著者

Shim Unyob Cahn Sidney B. Kumarakrishnan Anantharaman Sleator Tycho Kim Jin-Tae

出版者

The Japan Society of Applied Physics

雑誌

Japanese Journal of Applied Physics (ISSN:00214922)

巻号頁・発行日

vol.44, no.1, pp.168-173, 2005

被引用文献数

4

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We have observed optical nutation in cold <SUP>85</SUP>Rb atoms with a negligible Doppler broadening. The optical nutation of a two-level atom arranged by optical pumping has been studied as a function of detuning frequency and Rabi frequency. The change of the nutation signal caused by magnetic substate degeneracy has also been observed for &sigma; and &pi; excitations. This can be explained by optical nutation beatings from different transition probabilities among magnetic sublevels. Absolute transition probabilities with &sigma; and &pi; transitions and a branching ratio between them have been measured.

著者

Taya-A.T著

出版者

女性モード社

巻号頁・発行日

1996

著者

Shinya Goto Chien-Hua Huang Seung-Jung Park Håkan Emanuelsson Takeshi Kimura

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.11, pp.2452-2460, 2015-10-23 (Released:2015-10-23)

参考文献数

37

被引用文献数

59 199

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Background:Few data on the relative efficacy and safety of new P2Y12inhibitors such as prasugrel and ticagrelor in Japanese, Taiwanese and South Korean patients with acute coronary syndromes (ACS) exist.Methods and Results:The multicenter, double-blind, randomized PHILO trial compared the safety and efficacy of ticagrelor vs. clopidogrel in 801 patients with ACS (Japanese, n=721; Taiwanese, n=35; South Korean, n=44; unknown ethnicity, n=1). All were planned to undergo percutaneous coronary intervention and randomized within 24 h of symptom onset. Primary safety and efficacy endpoints were time to first occurrence of any major bleeding event and to any event from the composite of myocardial infarction, stroke or death from vascular causes, respectively.At 12 months, overall major bleeding occurred in 10.3% of ticagrelor-treated patients and in 6.8% of clopidogrel-treated patients (hazard ratio (HR), 1.54; 95% confidence interval (CI): 0.94–2.53); the composite primary efficacy endpoint occurred in 9.0% and in 6.3% of ticagrelor- and clopidogrel-treated patients, respectively (HR, 1.47; 95% CI: 0.88–2.44). For both analyses, the difference between groups was not statistically significant.Conclusions:In ACS patients from Japan, Taiwan and South Korea, event rates of primary safety and efficacy endpoints were higher, albeit not significantly, in ticagrelor-treated patients compared with clopidogrel-treated patients. This observation could be explained by the small sample size, imbalance in clinical characteristics and low number of events in the PHILO population. (Circ J 2015; 79: 2452–2460)

著者

Qing-Shan GAO Mei-Fu XUAN Zhao-Bo LUO Hyo-Jin PAEK Jin-Dan KANG Xi-Jun YIN

出版者

Japanese Association for Laboratory Animal Science

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

pp.19-0018, (Released:2019-07-15)

被引用文献数

3

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The nuclear receptor corepressor Hairless (HR) interacts with nuclear receptors and controls expression of specific target genes involved in hair morphogenesis and hair follicle cycling. Patients with HR gene mutations exhibit atrichia, and in rare cases, immunodeficiency. Pigs with HR gene mutations may provide a useful model for developing therapeutic strategies because pigs are highly similar to humans in terms of anatomy, genetics, and physiology. The present study aimed to knockout the HR gene in pigs using the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated-9 system and to investigate the molecular and structural alterations in the skin and thymus. We introduced a biallelic mutation into the HR gene in porcine fetal fibroblasts and generated nine piglets via somatic cell nuclear transfer. These piglets exhibited a lack of hair on the eyelids, abnormalities in the thymus and peripheral blood, and altered expression of several signaling factors regulated by HR. Our results indicate that introduction of the biallelic mutation successfully knocked out the HR gene, resulting in several molecular and structural changes in the skin and thymus. These pigs will provide a useful model for studying human hair disorders associated with HR gene mutations and the underlying molecular mechanisms.

