- 著者
- Antonio Tello-Montoliu José Rivera Diana Hernández Ana Silvente Eva Jover Ana I Rodriguez Miriam Quintana Ana Romero Esteban Orenes-Piñero José Miguel Rivera-Caravaca Francisco Marín Andrea Veliz Mariano Valdés
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.82, no.2, pp.353-360, 2018-01-25 (Released:2018-01-25)
- 参考文献数
- 30
- 被引用文献数
- 1 5
Background:Prasugrel has been shown to provide more potency and less variability than clopidogrel, but its potential temporal variability has not been described.Methods and Results:We conducted a prospective open-label study, evaluating platelet reactivity overtime in acute coronary syndrome (ACS) patients on aspirin and clopidogrel (n=60) or prasugrel (n=61), after a percutaneous coronary intervention (PCI). Blood samples were taken at discharge and at 3 and 6 months. Platelet function tests included VerifyNow (VN-P2Y12), and Multiplate Aggregometry (MEA). By means of VN-P2Y12, prasugrel patients displayed significantly (P<0.001) higher platelet inhibition than clopidogrel patients over time, although there were not significant differences using MEA. Prasugrel patients showed higher platelet inhibition at baseline than at 3 months (59.3±8.1 vs. 105.0±49.2; P<0.001), without significant change at 6 months (107.9±72.0; P=0.919 vs. 3 months). Clopidogrel patients showed a similar trend (160.1±65.1, 184.8±62.7 and 185.0±53.3; baseline vs. 3 months P=0.060; 3 months vs. 6 months P=0.974). High platelet reactivity (HPR) was shown in 16.3% prasugrel patients, with no patient consistently remaining in HPR over time. HPR was detected in 36.6% of the clopidogrel patients, being consistently observed in 15.0% of them. Low platelet reactivity (LPR) was detected in 60.5% prasugrel and 9.8% clopidogrel patients.Conclusions:Prasugrel patients showed less temporal variation than patients on clopidogrel in terms of HPR. In contrast, higher variability in LPR was detected in prasugrel patients for up to 6 months’ follow-up.
- 著者
- Yasutake Nobutoshi Hashimoto Masa-aki Eriguchi Yoshiharu Department of Physics Kyushu University Department of Physics Kyushu University Department of Earth Science and Astronomy Graduate School of Arts and Sciences University of Tokyo
- 出版者
- Published for the Yukawa Institute for Theoretical Physics and the Physical Society of Japan
- 雑誌
- Progress of theoretical physics (ISSN:0033068X)
- 巻号頁・発行日
- vol.113, no.5, pp.953-962, 2005-05-25
- 参考文献数
- 45
- 被引用文献数
- 17
We present a scenario for the formation of strange stars due to spin-down of rapidly rotating neutron stars left after supernova explosions. In this scenario the rapid rotation plays a crucial role. We assume that the total baryon mass is conserved but that both total energy and angular momentum are lost due to emission of gravitational waves and/or magnetic braking. Under this assumption, we calculate the transition from rapidly rotating neutron stars to slowly rotating strange stars. As a result, we find that a large amount of energy, ~10^<53>, ergs is released. The liberated energy might become a new energy source for the delayed explosion of a supernova. Furthermore, our scenario suggests that supernovas associated with gamma-ray bursts are feasible sources of observable gravitational waves.
