著者
兼本 雅章
雑誌
総合政策論叢
巻号頁・発行日
vol.6, no.1, pp.47-80, 2015-03-15
著者
牧角 俊郎
出版者
山口大学
雑誌
奨励研究(A)
巻号頁・発行日
1997

1. これまでの研究から、ラットに覚醒剤に対する逆耐性現象を形成する実験プロトコール及び、興奮性アミノ酸系NMDAレセプターアンタゴニストであるMK-801が逆耐性現象の発現を抑制することも明らかにしたので、今回は、これまでの研究に従い、ラットに覚醒剤(塩酸メタンフェタミン)5mg/kgを2、3日おきに5回腹腔内投与する際に、MK-801を前投与した群と非投与群とに分けた。最終の覚醒剤投与より24時間後にラットを深麻酔下に灌流固定後脳を摘出し、摘出脳を凍結後ミクロトームにて薄切し、切片に対して、一次抗体にanti-GAP(Growth-associated protein)43及びanti-MAP2(Microtuble-associated protein 2)を用い、二次抗体にはanti-mouse monoclonal IgGを用いて、ABC法に則り免疫染色を行った。2. MK-801非投与群(逆耐性群)では、線条体及び前頭皮質部においてMAP2の染色性の低下が見られ、カテコールアミン神経終末の変性が示唆され、一方でGAP43の染色性は亢進していた。MK-801投与群(非逆耐性群)では逆耐性群と同様に、線条体及び前頭皮質部においてMAP2の染色性の低下が見られ、カテコールアミン神経終末の変性が示唆されたが、一方でGAP43の染色性は低下していた。3. 以上の結果より、覚醒剤に対する逆耐性現象形成時にはカテコールアミン神経の可塑性が亢進していることが示唆され、覚醒剤に対する逆耐性現象の形成と、記憶形成のメカニズムの類似性が明らかとなった。
著者
沖谷 忠幸
出版者
社会経済史学会
雑誌
社會經濟史學 (ISSN:00380113)
巻号頁・発行日
vol.4, no.12, pp.1391-1405, 1935-03-15
著者
橋爪貫一 著
出版者
椀屋喜兵衛
巻号頁・発行日
1871
出版者
私製
巻号頁・発行日
0000
著者
新野 俊樹 山田 英典
出版者
公益社団法人 精密工学会
雑誌
精密工学会誌 (ISSN:09120289)
巻号頁・発行日
vol.75, no.12, pp.1454-1458, 2009
被引用文献数
1 4

A novel process that can fabricate transparent parts was developed for the purpose of improving mechanical and thermal performances of functional and transparent prototypes which is provided through an additive manufacturing technology. The process starts with plastic laser sintering process, which is widely applied to fabrication of functional prototype or rapid manufacturing, and following infiltration of the sinter, which is opaque after the first process, with thermosetting plastic of which refractive index after cure is tuned to have the same value as that of the sintered powder clearly eliminates opacity from the sinter. Experiments using styrene-methacrylate copolymer as powder material and thermosetting epoxy resin were carried out, and the minimum haze of 20% (at 5mm in thickness) was obtained. In terms of mechanical strength, impact strength (unnotched Izod) reached 3.5kJ/m<sup>2</sup> meeting standard of that for transparent grade stereolithography parts. In this paper, requirements both in laser sintering and infiltration, and problems to be solved to improve the mechanical strength are also discussed.
著者
Shogo TAKAHARA Masashi IIJIMA Kazumasa SHIMADA
出版者
日本保健物理学会
雑誌
保健物理 (ISSN:03676110)
巻号頁・発行日
vol.50, no.3, pp.172-181, 2015 (Released:2016-02-06)
参考文献数
30
被引用文献数
1