著者

edited by Thierry-Maxime Loriot

出版者

Phaidon Press

巻号頁・発行日

2019

著者

Alexander Fury and Roland Mouret in conversation creative director and editor: Sophia Neophitou-Apostolou

出版者

Rizzoli

巻号頁・発行日

2018

著者

上田-西脇 由美子 倭 英司 正木 志歩

出版者

日本臨床栄養学会

雑誌

日本臨床栄養学会雑誌 (ISSN:02868202)

巻号頁・発行日

vol.36, no.2, pp.119-123, 2014

著者

ボンズ-ガレット クリスティ

出版者

フレグランスジャーナル社

雑誌

Aromatopia : the journal of aromatherapy & natural medicine (ISSN:09184295)

巻号頁・発行日

vol.24, no.3, pp.6-10, 2015

著者

David Wechsler著 日本版WISC-IV刊行委員会訳編著

出版者

日本文化科学社

巻号頁・発行日

2010

著者

Hong Seong Su Lee Seon A Han Xiang Hua LEE Min Hee HWANG Ji Sang PARK Jeong Sook OH Ki-Wan HAN Kun LEE Myung Koo LEE Heesoon KIM Wook LEE Dongho HWANG Bang Yeon

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.56, no.2, pp.199-202, 2008-02-01

被引用文献数

1 27

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Two new melampolide-type sesquiterpene lactones, 8β-epoxyangeloyloxy-9α-ethoxy-14-oxo-acanthospermolide (1) and 8β-angeloyloxy-9α-ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8β-angeloyloxy-9α-acetoxy-14-oxo-acanthospermolide (7), 8β-angeloyloxy-14-oxo-acanthospermolide (8), 8β-methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8β-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.

著者

Junro KATO Tatsuya ODATE Yo-Han KIM Toshihiro ICHIJO Shigeru SATO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.7, pp.958-967, 2019 (Released:2019-07-11)

参考文献数

49

被引用文献数

1

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The objective of the present study was to identify the effect of feeding management on disease incidence and blood metabolite levels in dairy herds in Iwate Prefecture, Japan. A generalized linear model approach was used to identify the risk factors for ketosis and displaced abomasum (DA) in dairy herds (n=30), and metabolic profile test (MPT) results were compared to verify the involvement of the factors. Consequently, the proportion of corn silage (CS) with ≥30% of dry matter (DM) fed to cows during the lactation period was confirmed as the most reliable risk factor for ketosis, while no risk factor was identified for DA. Meanwhile, the incidence rates of ketosis and DA were significantly (P<0.05) higher in the herds that were fed CS (n=20) than in those fed a non-CS diet (n=10). When the MPT results of the herds fed with CS containing ≥30% of DM (HCS group, n=4; 76 cows), with CS containing <30% of DM (LCS group, n=14; 285 cows), and a non-CS diet (NCS group, n=12; 236 cows) were compared, the HCS group showed higher beta-hydroxybutyric and lower blood urea nitrogen concentrations for until 49 days after parturition. Overall, feeding cows with CS diets containing over 30% of DM might increase their risk of developing negative energy and protein balances, thereby resulting in increasing incidences of ketosis in the Iwate Prefecture.

