the three years. The mortality from AMI for 1973, 1974 and 1975 was 2.6%, 3.7% and 3.0%, respectively, showing a significantly higher value for 1974 (p<0.001). Among persons who died from AMI, the proportion of mental workers, particularly executives and managers, and unemployed/retired individuals was significantly higher (p<0.05) in 1974. As for randomly selected autopsy cases, the mortalities from AMI among mental workers in 1973, 1974 and 1975 were 7.8%, 17.0% and 6.2%, respectively, and the corresponding rates among physical workers were 2.0 %, 1.8% and 2.6%. Thus, the mortality among mental workers was significantly increased in 1974 (p<0.05), whereas there were no such variations among physical workers. In addition to the corroboration with the previous experience that deaths from AMI are more frequent among mental workers, particularly executives and managers, than among physical workers, we noted an increase in moratlity from AMI in the period of economic depression. It seems that stress derived from occupational circumstances rather than limited physical activities is involved in the occurrence of AMI.

著者

吉川 昌江 佐久間 長彦 日比 野剛 池内 玲子 佐藤 貴昭 米山 明彦 岩田 誠司 川口 正展 神谷 吉宣 伊藤 純子 藤浪 隆夫

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.22, no.2-3, pp.203-207, 1994-08-01 (Released:2011-09-21)

参考文献数

25

被引用文献数

1 1

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The Oxidative modification of low-density lipoprotein (LDL) could contribute to atherosclerosis as a result of its cytotoxic effect, uptake by the scavenger receptor, and its influence on monocyte and macrophage migration. Ascorbate is an important watersoluble, chain-breaking antioxidant in humans.In this study, we examined the effect of ascorbate on the Cu2+-induced oxidative modification of LDL. LDL was incubated for 24 hours with 2.5μM copper (Cu2+) in phosphate-buffered saline (PBS) in both the presence and absence of ascorbic acid (20μg/ml, 25μg/ml, 30μg/ml, and 35μg/ml). Ascorbate significantly inhibited the oxidative modification of LDL, as indicated by both the decreased electrophoretic mobility and the linoleic acid content. Oxidative modification was prevented in a concentration-dependent manner by the addition of ascorbate.Our data suggests that ascorbate may play an important physiological role in protection against the oxidative modification of LDL.

著者

G. Spiroglou Sofia G. Kostopoulos Christos N. Varakis John H. Papadaki Helen

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis

巻号頁・発行日

vol.17, no.2, pp.115-130, 2010

被引用文献数

175

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Aim: Adipokines are protein products of adipose tissue with paracrine and endocrine actions, which have been implicated in the pathogenesis of cardiovascular disease. Locally produced adipokines, especially by periadventitial adipose tissue, may affect vascular physiology and pathology. We investigated the expression of adiponectin, visfatin, leptin and novel adipokines chemerin and vaspin in human periaortic and epicardial adipose tissue, as well as their correlation to aortic and coronary atherosclerosis.<BR>Methods: Standard immunohistochemical staining for the adipokines was performed on samples of human periaortic, pericoronary and apical epicardial adipose tissue. Atherosclerotic lesions of the adjacent vascular wall were assessed using the AHA classification.<BR>Results: Adipokines were expressed in periadventitial and apical epicardial adipose tissue and - except for adiponectin - in vascular smooth muscle cells and foam cells in atherosclerotic lesions. Aortic atherosclerosis was positively correlated with chemerin, vaspin, visfatin and leptin periaortic fat expression. Coronary atherosclerosis was positively correlated with chemerin and visfatin pericoronary fat expression. Adipose tissue adiponectin expression was negatively correlated to atherosclerosis in both locations. Expression of adipokines in apical epicardial fat was not associated with atherosclerosis.<BR>Conclusions: Our results show: a) a different expression pattern of adiponectin, visfatin, leptin, chemerin and vaspin in periaortic, pericoronary and apical epicardial adipose tissue, b) a correlation of these adipokines with either aortic or coronary atherosclerosis or both in a pattern characteristic for each adipokine and suggest that locally produced adipokines might differently affect the atherosclerotic process in different locations.

