著者

川島 嘉明/内藤 雅文/林 山陽/竹中 英雄 カワシマ ヨシアキ/ナイトウ マサフミ//タケナカ ヒデオ KAWASHIMA YOSHIAKI/NAITO MASAFUMI/LIN SHAN-YANG/TAKENAKA HIDEO

雑誌

岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy

巻号頁・発行日

vol.33, 1984-06-15

著者

MURATA Akihiko WATANABE I. Shun-ichi SASAKI Hidetaka KAWASE Hiroaki NOSAKA Masaya

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-035, (Released:2019-02-04)

被引用文献数

7

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A novel method for detecting tropical cyclones in high-resolution climate model simulations is proposed herein and subjected to examination. The proposed method utilizes a two-dimensional scatterplot based on two quantities that represent the radial gradient and the tangential asymmetry of mid-to upper-level thickness around a simulated vortex. A comparison between the modeled and observed tropical cyclones using the non-hydrostatic regional climate model (NHRCM) with 20-km grid spacing under reanalysis-driven boundary conditions for one year revealed that no cyclones were missed and there was only one false alarm over a part of the western North Pacific near Japan. The simulated vortices were classified into two categories; tropical cyclones and extratropical cyclones. These two groups, having specific features, were also found in the results using present-day climate datasets, indicating that the tropical cyclones were reasonably distinguished from extratropical cyclones although a one-by-one comparison could not, in principle, be conducted. Comparison of the results obtained from datasets with 5-km and 20-km grid spacing demonstrated that the detection scheme was only weakly dependent on the horizontal resolution. This dependence was further reduced by using the radial gradient over the outer radii instead of near the center of the vortex. The resolution-independent feature in this method is due to a procedure in which the tangential asymmetry of mid-to upper-level thickness is utilized instead of the relative vorticity at 850 hPa, often used in conventional schemes. This procedure allows the method to identify tropical cyclones without the need to determine a grid-dependent threshold. The method proposed here provides a useful tool for detecting tropical cyclones in high-resolution climate simulations.

著者

Bo-in Kim Ju-Hyeon Jung Jemyung Shim Hae-Yeon Kwon Haroo Kim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.1, pp.77-79, 2014 (Released:2014-02-06)

参考文献数

16

被引用文献数

5 10

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[Purpose] This study analyzed the activities of the back and hip muscles during Pilates exercises conducted in a prone position. [Subjects] The subjects were 18 healthy women volunteers who had practiced at a Pilates center for more than three months. [Methods] The subjects performed three Pilates exercises. To examine muscle activity during the exercises, 8-channel surface electromyography (Noraxon USA, Inc., Scottsdale, AZ) was used. The surface electrodes were attached to the bilateral latissimus dorsi muscle, multifidus muscle, gluteus maximus, and semitendinous muscle. Three Pilates back exercises were compared: (1) double leg kick (DLK), (2) swimming (SW), and (3) leg beat (LB). Electrical muscle activation was normalized to maximal voluntary isometric contraction. Repeated measures analysis of variance was performed to assess the differences in activation levels among the exercises. [Results] The activity of the multifidus muscle was significantly high for the SW (52.3±11.0, 50.9±9.8) and LB exercises(51.8±12.8, 48.3±13.9) and the activity of the semitendinosus muscle was higher for the LB exercise (49.2±8.7, 52.9±9.3) than for the DLK and SW exercises. [Conclusion] These results may provide basic material for when Pilates exercises are performed in a prone position and may be useful information on clinical Pilates for rehabilitation programs.

著者

Koji NISHIFUJI Seong-Jun PARK Toshiroh IWASAKI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.69, no.4, pp.455-457, 2007 (Released:2007-05-08)

参考文献数

8

被引用文献数

2 5

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A 3.5-year-old, male West Highland White Terrier was diagnosed as having hyperplastic dermatosis by clinical and histopathological findings. Controlling of Malassezia overgrowth by antifungal drugs provided a temporal improvement of the skin lesions, but the disease was deteriorated within the next 2 months despite the negative demonstration of the yeasts. Induction of recombinant canine interferon-γ (rCaIFN-γ) therapy resulted in almost complete cure of the skin lesions within 2 months after the initiation of the therapy. No adverse effects were detected during the therapy. Our results suggested that the rCaIFN-γ therapy is potential to be a novel therapeutic option for controlling the breed-specific hyperplastic skin disease.

