著者

Jaesung Choi Ji-Yeob Choi Aesun Shin Sang-Ah Lee Kyoung-Mu Lee Juhwan Oh Joo Yong Park Jong-koo Lee Daehee Kang

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.29, no.4, pp.125-132, 2019-04-05 (Released:2019-04-05)

参考文献数

46

被引用文献数

14

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Background: We aimed to report the prevalence and correlates of high-risk alcohol consumption and types of alcoholic beverages.Methods: The baseline data of the Health Examinees-Gem (HEXA-G) study participants, including 43,927 men and 85,897 women enrolled from 2005 through 2013, were used for analysis. Joinpoint regression was performed to estimate trends in the age-standardized prevalence of alcohol consumption. Associations of demographic and behavioral factors, perceived health-related effects, social relationships, and the diagnostic history of diseases with alcohol consumption were assessed using multinomial logistic regression.Results: The prevalence of alcohol consumption remained higher in men during the study period and increased in women. The amount of alcohol consumed has increased in women, especially that from beer and makgeolli, a traditional Korean fermented rice wine. Older participants were less likely to be high-risk drinkers (men and women who drink more than 40 or 20 g/day of alcohol, respectively) and drink Soju, a distilled liquor, and beer, and more likely to drink makgeolli. Educational level was negatively associated with high-risk drinking. However, it was positively associated with the consumption of strong spirits and wine. Smoking was associated with high-risk drinking and the consumption of soju and strong spirits. Engaging in regular exercise and having stress were associated with drinking all types of beverages except for soju.Conclusions: Sex-specific trends in alcohol consumption were influenced by demographic, behavioral, and perceived health-related factors. The findings will help improve the understanding of alcohol-related problems and provide evidence for establishing country-specific policies and campaigns in Korea.

著者

Cathal Gurrin Klaus Schoeffmann Hideo Joho Andreas Leibetseder Liting Zhou Aaron Duane Duc-Tien Dang-Nguyen Michael Riegler Luca Piras Minh-Triet Tran Jakub Lokoč Wolfgang Hürst

出版者

The Institute of Image Information and Television Engineers

雑誌

ITE Transactions on Media Technology and Applications (ISSN:21867364)

巻号頁・発行日

vol.7, no.2, pp.46-59, 2019 (Released:2019-04-01)

参考文献数

31

被引用文献数

69

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The Lifelog Search Challenge (LSC) is an international content retrieval competition that evaluates search for personal lifelog data. At the LSC, content-based search is performed over a multi-modal dataset, continuously recorded by a lifelogger over 27 days, consisting of multimedia content, biometric data, human activity data, and information activities data. In this work, we report on the first LSC that took place in Yokohama, Japan in 2018 as a special workshop at ACM International Conference on Multimedia Retrieval 2018 (ICMR 2018). We describe the general idea of this challenge, summarise the participating search systems as well as the evaluation procedure, and analyse the search performance of the teams in various aspects. We try to identify reasons why some systems performed better than others and provide an outlook as well as open issues for upcoming iterations of the challenge.

著者

Tomonari Akiko Katanuma Akio Matsumori Tomoaki Yamazaki Hajime Sano Itsuki Minami Ryuki Sen-yo Manabu Ikarashi Satoshi Kin Toshifumi Yane Kei Takahashi Kuniyuki Shinohara Toshiya Maguchi Hiroyuki

出版者

WJG Press

雑誌

World Journal of Gastroenterology (ISSN:22192840)

巻号頁・発行日

vol.21, no.27, pp.8458-8461, 2015-07-21

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Endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically.

著者

Hsi-Te Shih Yixiong Cai 丹羽 信彰 中原 泰彦

出版者

日本甲殻類学会

雑誌

CANCER (ISSN:09181989)

巻号頁・発行日

vol.27, pp.107-108, 2018-08-01 (Released:2018-08-31)

参考文献数

2

著者

MENSA-BONSU A.

