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Cerebrovascular disease is a kind of complications in diabetes mellitus which is induced by suger, fat and protein metabolic disorder. These series of nutrient metabolic disorder can lead to intracranial large blood vessels and microvascular lesions. About 20-40 percent of type 2 diabetes patients will suffer from cerebrovascular diseases which become the main causes of death in diabetic patients. Recently many kinds of pathogenesis have been found by researchers about cerebrovascular diseases in diabetes mellitus such as hyperglycemia, insulin resistance, endothelial cell dysfunction, abnormal lipids metabolism and so on. The major clinical manifestations of diabetic cerebrovascular diseases are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel diseases and acute cerebral vascular diseases. This article will introduce the pathogenesis and clinical features of diabetic cerebrovascular diseases in detail. We will also focus on its latest research progress.

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA One case report of myofibrillar myopathy with chests tuffiness and limb weakness

著者: Cong Li Xiang-lin Chi
出版者: Japan Brain Science society
雑誌: 脳科学誌 (ISSN:13415301)
巻号頁・発行日: vol.44, pp.24-33, 2014-12-30 (Released:2017-06-01)

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA To alleviate the mental stress of the hospital staff by the use of Morita therapy

著者: Yandong Wang Yan Wu Xuelong Jin
出版者: Japan Brain Science society
雑誌: 脳科学誌 (ISSN:13415301)
巻号頁・発行日: vol.45, pp.35-44, 2015-03-30 (Released:2017-06-01)

China is a populous country, it is well known that there are many people who need treatment. The majority of patients are looking forward to big hospitals of urban to accept treatments. As the number of patients is increasing, the load of medical workers is more and more heavy. It is hard-won for medical workers to have a long holiday, because it will take a huge burden to colleagues. So to alleviate the mental stress has become a urgent affair instead of a long holiday. The Morita therapy is a kind of behavioral treatment which comes from Japan. It is valuable to consider whether this kind of treatment is useful for medical workers. We begin our research towards the direction of alleviating the mental stress of the hospital staff. As the core of the Morita therapy, it is important to understand the meaning of leting nature taking its course. It is impossible to alleviate the tension and reduce the incidence rate of obsessive compulsive disorder even if doing a lot of works. We advance our research based on this opinion. The fear in the obsessive concept is a difficulty in the Morita therapy. We want to provide a relaxing circumstance for patients to help them relax themselves. Thus we consider that it is impossible to help them relax by the use of music. Not all the music is available for one person. People have found that the treatment effect is related to the frequency of music. For example: some people hold the idea that listening to high frequency music does not have a good effect on people who are deeply mired in depression. However, letting them listen to the appropriate music has the effect of adjusting heart.

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA Identification and characterization of a novel splice variant of disrupted in schizophrenia 1 (Disc1)

著者: Yuki Miyatake Shinsuke Matsuzaki Manabu Taniguchi Hironori Takamura Kohei Yamada Tsuyoshi Hattori Toshiki Kameyama Takayuki Manabe Masaya Tohyama Taiichi Katayama
出版者: Japan Brain Science society
雑誌: 脳科学誌 (ISSN:13415301)
巻号頁・発行日: vol.45, pp.5-34, 2015-03-30 (Released:2017-06-01)

Alternative splicing (AS) contributes to the generation of distinct mRNAs from the same pre-mRNA. This mechanism is highly conserved in eukaryotes and yields proteomic diversity. Furthermore, AS can be tissue- and developmental stage-specific and is an important process in the development of the central nervous system. Although these features suggest that AS variants contribute the complexity of the brain, the characteristics of most AS variants are unclear. Therefore, it is important to identify and examine novel AS variants in neuronal tissues to fully understand neuronal functions. We have identified a novel AS variant of murine disrupted in schizophrenia 1 (Disc1), a neural developmental gene. This variant lacks exon 2 and is named 'ΔE2'. We also show differences in the expression levels and localization patterns between ΔE2 and full length Disc1 (FL) in the murine brain. Differences in the subcellular localization patterns of both isoforms in cultured SK-N-SH cells suggest that ΔE2 has different functions compared with those of FL. Further functional analysis of ΔE2 may indicate additional roles of Disc1, and may further our understanding of the developmental mechanisms for neurodevelopmental disorders such as schizophrenia.