- 著者
- Fujii Yoshiaki Takahashi Kei Fukuda Daisuke Kodama Jun-ichi
- 出版者
- Japanese Committee for Rock Mechanics
- 雑誌
- Workshop on Rock Engineering and Environment proceedings(ARMS8)
- 巻号頁・発行日
- vol.2014, pp.41-46, 2014-10-13
An equation that represents the relationship between the volume of the injected water V and the maximum magnitude Mmax of induced earthquakes for various cases, including EGS (Enhanced Geothermal System), is expressed as M max = 0.75logV - 0.48 (1) Another equation that represents the relationship between the magnitude and the JMA (Japan Meteorological Agency) maximum seismic intensity scale SISmax of 40 randomly-selected, inland earthquakes in Japan is expressed as: SIS max = 1.36M - 1.12logd - 1.11 (2) where d is the focal depth (m). The equation that follows was derived from the preceding equations. SIS max = 1.02logV - 1.12logd - 1.76 (3) The volume of water injection by shale gas extraction in US was estimated and substituted into the equations, assuming that Eq. (2) could be used also for US earthquakes. The maximum magnitude and seismic intensity scale was predicted to be 6.0 and 3.5 (slight damage to residences), respectively, for the case where extraction had continued for 30 years. This estimate does not conflict with the fact that an M 5.6 event occurred five years after shale gas extraction began in the US. The same procedure was adopted for CCS (Carbon dioxide Capture and Storage) assuming that supercritical CO2 injection had the same effect in inducing seismicity. The injection volume is just 0.001% of the annual CO2 emission in Japan assuming that the allowable seismic intensity scale is 1. The injection of this small amount of CO2 is meaningless. We may have an M 7.1 whose SIS is 5.3 (heavy, significant damage to residences) if we inject 17% (this is IPCC's expectation) of the CO2 in Japan for 30 years into a CCS site. An M 7.1 is apparently not allowed. We need 510,000 CCS sites in Japan in order to inject 17% CO2 safely. It is impossible to construct so many CCS sites. In conclusion, either shale gas extraction or CCS should be carried out very carefully or we may have severe seismicity.
1 0 0 0 OA 暗号VLSIの電磁波セキュリティを確保するサイドチャネル攻撃センサの構成法と実証
サイドチャネル攻撃への耐性を有し、高度に電磁波セキュリティを保証する暗号VLSI技術を確立した。具体的には、(1)暗号コア近傍に接近する電磁界マイクロプローブをオンチップで検知するサイドチャネル攻撃センサの回路技術、(2)暗号コア近傍における電磁界マイクロプローブとサイドチャネル攻撃センサの結合の電磁界シミュレーション及びセンサ回路の動作シミュレーション手法、(3)暗号コアから漏洩するサイドチャネル情報を用いて暗号コアを認証・真正性を確認する技術の開発に成功した。また、半導体集積回路の試作チップを用いたプロトタイプシステムを構築し、研究成果の効果を実証した。
- 著者
- Chin-Liang Chang Richard Char-Tung Lee
- 出版者
- Academic Press
- 巻号頁・発行日
- 1973
- 著者
- ジック-ア グレア スミス ガル
- 出版者
- 技術と人間
- 雑誌
- 技術と人間 (ISSN:02855186)
- 巻号頁・発行日
- vol.25, no.9, pp.50-59, 1996-11
- 著者
- JUN-ICHI YAMASHITA SETSUO TAKEDA HIROSHI MATSUMOTO TADAFUMI TERADA NORIO UNEMI MITSUGI YASUMOTO
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.35, no.5, pp.2090-2094, 1987-05-25 (Released:2009-10-19)
- 参考文献数
- 14
- 被引用文献数
- 6 6
Various O-acyl and N-acyl derivatives of 2'-deoxy-5-trifluoromethyluridine (F3Thd) were synthesized; namely 5'-O-acyl, 3', 5'-di-O-acyl, N3-acyl, 3', 5'-di-O-acetyl-N3-acyl, 3', 5'-di-O-carbamoyl and 3', 5'-di-O-ethoxycarbonyl compounds. 5'-O-Acyl derivatives of 2'-deoxy-5-trifluoromethylcytidine were also synthesized.The antitumor activities of these compounds against sarcoma 180 were examined by oral administration to mice. Among the 5'-and 3', 5'-diester compounds with aliphatic acids, the 5'-O-hexanoyl compound showed the highest activity. Full protection of the sugar moiety with aroyl or carbamoyl groups considerably decreased the activities, and those of the 3', 5'-di-O-m-fluorobenzoyl and 3, 5'-di-O-butylcarbamoyl compounds were the smallest. N3-Benzoyl compounds were slightly more effective than F3Thd but none of them showed higher activity than the effective O-acyl compounds. In the case of 5'-O-acylates of 2'-deoxy-5-trifluoromethylcytidine, the 5'-O-benzoyl compound showed the highest activity.
