著者
Jeong-Woo Lee Jong-Min Song Jong Pil Park Jae Won Lee Duk-Hyun Kang Jae-Kwan Song
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.74, no.2, pp.375-380, 2010 (Released:2010-01-25)
参考文献数
25
被引用文献数
52 138

Background: The prognostic implications and surgical benefit of isolated significant tricuspid regurgitation (TR) and prognostic factors in patients with TR were investigated. Methods and Results: In 870 consecutive patients with significant isolated TR, all-cause mortality was analyzed over 4.9±2.9 years. It was found that the survival rate tended to be higher in the 57 patients who underwent tricuspid valve (TV) surgery than the 813 patients who did not by using propensity-score matching (P=0.068), although it was not significant. Of the 813 patients that did not undergo TV surgery, the 5-year survival rate was 74%. According to the Cox proportional hazards model, the initial TR jet area (hazard ratio [HR], 1.044; 95% confidence interval [CI], 1.016-1.073), pulmonary artery systolic pressure (HR, 1.024; 95%CI, 1.017-1.032) and presence of right ventricular (RV) dysfunction (HR, 2.256; 95% CI, 1.329-3.828) were predictors of mortality independent of patient age and presence of diabetes mellitus and renal failure in medically managed patients. Conclusions: In patients with isolated significant TR, there was a tendency, although not significant, towards a higher survival rate after TV surgery. The severity of TR and pulmonary hypertension, and the presence of RV dysfunction are independent prognostic factors in medically managed patients. Further prospective randomized studies are necessary to demonstrate the benefit of TV surgery in these poor prognostic populations. (Circ J 2010; 74: 375-380)
著者
Atsushi Ishihara Kana Ando Anna Yoshioka Koichi Murata Yu Kokubo Noriko Morimoto Naoki Ube Yukinori Yabuta Makoto Ueno Shin-ichi Tebayashi Kotomi Ueno Kumiko Osaki-Oka
出版者
Pesticide Science Society of Japan
雑誌
Journal of Pesticide Science (ISSN:1348589X)
巻号頁・発行日
pp.D18-063, (Released:2019-03-12)
参考文献数
36
被引用文献数
10

We investigated the effect of treatment with hot water extracts from the spent mushroom substrates (SMSs) of Lentinula edodes and Hypsizygus marmoreus on the resistance of rice leaves to Pyricularia oryzae infection. The spraying of the SMS extracts clearly suppressed the development of lesions caused by Py. oryzae infection. The accumulation of phytoalexins momilactones A and B, oryzalexin A, and sakuranetin was markedly induced by the spraying of extracts. The enhanced expression of defense related genes PR1b and PBZ was also found in leaves sprayed with the extracts. Treatments with the extracts also affected phytohormone levels. The levels of N6-(Δ2-isopentenyl)adenine and trans-zeatin markedly increased in response to treatment, whereas the levels of salicylic and jasmonic acids were largely unchanged.
著者
Naoki Tamada Kazuhiko Nakayama Kenichi Yanaka Hiroyuki Onishi Yuto Shinkura Yu Taniguchi Hiroto Kinutani Yasunori Tsuboi Kazuhiro P. Izawa Seimi Satomi-Kobayashi Hiromasa Otake Hiroshi Tanaka Toshiro Shinke Yutaka Okita Noriaki Emoto Ken-ichi Hirata
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.1, no.5, pp.228-234, 2019-05-10 (Released:2019-05-10)
参考文献数
27
被引用文献数
4