雑誌

Insectes Sociaux

巻号頁・発行日

vol.23, pp.155-166, 1976

被引用文献数

1 17

著者

Weibin Du Chiharu Fukano Mari Yonemoto Tomokazu Matsuoka Keisuke Masuyama Katsuyo Ohashi-Doi

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.42, no.4, pp.601-606, 2019-04-01 (Released:2019-04-01)

参考文献数

29

被引用文献数

5

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Subcutaneous allergen immunotherapy (SCIT) with non-standardized house dust (HD) extracts has been used in Japan since 1963 for house dust mite (HDM)-allergic patients. Since the potencies of HD extracts are unknown, the allergenic potency of HD extracts was examined by comparing with a standardized HDM allergen extracts. The major allergen content of HDM in the extracts was measured using a sandwich enzyme-linked immunosorbent assay (ELISA). The immunoglobulin E (IgE) inhibitory activities of the extracts were measured by a competitive ELISA. The extract concentrations giving 50% inhibition of IgE binding (log10 IC50) were determined from dose–response curves and defined as inhibitory activities. A linear regression line was constructed from the log10 IC50 values of the standardized HDM extract to interpolate the relative potency of the HD extract with strength of 1 : 10 w/v (HD 1 : 10). The amounts of major allergens (Der f 1, Der p 1 and Der 2) were 116.3 µg/mL in the HDM allergen extract (100000 Japanese Allergy Units [JAU]/mL) and 0.77 µg/mL in the HD 1 : 10. The inhibitory activity (log10 IC50 values) of HD 1 : 10 was 2.389 ± 0.078, indicating the allergenic potency was between 200 and 2000 JAU/mL. Based on regression analysis (R2 >0.99), the allergenic potency of HD 1 : 10 was estimated to be 842 ± 128 JAU/mL. The present study determined the major allergen content of HD extract, which contributes to its allergenic potency. The allergenic potency of HD 1 : 10 was ca. 100-fold less than that of HDM allergen extract.

著者

Anne E. Duggan traduit de l'anglais par Jean-François Cornu

出版者

Presses universitaires de Rennes

巻号頁・発行日

2015

著者

Pey-Yu Wang Takashi Kaneko Yuan Wang Masato Tawata Akio Sato

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.189, no.1, pp.59-70, 1999 (Released:2005-07-05)

参考文献数

17

被引用文献数

6 11

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Some normal people are falsely classified as having impaired glucose tolerance (IGT) if they are given an oral glucose tolerance test (OGTT) when their last meal contained very few carbohydrates. In this study, the duration of carbohydrate restriction was extended to one and three days and the relationship between the carbohydrate restriction and the glucose tolerance after an OGTT was examined. Two different groups of normal subjects were placed on high-carbohydrate (80% carbohydrates) and low-carbohydrate (10%) diets before an OGTT; one group for one day and the other for 3 days. None of the subjects showed impairment of glucose tolerance when placed on the high-carbohydrate regimens. In contrast, 3 of 12 subjects and 2 of 8 subjects placed on the low-carbohydrate diets for 1 and 3 days, respectively, were classified as having IGT. The impairment of glucose tolerance was invariably accompanied by an increase in the fasting plasma free fatty acid level. The longer the period of carbohydrate restriction, the severer was the glucose tolerance impairment. However, the number of subjects who were classified as having IGT did not depend on the duration of carbohydrate restriction. The impairment of glucose tolerance after carbohydrate restriction may be associated with the Randle effect, which is the activation of the glucose-free fatty acid cycle.

著者

Miyuki Tsuchihashi-Makaya Hisashi Matsuo Shigeo Kakinoki Shigeru Takechi Shintaro Kinugawa Hiroyuki Tsutsui for the J-HOMECARE Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.4, pp.926-933, 2013 (Released:2013-03-25)