著者

HASEGAWA Mitsuhiro IZAWA Shizuka HSU Ming-Chien SUDO Makoto KIDA Tetsukazu KATO Kiyoshi IMANO Makoto KATO Naoki

出版者

日本学術会議 「機械工学委員会・土木工学・建築学委員会合同IUTAM分科会」

雑誌

Theoretical and Applied Mechanics Japan (ISSN:13480693)

巻号頁・発行日

vol.54, pp.83-91, 2005

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There is a difficult problem that the present freezing and thawing test method indicates the structure-insensitive properties from the point of view of materials science concerning the specimen size, shape and exposure condition, in addition, the mass variation. The &ldquo;surface defect ratio&rdquo; as a new index in place of the above-mentioned factors has been proposed. The fundamental deterioration is dependent on the repetitional scaling of surface layer; further, it has been basically analyzed that the freezing and thawing action makes concrete neutralize from the outside by virtue of the environmental contact water. The wet and dry action as well as the freeze-thaw action is one of the principal deterioration causes and these are the extreme phenomena at both ends on the temperature axis. It has been already understood that the either action contributes to the neutralizing acceleration of concrete.<br>The present paper particularly deals with the quantification of the concentration dilution of pore solution and the neutralization of matrix of concrete, from the viewpoint of the potential Hydrogen (pH) range of general environmental water.

著者

Sung-Ryoung Ma Jong-Bae Choi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.31, no.1, pp.93-94, 2019 (Released:2019-01-29)

参考文献数

5

被引用文献数

4

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[Purpose] This study aims to investigate the effect of electrical stimulation on aspiration in children with cerebral palsy and dysphagia. [Participants and Methods] Five children with cerebral palsy and dysphagia were recruited. Electrical stimulation was applied to the submental region targeting submental muscles. All participants received electrical stimulation 30 min/day, 5 days/week, for 4 weeks. Evaluation was performed using the penetration-aspiration scale (PAS), based on a videofluoroscopic swallowing study. [Results] PAS scores showed a statistically significant decrease from 3.8 ± 1.5 to 2.1 ± 1.2 and from 6.4 ± 2.1 to 4.3 ± 2.5 for semisolids type and liquids respectively. [Conclusion] The use of electrical stimulation is effective in reducing aspiration in children with cerebral palsy and dysphagia.

著者

Tomomi Egawa-Takata Yutaka Ueda Akiko Morimoto Yusuke Tanaka Asami Yagi Yoshito Terai Masahide Ohmichi Tomoyuki Ichimura Toshiyuki Sumi Hiromi Murata Hidetaka Okada Hidekatsu Nakai Masaki Mandai Shinya Matsuzaki Eiji Kobayashi Kiyoshi Yoshino Tadashi Kimura Junko Saito Yumiko Hori Eiichi Morii Tomio Nakayama Mikiko Asai-Sato Etsuko Miyagi Masayuki Sekine Takayuki Enomoto Yorihiko Horikoshi Tetsu Takagi Kentaro Shimura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.28, no.3, pp.156-160, 2018-03-05 (Released:2018-03-05)