Background:While hemodynamics and exercise capacity in patients with chronic thromboembolic pulmonary hypertension (CTEPH) can be improved by invasive therapy such as pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA), there has been little data on the health-related quality of life (HRQOL) in such patients.Methods and Results:This single-center and observational study compared the impact of invasive therapy on HRQOL. We utilized the Medical Outcome Study 36-Item Short Health Survey (SF-36) to measure HRQOL and compared HRQOL changes after PEA and BPA. A total of 48 patients were diagnosed with CTEPH. Of these, 39 patients completed questionnaires before and after invasive therapy. The PEA group (n=15) and the BPA group (n=24) had similar improvements in clinical parameters. With regard to HRQOL score, both groups had fairly low scores in physical functioning (PF), role physical (RP), general health (GH), social functioning (SF), role emotional (RE), and physical component summary (PCS) at baseline. PF, GH, vitality (VT), mental health (MH), and PCS had significant improvements in the PEA group while PCS and all subscales except for bodily pain (BP) had significant improvements in the BPA group. Furthermore, changes between baseline and follow-up were not significantly different between the 2 groups.Conclusions:BPA for patients who are ineligible for PEA can recover HRQOL to a similar level to that achieved by PEA.
著者
寺本(稲福) さゆり 住 秀和 金城 秀安 川満 芳信 Inafuku-Teramoto Sayuri SUMI Hidekazu KINJYO Hideyasu KAWAMITSU Yoshinobu 琉球大学農学部 大宜味村シークヮーサー振興室 沖縄県北部農林水産振興センター
出版者
沖縄農業研究会
雑誌
沖縄農業 (ISSN:13441477)
巻号頁・発行日
vol.44, no.1, pp.73-81, 2010-08

琉球列島には多くのシークヮーサー遺伝資源が古くより栽培され,残されている.クガニーとは,これらのうちで果実形質の優良なシークヮーサー(C. depressa Hayata) 系統の総称であり,沖縄県で栽培される主要品種である.これらのうち,特に著名な4種のクガニーの品種(大宜味クガニー,勝山クガニ一,カーアチー,伊豆味クガニー)について,フラボノイド類,フェネチルアミン類,香気成分といった機能性成分を分析し,品種間差の調査を行なった.ポリメトキシフラボノイド類 (PMFs) のノピレチンはすべてのクガニーで高く,タンゲレチン,シネセチンとあわせて3種類のPMFsが未熟果皮に多く含まれていた.フェネチルアミンのシネフリンは,PMFs同様に未熟果皮に多く含まれていた.一方,香気成分とフラパノン類については,伊豆味クガニーにおいて他のクガニーには含まれない1,8-シネオールやネオヘスペリジンといった成分が多く含まれていた.品種間差異は特に香気成分において大きく現れる傾向があり,最も主要な経済栽培品種となっている大宜味クガニーと勝山クガニーとの差は小さかった.これらの結果をもとに,沖縄独自の貴重な地方資源として,今後クガニ一品種毎の特性を活かした加工品開発の進展が期待される.Shiikuwahsa (C. depressa Hayata) that has been cultivated for long time and there are many accessions in Ryukyu Islands. Kuganii is the name of the superior cultivars of shiikuwasha that are also major cultivars in present Okinawa. Among of them, we selected 4 famous cultivars of kuganii and analyzed polymethoxyflavones, flavanones, phenethylamine (synephrine) and volatile constitutions to identify the difference between each cultivar. Nobiletin, it was the most abundant polymethoxyflavone in all of kuganii. Three of PMFs (nobiletin, sinensetin and tangeretin) detected in all kucanii, and they were contained high in immature peels. Synephrine, categorized phenylethylamine, was also high in immature peels of all kuganii. However, the difference had shown clearly in the content of flavanones and aromatic constitution. 'Izumikuganii' contained high percentages of 1,8-cineole in volatile components and flavanone neohesperidin, they were not contained in other kuganii peels. 'Ogimikuganii', the main cultivars in Okinawa was closely similar to 'Katsuyamakuganii' in all phytochemicals that analyzed in this study. These phytochemicals data will be contribute to develop various applications in each cultivar that is the important local resources for further utilization.
著者
Lee Hae-Pyeong Park Young-Ju Lee Si Young Cha Joo Yanng Ohga Shoji 大賀 祥治
出版者
Faculty of Agriculture, Kyushu University
雑誌
九州大学大学院農学研究院紀要 (ISSN:00236152)
巻号頁・発行日
vol.55, no.2, pp.209-213, 2010-10-29