参考文献数

36

被引用文献数

20 52

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Background: A disease management program can reduce mortality and rehospitalization of patients with heart failure (HF), but little is known about whether it can improve psychological status. The purpose of this study was to determine the effects of home-based disease management on the psychological status of patients with HF. Methods and Results: We randomly assigned patients hospitalized for HF to undergo either home-based disease management (n=79) or usual care (n=82). The mean age of the study patients was 76 years, 30% were female, and 93% were in NYHA class I or II. Home-based disease management was delivered by nurses via home visit and telephone follow-up to monitor symptoms and body weight and to educate patients. The primary endpoint was psychological status, including depression and anxiety assessed by the Hospital Anxiety and Depression Scale during follow-up of 1 year. Secondary endpoints included quality of life, all-cause death and hospitalization for HF. The intervention group had significantly lower depression (P=0.043) and anxiety (P=0.029) scores than the usual-care group. There were no significant differences in all-cause death [hazard ratio (HR) 1.02, 95% confidence interval (CI) 0.37–2.61, P=0.967]. However, hospitalization for HF was significantly lower in the intervention group than in the usual-care group (HR 0.52, 95% CI 0.27–0.96, P=0.037). Conclusions: Home-based disease management improved psychological status and also reduced rehospitalization for HF in patients with HF.  (Circ J 2013; 77: 926–933)

著者

WANG Mei YAN Guo-Hui YUE Wen-Sheng SIU Chung-Wah YIU Kai-Hang LEE Stephen W. L. LAU Chu Pak TSE Hung-Fat

出版者

一般社団法人 日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.76, no.3, pp.682-688, 2012-02-25

参考文献数

35

被引用文献数

1 9

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<b><i>Background:</i></b> Left ventricular (LV) mechanical dyssynchrony can lead to impairment of LV function and is associated with adverse clinical outcomes in coronary artery disease (CAD) patients. The impact of LV dyssynchrony on exercise capacity (EC) in patients with CAD was investigated. <b><i>Methods and Results:</i></b> An echocardiographic examination with tissue Doppler imaging and exercise treadmill testing in 151 CAD patients with normal LV ejection fraction was performed. LV intra- and inter-ventricular dyssynchrony were defined by the standard deviation of time interval between LV 6 basal segments (Ts-SD), and the time interval from the right ventricular (RV) free wall to LV lateral wall (Ts-RV) respectively, and EC was measured as metabolic equivalents (METs) on the treadmill. Patients with impaired EC (defined by a METs &le;8, which is the mean MET of the study population) were older (71&plusmn;7 vs. 62&plusmn;2 years, P<0.01), however, there were no differences in gender and clinical status such as prevalence of prior myocardial infarction (MI), regional wall motion abnormality (RWMA), and coronary revascularization between patients with (n=90) or without (n=61) impaired EC. Univariate analysis showed that age, body mass index, LV systolic and diastolic volume, mitral inflow A velocity, and Ts-SD were all significantly associated with METs (all P<0.05). However, multivariate regression analysis revealed that old age (odd ratio [OR]: 1.136, 95% confidence interval [CI]: 1.080-1.196, P<0.001), and Ts-SD (OR: 1.026, 95%CI: 1.003-1.049, P=0.027) only were independent predictors for impaired EC. <b><i>Conclusions:</i></b> In patients with CAD, LV systolic dyssynchrony predicts impaired EC independently of history of previous MI or RWMA. (<i>Circ J</i> 2012; <b>76:</b> 682-688)<br>

著者

犬塚 潤一郎 イヌツカ ジュンイチロウ Jun-ichiro INUTSUKA

雑誌

実践女子大学生活科学部紀要

巻号頁・発行日

no.45, pp.21-39, 2008-04

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How have we received "actual feeling" from the images which we see in our media-society? There is more what we see through media than that with which we actually meet. Media technology fills society with signs through reproducing a sign from a sign. For this mediological inquiry, I refer to Benjamin's "The Work of Art in the Age of Mechanical Reproduction", comparing to other essays on photography as Barthes' and Sontag's, with the conceptual framework from Augustin Berque's mesological approach, which distinguishes three levels for the world; the earth, biosphere, and a level of milieu, and Jakobson's linguistic model of the sifter.

著者

犬塚 潤一郎 イヌツカ ジュンイチロウ Jun-ichiro Inutsuka

雑誌

実践女子大学生活科学部紀要

巻号頁・発行日

no.47, pp.1-11, 2010-03-19

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The theory of mediance, developed by Augustin Berque through synthesis of the ontology and the geography, inspired by the idea of Fudosei of Japanese philosopher and phenomenologist Tetsuro Watsuji, has a range to reorganize our relation to the environment, as called reconstituting the cosmos of human. In this essay, I will try to retranscribe his theory to solve the subject of modern society, especially focusing on the role of the university for solving the subject of business organizations and showing the draft of an educational program.