著者

François-Xavier Coudert

出版者

Japan Society of Coordination Chemistry

雑誌

Bulletin of Japan Society of Coordination Chemistry (ISSN:18826954)

巻号頁・発行日

vol.73, pp.15-23, 2019-05-31 (Released:2019-07-10)

参考文献数

94

被引用文献数

5

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Recent years have seen a large increase in the number of reported framework materials, including the nowadays-ubiquitous metal–organic frameworks (MOFs). Many of these materials show flexibility and stimuli-responsiveness, i.e. their structure can undergo changes of large amplitude in response to physical or chemical stimulation. We describe here a toolbox of theoretical approaches, developed in our group and others, to shed light into these materials’ properties. We focus on their behavior under mechanical constraints, temperature changes, adsorption of guest molecules, and exposure to light. By means of molecular simulation at varying scale, we can now probe, rationalize and predict the behavior of stimuli-responsive materials, producing a coherent description of soft porous crystals from the unit cell scale all the way to the behavior of the whole crystal. In particular, we have studied the impact of defects in soft porous crystals, and developed a methodology for the study of their disordered phases (presence of correlated disorder, MOF glasses, and liquid MOFs)

著者

Usami Masahide Sasayama Daimei Sugiyama Nobuhiro Hosogane Nana Kim Soo-Yung Yamashita Yushiro Kodaira Masaki Watanabe Kyota Iwadare Yoshitaka Sawa Tetsuji Saito Kazuhiko

出版者

BIOMED CENTRAL LTD

雑誌

CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH

巻号頁・発行日

vol.7, pp.11, 2013-01

被引用文献数

9

---

Background: The aim of this study was to evaluate the reliability and validity of the Questionnaire-Children with Difficulties (QCD), which was developed for the evaluation of children's daily life behaviors during specified periods of the day. Methods: The subjects were 1,514 Japanese public elementary and junior high school students. For the examination of reliability, Cronbach's alpha was calculated to assess the internal consistency of the questionnaire. With regard to validity, correlation coefficients were calculated to examine whether QCD scores correlated with those of the ADHD-Rating Scale (ADHD-RS) and the Oppositional Defiant Behavior Inventory (ODBI). Results: Cronbach's alpha coefficient for the total score of the QCD was .876. The correlation coefficients of the QCD score with ADHD-RS and ODBI scores were -.514 and -.577, respectively. Conclusions: The internal consistency and validity of the QCD were demonstrated. The QCD is a reliable and valid instrument for evaluating daily life problems for children during different time periods of the day.

著者

SEO Won-Kyeong CHOI Jae-In CHO You-Ze

出版者

一般社団法人 電子情報通信学会

雑誌

IEICE Transactions on Communications (ISSN:09168516)

巻号頁・発行日

vol.97, no.11, pp.2327-2336, 2014

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The Internet Engineering Task Force (IETF) has been actively standardizing distributed mobility management (DMM) schemes with multiple Mobility Anchors (MAs). Yet, all existing schemes have limitations that preclude the efficient distribution of mobile data traffic, including single point failure problems, heavy tunneling overheads between MAs, and a restrictive traffic distribution for external nodes in a mobility domain. Therefore, this paper proposes an efficient mobility management scheme with a virtual Local Mobility Anchor (vLMA). While the vLMA is designed assuming multiple replicated LMAs for a PMIPv6 domain, it acts virtually as a single LMA for the internal and external nodes in the PMIPv6 domain. Furthermore, the vLMA distributes mobile data traffic using replicated LMAs, and routes packets via a replicated LMA on the optimal routing path. Performance evaluations confirm that the proposed scheme can distribute mobile data traffic more efficiently and reduce the end-to-end packet delay than the Distributed Local Mobility Anchor (DLMA) and the Proxy Mobile IPv6 (PMIPv6).

著者

Yun Yao Fang-Fei Guo Bo Zhou Shi-Qing Zheng

出版者

The Society of Chemical Engineers, Japan

雑誌

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)

巻号頁・発行日

vol.42, no.Supplement., pp.s149-s155, 2009-12-30 (Released:2009-12-30)