Combustion tests were conducted with living leaves of P. densiflora to examine the combustion characteristics of this species at different altitudes. An ignition temperature tester, cone calorimeter, and smoke density chamber were used for the tests. Leaf moisture content was measured prior to combustion, yielding a range of between 148 and 177%. The temperature of non-flame ignition was 300-310 ℃ and did not vary with altitude. Flame ignition occurred in the samples taken at 900 m and 1300 m, but lasted for only 7 and 8 s, respectively. These two samples released similar heat, with the sample from 1300 m producing slightly more heat. The sample from 1400 m released more than twice the smoke yielded by the other samples. Maximum smoke density was highest for the higher altitude samples, and the amount of smoke released varied proportionately with altitude. The mean release density of CO increased abruptly at 1100 m and decreased after that point before an abrupt increase at 1500 m, and that of CO2 showed almost the same pattern as for CO.
著者
Park Young-Ju Lee Hae-Pyeong Lee Si Young Cha Joo Yanng Ohga Shoji 大賀 祥治
出版者
Faculty of Agriculture, Kyushu University
雑誌
九州大学大学院農学研究院紀要 (ISSN:00236152)
巻号頁・発行日
vol.55, no.2, pp.215-219, 2010-10-29

In this study, combustion tests were conducted on living Q. mongolica leaves to compare their combustion characteristics at different altitudes. Leaf moisture content was measured and combustion characteristics were then studied using an ignition temperature tester, a cone calorimeter, and a smoke density chamber. The samples contained 117-145% moisture. The temperature of non-flame ignition was 275-308℃ and did not vary with altitude. Samples from 1,300m and 1,500m ignited more quickly than the others, but went out after 2 and 4 seconds, respectively. Heat release increased and reached its peak at 1,100 m, thereafter decreasing. Smoke release decreased and smoke density increased in proportion to altitude. The mean release density of CO rose gradually with increasing altitude while that of CO2 increased from 1,200 m.
著者
Hyue Mee Kim Dae-Won Sohn Jin Chul Paeng
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.18-345, (Released:2019-04-25)
参考文献数
19
被引用文献数
13

Senile or wild-type transthyretin (wtTTR) amyloidosis is an age-related disease caused by the deposition of wtTTR amyloid protein. In contrast to light chain amyloidosis, 99 mTc-DPD scintigraphy (DPD scan) is a useful diagnostic modality for wtTTR amyloidosis.We retrospectively analyzed patients older than 30 years who underwent DPD scanning for non-cardiac reasons at our hospital between June 2014 and March 2017 (n = 9,581). Transthoracic echocardiography was used to assess left ventricular hypertrophy (LVH), as well as systolic and diastolic function.A positive DPD scan was observed in only six patients (0.06%). All six of these patients were older than 70 years, and they constitute only 0.4% of patients in this age group (6/1652). Among the patients with a positive DPD scan, four showed concentric LVH and two showed a normal wall thickness. With respect to the severity of diastolic dysfunction and pulmonary artery pressure, patients with a positive DPD scan showed the expected E' and pulmonary artery systolic pressure for their age.Even considering the limited sensitivity of a positive DPD scan detecting wtTTR amyloidosis, the incidence of a positive DPD scan in non-cardiac patients indicated that wtTTR amyloid deposition does not seem to be a major cause for age-related diastolic dysfunction, nor does appear to have a high incidence in patients with heart failure with preserved EF in the elderly.
著者
Do Jung Kim Seung Hyun Lee Hyun-Chel Joo Kyung-Jong Yoo Young-Nam Youn
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.17-283, (Released:2019-04-25)
参考文献数
37
被引用文献数
5