参考文献数

14

被引用文献数

2 8

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Background: In Japan, the rate of cervical cancer screening is remarkably low, especially among women in their twenties and thirties, when cervical cancer is now increasing dramatically. The aim of this study was to test whether a modified government reminder for 20-year-old women to engage in cervical cancer screening, acting through maternal education and by asking for a maternal recommendation to the daughter to receive the screening, could increase their participation rate.Methods: In two Japanese cities, 20-year-old girls who had not received their first cervical cancer screening before October of fiscal year 2014 were randomized into two study arms. One group of 1,274 received only a personalized daughter-directed reminder leaflet for cervical cancer screening. In the second group of 1,274, the daughters and their mothers received a combination package containing the same reminder leaflet as did the first group, plus an additional informational leaflet for the mother, which requested that the mother recommend that her daughter undergo cervical cancer screening. The subsequent post-reminder screening rates of these two study arms were compared.Results: The cervical cancer screening rate of 20-year-old women whose mothers received the information leaflet was significantly higher than that for women who received only a leaflet for themselves (11% vs 9%, P = 0.0049).Conclusions: An intervention with mothers, by sending them a cervical cancer information leaflet with a request that they recommend that their daughter receive cervical cancer screening, significantly improved their daughters’ screening rate.

著者

Ye-In OH Doo-Sung CHEON Jung-Keun LEE Mi-Hyun CHOI Sun-Young HWANG Hyun-Wook KIM Byung-Jae KANG Hwa-Young YOUN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.9, pp.1445-1449, 2018 (Released:2018-09-26)

参考文献数

39

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A 12-year-old neutered male domestic shorthair cat was presented with a 3-year history of multiple nonpruritic, ulcerated, plaque-like skin lesions but no other clinical signs. A systemic examination revealed mild lymphadenopathy. Histopathologic analysis of the skin lesions revealed multicentric basosquamous carcinoma (BSC). Immunohistochemical analysis, PCR, and sequencing detected Felis catus papillomavirus type 2 (FcaPV-2) within the tumors. As BSC is rare in cats, clinical behavior has not been established. To our knowledge, this is the first case report to demonstrate detection of FcaPV-2 within a BSC in a domestic cat.

著者

谷口 輝 梅田 眞三郎 長谷川 盛三 Yang Wen-Jei

出版者

社団法人 可視化情報学会

雑誌

可視化情報学会論文集

巻号頁・発行日

vol.24, no.11, pp.62-69, 2004

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菱形角柱群管路からの流出噴流にフリップ・フロップ流れが発現する条件の一つには,少なくとも三列以上の菱形角柱群管路であることが必要となっているが,菱形角柱群の列数の違いによる流路内の分流領域における流れの特性については十分に明らかにされていない. 本研究では,単一菱形角柱の後流との比較も含め,菱形角柱の列数を変化させた場合の流路内での流速変動を二次元レーザ・ドップラー流速計(LDV)を用いて計測を行い,パワースペクトル特性を調べた.その結果,カルマン渦列とフリップ・フロップ流れのそれぞれの振動に関する定量的な違いや菱形角柱列数を変化させた場合の分流領域での流れの違いを明らかにするとともに, 第三列目の分流領域の分岐点付近には,カルマン渦列と交差流れのせん断層及びフリップ・フロップ流れのそれぞれの振動が干渉し合っている特異な点が存在することを発見することができた.

著者

Mayu Minamoto-Higashioka Ryoichi Kawamura Hironobu Umakoshi Maki Yokomoto-Umakoshi Daisuke Utsunomiya Haruhiko Osawa Shiori Kondo

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.1360-18, (Released:2019-01-10)

参考文献数

29

被引用文献数

2

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Objective Glucose-lowering drug-induced hypoglycemia is a serious complication and there have been a few reports of seasonal variations in hypoglycemia in patients with type 2 diabetes. The aim of the present study was to examine the association between severe drug-induced hypoglycemia and seasonal variations, and to elucidate the contributing factors. Methods This retrospective, single center clinical study, analyzed the cases of 125 patients who required emergency hospitalization for severe drug-induced hypoglycemia between January 1, 2001 and December 31, 2014. The period from November to April was defined as the cold season. Results Severe hypoglycemia occurred more often in the cold season than in the warm season. In the cold season, 62 of 9,981 (0.6%) emergency department visits involved patients who required hospitalization for drug-induced hypoglycemia. In contrast, in the warm season, 27 of 8,649 (0.3%) visits involved patients who required hospitalization for drug-induced hypoglycemia (p=0.002). The proportion of patients treated with sulfonylurea (SU) in the cold season was higher than that in the warm season. Even the use of low-dose SU caused hypoglycemia in the cold season. In the SU-treated group, the proportion of patients with white blood cell and/or C-reactive protein elevation was higher in the cold season than in the warm season (p=0.04). Conclusion Severe glucose-lowering drug-induced hypoglycemia occured more frequently in the cold season than in the warm season, and was associated with an inflammatory state in patients treated with SU.