参考文献数

22

被引用文献数

2 3

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Experimental study has been aimed at examining the flow regimes of gas–liquid in up-flow ejectors by planar laser induced fluorescence (PLIF) technology under air–water and carbon dioxide–water system, the velocity fields by particle image velocimetry (PIV) under carbon dioxide–water system and gaining the bubble photos under air–water system. The conclusions were as follows: (1) The PLIF experimental results showed that in the absence of swirl, the liquid formed and maintained jet in the lower part of ejector and the air flowed up around the liquid jet annularly. At some point along the ejector axis, the jet broke up and the gas dispersed into small bubbles in the liquid. In the presence of swirl, the liquid jet didn’t exist any longer and the two phases interpenetrated and diffused immediately when two phases contact each other. (2) In the PIV measurements, the experimental data showed that at steady state the gas bubbles in the liquid flowed up along the axial direction or paralleled to the wall without swirl. However, the existence of swirl makes the velocity vectors of gas bubbles rotated and flowed up with some extent helicity. (3) The bubble photos showed that at low G/L the bubbles in the presence of swirl form the bubble chain while in the absence of swirl the bubbles disperse uniformly. However, when the G/L ratio increases, the difference in the bubble distribution diminish and the bubble tend to fill of the whole diffuser of the ejector with and without swirl.

著者

Seong-Yeol Kim Sung-Ja Koo

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.6, pp.1669-1672, 2016 (Released:2016-06-24)

参考文献数

19

被引用文献数

17 101

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[Purpose] The effect of duration of smartphone use on neck and shoulder muscle fatigue and pain was investigated in adults with forward head posture. [Subjects and Methods] Thirty-four adults with forward head posture were classified into groups by duration of smartphone use: 11 used a smartphone for 10 minutes each (group 1), 12 for 20 minutes each (group 2), and 11 for 30 minutes each (group 3). Fatigue cervical erector spinae and upper trapezius muscles was measured by electromyography, and pain before and after the experiment was evaluated using Visual Analog Scale (VAS) scores. [Results] There was a significant difference in the degree of fatigue in the left upper trapezius muscles in group 2 and left cervical erector spinae and bilateral upper trapeziuses group 3. There was a significant difference in fatigue in the left upper trapezius in groups 1 and 3. The VAS showed significant differences in all groups before and after the experiment and between groups 1 and 3. [Conclusion] Pain and fatigue worsened with longer smartphone use. This study provided data on the proper duration of smartphone use. Correct posture and breaks of at least 20 minutes are recommend when using smartphones.

著者

Satoshi WATANABE Shin-ichi TOGASHI Noriko TAKAHASHI Tetsuya FUKUI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.48, no.1, pp.36-39, 2002 (Released:2009-04-28)

参考文献数

22

被引用文献数

25 46

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An antioxidant Was purified from human placenta extract (HPE) by using gel filtration, liquid-liquid extraction, silicagel column chromatography, and HPLC. The purified antioxidant was identified to be L-tryptophan (L-Trp). L-Trp showed higher inhibitory activity than mannitol and DMSO on the Fenton reaction-induced degradation of 2-deoxy-D-ribose. L-Trp also had much higher inhibitory activity on the cytochrome P-450-dependent lipid peroxidation than the previously identified antioxidants of HPE, L-phenylalanine, L-tyrosine and uracil. On the other hand, the inhibitory effect of L-Trp on the Fenton reactioninduced protein oxidation was smaller than that of uracil. These results suggest that L-Trp is a main antioxidant of HPE of which the effect is based on the suppression of lipid peroxidation in the oxidative stress status.

著者

Jeon Jeong-Ryae Kim Jong-Yeon

出版者

公益社団法人日本薬学会

雑誌

Biological & pharmaceutical bulletin (ISSN:09186158)