- 著者
- Atsuhiko UEMURA Yukio TADA Setsuo TAKEDA Junji UCHIDA Jun-ichi YAMASHITA
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.44, no.1, pp.150-155, 1996-01-15 (Released:2008-03-31)
- 参考文献数
- 20
- 被引用文献数
- 3 3
Various O-alkyl derivatives of 2'-deoxy-5-fluorouridine (FUdR) were synthesized and their antitumor activities in mice bearing sarcoma 180 (s.c.-p.o.) were evaluated in terms of the ED50 values (mg/kg/d). Most of these compounds were superior to FUdR in antitumor activity. In particular, the antitumor activity of 3'-O-(p-chloro-benzyl)-FUdR (3e) (ED50 =0.87mg/kg/d) was as much as 100 times that of FUdR (ED50=84mg/kg/d). Further, various 5'-O-aminoacyl derivatives of 3e were synthesized and evaluated in terms of ED50 value and therapeutic index (T.I.). Both the ED50 value (0.41mg/kg/d) and the T.I. (4.18) of 3'-O-(p-chlorobenzyl)-5'-O-glycyl-FUdR hydrochloride (6a) were significantly improved, compared with those of 3e and FUdR. FUdR plasma concentration after a single p.o. dosing of 6a was maintained for as long as 24h.
- 著者
- Tomotaka Ugai Keitaro Matsuo Norie Sawada Motoki Iwasaki Taiki Yamaji Taichi Shimazu Shizuka Sasazuki Manami Inoue Shoichiro Tsugane the Japan Public Health Center-based Prospective Study Group
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- vol.27, no.7, pp.305-310, 2017 (Released:2017-07-05)
- 参考文献数
- 23
- 被引用文献数
- 10
Background: Cigarette smoking has been reported to be associated with an increased risk of leukemia. Most epidemiological evidence on the association between cigarette smoking and leukemia risk is from studies conducted in Western populations, however, and evidence from Asian populations is scarce.Methods: We conducted a large-scale population-based cohort study of 96,992 Japanese subjects (46,493 men and 50,499 women; age 40–69 years at baseline) with an average 18.3 years of follow-up, during which we identified 90 cases of acute myeloid leukemia (AML), 19 of acute lymphoblastic leukemia (ALL), and 28 of chronic myeloid leukemia (CML). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a Cox regression model adjusted for potential confounders.Results: When we adjusted for age, sex, and study area, our findings showed no significant association or increasing dose–response relationship between risk of AML and cigarette smoking overall. However, after further adjustment for body mass index and occupation, current smokers with more than 30 pack-years of cigarette smoking had a significantly increased risk of AML compared to never smokers among men (HR 2.21; 95% CI, 1.01–4.83). This increased risk was not clear among women.Conclusions: Our results suggest that cigarette smoking increases the risk of AML in Japanese men. The associations of smoking with AML among women, and with CML and ALL among men and women, should be assessed in future studies.
1 0 0 0 A history of food
- 著者
- by Maguelonne Toussaint-Samat translated by Anthea Bell
- 出版者
- Wiley-Blackwell
- 巻号頁・発行日
- 2009
- 著者
- Xue-Song ZHU Hui YU
- 出版者
- Meteorological Society of Japan
- 雑誌
- 気象集誌. 第2輯 (ISSN:00261165)
- 巻号頁・発行日
- vol.97, no.1, pp.153-173, 2019 (Released:2019-02-14)
- 参考文献数
- 53
- 被引用文献数
- 6
Using brightness temperature data from passive microwave satellite imagery, this study examines tropical cyclones (TCs) with concentric eyewall (CE) in the western North Pacific between 1997 and 2011. The identified CEs are divided into two types according to the characteristics of the eyewall replacement cycle (ERC) in the microwave imagery: a CE with a typical ERC (T-ERC) and a CE without an ERC (N-ERC). It is indicated that 88% T-ERCs reach peak intensity near (0.2 h after on average) CE formation, whereas 90% N-ERCs reach peak intensity prior to (22.0 h on average) CE formation. In general, N-ERCs tend to occur when there are strong interactions between the environment and the CE, whereas T-ERCs occur in a relatively quiet environment. The three-dimensional conceptual models of the environmental configurations for both CE types are proposed. Specifically, N-ERCs are accompanied by stronger southwesterly and southeasterly inflows, active low-level trough, and stronger subtropical high (SH) and South Asia high (SAH), compared with T-ERCs. For N-ERCs, the stronger inflows may bring in a large amount of moisture, and the active low-level trough may result in a large vertical wind shear (VWS). The stronger SH and SAH may contribute to changes in the intensity and direction of the VWS for N-ERCs, and hence trigger the development of local convection in the outer eyewall. The asymmetries in the convection of the outer eyewall may weaken the ability to cut off the radial inflow to the inner eyewall. Consequently, N-ERCs fail to finish the ERC and weaken rapidly in intensity, even though the moisture remains sufficient after CE formation.