Severe aortic atherosclerosis is a risk factor for stroke during coronary artery bypass grafting (CABG). The purpose of this study was to evaluate the incidence of postoperative neurologic complications after off-pump CABG (OPCAB) with a proximal seal system (Heartstring).From January 2011 to December 2014, 729 patients underwent isolated OPCAB. The cohort was divided into two groups (Heartstring [HS] and aortic no-touch [NT]). The severity of aortic atherosclerosis (Katz grade) was evaluated by intraoperative epiaortic ultrasonography (EUS). The primary endpoints were postoperative neurologic complications (early stroke and minor events (delirium, transient ischemic attack, and syncope) ), and the secondary endpoints were late major adverse cardiac and cerebrovascular events (MACCEs) and death.The mean age of all patients was 65.1 ± 9.5 years, and a severe Katz grade (IV or V) was demonstrated to be an independent risk factor of long-term mortality (HR 3.53; 95% CI 1.06-11.75; P = 0.04) and MACCEs (HR 2.41; 95% CI 1.19-4.92; P = 0.02), but no significant differences were found for early stroke (0.9% versus 1.7%; P = 0.53) and minor neurologic complications (14.6% versus 9.9%; P = 0.05) between the groups regardless of the Katz grade. The 5-year overall survival rate did not differ significantly between the groups (90.9% versus 87.6%; P = 0.61).Although a higher Katz grade was identified as an independent risk factor of death and MACCEs, the HS group was not inferior in terms of neurologic complications regardless of the Katz grade. Therefore, the Heartstring system might be safely and efficiently used with EUS to decrease the incidence of neurologic complications.
著者
Min Chen Yu-Feng Jiang Hua-Jia Yang Nan-Nan Zhang Qing Rui Ya-Feng Zhou
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.17-293, (Released:2019-04-25)
参考文献数
46
被引用文献数
4

The issue that genetic polymorphism of tumor necrosis factor-α (TNF-α) is associated with dilated cardiomyopathy (DCM) is debatable. We sought to investigate the potential role of TNF-α gene polymorphism (G-308A) in the susceptibility to dilated cardiomyopathy.We retrieved PubMed, EMBASE, and CNKI to collect all articles which reported on the association between TNF-α G-308A polymorphism and dilated cardiomyopathy. Two authors used the Newcastle-Ottawa Scale (NOS) checklist to assess the quality of the included studies. The odds ratio (OR) with 95% confidence intervals (CI) were pooled in a specific genetic model to assess the association and Stata version 14.0 software was used.A total of 9 studies with 1338 patients and 1677 controls were included in this study. The results from this meta-analysis indicated that TNF-α G-308A polymorphism significantly increased the risk of dilated cardiomyopathy in heterozygous comparison (GA versus GG: OR = 1.87; 95%CI = 1.03-3.40; P < 0.05). The increased risk of DCM was also found in Asian populations using a dominant model and heterozygous comparison (GA+AA versus GG: OR = 2.00, 95%CI = 1.02-3.92, P < 0.05; GA versus GG: OR = 1.94, 95%CI = 1.23-3.06, P < 0.05).The current meta-analysis revealed that TNF-α gene polymorphism (G-308A) may be associated with the susceptibility to DCM.
著者
Tien-Yu Chen Wen-Jung Chung Chien-Ho Lee Po-Jui Wu Shu-Kai Hsueh Tzu-Hsien Tsai Chien-Jen Chen Chiung-Jen Wu Cheng-I Cheng
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.18-377, (Released:2019-04-25)
参考文献数
19
被引用文献数
1