著者

張 貞旭 Jung-ouk Chang 松山大学経済学部 Matsuyama UniversityFaculty of Economics

雑誌

松山大学論集 = Matsuyama University review (ISSN:09163298)

巻号頁・発行日

vol.22, no.3, pp.1-26, 2010-08-01

著者

Katsuhiko Sekimata Tomohiro Sato Naoki Sakai Hisami Watanabe Chiemi Mishima-Tsumagari Tomonori Taguri Takehisa Matsumoto Yoshifumi Fujii Noriko Handa Teruki Honma Akiko Tanaka Mikako Shirouzu Shigeyuki Yokoyama Kohei Miyazono Yoshinobu Hashizume Hiroo Koyama

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.67, no.3, pp.224-235, 2019-03-01 (Released:2019-03-01)

参考文献数

17

被引用文献数

11

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Mutant activin receptor-like kinase-2 (ALK2) was reported to be closely associated with the pathogenesis of fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG), and therefore presents an attractive target for therapeutic intervention. Through in silico virtual screenings and structure–activity relationship studies assisted by X-ray crystallographic analyses, a novel series of bis-heteroaryl pyrazole was identified as potent inhibitors of ALK2 (R206H). Derived from in silico hit compound RK-59638 (6a), compound 18p was identified as a potent inhibitor of ALK2 (R206H) with good aqueous solubility, liver microsomal stability, and oral bioavailability.

著者

Sumire Fujiwara Keiko Kigoshi Nobutaka Mitsuda Kaoru Suzuki Masaru Ohme-Takagi

出版者

Japanese Society for Plant Cell and Molecular Biology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

pp.14.0121a, (Released:2014-03-20)

参考文献数

58

被引用文献数

5 7

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Proper gene expression regulated by transcription factors is essential for plants to achieve proper growth and development. However, the biological functions of many transcription factors remain largely unknown. Furthermore, although there are transcription factors which possess a plant-specific repression domain(s), their biological functions and whether such transcription factors function as transcriptional repressors are unclear. Thus, aiming for searching clues to understand their functions, we generated transgenic plants in which a putative transcriptional repressor fused with a VP16 viral trans-activation domain was expressed constitutively. Several plants with strong morphological phenotypes such as leaf and flower development defects were isolated from those lines expressing potential transcriptional repressors with unknown functions, giving the clue to reveal the yet-to-be analyzed functions of each protein. Reversal of function of the well-known transcriptional and floral repressor SHORT VEGETATIVE PHASE by VP16 fusion was observed, exemplifying successful functional reversion by this system. Plants constitutively expressing VP16 fused WUSCHEL, which is known to function both as a transcriptional activator and repressor, showed both phenotypes reported in its overexpression and loss-of-function lines. Taken together, our data provide examples showing the efficacy of VP16 fusion to provide helpful information to uncover the unknown functions of potential transcriptional repressors. This technique could also be effective to produce “super plants” which obtained strong and useful traits for application by strongly activating genes which are usually silent.

著者

Han Lee-Long Lin Chun-Ming Shih Yih-Shiun

出版者

公益社団法人 日本金属学会

雑誌

Materials transactions (ISSN:13459678)

巻号頁・発行日

vol.54, no.5, pp.833-838, 2013-05-01

参考文献数

14

被引用文献数

6

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This study compared cryogenic treatment, ultra-cryogenic treatment, and high-low temperature tempering treatment using ASSAB Stavax ESR, and conducted the following analyses of the prepared specimens: (1) analysis the structure by X-ray diffraction, (3) analysis of the texture of the processed specimens by optical microscopy, (2) using a hardness tester to analyze the changes in hardness of specimens processed by cryogenic and heat treatment, (3) analyzing the hydrophilicity and hydrophobicity by the water contact angle test, and (4) analyzing corrosion resistance by the corrosion resistance test. The experimental results showed that cryogenic temperature affects the amount and shape of the carbides, which are significantly reduced in cases of high-temperature tempering. The water contact angle test analysis showed that the coating film&rsquo;s water contact angle performance is the best, followed by specimens of ultra-cryogenic treatment, specimens of cryogenic treatment, and specimens of traditional heat treatment. It was found that cryogenic treatment can increase polishability, and empower the specimens with good mold release performance. The coating-film corrosion resistance test showed that ultra-cryogenic treatment and cryogenic treatment can improve corrosion resistance; however, the performances of specimens by traditional heat treatment were the worst.