- 著者
- KUO Kuan-Ting WU Chien-Ming
- 出版者
- Meteorological Society of Japan
- 雑誌
- 気象集誌. 第2輯 (ISSN:00261165)
- 巻号頁・発行日
- pp.2019-031, (Released:2019-02-02)
- 被引用文献数
- 11
In this study, the mechanism for precipitation hotspots (PHs) of locally developed afternoon thunderstorms in the Taipei Basin is investigated using a three-dimensional Vector Vorticity equation cloud resolving Model (VVM) with an idealized topography and surface properties. A 500-m horizontal grid resolution is used in all experiments. The results show that the local circulation is a key for PHs at the south of the Taipei Basin. The two valleys guide background southwesterly flow along with the sea breezes to penetrate into the basin. The urban heat island effect enhances the sea breeze convergence at the south of the basin and produces strong convection there. Interactions between cold pools generated by the convection and the sea breezes produce northward propagating new convective cells. Besides, the background wind direction is important in determining the location of sea breeze convergence. If the background wind direction changes from westerly to west-northwesterly, there might be no precipitation at all in the basin. This study suggests that the idealized experiments also provide a useful framework for studying the impacts of future climate change on the PHs in the Taipei Basin by applying the pseudo-global warming approach.
- 著者
- Kazuomi Kario Eiichiro Yamamoto Hirofumi Tomita Takafumi Okura Shigeru Saito Takafumi Ueno Daiki Yasuhara Kazuyuki Shimada on behalf of the SYMPLICITY HTN-Japan Investigators
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-18-1018, (Released:2019-02-13)
- 参考文献数
- 32
- 被引用文献数
- 27
Background: SYMPLICITY HTN-Japan is a prospective, randomized, controlled trial comparing renal denervation (RDN) with standard pharmacologic therapy for treatment of uncontrolled hypertension (HTN). Methods and Results: Patients enrolled had uncontrolled HTN, defined as office systolic blood pressure (SBP) ≥160 mmHg and 24-h ambulatory SBP ≥135 mmHg, on ≥3 antihypertensive drugs of maximally tolerated dose for at least 6 weeks prior to enrollment. Randomization was 1:1 to RDN or maintenance of current medical therapy (control). Patients were followed every 6 months post-randomization for up to 36 months. There were 22 patients randomized to RDN and 19 to control, and 11 patients were crossed over and received RDN at 6 months post-randomization. For the RDN group (n=22), office SBP reduction was −32.8±20.1 mmHg and office DBP reduction was −15.8±12.6 mmHg at 36 months post-procedure, both P<0.001. For the combined RDN and crossover group (n=33), office SBP reduction was −26.7±18.9 mmHg and office DBP reduction was −12.7±11.8 mmHg at 30 months post-procedure, both P<0.001. There were no procedural-, device- or treatment-related safety events through 36 months. Conclusions: SYMPLICTY HTN-Japan is the first randomized controlled trial to evaluate RDN in an Asian population. Despite the small number of enrollments, results show patients who received RDN therapy maintained SBP reduction out to 36 months.