著者

Nobuko Mibu Kazumi Yokomizo Marina Sano Yuuna Kawaguchi Kenta Morimoto Syunsuke Shimomura Ryo Sato Nozomi Hiraga Aya Matsunaga Jian-Rong Zhou Tomonori Ohata Hatsumi Aki Kunihiro Sumoto

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.66, no.8, pp.830-838, 2018-08-01 (Released:2018-08-01)

参考文献数

15

被引用文献数

18

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We report the preparation of new C3- and CS-symmetrical molecules constructed on a triazine (TAZ) template. Anti-herpes simplex virus type 1 (anti-HSV-1) and cytotoxic activities against Vero cells of synthesized TAZ derivatives were evaluated. The results suggested that the presence of an electron-donating group(s) on the benzene ring in benzylamine groups on the TAZ template is an important structural factor for expressing a high level of anti-HSV-1 activity and low cytotoxicity for these C3 types of TAZ derivatives. Among the tested TAZ derivatives, compounds 4f and 7h showed the highest anti HSV-1 activities (EC50=0.98 and 1.23 µM, respectively) and low cytotoxic activities to Vero cells (50% cytotoxic concentration (CC50)=292.2 and >200 µM, respectively).

著者

Sarjiya Eua-arporn Bundhit Yokoyama Akihiko

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌. B, 電力・エネルギー部門誌 = The transactions of the Institute of Electrical Engineers of Japan. B, A publication of Power and Energy Society (ISSN:03854213)

巻号頁・発行日

vol.127, no.11, pp.1159-1167, 2007-11-01

参考文献数

25

被引用文献数

1 5

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One of the common problems faced by many electric utilities concernes with the uncertainty from both load forecast error and generating unit unavailability. This uncertainty might lead to uneconomic operation if it is not managed properly in the planning stage. Utilities may have many operational tools, e.g. unit commitment, economic dispatch. However, they require a proper operating strategy, taking into account uncertainties. This paper explicitly demonstrates how to include the uncertainties to obtain the best operating strategy for any power systems. The uncertainty of the load forecast is handled using decision analysis method, meanwhile the uncertainty of the generating unit is approached by inclusion of risk cost to the total cost. In addition, three spinning reserve strategies based on deterministic criteria are incorporated in the development of scenario. Meanwhile, Mixed Integer Linear Programming method is utilized to generate unit commitment decision in each created scenario. The best strategy which gives the minimum total cost is selected among the developed scenarios. The proposed method has been tested using a modified of IEEE 24-bus system. Sensitivity analysis with respect to the number of unit, expected unserved energy price, standard deviation of load forecast, and probability of load level is reported.

著者

TAKASAKI Yoshinori YOSHIZAKI Masanori SUZUKI-PARKER Asuka WATARAI Yasushi

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-026, (Released:2018-12-24)

被引用文献数

5

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The Okazaki heavy rainfall event, which occurred at midnight on 28 August 2008 around Okazaki city in Japan, was produced by a quasi-stationary band-shaped precipitation system. This precipitation system remained quasi-stationary for approximately 5 hours over Okazaki city and the surrounding area, and produced prolonged intense precipitation. This study presents sensitivity numerical experiments to examine the impact of surrounding mountainous topography on the quasi-stationarity of the precipitation system using the Weather Research and Forecasting (WRF) model with 500 m horizontal resolution. In an experiment without the mountains to the east of Okazaki city, the quasi-stationary precipitation system was not reproduced. On the other hand, experiments including eastside mountains produced a low-level convergence in south of Okazaki city, resulting in the quasi-stationary precipitation system and prolonged precipitation as observed near Okazaki city. The convergence was formed by sustained easterlies together with northerly winds blowing in west of Okazaki city. The easterlies were maintained by westward shift of southeasterly inflow from the Pacific Ocean due to the enhanced pressure gradient on the upstream side of the eastside mountains in the low-level atmosphere with low Froude numbers (Fr < 0.5). The easterlies also steadily supplied warm and moist air to the quasi-stationary system, leading to the prolonged intense precipitation observed in the Okazaki heavy rainfall event.

