著者

Kenji TAKATA Yoshiaki HIKASA Hiroshi SATOH

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.12, pp.1545-1550, 2012 (Released:2012-12-28)

参考文献数

27

被引用文献数

2

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This study elucidated differences in predisposition to the gastrointestinal adverse effects of ketoprofen between young and adult cats. Ketoprofen was administered subcutaneously (2.0 mg/kg, s.c.) once a day for 3 days. The animals were sacrificed 24 hr after final injection to allow examination of gastrointestinal mucosal lesions. Ketoprofen caused gastric lesions in adult cats (>6 months) but not in young cats (<3 months). Ketoprofen caused more severe small intestinal lesions in adult cats than in young cats. In the study of prevention of lipopolysaccharide (LPS)-induced hyperthermia using ketoprofen, young and adult cats of both sexes were administered LPS (0.3 μg/kg, intravenously), and body temperature was measured 24 hr later. Ketoprofen was administered subcutaneously 30 min before LPS injection. LPS-induced hyperthermia was almost completely inhibited by pretreatment with ketoprofen in both adult and young cats. In the pharmacokinetics of ketoprofen, plasma concentrations were analyzed by high-performance liquid chromatography. No significant differences were observed in plasma concentrations of two mirror-image R(-) and S(+) ketoprofen between young and adult cats from 0.5–4 hr after injection. As observed in a previous study using flunixin, the degree of gastrointestinal damage was unrelated to plasma concentrations of ketoprofen. The results of this study demonstrated that ketoprofen is safer for use in young cats than in adult cats from the viewpoint of gastrointestinal adverse effects.

著者

Hiroyuki TSUDA Yutaka OHSHIMA Hiroshi NOMOTO Ken-ichi FUJITA Eiji MATSUDA Masaaki IIGO Nobuo TAKASUKA Malcolm A. MOORE

出版者

日本薬物動態学会 会長/日本薬物動態学会 DMPK編集委員長

雑誌

Drug Metabolism and Pharmacokinetics (ISSN:13474367)

巻号頁・発行日

vol.19, no.4, pp.245-263, 2004 (Released:2004-09-29)

参考文献数

152

被引用文献数

132 154

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Increasing attention is being paid to the possibility of applying cancer chemopreventive agents for individuals at high risk of neoplastic development. For this purpose by natural compounds have practical advantages with regard to availability, suitability for oral application, regulatory approval and mechanisms of action. Candidate substances such as phytochemicals present in foods and their derivatives have been identified by a combination of epidemiological and experimental studies. Plant constituents include vitamin derivatives, phenolic and flavonoid agents, organic sulfur compounds, isothiocyanates, curcumins, fatty acids and d-limonene. Examples of compounds from animals are unsaturated fatty acids and lactoferrin. Recent studies have indicated that mechanisms underlying chemopreventive potential may be combinations of anti-oxidant, anti-inflammatory, immune-enhancing, and anti-hormone effects, with modification of drug-metabolizing enzymes, influence on the cell cycle and cell differentiation, induction of apoptosis and suppression of proliferation and angiogenesis playing roles in the initiation and secondary modification stages of neoplastic development. Accordingly, natural agents are advantageous for application to humans because of their combined mild mechanism. Here we review naturally occurring compounds useful for cancer chemprevention based on in vivo studies with reference to their structures, sources and mechanisms of action.

著者

野田 弘志 三原 捷宏 堀 研 友安 一成 吉井 章 森永 昌司 Noda Hiroshi Mihara Katsuhiro Hori Ken Tomoyasu Kazunari Yoshii Akira Morinaga Syoji ノダ ヒロシ ミハラ カツヒロ ホリ ケン トモヤス カズナリ ヨシイ アキラ モリナガ ショウジ

出版者

広島市立大学芸術学部

雑誌

広島市立大学芸術学部紀要

巻号頁・発行日

no.7, pp.54-66, 2002-04

著者

Lee Sang-Min Byun Hi-Ryong Tanaka Hiroshi L.