著者

Da-Eun LEE Kyu-Chang KIM Soon-Wuk JEONG Hun-Young YOON

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.2, pp.237-240, 2019 (Released:2019-02-19)

参考文献数

18

被引用文献数

6

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A castrated male Shih-Tzu dog was presented for evaluation of urine leakage after urethrotomy. A fistula with urine leakage was identified in the perineal region. On retrograde urethrography, the contrast extravasated from the penile urethra into the subcutaneous tissue of the perineum. Urine leakage with urethrocutaneous fistula was diagnosed. During surgery, the disrupted urethra wall and two urethral defects were identified. A fascia lata autograft was used, rather than primary repair of the urethra. Two pieces of fascia lata were harvested and sutured to the urethral defects. The fistula was treated with debridement and drainage. No evidence of urine leakage and dysuria was noted 6 months postoperatively. Thus, this case report describes successful urethral reconstruction using a fascia lata autograft.

著者

Du-Min GO Sang-Ho WOO Su-Hyung LEE Dae-Yong KIM

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.2, pp.177-181, 2019 (Released:2019-02-09)

参考文献数

19

被引用文献数

3

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A 3.9-year-old female African pygmy hedgehog (Atelerix albiventris) had a firm, tan-colored mass with an uneven surface arising from the mandibular salivary gland. A histopathologic examination revealed that the mass was composed of neoplastic proliferation of epithelial and spindle cells. The neoplastic spindle cells showed positive for vimentin, smooth muscle actin, calponin and cytokeratin 14 and, negative for cytokeratin 19, suggesting that spindle cells were derived from myoepithelial cells. Based on the histological findings and immunohistochemistry results, the mass was diagnosed as pleomorphic adenoma. Pleomorphic adenoma is the most common benign tumor found in human salivary glands, but it is rare in animals. To the best of our knowledge, this is the first report of pleomorphic adenoma in hedgehogs.

著者

Keisuke SAITO Mohie HARIDY Walied ABDO Ahmed EL-MORSEY Samy KASEM Yukiko WATANABE Tokuma YANAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.2, pp.338-342, 2019 (Released:2019-02-28)

参考文献数

23

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A severely emaciated adult Steller’s sea eagle (Haliaeetus pelagicus) was found dead with electrocution-induced severe wing laceration, and with multiple cutaneous pock nodules at the periocular regions of both sides nearby the medial canthi and rhamphotheca. Histopathological examination of the nodules revealed hyperplasia of the epidermis with vacuolar degeneration and intracytoplasmic inclusion bodies (Bollinger bodies). The proventriculus was severely affected by nematodes and was ulcerated. Nucleotide sequencing of a PCR-amplified product of Avipoxvirus 4b core gene revealed 100% identity to the sequence of Avipoxvirus derived from other eagle species. This report describes the first detection of Avipoxvirus clade A from a Steller’s sea eagle.

著者

梅村 坦 庄垣内 正弘 三友 健容 吉田 豊 松井 太 鈴木 健太郎 李 肖 DESMOND Durkin-Meisterernst

出版者

中央大学

雑誌

基盤研究(B)

巻号頁・発行日

2007

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研究対象は、ベゼクリク千仏洞から1980~1981年に出土した非漢字の古文献約600点であり、その大部分は未公開の断片類である。使用される文字はウイグル文字、ソグド文字、ブラーフミー文字を中心とし、言語は古ウイグル語、ソグド語、サンスクリット語、トカラ語、漢語などにおよび、形式には写本、印刷があり、内容は仏教文献を中心として契約や公文書、詩、手紙などの俗文献に至り、10~13世紀頃のトゥルファンの複合文化を浮き彫りにする第一級の資料群であることが判明した。