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In infected cells, the chromatin structure of the adenovirus genome DNA plays critical roles in its genome functions. Previously, we reported that in early phases of infection, incoming viral DNA is associated with both viral core protein VII and cellular histones. Here we show that in late phases of infection, newly synthesized viral DNA is also associated with histones. We also found that the knockdown of CAF-1, a histone chaperone that functions in the replication-coupled deposition of histones, does not affect the level of histone H3 bound on viral chromatin, although CAF-1 is accumulated at viral DNA replication foci together with PCNA. Chromatin immunoprecipitation assays using epitope-tagged histone H3 demonstrated that histone variant H3.3, which is deposited onto the cellular genome in a replication-independent manner, is selectively associated with both incoming and newly synthesized viral DNAs. Microscopic analyses indicated that histones but not USF1, a transcription factor that regulates viral late gene expression, are excluded from viral DNA replication foci and that this is achieved by the oligomerization of the DNA binding protein (DBP). Taken together, these results suggest that histone deposition onto newly synthesized viral DNA is most likely uncoupled with viral DNA replication, and a possible role of DBP oligomerization in this replication-uncoupled histone deposition is discussed.

2013-07-24 08:30:26
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1 0 0 0 OA Raman optical activity by coherent anti-Stokes Raman scattering spectral interferometry

著者: Hiramatsu Kotaro Kano Hideaki Nagata Takashi
出版者: Optical Society of America
雑誌: Optics Express (ISSN:10944087)
巻号頁・発行日: vol.21, no.11, pp.13515-13521, 2013-05
被引用文献数: 19 1

We demonstrate a method to measure Raman optical activity (ROA) by using coherent anti-Stokes Raman scattering (CARS) spectral interferometry. An extremely weak chirality-induced CARS field is amplified through the interference with a strong CARS field generated from an external reference and is extracted by the Fourier transformation. In this interferometric coherent Raman optical activity (iCROA), both the sign and the magnitude of optical active non-resonant background susceptibility can be directly determined. Measurement of a CARS-ROA spectrum with less artifact is obtained because a broad offset artifact due to optical rotatory dispersion is clearly distinguished in iCROA.

2013-07-23 08:30:26
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1 0 0 0 OA 「伏見天皇宸記」の敬語表現

著者: 西田直敏
出版者: 北海道大學文學部 = The Faculty of Letters, Hokkaido University
雑誌: 北海道大學文學部紀要 (ISSN:04376668)
巻号頁・発行日: vol.33, no.3, pp.1-49, 1985-03-26

2013-07-22 20:52:42
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http://hdl.handle.net/2115/33495

1 0 0 0 OA 特性曲線有限差分法の離散$L^2$理論 (科学技術計算における理論と応用の新展開)

著者: 野津裕史田端正久
出版者: 京都大学数理解析研究所
雑誌: 数理解析研究所講究録 (ISSN:18802818)
巻号頁・発行日: vol.1791, pp.151-157, 2012-04

2013-07-22 17:20:57
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http://hdl.handle.net/2433/172829

1 0 0 0 OA パターン形成の物理

著者: 甲斐昌一
出版者: 物性研究刊行会
雑誌: 物性研究 (ISSN:07272997)
巻号頁・発行日: vol.97, no.6, pp.1243-1272, 2012-03-05

この論文は国立情報学研究所の電子図書館事業により電子化されました。

2013-07-21 14:44:13
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http://hdl.handle.net/2433/172062

1 0 0 0 OA うつ病患者の生活困難感 : メランコリー親和型うつ病患者とメランコリー親和型でないうつ病患者の2事例の分析から

著者: 廣島麻揚笠井翔太
出版者: 京都大学大学院医学研究科人間健康科学系専攻
雑誌: 京都大学大学院医学研究科人間健康科学系専攻紀要 : 健康科学 : health science (ISSN:18802826)
巻号頁・発行日: vol.8, pp.31-38, 2013-03-31

To clarify how patients with depression perceived their living difficulties, two case studies were performed: of patients with depression with and without Typus melancholicus. Semi-structured interviews were conducted in accordance with an interview guide, and data were analyzed using the KJ method. Data from the interviews of the patient with depression with Typus melancholicus could be summarized under the title "Perception of Living Difficulties in Patients with Depression: the Process of Resolving Distress." The interview data from the patient with depression without Typus melancholicus could be summarized under the title "The Self-contained Cycle of All or Nothing and a Hint on How to Get out of it." In each case study, patients expressed either of the following: "I am consumed by my own thoughts and what I consider to be 'depression,' and can't shake off the sense of tiredness" (Fatigue) or "Because I think it has to be all or nothing, I drown myself in a 'worthless me' attitude and get depressed because I think I can't do anything" (Quicksand). A common factor between them was "I am caught up in my own thoughts and thus feel bad." The findings suggested that patients with depression perceive their living difficulties in this way.