出版者

American Meteorological Society

雑誌

Journal of applied meteorology and climatology (ISSN:15588424)

巻号頁・発行日

vol.51, no.6, pp.1087-1098, 2012-06

被引用文献数

29 1

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The drought climate of Japan from 1902 to 2009 was analyzed using an effective drought index (EDI). Drought regions were identified by hierarchical cluster analysis using drought characteristics (duration, severity, and onset and end dates) obtained from 50 observation stations. The results indicated that droughts could be divided into four groups (G1–G4) that reflected the local climate. The four groups were related to precipitation as follows. The summer rainy season affected groups G2–G4, in which droughts occurred mainly during spring and summer and were relieved before and after the rainy season. The G1 group was not affected by the summer rainy season and droughts were spread evenly throughout the year; it even had cases of droughts relieved by winter snow. All groups included dry conditions over the 108-yr period, and the driest conditions occurred in the late twentieth century. The statistical analysis of drought data showed that a total of 23 country-wide droughts occurred and that the most extreme droughts occurred in 1939–41 and 1984–85, with an EDI of −1.55. In addition, four dry seasons (1939–45, 1997–98, 1994–97, and 2005–09) were found using regime shift analysis. Regional droughts occurred 54, 54, 49, and 59 times in groups G1–G4, respectively. On average, short-term droughts with a duration shorter than 6 months occurred 3.5 times per decade, whereas long-term droughts extending over 1 yr occurred 0.3 times per decade. The drought duration and intensity were used to calculate the statistical return period of country-wide droughts. The 1939–41 drought had the longest return period, at 104.7 yr. The 1987–88 and 1995–97 droughts had return periods of 65.9 and 65.5 yr, respectively.

著者

姜 瑩基 若山 浩司 Kee Kang Hyung Hiroshi WAKAYAMA 四国大学経営情報研究所 Institute of Management and Information Science of Shikoku University

出版者

四国大学経営情報研究所

雑誌

四国大学経営情報研究所年報 (ISSN:13417436)

巻号頁・発行日

no.8, pp.85-98, 2002-12

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Recently, the motion which is going to build the electronic government in many countries including Asia and Western Europe is developing actively. Thus, many countries are searching for ways to support efficient management of firms and enhance their competitiveness. Electronic government is a new paradigm of administrative system to properly deal with environmental changes surrounding governments. Therefore, it is the essential model of government in the future, one in which administrative operation is redesigned and administrative services are enhanced by means of information infrastructure technologies, improving the quality of life of the public and further realizing democracy.

著者

小宮山 貴史 大西 洋 栗山 健吾 田中 史穂 荒木 力 加藤 大基 原 竜介 伊丹 純 コミヤマ タカフミ オオニシ ヒロシ クリヤマ ケンゴ タナカ シホ アラキ ツトム カトウ ダイキ ハラ リュウスケ イタミ ジュン Komiyama Takafumi Onishi Hiroshi Kuriyama Kengo Tanaka Shiho Araki Tsutomu Kato Daiki Hara Ryusuke Itami Jun

出版者

日本医学放射線学会

雑誌

日本医学放射線学会雑誌 (ISSN:00480428)

巻号頁・発行日

vol.64, no.3, pp.139-145, 2004-03-25

著者

HIROSHI SASAKI TOMOYOSHI HOSOKAWA MIKIO SAWADA KUNIO ANDO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.26, no.11, pp.676-680, 1973-11-25 (Released:2006-04-12)

参考文献数

15

被引用文献数

43 68

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A new antibiotic with hypolipidemic activity, ascofuranone, C23H29C1O5, and related substance, ascofuranol, C23H31C1O5, were isolated from the filter cake of the fermented broth of Ascochyta viciae LIBERT, an ascochlorin-producing fungus, and their structures were elucidated. They possess 3-substituted-5-chloro-orcylaldehyde moiety with novel sesquiterpenyl side chains.