著者

ABBOU-KEBIR Khadidja ARAI Shoji HASSAN AHMED Ahmed CEULENEER Georges

出版者

一般社団法人 日本鉱物科学会

雑誌

Journal of mineralogical and petrological sciences (ISSN:13456296)

巻号頁・発行日

vol.106, no.5, pp.235-245, 2011-10-01

参考文献数

45

被引用文献数

3

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Enigmatic dunitic veins and veinlets crosscutting a podiform chromitite ore body discovered in Wadi Rajmi, northern Oman ophiolite, display a peculiar characteristic of being almost or completely spinel-free. Olivines show an evolution trend from the spinel-free dunites (Fo_93-94 and 0.4 wt% NiO) to the spinel-bearing dunites (Fo_91-93 and 0.2-0.3 wt% NiO). The Cr/(Cr + Al) of chromian spinel grains increases from 0.6 to 0.8, accompanied by a slight increase in Fe³⁺ ratio, and the Fo content of olivine decreases in the spinel-bearing dunites. A high-Mg magma, initially undersaturated with chromian spinel, precipitated the spinel-free dunites. Once the spinel saturation of the melt was attained by fractionation, the spinel-bearing dunites precipitated. The initial magma was possibly komatiitic in nature, which was produced at an early stage of detachment of the oceanic lithosphere that formed the Oman ophiolite.

著者

Seung-Hun LEE Dongmi KWAK Kyoo-Tae KIM

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.8, pp.1255-1258, 2018 (Released:2018-08-10)

参考文献数

25

被引用文献数

14

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This study reports two clinical cases of avian haemosporidian infection caused by a Haemoproteus sp., involving a snowy owl (Bubo scandiacus) and a goshawk (Accipiter gentilis), at a zoo. The snowy owl died after presenting with anorexia, depression and lethargy. A blood smear with Wright’s staining confirmed Haemoproteus infection. Necropsy of the snowy owl revealed hypertrophy of the internal organs, including the liver, gallbladder, kidney and adrenal glands. The goshawk showed anorexia, depression and a lowered head position, and was diagnosed with a Haemoproteus infection based on a blood smear. The goshawk was completely cured by treatment with a combination of atovaquone and proguanil hydrochloride. Both cases showed decreased erythrocytes, hemoglobin and hematocrit values on complete blood count.

著者

Kyong-Il Ki Mi-Sun Kim Young Moon Jong-Duk Choi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.27, no.4, pp.1267-1269, 2015 (Released:2015-04-30)

参考文献数

16

被引用文献数

7 16

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[Purpose] This study examined the effects of auditory feedback during gait on the weight bearing of patients with hemiplegia resulting from a stroke. [Subjects] Thirty hemiplegic patients participated in this experiment and they were randomly allocated to an experimental group and a control group. [Methods] Both groups received neuro-developmental treatment for four weeks and the experimental group additionally received auditory feedback during gait training. In order to examine auditory feedback effects on weight bearing during gait, a motion analysis system GAITRite was used to measure the duration of the stance phase and single limb stance phase of the subjects. [Results] The experimental group showed statistically significant improvements in the duration of the stance phase and single limb stance phase of the paretic side and the results of the Timed Up and Go Test after the training. [Conclusion] Auditory feedback during gait training significantly improved the duration of the stance phase and single limb stance phase of hemiplegic stroke patients.