Radiation-induced cancer is one of the key issues in a consequence analysis on a Nuclear Power Plant accident. U. S. Nuclear Regulatory Commission (USNRC) developed the estimation model of those risks for the use of accident consequence analysis in 1980s and 1990s. This model is still used as a leading model in this field. In this paper, we aimed to explore the differences between the results of risk prediction from the model of USNRC and those from a latest model. To achieve this aim, radiation-induced cancer risks were projected based on the Japanese population statistics using the models developed by USNRC and the latest model, which was developed by U. S. Environmental Protection Agency (USEPA). As compared to the model of USEPA, the lifetime attributable risks of all cancers projected by the model of USNRC were about 30% higher for male and about 35% lower for female in both morbidity and mortality. When the sex-averaged values were compared between them, the difference is within 10%.
著者
Keiko FUJIWARA Tomoyuki TAKAHASHI Tadatoshi KINOUCHI Satoshi FUKUTANI Yuki HATTORI Sentaro TAKAHASHI
出版者
日本保健物理学会
雑誌
保健物理 (ISSN:03676110)
巻号頁・発行日
vol.50, no.3, pp.189-193, 2015 (Released:2016-02-06)
参考文献数
8
被引用文献数
1

Various radionuclides, including radioactive tellurium (Te), were released to the environment by the Fukushima nuclear power plant accident. The total amount of Te-127m released from the power plant was estimated to be 1.1 × 1015 Bq. The radioactive Te may have contributed to the internal radiation dose at the initial stage of the accident. However, data on the environmental behavior of radioactive Te are limited. In this study, therefore, the uptake of Te in plants was investigated. Radishes (Raphanus sativus var. sativus) were cultivated into a nutrient solution, grown for 20-30 days, and then their fine roots (taproots in the plant anatomy) and a part of fleshy roots (hypocotyls in the plant anatomy) were immersed for two hours into nutrient solutions with different Te and Cs concentrations. After soaking, plants were returned to the initial Te- and Cs-free nutrient solution for further maturation. ICP-MS measurements were made to assess concentrations of Te and Cs in the plants' leaves and fleshy roots (the fine roots were removed). Resulting differences among the individual plants were large. The leaf/fleshy root ratios of the concentration of Te and Cs were 0.09-1.14 and 1.59-5.00 on a fresh-matter basis, respectively. Both Te and Cs were absorbed by the radishes through the fine roots. There was a general tendency for Te to be retained in the fleshy roots, whereas Cs was mainly absorbed by the fine roots and then transferred to the leaves.
著者
Yuki HATTORI Tadatoshi KINOUCHI Satoshi FUKUTANI Tomoyuki TAKAHASHI Keiko FUJIWARA Kayoko IWATA Sentaro TAKAHASHI
出版者
日本保健物理学会
雑誌
保健物理 (ISSN:03676110)
巻号頁・発行日
vol.50, no.3, pp.194-196, 2015 (Released:2016-02-06)
参考文献数
11
被引用文献数
1

Three different types of soil were collected at each of three locations: a persimmon orchard, an ume (Prunus mume, so to speak, ‘a Japanese apricot’) orchard, and a paddy field located 50-55 km northwest from Fukushima Daiichi Nuclear Power Plant. The goal was to investigate the involvement of microbes inhabiting these soils on the behavior of 137Cs. The soils were sterilized with gamma ray irradiation for 30 hours (absorbed dose of 60 kGy) or with high-pressure steam (autoclave sterilization) at 121°C for 20 minutes. A radish cultivar (Raphanus sativus var. sativus) was then cultivated in those soils for 45 days, and the harvested taproots and leaves were testing using a Ge semiconductor detector for concentration of 137Cs. The result showed that the concentration of 137Cs in radishes cultivated in the sterilized soils with autoclave sterilization or gamma ray irradiation were significantly higher than in those cultivated in the unsterilized soils. An increase in the plant available 137Cs could be caused by NH4+ arisen from the multiple effects of the structural change of the soil, decomposition of organic matter, and/or extinction of the microbes by sterilization.
著者
小川 寛大
出版者
K&Kプレス
雑誌
月刊日本
巻号頁・発行日
vol.20, no.2, pp.110-113, 2016-02