著者

Mitsutoshi Tominaga Kenji Takamori

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.8, pp.1241-1247, 2013-08-01 (Released:2013-08-01)

参考文献数

80

被引用文献数

14 46

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Histamine H1-receptor blockers are used to treat all types of itch resulting from serious skin diseases such as atopic dermatitis, as well as from renal and liver diseases. However, they often lack efficacy in chronic itch, a profound clinical problem that decreases quality of life. The development of effective treatments requires a full understanding of the fundamental mechanisms of itch. Recent studies have indicated that the pathogenic mechanisms of itch also involve agonists other than histamine, including proteases, neuropeptides, cytokines, and opioids, as well as their cognate receptors. Release of these pruritogenic mediators and modulators into the periphery may directly activate itch-mediating C-fibers via specific receptors on the nerve terminals. Histological observations have shown increased epidermal nerve densities in patients with atopic dermatitis, suggesting that the higher density is at least partly responsible for itch sensitization. This hyperinnervation is likely induced by an imbalance between nerve elongation and repulsion factors produced by keratinocytes. Neuronal matrix metalloproteinases are also involved in the penetration of nerve fibers into the extracellular matrix. Moreover, itch-mediating fibers such as gastrin-releasing peptide+ (GRP+) and Mas-related G-protein coupled receptor A3+ (MrgprA3+) fibers are present in the skin. Clinically, emollients or UV-based therapies can partly control epidermal nerve density, but new substances and classes of antipruritic drugs are needed. This review highlights recent knowledge regarding epidermal nerve fibers that are partly involved in itch sensitization, and discuss peripheral mechanisms and treatments of itch, especially in atopic dermatitis.

著者

田原

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.168, 1896-02-26

著者

山内 盛 滝戸 道夫 三川 潮 柴田 承二

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.96, no.12, pp.p1492-1493, 1976-12

被引用文献数

2

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From the fruits of Arctium lappa L. (Japanease name"goboshi, ""akujitsu, "or "dairikishi"), two new sesquilignan derivatives, AL-D and AL-F, were isolated along with arctin, arctigenin, and matairesinol. From spectroscopic and chemical investigations, the structure of AL-D was elucidated as 2-[2-(3-methoxy-4-hydroxy) phenyl-3-hydroxymethyl-7-methoxy-2,3-dihydrobenzofuran-5-yl] methyl-3-(3-methoxy-4-hydroxy)-benzyl-buthyrolactone [I] or 2-(3-methoxy-4-hydroxy) benzyl-3-[2-(3-methoxy-4-hydroxy)-phenyl-3-hydroxymethyl-7-methoxy-2,3-dihydrobenzofuran-5-yl] methyl-buthyrolactone [II]. AL-F was found to be a stereoisomer of AL-D.

著者

神田 博史 徳本 和佳子 坂本 季代恵 藤井 美智子 平井 裕子 山崎 和男 菰田 泰夫 中村 英雄 石原 茂正 内田 勝

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.33, no.4, pp.1367-1374, 1985-04-25

被引用文献数

12

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The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. From the physiologically active fraction of the extract, along with the known triterpenes ganoderic acids A and B, two new triterpenes were isolated and named ganoderic acids C and D. The structures of ganoderic acids C and D were determined to be 3β, 7β, 15α-trihydroxy-11,23-dioxo-5α-lanost-8-en-26-oic acid and 7β-hydroxy-3,11,15,23-tetraoxo-5α-lanost-8-en-26-oic acid respectively. Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. Quantitative analysis of these triterpenes was performed for the purpose of crude drug quality control.

