著者

寺井 仁 種市 淳子 逸村 裕 TERAI Hitoshi TANEICHI Junko ITSUMURA Hiroshi

出版者

名古屋大学附属図書館研究開発室

雑誌

名古屋大学附属図書館研究年報 (ISSN:1348687X)

巻号頁・発行日

vol.6, pp.39-45, 2008-03-31 (Released:2009-02-10)

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Recently, the information environment has become more complex due to the spread of digital information resources. Information seeking is a dynamic process which is influenced from information resources and the information content included in those resources. It is important that how to facilitate users’ information behavior in a hybrid information environment. In this study, we conducted a psychological experiment to understand what effects planning exert on the information seeking process by controlling planning of information needs and selection of information resources upon an information search behavior.

著者

Takuma AOKI Keisuke SUGIMOTO Hiroshi SUNAHARA Yoko FUJII

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0322, (Released:2012-09-18)

被引用文献数

8 14

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We report two feline cases of patent ductus arteriosus (PDA) with pulmonary hypertension (PH). The subjects were both intact domestic shorthair cats, a 4-month-old, 2.5 kg male (case 1) and an 8-month-old, 2.12 kg female (case 2). At the first presentation, left-sided congestive heart failure was diagnosed in case 1 and severe aortic stenosis (AS) in case 2. Following surgical ligation of the ductus arteriosus (DA), furosemide therapy was no longer required in case 1, and the severe AS improved to mild status in case 2 perhaps because of reduced volume overload. In case 2, severe hypoxemia was revealed after surgery; however, this normalized within 96 days after surgery.

著者

Hiroshi Fujii Yu Ikeuchi Yasutaka Kurata Nobuhito Ikeda Udin Bahrudin Peili Li Yuji Nakayama Ryo Endo Akira Hasegawa Kumi Morikawa Junichiro Miake Akio Yoshida Kyoko Hidaka Takayuki Morisaki Haruaki Ninomiya Yasuaki Shirayoshi Kazuhiro Yamamoto Ichiro Hisatome

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-12-0126, (Released:2012-09-04)

参考文献数

27

被引用文献数

3 2

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Background: The prion protein (PrP) has been reported to serve as a surface maker for isolation of cardiomyogenic progenitors from murine embryonic stem (ES) cells. Although PrP-positive cells exhibited automaticity, their electrophysiological characteristics remain unresolved. The aim of the present study was therefore to investigate the electrophysiological properties of PrP-positive cells in comparison with those of HCN4p-or Nkx2.5-positive cells. Methods and Results: Differentiation of AB1, HCN5p-EGFP and hcgp7 ES cells into cardiac progenitors was induced by embryoid body (EB) formation. EBs were dissociated and cells expressing PrP, HCN4-EGFP and/or Nkx2.5-GFP were collected via flow cytometry. Sorted cells were subjected to reverse transcriptase-polymerase chain reaction, immunostaining and patch-clamp experiments. PrP-positive cells expressed mRNA of undifferentiation markers, first and second heart field markers, and cardiac-specific genes and ion channels, indicating their commitment to cardiomyogenic progenitors. PrP-positive cells with automaticity showed positive and negative chronotropic responses to isoproterenol and carbamylcholine, respectively. Hyperpolarization-activated cation current (If) was barely detectable, whereas Na+ and L-type Ca2+ channel currents were frequently observed. Their spontaneous activity was slowed by inhibition of sarcoplasmic reticulum Ca2+ uptake and release but not by blocking If. The maximum diastolic potential of their spontaneous firings was more depolarized than that of Nkx2.5-GFP-positive cells. Conclusions: PrP-positive cells contained cardiac progenitors that separated from the lineage of sinoatrial node cells. PrP can be used as a marker to enrich nascent cardiac progenitors.

著者

Takuma AOKI Yoko FUJII Hiroshi SUNAHARA Hiroshi TAKANO Yoshito WAKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.11-0486, (Released:2012-09-07)

被引用文献数

1

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Mitral valvuloplasty (MVP) is used in dogs with refractory mitral regurgitation (MR); however, it is difficult to tie the artificial chord, i.e., the expanded polytetrafluoroethylene suture, at the planned height of the mitral valve because of the slippery nature of the knot. The loop technique has resolved these difficulties in humans. Premanufactured loops (length, 8.0–15.0 mm with 1.0-mm increments) were used in the new modified loop technique. In the current study, cardiac murmurs disappeared, and the MR markedly improved or completely disappeared approximately 3 months after surgery in 3 dogs. Therefore, this new technique might be effective in dogs.

著者

Sayuri ITOI Rui KANO Atsuhiko HASEGAWA Hiroshi KAMATA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.8, pp.1067-1069, 2012 (Released:2012-09-03)

参考文献数

12

被引用文献数

3 27

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Although the susceptibility of dermatophytes to antifungal drugs is well documented in humans, the effectiveness in animals has not been previously investigated. The in vitro susceptibility of 54 clinical isolates from animal dermatophytoses to ketoconazole (KTZ), itaconazole (ITZ) and terbinafine (TFN) was measured using microdilution assay (CLSI M38-A2 test) and by the E-test (KTZ and ITZ). All 3 drugs showed antifungal activity, while KTZ displayed the broadest minimum inhibition concentration (MIC) range (0.125–16 μg/ml) against M. canis and M. gypseum. The MIC of KTZ and ITZ was almost the same for human and animal isolates of T. mentagrophytes and T. rubrum. The MIC of TFN was almost the same for dermatophytes isolated from humans and animals.