著者

工藤 直志 山中 浩司 クドウ タダシ ヤマナカ ヒロシ Kudoh Tadashi Yamanaka Hiroshi

出版者

大阪大学大学院人間科学研究科

雑誌

大阪大学大学院人間科学研究科紀要 (ISSN:13458574)

巻号頁・発行日

vol.35, pp.153-171, 2009-03

著者

OYAMA Yukio YAMAGUCHI Seiya MAEKAWA Hiroshi

出版者

Atomic Energy Society of Japan

雑誌

Journal of Nuclear Science and Technology (ISSN:00223131)

巻号頁・発行日

vol.25, no.5, pp.419-428, 1988

被引用文献数

5

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Angular neutron fluxes leaking from the surface of lithium-oxide and graphite slab assemblies have been measured with irradiation of D-T neutrons. The spectrum measurement was performed using the time-of-flight technique with an NE213 scintillation detector. The thicknesses of the slabs were 0.6 to 5 mean free path for 14.8 MeV neutrons, and the measured leaking angles of the angular fluxes were 0.0°, 12.2°, 24.9°, 41.8° and 66.8°. The experimental results have been compared with the results calculated by the continuous energy Monte Carlo transport code MCNP, using the data in the JENDL-3PR1, -3PR2, and ENDF/B-V nuclear data files. The comparisons between the experimental and calculated results show that the data of <SUP>7</SUP>Li in JENDL-3PR2 is improved for the secondary emission spectra of the 4.63 MeV level and (n, 2n) reactions; the angular distributions of 3rd- and 4th-level inelastic reactions of C in the JENDLs are questionable. The thickness dependences for high energy neutrons also suggest that the total cross section of <SUP>7</SUP>Li and the elastic cross sections of C are slightly inadequate.

著者

Tatsuya Suzuki Kenzo Oba Yoshimasa Igari Noriaki Matsumura Kentaro Watanabe Shoko Futami-Suda Hiroko Yasuoka Motoshi Ouchi Kazunari Suzuki Yoshiaki Kigawa Hiroshi Nakano

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.74, no.5, pp.338-343, 2007 (Released:2007-10-26)

参考文献数

20

被引用文献数

45 75

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Background: Colestimide has been reported to lower blood glucose levels in patients with type 2 diabetes complicated by hypercholesterolemia. Aim: To examine the mechanism by which colestimide decreases plasma glucose levels in the above patients. Methods: A total of 16 inpatients with type 2 diabetes complicated by hypercholesterolemia received colestimide for 1 week after their plasma glucose levels stabilized. We measured plasma glucose, serum immunoreactive insulin (IRI), serum lipid, plasma glucagon, and plasma glucagon-like peptide-1 (GLP-1) levels. These variables at baseline and 1 week of colestimide administration were compared. Results: Preprandial plasma glucose levels (baseline: 132 ± 33 mg/dL vs. completion: 118 ± 43 mg/dL, P=0.073) tended to decrease after colestimide administration, while 1-hr postprandial plasma glucose levels (baseline: 208 ± 49 mg/dL vs. completion: 166 ± 30 mg/dL, P<0.001) and 2-hr postprandial plasma glucose levels (baseline: 209 ± 56 mg/dL vs. completion: 178 ± 39 mg/dL, P=0.015) decreased significantly at 1 week of colestimide administration. The 2-hr postprandial plasma GLP-1 level was significantly (P=0.015) higher at 1 week of colestimide administration as compared with the baseline level, while there were no significant changes in preprandial and 1-hr postprandial plasma GLP-1 levels. Conclusions: The GLP-1-increasing activity of colestimide may explain, at least in part, the mechanism of its blood glucose-lowering activity in patients with type 2 diabetes complicated by hypercholesterolemia.