著者

Shi-Lin Tang Zhen-Wang Zhao Shang-Ming Liu Gang Wang Xiao-Hua Yu Jin Zou Si-Qi Wang Xiao-Yan Dai Min-Gui Fu Xi-Long Zheng Da-Wei Zhang Hui Fu Chao-Ke Tang

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0700, (Released:2019-01-18)

参考文献数

41

被引用文献数

25

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Background: Recent studies have suggested that pregnancy-associated plasma protein-A (PAPP-A) is involved in the pathogenesis of atherosclerosis. This study aim is to investigate the role and mechanisms of PAPP-A in reverse cholesterol transport (RCT) and inflammation during the development of atherosclerosis. Methods and Results: PAPP-A was silenced in apolipoprotein E (apoE−/−) mice with administration of PAPP-A shRNA. Oil Red O staining of the whole aorta root revealed that PAPP-A knockdown reduced lipid accumulation in aortas. Oil Red O, hematoxylin and eosin (HE) and Masson staining of aortic sinus further showed that PAPP-A knockdown alleviated the formation of atherosclerotic lesions. It was found that PAPP-A knockdown reduced the insulin-like growth factor 1 (IGF-1) levels and repressed the PI3K/Akt pathway in both aorta and peritoneal macrophages. The expression levels of LXRα, ABCA1, ABCG1, and SR-B1 were increased in the aorta and peritoneal macrophages from apoE−/−mice administered with PAPP-A shRNA. Furthermore, PAPP-A knockdown promoted RCT from macrophages to plasma, the liver, and feces in apoE−/−mice. In addition, PAPP-A knockdown elevated the expression and secretion of monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), tumor necrosis factor-α, and interleukin-1β through the nuclear factor kappa-B (NF-κB) pathway. Conclusions: The present study results suggest that PAPP-A promotes the development of atherosclerosis in apoE−/−mice through reducing RCT capacity and activating an inflammatory response.

著者

Yupadee HENGJAN Nikom SAE-KOO Thanmaporn PHICHITRASILP Yasushige OHMORI Hatsuki FUJINAMI Eiichi HONDO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.8, pp.1364-1367, 2018 (Released:2018-08-30)

参考文献数

16

被引用文献数

1

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Flying foxes have been widely studied as they are well-known reservoirs of infectious agents. Understanding their population dynamics might help to explain seasonal patterns of disease prevalence, and contribute towards the conservation of flying fox populations. Therefore, this study explored the annual variation in the number of deaths in P. lylei. The study was conducted from 2015–2017, at a Buddhist temple in Thailand, which is the roosting site of P. lylei. The average total number of bat deaths in a month significantly varied between times of a year. A peak was observed during March and May, which ranged in the period of birthing and lactating. There were no significant differences in the average total number of bat deaths in a month between sexes or age classes across times of a years.

著者

herausgegeben vom Institut für Marxismus-Leninismus beim Zentralkomitee der Kommunistischen Partei der Sowjetunion und vom Institut für Marxismus-Leninismus beim Zentralkomitee der Sozialistischen Einheitspartei Deutschlands

出版者

Dietz Verlag

著者

Yuki Takada-Takatori Toshiaki Kume Yasuhiko Izumi Tetsuhiro Niidome Takeshi Fujii Hachiro Sugimoto Akinori Akaike

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.112, no.3, pp.265-272, 2010 (Released:2010-03-19)

参考文献数

24

被引用文献数

4

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We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor is involved in this enhancement. In this study, we examined whether nicotinic receptor stimulation is sufficient to make neurons more sensitive to donepezil. We treated primary cultures of rat cortical neurons with nicotine and confirmed that chronic nicotine treatment induced nicotinic receptor up-regulation and made the neurons more sensitive to the neuroprotective effects of donepezil. Analyses with receptor antagonists and kinase inhibitors revealed that the effects of chronic nicotine treatment are mediated by nicotinic receptors and their downstream effectors including phosphatidylinositol 3-kinase. In contrast to chronic donepezil treatment that enhanced the level of nicotine-induced Ca2+ influx, chronic nicotine treatment did not significantly alter the level of Ca2+ influx.