著者

Uchida Eriko Mizuguchi Hiroyuki Ishii-Watabe Akiko HAYAKAWA Takao

出版者

公益社団法人日本薬学会

雑誌

Biological & pharmaceutical bulletin (ISSN:09186158)

巻号頁・発行日

vol.25, no.7, pp.891-897, 2002-07-01

被引用文献数

3 96

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Non-viral gene transfer into a wide range of human cells was examined in order to clarify the factors that affect the efficiency and safety of non-viral vectors and to optimize the conditions so that high efficiency and low toxicity could be achieved. Six non-viral vectors (Lipofectin, LipofectAMINE PLUS, SuperFect, Effectene, DMRIE-C and DOTAP) were used to transfect a mammalian expression plasmid pCMVβ into 16 types of human primary cells and cultured cell lines. Transfection efficiency was quantified using a galactosidase assay. Cytotoxic effects were measured by lactate dehydrogenase (LDH) assay and WST-8 assay. In serum-free conditions, LipofectAMINE PLUS, Effectene and SuperFect, on average, transfected DNA more successfully than Lipofectin, DMRIE-C, and DOTAP, although the levels of gene expression with these vectors varied remarkably in different cells. The most effective vector also differed depending on the cell type. Serum was found to inhibit gene transfer and reduce the cytotoxicity of all of these vectors except Effectene. The efficiency and toxicity of the non-viral vectors used depended on the type of vector, the DNA/vector ratio, the type of cell, and the presence of serum. These results provided useful information for the optimization of transfer conditions of these non-viral vectors.

著者

ISHIGURO J TADA Toshito OGIHARA Takuo OHZAWA Nobuo MURAKAMI Kimihiro KOSUZUME Hiroshi

出版者

公益社団法人日本薬学会

雑誌

J Pharmacobiodyn. (ISSN:0386846X)

巻号頁・発行日

vol.11, pp.251-261, 1988

被引用文献数

1

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When orally administered to rats, ^<14>C-labelled ethyl eicosapentaenoate (^<14>C-EPA-E) was hydrolyzed and, in the lymph, incorporated mainly into triglycerides (TG) in chylomicrons. In plasma and other tissues, eicosapentaenoic acid (EPA) and its metabolites, such as docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), were detected in TG and phospholipid fractions. In plasma, EPA and its metabolites were found to be integrated into lipoproteins. Tissue distribution of these metabolites showed characteristic patterns from one tissue to another, as did their compositional distribution in lipids. EPA, DPA and DHA were found to be metabolized via β-oxidation in in vitro experiments with mitochondrial fraction.

著者

Mitsue Ishisaka Kenichi Kakefuda Mika Yamauchi Kazuhiro Tsuruma Masamitsu Shimazawa Akifumi Tsuruta Hideaki Hara

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.9, pp.1481-1486, 2011-09-01 (Released:2011-09-01)

参考文献数

34

被引用文献数

18 71

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Depression is a significant public health problem and some reports indicate an association between depression and endoplasmic reticulum stress. Luteolin is a flavonoid contained in many plants and with a variety of known pharmacological properties such as anti-inflammatory, anti-anxiety, and memory-improving effects, suggesting that luteolin penetrates into the brain. In the present study, we investigated the effects of luteolin on endoplasmic reticulum stress-induced neuronal cell death. Luteolin significantly suppressed tunicamycin-induced cell death at 1 to 10 μM in human neuroblastoma cells. Luteolin increased in the expression of the 78 kDa glucose-regulated protein and 94 kDa glucose-regulated protein and decreased in the cleavage activation of caspase-3. Additionally, to investigate whether chronic luteolin treatment has an antidepression effect, we performed some behavioral tests. Chronic luteolin treatment showed antidepressant-like effects in behavioral tests and, luteolin attenuated the expression of endoplasmic reticulum stress-related proteins in the hippocampus of corticosterone-treated depression model mice. These findings indicate that luteolin has antidepressant-like effects, partly due to the suppression of endoplasmic reticulum stress.

著者

内林 政夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.126, no.1, pp.27-36, 2006-01-01

被引用文献数

2

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Bencao Pinhui Jingyao complied in 1505 shows a drawing of maize under the caption of Yiyi-ren (Job's Tear). Also, a Chinese poem written around 1368 contains a term yumi, which indicates maize. These new findings offer clear evidence that maize existed in China in the pre-Columbian era. Details of this evidence, together with probable routes of introduction of maize to China, are discussed here.

著者

内林 政夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.126, no.6, pp.423-427, 2006-06-01

被引用文献数

1 3

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An overview is presented on the reports available so far on pre-Columbian maize covering the regions of India, Mideast, Africa and Iberia. Frequent observations of maize recorded in the past on the East and the West Coast of Africa and at the ports in the Mideast show that maize was one of the staples of the natives well before 1492. It is also evident that maize in the West Africa was disseminated to Iberia and Lombardy in the pre-Columbian time. An earlier contact between the Old and the New World is strongly suggested.