著者

NAKA Hiroshi IKI Masayuki MORITA Akemi IKEDA Yukihiro

雑誌

Journal of bone and mineral metabolism (ISSN:09148779)

巻号頁・発行日

vol.23, no.6, pp.463-469, 2005-09-30

被引用文献数

4

著者

Akiyoshi HAYASHI Hiroshi TANAKA Tomoko TAJIMA Masanari NAKAYAMA Fumihito OHASHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0375, (Released:2012-11-02)

被引用文献数

1 6

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A seven-year-old spayed female domestic short-haired cat presented with dysuria and hematuria having been unresponsive to medical therapy. Some imaging tests such as ultrasonography, urethrocystography and computed tomography revealed the pelvic mass compressing urethra. Based on histological examination of the mass following surgical resection, the cat was diagnosed squamous cell carcinoma (SCC) derived from uterine remnant. After surgery, dysuria was resolved, but on instead, urine and fecal incontinence were observed. Then, about four months after surgery, recurrence of the mass and the symptoms was observed. Consequently, the cat was ultimately euthanized. This is the first report of SCC arising from the uterine remnant in a spayed female cat.

著者

Yasutsugu MIWA Makoto NAKATA Asuka KUROSAWA Hiroshi SASAI Nobuo SASAKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.70, no.12, pp.1323-1326, 2008 (Released:2009-01-01)

参考文献数

14

被引用文献数

2 11

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Adrenal diseases are quite common in Japanese pet ferrets; however, there have been no reports concerning the epidemiology of ferret adrenal disease in Japan. The purpose of this study was to collect epidemiological data on ferret adrenal disease in Japan by sending a questionnaire to veterinarians throughout Japan. Among the 521 cases that met the criteria for this study, 307 were adrenocortical carcinoma (58.9%), 117 were adrenocortical adenoma (22.5%) and 87 were adrenocortical hyperplasia (16.7%), respectively. Sex, clinical signs, concurrent diseases, age and the sites of the affected adrenal gland in these cases were similar to those reported in North America. Most pet ferrets in Japan are imported from North America, and their husbandry in Japan is similar to that in North America, which may be the cause of the similarity in ferret adrenal disease between North America and Japan. Because a difference in the incidence of ferret adrenal diseases among countries has been reported, further research is necessary to investigate the factors related to the similarities and how to decrease the incidence of adrenal diseases in ferrets in Japan.

著者

白神 浩志 シラガミ ヒロシ SHIRAGAMI Hiroshi

出版者

東北芸術工科大学

雑誌

東北芸術工科大学紀要 = Bulletin of Tohoku University of Art and Design

巻号頁・発行日

vol.18, pp.38-46, 2011-10-31

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This report describes video game market trends by data on Japan, North America, and Europe, in 2001- 2010 ( based on "Famitsu Game Hakusyo 2005,..,2011") and shows the main factors of the trends. In this paper, the global video game market includes 1) household games, 2) online games, 3) mobile phone games and 4) pc package games. In 2004-2009, market size and share of 2)& 3) increased and 1)'s share decreased. Though 1) kept the major portion of the video game market, the market size increased to the 2008 peak, then decreased. In Japanese market analysis, in addition to above 1), 2) & 3) ategories, 4) commercial games and 5) social games are applied. 4) decreases but 5) is highly growing to almost exceed the household game market size in 2011/1st, 2nd quarter. NDS and Wii, evolutional game consoles, intended to expand gaming population achieved the peak of household game market in 2008 in the world, but it shrinks now. Recent market trends are the shift on delivery method from package type to online type and the shift on business model from fixed-fee model to freemium model. There seem to be two reasons for these trends. One is the 6 years model-change timing of game consoles. And the other is the shift of user's taste to the new play style known as "social game". Therefore the recent game market trends might continue to shrink traditional household game market. Keywords: ソーシャルゲーム、ゲーム市場、NDS, Wii, freemium model

著者

松本 紳 逸村 裕 歳森 敦 MATSUMOTO Makoto ITSUMURA Hiroshi TOSHIMORI Atsushi

出版者

大学図書館研究編集委員会

雑誌

大学図書館研究 (ISSN:03860507)