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA Endothelial Progenitor Cells : implications for radiation-induced brain injury

著者: Qiaoyan Liu Xuelong Jin
出版者: Japan Brain Science society
雑誌: 脳科学誌 (ISSN:13415301)
巻号頁・発行日: vol.44, pp.42-62, 2014-12-30 (Released:2017-06-01)

Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in China. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. An initial brain pathology resulting from exposure to radiation appears to be the dysfunction or disruption of the blood-brain barrier (BBB) and edema formation, which resulted from loss of tight junction (TJ) proteins and BBB components pericytes and astrocyte end-feet. Both of these scenarios lead to apoptosis of endothelial and neural cells and neuroinflammation in and around capillaries, which may progress into a variety of neurological impairments. It's been found that Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the regulation and protection of the endothelium, as well as new vessel formation. It can incorporate into injured vessels and become mature endothelial cells during re-endothelialization and neovascularization processes, so the transplantation of EPCs into ischemic tissues provide a novel therapeutic option for radiation-induced brain injury. The efficacy of EPCs repairing disrupted BBB can be evaluated from the changes of expression of S100B, VEGF and EBA. MRI is a non-invasive method that can be used to track labeled transplanted cells,which can show the exact trace of EPCs in the region of brain injury. This review discusses the therapeutic potential of EPCs for vascular ischemic diseases associated with radiation-induced brain injury.

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats

著者: Yukiko Ishibashi Nobuo Izumo Keiko Iwata Tomomi Morikawa Toshiki Kameyama Yasuo Watanabe Takayuki Manabe Hideo Matsuzaki
出版者: Japan Brain Science society
雑誌: 脳科学誌 (ISSN:13415301)
巻号頁・発行日: vol.46, pp.5-19, 2016 (Released:2017-05-09)
参考文献数: 20

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA Yokukansan increases serum Brain-derived neurotrophic factor (BDNF) levels in Gunn rat

著者: Motohide Furuya Tsuyoshi Miyaoka Sadayuki Hashioka Rei Wake Keiko Tsuchie Jun Horiguchi
出版者: Japan Brain Science society
雑誌: 脳科学誌 (ISSN:13415301)
巻号頁・発行日: vol.44, pp.34-41, 2014-12-30 (Released:2017-06-01)

Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.

2022-09-29 18:07:00
1 はてなブックマーク

1 0 0 0 OA Mixed associations of postnatal body mass index change with cognitive function at 4 years: Hamamatsu Birth Cohort for Mothers and Children Study

1 0 0 0 OA Effects of Yokukansan on serotonin1A receptor binding in monkey brain

1 0 0 0 OA Speech perception ability and language perception ability in Japanese children with persistent functional articulation disorder

1 0 0 0 OA Investigation of the reliability and validity of the Japanese Deliberate Self-Harm Inventory

1 0 0 0 OA The relationship between multisensory hypersensitivity and behavioral problems in children with autism spectrum disorders

1 0 0 0 OA Individual Schema Therapy for high-functioning autism spectrum disorder with comorbid psychiatric conditions in Young Adults: Results of a Naturalistic Multiple Case Study

1 0 0 0 OA 信濃史学会 一志茂樹八十年回顧編集委員会編『地方史に生きる : 聞き書き一志茂樹の回想』, 平凡社, 一九八四・一〇刊, B6, 二八四頁, 一八〇〇円

1 0 0 0 OA Microglial activation in healthy adult Japanese subjects: apositron emission tomography study

1 0 0 0 OA BMP signaling-related proteins are differentially expressed in the adult cerebellum

1 0 0 0 OA Bone Morphogenetic Protein Receptor IA and IB expression in the adult rat trigeminal nuclei

1 0 0 0 OA Conversations between individuals with autism and typical development: similarities, differences, and exchange characteristics and patterns from the perspective of verbal response modes

1 0 0 0 OA Influence of unbalanced large head on neurodevelopment in infancy: a longitudinal birth cohort study

1 0 0 0 OA Placenta-derived hypo-serotonin situations in the developing forebrain inhibits dopaminergic fiber development, resulting in ADHD

1 0 0 0 OA The pathogenesis and clinical features of cerebrovascular disease in diabetes mellitus