巻号頁・発行日

vol.29, no.10, pp.2111-2115, 2006-10-01

参考文献数

19

被引用文献数

1 28

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The present study examined the anti-obesity effects of pine needle extract (PNE) in 3T3-L1 preadipocytes and <i>in vivo</i> studies. PNE treatment suppressed both glycerol-3-phosphate dehydrogenase activity and expression of peroxisome proliferator-activated receptor (PPAR) &gamma; in cultured 3T3-L1 adipocytes. To investigate the effect of PNE on obesity in rats fed high-fat diet, four types of diet, which included a normal diet (ND), high-fat diet (HFD), ND+PNE, and HFD+PNE diets, were fed to the rats <i>ad libitum</i> for 6 weeks. The PNE supplement significantly decreased body weight gain and visceral fat mass compared to the HFD group. The total cholesterol, TG, and leptin levels in the plasma were significantly reduced by PNE supplementation compared with those of the HFD group. Histological findings in liver tissue showed that PNE supplementation alleviated steatosis induced by HFD. In conclusion, PNE treatment suppressed differentiation of 3T-L1 adipocytes, in part by down-regulating expression of PPAP&gamma; mRNA, and reduced adipose tissue mass, hyperlipidemia, and hepatic steatosis in obese rats fed HFD. Therefore, pine needle water extract may be considered for use in therapy to control obesity.

著者

神田 浩路 イブラハム-ジブリン ビルキス ンニシ リリアン イユル モハメド マラカ モナパシ ニャングル ムテンワ ドゥラミニ ムーレ デリー サミュエル マディディマロ テボゴ 大林 由英 新井 明日奈 リー ロメオ 玉城 英彦

雑誌

北海道醫學雜誌 = Acta medica Hokkaidonensia (ISSN:03676102)

巻号頁・発行日

vol.87, no.2, 2012-04-01

著者

佐々木 晶 加藤 学 SELENE-B サイエンスチーム

出版者

日本惑星科学会

雑誌

日本惑星科学会秋季講演会予稿集

巻号頁・発行日

vol.2003, pp.47, 2003

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月の起源・進化の解明の上で、月を構成する物質の起源の解明のために、月面での直接探査が不可欠である。理学と工学の研究者が協力して、月面での無人ローバ直接探査の検討を行ってきた。月の起源・進化の研究において、地殻形成・火成活動の初期と最終段階はまだ未解明である。そのため、クレータ中央丘の物質を直接観測することで、月の地下物質の組成を同定し、マグマオーシャンからの成層構造形成モデルに制約を与える探査、海の玄武岩火成活動の後期に進行した火山体形成を調べることで、マグマ進化の最終段階の情報得る探査が重要である。SELENE‐B 計画へのローバ搭載を目指して、シナリオ検討、科学機器開発を行っている。月の起源・進化の解明を目指して、SELENE 計画がはじまり、極軌道衛星による月全体のリモートセンシング探査が行われる。しかし、月を構成する物質がどのように形成されたのかを知るためには、月面での直接探査が不可欠である。我々は1年半前より、理学と工学の研究者が協力して、ローバを使った月面での無人直接探査の検討を行ってきた。これまでにクレータ中央丘探査による初期地殻・マントル物質の探査が重要であるという結論に達した。月の起源・進化の研究において、地殻形成・火成活動の初期と最終段階はまだ未解明である。クレータ中央丘の物質を直接観測することで、月の地下物質の組成を同定し、マグマオーシャンからの成層構造形成モデルに制約を与えることができる。月面探査で着陸船(ランダ)だけによる探査を行う場合は、表面試料の直接観察対象はアームなどを使用したとしても、周囲数 m が限界である。ローバを利用すると、広範囲の目標に対し、物質科学的特徴を知るための 1次分析、サンプルの採取が可能である。ランダのみの探査や有人探査が困難な地域(影、急傾斜地、崩壊地)の探査が可能になる。詳細分析が必要な場合は、ランダに戻り高感度・精度の分析機器を使用したり、さらにサンプルリターンを行えばよい。特にローバ・ランダの直接交信による高いデータ輸送量を保つためには、ローバの移動距離が数 100m 程度に制限されるため、ローバ・ランダの協調ミッションが現実として重要になる。いずれにせよ、月・惑星探査の将来ビジョンではサンプルリターンは重要な目標となる。その基礎技術としてローバは不可欠である。