ランキング (合計) - Ceek.jp Altmetrics

本邦では比較的まれな乳癌癌性髄膜症の1例を経験した.症例は59歳,女性.再発乳癌に対して化学内分泌療法施行中に頭痛,めまい,舌下神経麻痺が出現. CT, MRIにても中枢神経系の異常を指摘しえず入院のうえ対症療法を行っていた.入院後1カ月目のMRIにて左大脳半球の硬膜および左側テントの肥厚を認め癌性髄膜症と診断した.中枢神経系の症状の増悪が見られたためMethotrexateの髄膜内注入を2回施行したが症状の改善が得られる事なく癌性髄膜症発症から7カ月で死亡した.本邦でも浸潤性小葉癌の増加や術後補助療法の改善により今後本病態が増加することが予想されるため乳腺外科医は本病態の存在を常に念頭におき中枢神経系への転移の検索には積極的にMRI検査を行うべきと考える.

2017-01-09 23:10:08
1 + 0 Twitter

1 0 0 0 ガイドを伴う狩猟活動の特徴 : 北海道西興部村猟区におけるエゾシカ猟を事例に (第19回公募研究プロジェクト)

著者: 東城義則
出版者: 旅の文化研究所
雑誌: 旅の文化研究所研究報告
巻号頁・発行日: no.23, pp.35-48, 2013-12

2017-01-09 23:07:38
1 + 0 Twitter

https://ci.nii.ac.jp/naid/40019903280

1 0 0 0 熊本の治水策 . 水害と白川改修の方策

著者: 中村左衛門太郎著 . 坂田昌亮著
出版者: 熊本日日新聞社
巻号頁・発行日: 1953

2017-01-09 22:58:42
1 + 1 Wikipedia

https://ci.nii.ac.jp/ncid/BA48124196

1 0 0 0 OA 航海訓練所練習船「青雲丸」の概要

著者: 矢吹英雄倉持貴好
出版者: 公益社団法人日本船舶海洋工学会
雑誌: Techno marine : bulletin of the Society of Naval Architects of Japan : 日本造船学会誌 (ISSN:09168699)
巻号頁・発行日: no.826, pp.262-267, 1998-04
被引用文献数: 4

2017-01-09 22:43:17
1 + 1 Wikipedia

https://ci.nii.ac.jp/naid/110003868470

1 0 0 0 OA Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in Gastrocnemius Muscle

著者: Ryo Fujita Yoshinori Tanaka Yasuhiro Saihara Mitsuya Yamakita Daisuke Ando Katsuhiro Koyama
出版者: 日本生理人類学会
雑誌: Journal of PHYSIOLOGICAL ANTHROPOLOGY (ISSN:18806791)
巻号頁・発行日: vol.30, no.5, pp.195-201, 2011-09-30 (Released:2011-10-01)
参考文献数: 29
被引用文献数: 8 21

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were divided into four groups: (1) the control (CONT); (2) the Hindlimb unloading (HU, for 3 weeks) given purified normal water (HU-NW); (3) the HU given alkaline electrolyzed reduced water (HU-AEW); and (4) the HU given HSW (HU-HSW). We showed that 8-OHdG, but not MDA, significantly increased by 149% and 145% in HU-NW and HU-AEW, respectively, when compared with CONT. In contrast, there was a trend toward suppression in 8-OHdG levels (increased by 95% compared with CONT) by treatment of HSW, though this effect was not prominent. Additionally, SOD-like activity significantly increased in both HU-NW (184%) and HU-AEW (199%) when compared with CONT. This result suggests the elevation of O2−· in the atrophied gastrocnemius. However, upregulation of SOD-like activity in the HU-HSW was increased by only 169% compared with CONT, though this difference is too small to detect statistical significance. HU led to 13% and 15% reduction of gastrocnemius wet weights in HU-NW and HU-AEW, respectively, compared with CONT. And the reduction of gastrocnemius wet weights in HU-HSW was attenuated by 7% compared with CONT. The gastrocnemius wet weights in the HU-HSW group were significantly greater than those in the HU-AEW, but not statistically significant with HU-NW. These results indicate that HU causes an increase in oxidative stress, but, in this experimental protocol, continuous consumption of HSW during HU does not demonstrate successful attenuation of oxidative stress and HU-mediated gastrocnemius atrophy.

2017-01-09 22:21:08
1 Google+

1 0 0 0 サピエンス全史 : 文明の構造と人類の幸福

著者: ユヴァル・ノア・ハラリ著柴田裕之訳
出版者: 河出書房新社
巻号頁・発行日: 2016

2017-01-09 22:17:34
1 + 0 Twitter

https://ci.nii.ac.jp/ncid/BB22036374

1 0 0 0 OA 文選60卷目1卷

著者: 梁蕭統撰
巻号頁・発行日: 1625

「文選」は周から南朝梁代まで一千年間、百数十人の詩・賦・文章800編余を集めた最古の詩文集。梁蕭統(昭明太子)撰。本書はその註釈書。文章作法の規範として後代知識人の必読の書となった。本版は寛永2年(1625)木活字印本。古活字版。慶長12年(1607)直江兼続が京都の要法寺の活字で印刷させた、いわゆる直江版文選の翻印本。巻末に慶長12年の原刊記があり、続いて本版の刊記が「寛永二乙丑孟夏上旬日板行畢」とある。活字は摩滅少なく佳版である。欠丁があり、補写が加えられている。