We investigated the accuracy of various bleeding risk scores to estimate the bleeding risk in patients with acute myocardial infarction (AMI) managed with percutaneous coronary intervention (PCI) access via the radial artery.We retrospectively enrolled 1,651 patients who were definitively diagnosed with ST-elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI). We assessed the predictive validities of 30-day bleeding events in various scoring systems using receiver operating characteristic curves.Overall, ACUITY-HORIZONS exhibited the highest area under the curve to predict 30-day bleeding, followed by ACTION and CRUSADE; HAS-BLED displayed the lowest score. With a cut-off of 17, ACUITY-HORIZONS demonstrated the best discrimination for the Thrombolysis in Myocardial Infarction (TIMI) 30-day serious bleeding rate. We observed significant differences among all-cause death, cardiovascular death, and major adverse cardiac events between the ACUITY-HORIZONS groups with a score of ≤ 17 and > 17. ACUITY-HORIZONS score > 17, initial systolic blood pressure (SBP) < 90 mmHg, and Killip III and IV upon admission positively predicted the 30-day bleeding risk, whereas myocardial infarction (MI) and TIMI major bleeding within 30 days, heart failure at admission, and initial SBP < 90 mmHg positively predicted the 30-day mortality.Comparatively, ACUITY-HORIZON is the most reliable system in predicting 30-day bleeding for patients with AMI via transradial PCI. In the transradial scenario, bleeding and MI within 30 days are substantially related to 30-day mortality.
著者
井上 英治 井上-村山 美穂 高崎 浩幸 西田 利貞
出版者
日本霊長類学会
雑誌
霊長類研究 Supplement
巻号頁・発行日
vol.25, pp.50, 2009

チンパンジーの第1位オスは,在位期間に受胎した3割以上の子供の父性を確保していることが多くの調査地で知られている。タンザニア,マハレ山塊国立公園の第1位オスの在位期間は平均5年強であるが,M集団のNTは,1979-91年,1992-95年の計15年間第1位オスであった。在位期間が長いと残した子供の総数も多いと考えられる。そこで,NTの繁殖成功を解明するため,父子判定を行なった。1995年以前に採取されたNTを含む21頭のワッジおよび毛からDNA抽出を行ない,マイクロサテライト8領域の遺伝子型を決定した。すでにM集団で1999年以降に採取された試料をもとに決定していた54頭の遺伝子型と合わせ,1981-96年に生まれた15頭の父子判定を行なった。このうち,NTの子供は1頭のみであり,他の14頭の父親であることは否定された。同集団で1999-2005年に生まれた子供の父子判定では,第1位オスが45%の子供の父親であったので,第1位オスの繁殖成功が低いことはこの集団の特徴とは言えない。NTの繁殖成功が低かった理由として,2つの可能性が考えられる。1つは,NTが第1位であるときM集団の個体数が90頭前後と多く,発情するメスの数およびライバルとなるオスの数が多かったために,交尾を独占できなかったと考えられる。もう1つは,NTは推定24歳で第1位になり,1981年ですでに26歳になっていたことである。他集団において,20歳以下の繁殖成功が高いことが知られているため,年齢が影響したことも考えられる。過去に保存していた貴重な試料を解析することにより,長期間第1位であったオスが在位期間中に多くの子供を残していなかったことが示された。
著者
Cui-Ling Ji Adnan Nomi Bin Li Cheng Shen Bing-Chun Song Jin-Guo Zhang
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.18-422, (Released:2019-04-25)
参考文献数
33
被引用文献数
6

Fractalkine has been reported to play an important role in the pathophysiology of various cardiovascular disorders. This research aims to study the change of soluble fractalkine (sFKN) in plasma level of patients with chronic heart failure (CHF) and evaluate its prognostic value.A total of 96 patients with CHF and 45 healthy subjects were included in this study. The plasma levels of sFKN, brain natriuretic peptide (BNP), and Interleukin-18 (IL-18) were determined by ELISA kits when they were first admitted to the hospital. Left ventricular ejection fraction (LVEF) was measured by echocardiogram. Rehospitalization status within 1 year after the first hospitalization was also recorded.The plasma levels of sFKN, BNP, and IL-18 in patients with CHF were significantly higher than in the control group (P < 0.05). The concentrations of sFKN and BNP were increased with the severity of heart failure classified by NYHA classification (P < 0.05). There were no statistical differences among all CHF subgroups classified by etiology (P > 0.05). Plasma sFKN level in CHF group was positively correlated with BNP (r = 0.441, P < 0.001) and IL-18 (r = 0.592, P < 0.001). Receiver operating characteristic curve analysis showed that area under the curve values of FKN, BNP, and IL-18 were 0.885 (95%CI: 0.810 to 0.960, P < 0.001), 0.889 (95%CI: 0.842 to 0.956, P < 0.001), and 0.878 (95%CI: 0.801-0.954, P < 0.001), respectively. The concentrations of sFKN and BNP were increased in patients readmitted more than once within 1 year (P < 0.05).
著者
Kayo Tanigawa-Sugihara Taku Iwami Chika Nishiyama Tetsuhisa Kitamura Masashi Goto Masahiko Ando Tatsuya Nishiuchi Yasuyuki Hayashi Takashi Kawamura
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.77, no.8, pp.2073-2078, 2013 (Released:2013-07-25)
参考文献数
35
被引用文献数
11 24