著者

東田 千尋

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.38, no.9, pp.891-892, 2002-09-01

著者

遠藤 徹 田口 平八郎

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.93, no.1, pp.30-32, 1973-01

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Four glucosides were isolated from the fruits of Cornus officinalis SIEB. et ZUCC.(Cornaceae). Three of them were identified with morroniside (VII), loganin (IV), and sweroside. The other one was a new iridoid glucoside, 7-ο-methylmorroniside (VI), (tetraacetate (I), mp 103-105°) which seemed to be an artifact formed during the extraction process.

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.84, pp.88-94, 1889-02-02

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.81, pp.538-542, 1888-11-03

著者

高橋 順太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.82, pp.556-574, 1888-12-01

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.50, pp.155-157, 1886-04-26

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.58, pp.526-528, 1886-12-26

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.52, pp.253-254, 1886-06-26

著者

Lepsius 社家間 房吉

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.388, pp.695-703, 1914-06-26

著者

新川 蘭順 木曽 達也 片岡 博文 礒井 孝 柿田 孝雄 正垣 武志 大坪 義和

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.116, no.10, pp.783-791, 1996-10-25

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The antagonism of histamine H_2-receptor by SWR-104SA (1'-bromo-N-[3-[3-(1-piperidinylmethyl) phenoxy] propyl]-spiro [1,3-dioxolane-2,9'-pentacyclo-[4. 3. 0. 0.^<2,5>0.^<3,8>0.^<4,7>] nonane]-4'-carboxamide monooxalate) was estimated using the isolated guinea-pig atrium and gastric acid secretion in rats. The concentration-response curves for the positive chronotropic effect of histamine on the atrium were displaced to the right in parallel without change in the maximum response by SWR-104SA and roxatidine acetate hydrochloride (roxatidine). The pA_2 values of SWA-104SA and roxatidine acetate hydrochloride were 7.27 and 7.38,respectively. The slopes of the regression line of log (DR-1) against log SWR-104SA and roxatidine concentration were 1.00 and 0.92,respectively. There was no significant difference between the two compounds with respect to the histamine H_2-receptor antagonism and/or binding manner in vitro. In the rat gastric fistula model stimulated by histamine, however, antisecretory potency of SWR-104SA was 3 times less than that of roxatidine. SWR-104SA given p.o. prevented the formation of gastric lesion induced by HCl-ethanol and indomethacin dose-dependently, roxatidine also prevented its formation by HCl-ethanol, but failed to prevent that by indomethacine. These antiulcer activities of SWR-104SA were shown at the lesser doses of antisecretory activity. On the other hand, roxatidine did not prevent the ulcer formation at the same dose level of antisecretory activity. These results indicate that the antiulcer effect of SWR-104SA is not caused by the antisecretory action alone. In addition, the mucosal protective activity of SWR-104SA for HCl-ethanol induced gastric lesion was independent of endogenous prostaglandins. Moreover SWR-104SA had inhibitory effects on indomethacin-induced gastric hypermotility in rats. These actions may partly explain the gastric protection of this compound and additional mechanisms such as mucosal blood flow could be involved in the antiulcer efficacy. Consequently, it appears that SWR-104SA is a new antiulcer drug that exerts a potent cytoprotective effect in addition to its gastric antisecretory activity.

著者

王 誠明 太田 節子 篠田 雅人

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.109, no.12, pp.949-953, 1989-12-25

被引用文献数

2

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The survival effect of mice irradiated with a lethal dose of X-ray was studied by use of 60 kinds of Chinese traditional medicines. Methanol extracts of these medicines were prepared, and then each extract injected intraperitoneally into male mice before or after whole-body irradiation. As a result of these studies, the survival effects with Ogi-kentyu-to, Simotu-to, Sessyoin, Zokumei-to and Boi-ogi-to were observed by intraperitoneal injection before irradiation. Of these effective methanol extracts, only Zokumei-to was shown to have a significant survival effect by intraperitoneal injection after irradiation.