- 著者
- Blanca ALGARRA Verónica MAILLO Manuel AVILÉS Alfonso GUTIÉRREZ-ADÁN Dimitrios RIZOS María JIMÉNEZ-MOVILLA
- 出版者
- THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT
- 雑誌
- Journal of Reproduction and Development (ISSN:09168818)
- 巻号頁・発行日
- vol.64, no.5, pp.433-443, 2018 (Released:2018-10-12)
- 参考文献数
- 64
- 被引用文献数
- 17
Previously, our group demonstrated that recombinant porcine oviductin (pOVGP1) binds to the zona pellucida (ZP) of in vitro-matured (IVM) porcine oocytes with a positive effect on in vitro fertilization (IVF). The fact that pOVGP1 was detected inside IVM oocytes suggested that this protein had a biological role during embryo development. The aim of this study was to evaluate the effects of pOVGP1 on bovine in vitro embryo development. We applied 10 or 50 µg/ml of pOVGP1 during IVF, embryonic in vitro culture (IVC), or both, to evaluate cleavage and embryo development. Blastocyst quality was assessed by analyzing the expression of important developmental genes and the survival rates after vitrification/warming. pOVGP1 was detected in the ZP, perivitelline space, and plasma membrane of blastocysts. No significant differences (P > 0.05) were found in cleavage or blastocyst yield when 10 or 50 µg/ml of pOVGP1 was used during IVF or IVC. However, when 50 µg/ml pOVGP1 was used during IVF + IVC, the number of blastocysts obtained was half that obtained with the control and 10 µg/ml pOVGP1 groups. The survival rates after vitrification/warming of expanded blastocysts cultured with pOVGP1 showed no significant differences between groups (P > 0.05). The use of pOVGP1 during IVF, IVC, or both, increased the relative abundance of mRNA of DSC2, ATF4, AQP3, and DNMT3A, the marker-genes of embryo quality. In conclusion, the use of pOVGP1 during bovine embryo in vitro culture does not affect embryo developmental rates but produces embryos of better quality in terms of the relative abundance of specific genes.
- 著者
- Hung Hsu Powen Hsu Ming-Hui Cheng Yasuki Ito Eiichiro Kanda Ernst J Schaefer Masumi Ai
- 出版者
- Japan Atherosclerosis Society
- 雑誌
- Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
- 巻号頁・発行日
- pp.48330, (Released:2019-02-07)
- 参考文献数
- 49
- 被引用文献数
- 20
Aims: Prediabetes and diabetes are associated with increased insulin resistance and decreased insulin production, dyslipidemia, and increased cardiovascular disease (CVD) risk. Our goals were to assess lipoprotein subfractions using novel assays in such subjects.Methods: Fasting normal, prediabetic, and diabetic Taiwanese men and women (n=2,049) had their serum glucose, glycosylated hemoglobin, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), HDL3-C, apolipoprotein E-HDL-C, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-TG, and remnant lipoprotein cholesterol (RLP-C) levels measured using novel assays. HDL2-C, LDL-C, and large-buoyant LDL-C (lbLDL-C) were calculated.Results: Prediabetic male and female subjects had significantly higher levels of TG, RLP-C, sdLDL-C, the sdLDL-C/LDL-C ratio, and LDL-TG than normal subjects, and statin treatment abolished this effect in men, but not in women. Diabetic male and female subjects had significantly higher TG and sdLDL-C/LDL-C ratios, and significantly lower levels of HDL-C, HDL2-C, HDL3-C, and apoE HDL-C than normal subjects, as did prediabetic women. Median direct LDL-C levels were >100 mg/dL in all groups, even in those receiving statin therapy. Calculated LDL-C significantly underestimated direct LDL-C by >10% in diabetic subjects.Conclusions: Our data indicate that prediabetic subjects were more likely to have significantly elevated RLP-C, sdLDL-C, and LDL-TG, while diabetic subjects were more likely to have significantly decreased HDL-C, HDL2-C, HDL3-C, and apoE HDL-C than normal subjects, and calculated LDL-C significantly underestimated their direct LDL-C. In our view, direct LDL-C and sdLDL-C should be measured and optimized in both diabetic and prediabetic subjects to reduce CVD risk.