巻号頁・発行日

vol.91, pp.9-14, 2011-03-01

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2007年度より改組され新たなスタートを切った筑波大学情報学群知識情報・図書館学類について記した。知識科学,情報経営・図書館,知識情報システムの三主専攻からなる学類の使命,教育理念,輩出すべき人材,そして1年次からのカリキュラム構成とその特色,就職先/進路について述べた。また学類と附属図書館とが協同で設置したラーニングコモンズとそこから派生した「図書館情報学若手の会(ALIS:Around Library and Information Science)の活動について記述した。学類は発足して 年目であり,今後,評価活動を通じてカリキュラムの見直し,改定すべき所を検証していくところである。

著者

Okabe Yoshihiro Asamizu Erika Ariizumi Tohru Shirasawa Kenta Tabata Satoshi Ezura Hiroshi

出版者

Japanese Society of Breeding

雑誌

Breeding science (ISSN:13447610)

巻号頁・発行日

vol.62, no.2, pp.202-208, 2012-06

被引用文献数

26

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Novel mutant alleles of an ethylene receptor Solanum lycopersicum ETHYLENE RESPONSE1 (SlETR1) gene, Sletr1-1 and Sletr1-2, were isolated from the Micro-Tom mutant library by TILLING in our previous study. They displayed different levels of impaired fruit ripening phenotype, suggesting that these alleles could be a valuable breeding material for improving shelf life of tomato fruit. To conduct practical use of the Sletr1 alleles in tomato breeding, genetic complementation analysis by transformation of genes carrying each allele is required. In this study, we generated and characterized transgenic lines over-expressing Sletr1-1 and Sletr1-2. All transgenic lines displayed ethylene insensitive phenotype and ripening inhibition, indicating that Sletr1-1 and Sletr1-2 associate with the ethylene insensitive phenotype. The level of ethylene sensitivity in the seedling was different between Sletr1-1 and Sletr1-2 transgenic lines, whereas no apparent difference was observed in fruit ripening phenotype. These results suggested that it is difficult to fine-tune the extent of ripening by transgenic approach even if the weaker allele (Sletr1-2) was used. Our present and previous studies indicate that the Micro-Tom mutant library combined with TILLING could be an efficient tool for exploring genetic variations of important agronomic traits in tomato breeding.

著者

Mashimo Tomoji Takizawa Akiko Kobayashi Junya Kunihiro Yayoi Yoshimi Kazuto Ishida Saeko Tanabe Koji Yanagi Ami Tachibana Asato Hirose Jun Yomoda Jun-Ichiro Morimoto Shiho Kuramoto Takashi Voigt Birger Watanabe Takeshi Hiai Hiroshi Tateno Chise Komatsu Kenshi Serikawa Tadao

出版者

Elsevier

雑誌

Cell reports (ISSN:22111247)

巻号頁・発行日

vol.2, no.3, pp.685-694, 2012-09-27

被引用文献数

61

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重症免疫不全SCIDラットの作製 : ヒトiPS細胞、がん細胞、肝細胞をラット体内で培養することに成功. 京都大学プレスリリース. 2012-09-14.

著者

上地 宏 Uechi Hiroshi 名桜大学

出版者

名桜大学

雑誌

名桜大学紀要 = THE MEIO UNIVERSITY BULLETIN (ISSN:18824412)