Background: Weather conditions affect the occurrence of cardiovascular disease. The aim of this study was to investigate the associations between atmospheric conditions including temperature, pressure, and humidity, and the occurrence of out-of-hospital cardiac arrests (OHCAs) with cardiac etiology. Methods and Results: This study was a cross-sectional analysis of a prospective cohort that included all persons aged ≥18 years with OHCA in Osaka, from 1998 through 2007. The association between the number of daily OHCA events with various atmospheric conditions was analyzed using Poisson regression. A total of 28,806 adult OHCAs were presumed to be of cardiac etiology. The number of OHCAs in 1 day was inversely correlated with the day’s mean atmospheric temperature. The regression coefficient was greater on the days under 18°C (r=–0.317, P<0.001) than on days over 18°C (r=–0.088, P<0.001). A positive linear relation was found between the number of OHCAs in 1 day and the day’s mean atmospheric pressure (r=0.321, P<0.001). Under 18°C, every 5°C decrease in the daily mean temperature was associated with an 11% (95% confidence interval [CI]: 8–13%) increase in OHCA occurrence in the non-elderly group, and a 16% increase in the elderly group (95% CI: 14–19%). Conclusions: The occurrence of adult OHCA with cardiac etiology increases with decreasing temperature of the day. Elderly people are more susceptible to severe weather conditions.  (Circ J 2013; 77: 2073–2078)
著者
Yi-Heng Li Yu-Wei Chiu Jun-Jack Cheng I-Chang Hsieh Ping-Han Lo Meng-Huan Lei Kwo-Chang Ueng Fu-Tien Chiang Shih-Hsien Sung Jen-Yuan Kuo Ching-Pei Chen Wen-Ter Lai Wen-Lieng Lee Jyh-Hong Chen Taiwan ACS STENT Registry Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-18-1283, (Released:2019-04-27)
参考文献数
23
被引用文献数
2

Background:Little information is available in Asia about the real-world practice of dual antiplatelet therapy (DAPT) duration for acute coronary syndrome (ACS) and its influence on clinical outcomes.Methods and Results:The Taiwan ACS STENT Registry was a prospective, multicenter study to observe ACS patients using clopidogrel-based DAPT after percutaneous coronary intervention (PCI). The primary outcome was a composite of cardiovascular death, myocardial infarction, and stroke. Overall, 2,221 ACS patients (62 years, 83% men) were included. DAPT duration was ≤9 months in 935 (42.1%). The incidence of primary outcome was higher in patients receiving DAPT ≤9 months compared with those receiving DAPT >9 months at 1 year (3.5% vs. 1.6%, P=0.0026). The incidence of stent thrombosis (overall 0.5%) was similar between groups. Multivariable analysis showed that DAPT >9 months was associated with a significantly lower risk of primary outcome (odds ratio 0.725, 95% confidence interval 0.545–0.965).Conclusions:Our data showed that short duration of DAPT (≤9 months) was common (42.1%) in Taiwan for ACS patients undergoing PCI. DAPT ≤9 months increased the risk of the primary outcome.