- 著者
- Takeshi Kato Takeshi Yamashita Kouichi Sagara Hiroyuki Iinuma Long-Tai Fu
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.68, no.6, pp.568-572, 2004 (Released:2004-05-25)
- 参考文献数
- 27
- 被引用文献数
- 78 121
Background Atrial fibrillation (AF) is believed to occur first as paroxysmal, then be gradually perpetuated, and finally become chronic as the end result. However, this presumed clinical course has not been well confirmed. Methods and Results The clinical course of recurrent paroxysmal AF (PAF) from its onset was examined in 171 patients (mean follow-up period: 14.1±8.1 years). This study population consisted of patients with no structural heart disease (n=88), ischemic heart disease (n=28), dilated or hypertrophic cardiomyopathy (n=17), valvular heart disease (n=35) or other cardiac diseases. The mean age at the onset of AF was 58.3 ±11.8 years old. During the mean follow-up period of 14.1 years, PAF eventually developed into its chronic form in 132 patients under conventional antiarrhythmic therapy (77.2%, 5.5% of patients per year). The independent factors for early development into chronic AF were aging (hazard ratio (HR) 1.27 per 10 years, 95% confidence interval (CI) 1.06-1.47)), dilated left atrium (HR 1.39 per 10 mm, 95% CI 1.11-1.69), myocardial infarction (HR 2.33, 95% CI 1.13-4.81), and valvular diseases (HR 2.29, 95% CI 1.22-4.30). Conclusions The present long-term observations definitely and quantitatively revealed the progressive nature of PAF. (Circ J 2004; 68: 568 - 572)
- 著者
- Satoshi Ogawa Takeshi Yamashita Tsutomu Yamazaki Yoshifusa Aizawa Hirotsugu Atarashi Hiroshi Inoue Tohru Ohe Hiroshi Ohtsu Ken Okumura Takao Katoh Shiro Kamakura Koichiro Kumagai Yoshihisa Kurachi Itsuo Kodama Yukihiro Koretsune Tetsunori Saikawa Masayuki Sakurai Kaoru Sugi Toshifumi Tabuchi Haruaki Nakaya Toshio Nakayama Makoto Hirai Masahiko Fukatani Hideo Mitamura for the J-RHYTHM Investigators
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.73, no.2, pp.242-248, 2009 (Released:2009-01-23)
- 参考文献数
- 31
- 被引用文献数
- 85 161
Background Although previous clinical trials demonstrated the non-inferiority of a rate control to rhythm control strategy for management of atrial fibrillation (AF), the optimal treatment strategy for paroxysmal AF (PAF) remains unclear. Methods and Results A randomized, multicenter comparison of rate control vs rhythm control in Japanese patients with PAF (the Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM) study) was conducted. The primary endpoint was a composite of total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure, or physical/psychological disability requiring alteration of treatment strategy. In the study, 823 patients with PAF were followed for a mean period of 578 days. The primary endpoint occurred in 64 patients (15.3%) assigned to rhythm control and in 89 patients (22.0%) to rate control (P=0.0128). No significant differences between the treatment strategies were observed in the incidences of death, stroke, bleeding and heart failure. Meanwhile, significantly fewer patients requested changes of assigned treatment strategy in the rhythm control vs the rate control group, which was accompanied by improvement in AF-specific quality of life scores. Conclusion The J-RHYTHM study showed that rhythm control was associated with fewer primary endpoints than rate control. However, mortality and cardiovascular morbidity were not affected by the treatment strategy (umin-CTR No. C000000106). (Circ J 2009; 73: 242 - 248)
- 著者
- Sun-Kyoung Lee Chung-Moo Lee Jong-Hwan Park
- 出版者
- The Society of Physical Therapy Science
- 雑誌
- Journal of Physical Therapy Science (ISSN:09155287)
- 巻号頁・発行日
- vol.27, no.9, pp.2915-2919, 2015 (Released:2015-09-30)
- 参考文献数
- 18
- 被引用文献数
- 5 15
[Purpose] The purpose of the present study was to determine the effect of a jump rope and ball combined exercise program on the physical fitness the neurotransmitter (epinephrine, serotonin) levels of children with attention-deficit hyperactivity disorder. [Subjects and Methods] The subjects were 12 boys attending elementary school, whose grade levels ranged from 1–4. The block randomization method was used to distribute the participants between the combined exercise group (n = 6) and control group (n = 6). The program consisted of a 60-min exercise (10-min warm-up, 40-min main exercise, and 10-min cool down) performed three times a week, for a total of 12 weeks. [Results] The exercise group showed a significant improvement in cardiorespiratory endurance, muscle strength, muscle endurance and flexibility after 12 weeks. A significant increase in the epinephrine level was observed in the exercise group. [Conclusion] The 12-week combined exercise program in the current study (jump rope and ball exercises) had a positive effect on overall fitness level, and neurotransmission in children with attention-deficit hyperactivity disorder.