2013-07-21 10:52:00
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1 0 0 0 OA ライドシェア促進システムの開発に向けたユーザ心理分析とマッチングサイト実態分析

著者: 岩村祐佳
出版者: 奈良先端科学技術大学院大学
巻号頁・発行日: 2013-03-22

2013-07-20 23:39:03
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http://hdl.handle.net/10061/8684

1 0 0 0 OA キール型人工腎による血液透析の研究 --1人用透析液供給装置を使用した2人同時透析における透析装置の直列式と並列式連結の比較--

著者: 田中求平
出版者: 泌尿器科紀要刊行会
雑誌: 泌尿器科紀要 (ISSN:00181994)
巻号頁・発行日: vol.19, no.1, pp.3-7, 1973-01

Comparison was made between the series and the parallel connection of dialyzers in simultaneous hemodialysis of two patients with the dialysate supplier for single patient. 1) In the series connection, the top dialyzer showed the greater dialysis effect than the lower one, but the water deprivation effect was reverse. In the parallel connection, both dialyzers showed the equivalent work and the greater dialysis and water deprivation effect than either of the series dialyzers. 2) In the series connection, the patient of the lower dialyzer often complained chill due to lowering of the dialysate temperature. The parallel connection gave solution to this problem as well as to the psychological problem involved in the series connection. 3) In case of accident in the parallel connection, the dialyzer can be easily separated and the other dialyzer can continue dialysis without being disturbed.

2013-07-20 16:24:24
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http://hdl.handle.net/2433/121477

1 0 0 0 OA フランスにおける家事事件メディエーション : カップルと親子関係紛争

著者: ラリュークローディーヌ長田真里
出版者: 立命館大学法学会
雑誌: 立命館法学
巻号頁・発行日: vol.347, pp.467-495, 2013

2013-07-20 13:01:00
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http://hdl.handle.net/10367/4873

1 0 0 0 OA アフリカ/世界に向かう ―稲葉雅紀さんから

著者: 稲場雅紀立岩真也
出版者: 立命館大学生存学研究センター
雑誌: 生存学研究センター報告
巻号頁・発行日: vol.[2], pp.75-154, 2008-03

2013-07-20 12:48:15
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http://hdl.handle.net/10367/1499

1 0 0 0 OA フランスにおける家事事件メディエーション : カップルと親子関係紛争

著者: ラリュークローディーヌ長田真里
出版者: 立命館大学法学会
雑誌: 立命館法学 = 立命館法学 (ISSN:04831330)
巻号頁・発行日: vol.347, pp.467-495, 2013

2013-07-20 12:48:00
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1 0 0 0 OA 加硫ゴムのカーボンブラックによる力学的補強に関する基礎的研究

著者: 山下義裕
出版者: 京都大学
巻号頁・発行日: 1994-03-23

本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである

2013-07-20 11:53:00
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1 0 0 0 OA Rethinking the socio-spatial dimension in technopoles : Tsukuba Science City, Japan and One-North, Singapore

著者: Grace Lizzette Gonzalez Basurto
巻号頁・発行日: 2011

Thesis (Ph. D. in International Political Economy)--University of Tsukuba, (A), no. 5611, 2011.3.25

2013-07-20 08:30:32
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http://hdl.handle.net/2241/113149

1 0 0 0 OA Co-benefits of including CCS projects in the CDM in India's power sector

著者: Eto R. Murata A. Uchiyama Y. Okajima K.
出版者: Elsevier
雑誌: Energy policy (ISSN:03014215)
巻号頁・発行日: vol.58, pp.260-268, 2013-07
被引用文献数: 8

This study examines the effects of the inclusion of the co-benefits on the potential installed capacity of carbon dioxide capture and storage (CCS) projects with a linear programming model by the clean development mechanism (CDM) in India's power sector. It is investigated how different marginal damage costs of air pollutants affect the potential installed capacity of CCS projects in the CDM with a scenario analysis. Three results are found from this analysis. First, large quantity of IGCC with CCS becomes realizable when the certified emission reduction (CER) prices are above US$56/tCO2 in the integrated Northern, Eastern, Western, and North-Eastern regional grids (NEWNE) and above US $49/tCO2 in the Southern grid. Second, including co-benefits contributes to decrease CO2 emissions and air pollutants with introduction of IGCC with CCS in the CDM at lower CER prices. Third, the effects of the co-benefits are limited in the case of CCS because CCS reduces larger amount of CO2 emissions than that of air pollutants. Total marginal damage costs of air pollutants of US$250/t and US$200/t lead to CER prices of US$1/tCO2 reduction in the NEWNE grid and the Southern grid.

2013-07-20 08:30:26
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