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Clinical manifestation of arsenicism is different from acute type and chronic type. Some cutaneous symptoms of chronic type are characteristics of arsenicism. Especially, rain drops like depigmentations, spotty hyperkeratosis on the palms and soles, and multiple Bowen's disease on the trunk suggest chronic arsenicism. Over 10 years later, verious cancers derive from many organs. This is most terrible problem. We have to find out and treat them at early time.

2013-04-02 18:58:06
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https://ci.nii.ac.jp/naid/110007159893

1 0 0 0 Indigenous peoples of Asia

著者: edited by R. H. Barnes Andrew Gray and Benedict Kingsbury
出版者: Association for Asian Studies
巻号頁・発行日: 1995

2013-04-02 17:51:03
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https://ci.nii.ac.jp/ncid/BA26393660

1 0 0 0 治療の「中断」が分離不安のwork throughにもたらすもの

著者: 南里幸一郎
出版者: 日本精神分析学会
雑誌: 精神分析研究 (ISSN:05824443)
巻号頁・発行日: vol.41, no.4, pp.400-402, 1997-09-25

2013-04-02 17:46:05
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https://ci.nii.ac.jp/naid/10009535122

1 0 0 0 OA 機械学習を用いたコンタクトマップによるタンパク質機能部位予測

著者: 豊田毅嗣
巻号頁・発行日: 2008-02-04

修士論文

2013-04-02 17:34:04
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http://hdl.handle.net/2065/13157

1 0 0 0 OA Vertebral Histomorphometry in a Child with Glucocorticoid-Induced Osteoporosis

著者: Yuji Hatakeyama Naohisa Miyakoshi Yuji Kasukawa Arata Watanabe Masashi Hirayama Seietsu Senma Iwao Ono Yoichi Shimada
出版者: 東北ジャーナル刊行会
雑誌: The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日: vol.227, no.4, pp.263-267, 2012 (Released:2012-07-14)
参考文献数: 16
被引用文献数: 2 1

Vertebral fractures are an under-recognized problem in children with glucocorticoid-induced osteoporosis (GIO). They cause severe back pain and spinal column deformity with a decrease of quality of life. For evaluating the bone mass, bone mineral density measurements have been widely carried out using dual energy X-ray absorptiometry. However, bone histomorphometric analyses of GIO in children are scarce. Bone histomorphometric analyses of vertebral bodies have not been reported. Our aim is to report the first bone histomorphometric data for vertebrae from an autopsied child with GIO. A 15-year-old girl with systemic lupus erythematosus was started on a daily oral dose of 10 mg of prednisolone at 6 years of age. She presented with back pain from 12 years of age. Magnetic resonance imaging at 14 years of age showed a compression fracture of the first lumbar (L1) vertebral body. At 15 years of age, she died of heart failure owing to pulmonary hypertension. Collapsed (L1) and non-collapsed (seventh thoracic vertebrae; T7) vertebral bodies were autopsied for bone histomorphometry and compared. T7 showed severe osteoporosis (bone volume, 4.99%; trabecular thickness, 59 μm; trabecular separation, 1,134 μm). Compared with T7, L1 showed increased bone volume (33.9%) and trabecular thickness (77 μm), and decreased trabecular separation (156 μm) owing to the impact of the vertebral fracture. The bone formation and bone resorption parameters were comparable between the two vertebrae. These histological findings suggest that severe osteoporosis developed after long-term glucocorticoid administration, and that the remodeling activities were similar in the fractured and non-fractured vertebrae.