- 著者
- Mizuki Morisasa Naoko Goto-Inoue Tomohiko Sato Kazumasa Machida Mina Fujitani Taro Kishida Kenji Uchida Tsukasa Mori
- 出版者
- Japan Oil Chemists' Society
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.68, no.2, pp.141-148, 2019 (Released:2019-02-01)
- 参考文献数
- 13
- 被引用文献数
- 14
Alaska pollack protein (APP) was previously shown to reduce serum triacylglycerol and the atherogenic index and significantly increase gastrocnemius muscle mass in rats. To determine which myofibers are involved in this observed hypertrophy, we stained the gastrocnemius muscle with fast and slow fiber-specific antibodies and measured the muscle fiber diameter. We observed muscle hypertrophy in both the fast and slow fibers of APP-fed rats. Although muscle hypertrophy leads to drastic lipid changes, the amount of lipids did not differ significantly between casein-fed and APP-fed rats. To determine the lipid changes at the molecular species level and their localization, we performed matrix-assisted laser desorption/ionization mass spectrometry imaging to visualize lipids in the gastrocnemius muscles. We determined that lipid molecules were significantly changed due to APP feeding. Thus, APP feeding changes muscle lipid metabolism, and these metabolic changes might be related to hypertrophy.
- 著者
- Yoo Hai-Soo Kim Su-Jeong Park Dong-Won
- 出版者
- 社団法人 物理探査学会
- 雑誌
- 物理探査 = BUTSURI-TANSA Geophysical Exploration (ISSN:09127984)
- 巻号頁・発行日
- vol.58, no.1, pp.104-111, 2005-02-01
- 参考文献数
- 5
Dmitri Donskoi号 (1883年進水のロシア巡洋艦) は日露戦争に参戦中の1905年5月29日に韓国Ulleung島 (日本海) の近くで沈んだことが知られている。この船を見つけるために、その沈没位置に関する情報をロシアと日本の海事記録から得た。その船の沈没位置はおおよそ判明し、1999年から2003年まで5年にわたる物理探査が実施された。海底に関する三次元地形学踏査は、マルチ・ビーム音響測深器、海洋磁力計およびサイドスキャン・ソナーを使用して実行した。初期踏査により認識された異常体は、遠隔操作式無人有索探査船 (ROV) の深海カメラおよびミニ潜水艦『パスファインダー』を使用した詳細な調査によって確認された。得られたデータを解釈し、沈没船は海面下400mの急傾斜面に位置していることがわかった。その位置は、Ulleung島のJeodongから約2kmである。船の船体に残された152mmの艦砲、および他の戦闘資材が確認された。さらに、沈没時に燃上した操舵装置および他の機械類の残りが船体の近くで見つかった。調査エリアに分布する火山岩の強い磁性の影響を受け、磁気探査データから船の位置を正確に求めることはできなかった。船体のまわりの急峻な海底地形は、サイドスキャン・ソナー・データ中の反射波の拡散を増加させ、サイドスキャン・ソナーを用いた異常体 (船体) 検出を困難にした。それに対し、多重ビーム音響測深器を用いた探査では、探査船を最大限低速で運航したり、海底地形によりビーム角の調整行ったり等の工夫を行ったため、得られた海底イメージは船体位置の確認に非常に有効であった。