巻号頁・発行日

no.2, pp.7-12, 1996-07-01

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販売競争などの競合する二つの経営体に対し、変数係数の連立微分方程式により経営戦略の時間的な強度変化をモデル化して、ランチェスターの二乗法則を議論し、二乗法則が修正された形式で成立することを示した。変数係数の連立微分方程式に対する厳密解の表現のなかに、経常戦略の時間的強度変化を表現する関数が一般的な形で入っており、それらの関数の操作により二つの経営体の競合状態が詳細に表されている。人員補給や販売教育、経営計画や分業などの販売員の増減などによる経営戦略は、相手側経営体との相互作用を考慮して最適な操作をする時において、販売力の増加を助ける要因となりえることが示されており、コンピュータ・シミュレーションなどによる解析をとおして、最適過程制御など、オペレーションズ・リサーチへの応用に役立てることができるものと思われる。 Modelizing two competing managerial enterprises by a system of variable coefficient differential equations, and taking time-varying strategic management into consideration, Lanchester's law is rediscussed and modified in this paper. The general solution of the diffrential equation includes functions to control strategic management, and considering interaction with the opponent managerial strategy by manipulating the functions, the optimal control of strategic management can be performed in terms of a personel supply and reduction, for example, a division of work, a business-planning, and so forth. The expression of the rigorous solution of two interacting managerial enterprises will be useful for the analysis of the computer simulations in operations research and optimal control of management.

著者

Bandula Kumara WICKRAMASEKARA RAJAPAKSHAGE Masahiro YAMASAKI Shiang-Jyi HWANG Noboru SASAKI Masahiro MURAKAMI Yu TAMURA Sue Yee LIM Kensuke NAKAMURA Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1139-1148, 2012 (Released:2012-10-01)

参考文献数

34

被引用文献数

9 16

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The stability of the characteristics of the diminazene aceturate (DA)-resistant B. gibsoni isolate was initially determined invitro. Part of the DA-resistant B. gibsoni isolate was cultured without DA for 4 weeks, and then newly exposed to 200 ng/ml DA. As a result, this isolate could proliferate the same as the DA-resistant isolate, indicating that the characteristic of DA resistance was stable in the DA-resistant isolate. Additionally, the level of parasitemia in the DA-resistant isolate was comparatively lower than in the wild-type, suggesting that the proliferation potential of the DA-resistant isolate would be lower than that of the wild-type. Subsequently, to investigate the involvement of mitochondrial DNA (mtDNA) in DA resistance in B. gibsoni, the nucleotide sequences and deduced amino acid sequences of mitochondrial genes such as COXI, COXIII, and CYTb genes of the DA-resistant isolate, were compared with those of the wild-type. As a result, these three genes were not altered in the DA-resistant B. gibsoni isolate. Moreover, the transcription levels of COXI, COXIII, and CYTb genes were observed by semi-quantitative RT-PCR. As a result, the gene transcription of those genes in the DA-resistant isolate was not significantly altered. These results indicated that DA did not affect mtDNA directly in DA-resistant B. gibsoni. Thus, it is suggested that mtDNA should not be deeply involved in DA resistance in B. gibsoni.

著者

Kaoru TANIGUCHI Mitsuhisa WATANABE Yasuhiro SUZUKI Hiroshi SAWA

出版者

SEISMOLOGICAL SOCIETY OF JAPAN

雑誌

Zisin (Journal of the Seismological Society of Japan. 2nd ser.) (ISSN:00371114)

巻号頁・発行日

vol.64, no.1, pp.11-21, 2011-08-25 (Released:2011-10-18)

参考文献数

28

被引用文献数

1 2

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The 150 km long Itoigawa-Shizuoka Tectonic Line Active Fault System (ISTL) in central Japan is one of the most active fault systems in Japan. Paleoseismologcal studies 1980s have revealed that the most recent event and the average recurence interval of the ISTL. The approximately 7 km long portion of the fault system between Matsumoto and Okaya has been regarded as a gap without any active fault trace. The gap namely the “Shiojiri Pass Gap” has long been taken as a segment boundary owing to the geometric discontinuity. Recent geomorphological analyses of the gap have demonstrated a through-going left-lateral slip assocaited with recent earthquakes in this area, based on aerial photograph interpretation and excavation studies. Excavation study on this portion revealed that the latest faulting event occurred between 1,700 cal. B.P. to 1,310 cal. B.P. (255 A.D. -645 A.D.). The timing of the last faulting event at this study area coincides with the timing in the Gofukuji fault and Okaya fault. The active faults extending from the Matsumoto basin as far as the northwestern margin of the Suwa basin display the evidence for its recent reactivation at the same time.