著者
平田 文 石坂 正大 沢谷 洋平 柴 隆広 浦野 友彦
出版者
一般社団法人 日本老年医学会
雑誌
日本老年医学会雑誌 (ISSN:03009173)
巻号頁・発行日
vol.58, no.1, pp.134-142, 2021-01-25 (Released:2021-02-25)
参考文献数
20
被引用文献数
5

はじめに:要介護高齢者が地域で生活を続けるためには,サルコペニアなどの老年症候群の徴候を早期に発見し,適切な対応をしていくことが重要である.本研究の目的は,地域在住の要支援・要介護高齢者における嚥下機能の特徴を調査し,嚥下機能,栄養状態,サルコペニアなどの身体機能の関連性を明らかにする.方法:対象は,通所リハビリを利用している要支援1,2,要介護1の高齢者90名(男性55名,女性35名,平均年齢77.2±8.3歳).調査項目は,聖隷式嚥下質問紙,20品目摂取可能食品数調査,サルコペニアの簡易スクリーニング方法であるSARC-F,舌圧,握力,骨格筋指数(SMI),簡易栄養状態評価表(MNA-SF)だった.結果:聖隷式嚥下質問紙で「嚥下障害あり」「嚥下障害疑い」と判定された嚥下機能不良群は75名(83.3%),「嚥下障害無し」と判定された嚥下機能良好群は15名(16.7%)だった.対象者の30%以上に症状を認めた質問は,「食事中にむせることがありますか」「食べるのが遅くなりましたか」「硬いものが食べにくくなりましたか」だった.嚥下機能を従属変数とし,6つの調査項目全てを独立変数として強制投入したロジスティック回帰分析の結果,SARC-Fにおいて有意差を認めた(OR 1.994,95%CI 1.154~3.446,p=0.013).判別的中率は82.8%だった.結論:地域在住の要支援・要介護高齢者は嚥下障害のリスクが高く,特に咀嚼を含む口腔期に症状を呈していることが明らかになった.さらに,嚥下機能とSARC-Fに関連性を認めた.サルコペニアを早期に発見し予防することは,嚥下障害を防ぎ在宅生活を継続するために重要であることが示唆された.
著者
平田 文雄
出版者
The Society of Synthetic Organic Chemistry, Japan
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.41, no.2, pp.178-185, 1983-02-01 (Released:2009-11-13)
参考文献数
18

The current status of prostaglandin research is reviewed mainly on the primary prostaglandins, widely distributed in the living body, and on prostaglandin analogues having more stable structure and higher selective biological activities, which were developed by reference to the structures and activities of the primary PGs. Especially, recent aspect on their clinical application and development is explained. Moreover, the new field is viewed mainly on the future commercialization of PGI2 and TXA2 synthesis inhibitor, which will be applied mainly on circulatory system, from Yin-Yang theory. Further, recent rapid progress in leukotriene research on lipoxygenase system in arachidonic acid cascade will also been mentioned.
著者
図子 浩二 西薗 秀嗣 平田 文夫
出版者
一般社団法人日本体力医学会
雑誌
体力科学 (ISSN:0039906X)
巻号頁・発行日
vol.47, no.5, pp.593-600, 1998-10-01
参考文献数
22
被引用文献数
4 2

A study was conducted to investigate the relationship between the characteristics of torque production with special reference to eccentric and concentric muscle contraction and the structural and functional properties at the lower limb joints in the human kinetic chain. Ten male college athletes were tested with a isokinetic dynamometer (biodex) for eccentric and concentric torques during extension and flexion at the hip and knee, and plantar flexion and dorsiflexion at the ankle (angular velocity ; 30, 60, 120 deg/s) . The peak eccentric and concentric torques were higher in the order hip, knee and ankle joints, as the size of each muscle acting on its joint increased. However, the rate of peak concentric to eccentric torque (CON/ECC, %) was higher at the ankle joint than at the hip and knee joints. They tended to increase in the order of angular velocity ; 30, 60, 120 deg/s. These results suggest that the ankle joint is charactered by higher eccentric torque production. This characteristic is probably due to the fact that (1) the ankle joint is located at the end of the human kinetic chain and plays a role in transmitting the power to the ground effectively, (2) the muscle tendon complex acting at the ankle joint must have increased stiffness and tolerate great stretch loads to store and reuse the amount of elastic energy, (3) the hip and knee joints located at the center are the main sources of power supply. On the other hand, no significant correlations were observed among the torques at the hip, knee and ankle. These results suggest that torque production is independent at each of the lower limb joints, and is based on the structural and functional properties of each joint. These findings seem to be useful to clarifying the methods of strength and power training that can be adapted to the characteristics of torque production and the structural and functional properties of the hip, knee and ankle joints.
著者
平田 文夫
出版者
至文堂
雑誌
物理化學の進歩
巻号頁・発行日
vol.3, no.3, pp.242-276, 1930-12-09
著者
吉田 紀生 丸山 豊 PHONGPHANPHANEE Saree 清田 泰臣 平田 文男
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.51, no.5, pp.222-225, 2011 (Released:2011-09-25)
参考文献数
13
被引用文献数
2 1

Recent progress in the theory of molecular recognition in biomolecules is reviewed, which has been made based on the statistical mechanics of liquids or the 3D-RISM/RISM theory. The molecular recognition of a ligand by the protein is realized by the 3D-distribution functions: if one finds some conspicuous peaks in the distribution of a ligand inside protein, then the ligand is regarded as “recognized” by the protein. 3D-distribution functions can be obtained by means of 3D-RISM/RISM theory. Some biochemical processes are investigated, which are intimately related to the molecular recognition of small ligands such as water, ions, and carbon monoxide by a protein.