著者

佐藤 敬 高松 滋 逸見 一穂 作田 茂 水野 成徳 目時 弘文 高松 むつ

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.7, no.2, pp.271-277, 1979-07-01 (Released:2011-09-21)

参考文献数

12

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The HDL-cholesterol (HDL-Ch) concentration of 153 cerebrocascular patients within 1 year from onset and 257 controls were determined in the supernatant of serum in heparin-Ca++ precipitation method. In some patients, serum HDL-phospholipid (HDL-PL) concentrations were also determined. Liver function tests (GOT, GPT, TTT, ZST) were normal in all of these subjects, and control subjects had no adnormalities in physical findings, blood pressure, ECG, urinalysis etc.The average values in male and female controls were 65±20.9mg/dl and 65±22.3mg/dl, respectively. The value of female subjects over 55 years of age was lower than those of age-matched male and female under 54. There was no significant change by age in values of male control. In male patients with cerebral infarction, average HDL-Ch value was 55±18.6mg/dl and it was significantly lower than the control value. The value of female patients was 62±15.0mg/dl. In female, there was no significant difference between patients and control. Among the patients with cerebral infarction, the cases with angiographically demonstrated obstruction of internal carotid or middle cerebral arteries showed lower value as compared to those without such findings. In male and female patients with cerebral hemorrhage, average HDL-Ch concentrations were 55±13.3mg/dl and 60±16.8mg/dl respectively. Again only the value of male patients was significantly lower than that of control.Considering the importance of balance between atherogenic and anti-atherogenic properties of cholesterol in various lipoprotein fractions, HDL-cholesterol/total cholesterol (HDL-Ch/TC) ratio was calculated in each subjects. The average values of this ratio in healthy men and women were 0.37±0.13 and 0.37±0.14, respectively. The value of male patients with cerebral infarction was 0.30±0.10, it was significantly lower than the control value. The values of female patients with cerebral infarction, male and female patients with cerebral hemorrhage were 0.33±0.09, 0.35±0.10 and 0.35±0.11, respectively. These values exhibited no significant difference when compared with each controls. From these results, it was recognized that at a given concentration of serum total cholesterol, male patients with cerebral infarction had relatively less cholesterol in their HDL fraction as compared to healthy subjects.Serum HDL-PL concentrations in male patients either with cerebral infarction or cerebral hemorrhage, were significantly lower than the control value. The difference between female patients and control was insignificant.These results may suggest the importance of HDL-Ch for the development of cerebral atherosclerosis and subsequent cerebral infarction at least in man.

著者

森 聖二郎

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.26, no.2, pp.81-86, 1998-10-10 (Released:2011-09-21)

参考文献数

19

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Glucocorticoid-induced alterations of blood lipoprotein metabolism were analyzed in patients with various collagen diseases. Serum triglyceride concentration was rapidly and transiently increased by prednisolone treatment; it reached the maximal level after 2 weeks, and then gradually decreased to the initial level. On the other hand, serum total cholesterol concentration was slowly increased to the maximal level by 8 weeks and, thereafter, remained constant. Mathematical analysis has revealed that the average prednisolone-induced increase was about 2.5mg/dl/mg prednisolone for both serum total cholesterol and triglyceride levels. Ultracentrifugation analysis showed that not only low density but also very low density and high density lipoproteins were increased by prednisolone treatment. In a female patient with angina pectoris and xanthelasma, probucol treatment effectively normalyzed her glucocorticoid-induced hypercholesterolemia and, furthermore, the effective lowering of serum cholesterol level was also followed by successful cessation of angina attack and healing of xanthelasma. The data suggest the possible importance of glucocorticoid-induced hyperlipidemia in the development of atherosclerosis.