著者

Hiroshi Masuya

出版者

公益社団法人 日本実験動物学会

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

vol.61, no.4, pp.365-373, 2012 (Released:2012-07-26)

参考文献数

37

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A huge amount of experimental data from past studies has played a vital role in the development of new knowledge and technologies in biomedical science. The importance of computational technologies for the reuse of data, data integration, and knowledge discoveries has also increased, providing means of processing large amounts of data. In recent years, information technologies related to “ontologies” have played more significant roles in the standardization, integration, and knowledge representation of biomedical information. This review paper outlines the history of data integration in biomedical science and its recent trends in relation to the field of experimental animal science.

著者

Shiro Oguma Itiro Ando Takuo Hirose Kazuhito Totsune Hiroshi Sekino Hiroshi Sato Yutaka Imai Masako Fujiwara

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.227, no.3, pp.217-223, 2012 (Released:2012-07-07)

参考文献数

27

被引用文献数

5 22

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Patients with renal failure undergoing hemodialysis often have muscle cramps during and after the dialysis therapy. Muscle cramps are defined as the sudden onset of a prolonged involuntary muscle contraction accompanied with severe pain, resulting in early termination of a HD session and inadequate dialysis. The etiology of the cramps is unknown and effective anti-cramp medicine is not available. We have hypothesized that water-soluble vitamins are deficient in HD patients. Accordingly, we administrated biotin to 14 patients who had frequent muscle cramps during HD sessions. Oral administration of 1 mg/day biotin promptly reduced the onset and the severity of cramps in 12 patients both during and after HD. Then, the plasma biotin levels were measured by an enzyme-linked immunosorbent assay method (ELISA) in HD patients, including 14 patients with cramps and 13 patients without cramps, and 11 healthy volunteers. Plasma biotin levels were elevated in 27 HD patients at baseline compared with healthy volunteers [451 (377 - 649) vs. 224 (148 - 308) ng/l, median (lower-upper quartiles); p < 0.0001]. Unexpectedly, among the 14 cramp patients, the biotin levels were significantly higher in biotin-ineffective 7 patients than biotin-effective 7 patients [1,064 (710 - 1,187) vs. 445 (359 - 476) ng/l; p < 0.001]. Thus, the biotins measured by ELISA may consist of not only intact biotin but also its metabolites that do not function as a vitamin. In conclusion, biotin administration is one choice to relieve HD patients from muscle cramps regardless of their elevated plasma biotin levels.

著者

Kenji TAKATA Yoshiaki HIKASA Hiroshi SATOH

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.11-0563, (Released:2012-07-10)

被引用文献数

2

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This study elucidated differences in predisposition to the gastrointestinal adverse effects of ketoprofen between young and adult cats. Ketoprofen was administered subcutaneously (2.0 mg/kg, s.c.) once a day for 3 days. The animals were sacrificed 24 hr after final injection to allow examination of gastrointestinal mucosal lesions. Ketoprofen caused gastric lesions in adult cats (>6 months) but not in young cats (<3 months). Ketoprofen caused more severe small intestinal lesions in adult cats than in young cats. In the study of prevention of lipopolysaccharide (LPS)-induced hyperthermia using ketoprofen, young and adult cats of both sexes were administered LPS (0.3 μg/kg, intravenously), and body temperature was measured 24 hr later. Ketoprofen was administered subcutaneously 30 min before LPS injection. LPS-induced hyperthermia was almost completely inhibited by pretreatment with ketoprofen in both adult and young cats. In the pharmacokinetics of ketoprofen, plasma concentrations were analyzed by high-performance liquid chromatography. No significant differences were observed in plasma concentrations of two mirror-image R(−) and S(+) ketoprofen between young and adult cats from 0.5–4 hr after injection. As observed in a previous study using flunixin, the degree of gastrointestinal damage was unrelated to plasma concentrations of ketoprofen. The results of this study demonstrated that ketoprofen is safer for use in young cats than in adult cats from the viewpoint of gastrointestinal adverse effects.

著者

Kozo NAKAMURA Taku MIYASHO Sachiko NOMURA Hiroshi YOKOTA Tetsuya NAKADE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.751-756, 2012 (Released:2012-07-04)

参考文献数

19

被引用文献数

10 21

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We performed proteomics analysis of the cerebrospinal fluid (CSF) of healthy dogs and dogs with meningoencephalitis of unknown etiology (MUE). By comparing two-dimensional electrophoreses (2DE), an upregulated spot was found in MUE dogs. This protein was identified as a neuron-specific enolase (NSE) by analysis with MALDI-TOF mass spectrometry. In comparing dot blots using an antibody against NSE, the NSE levels in the CSF of MUE dogs was significantly higher than that of the controls. NSE is a diagnostic marker of neuroendocrine tumors, brain injury and spinal cord trauma in humans. It seems that the NSE concentration in the CSF is increased by cellular destruction in canine encephalitis. Though elevation of NSE may not be specific in canine encephalitis because the NSE level was increased in other CNS diseases, further study including measurement with serum is necessary.

著者

Mai UWANO Rui KANO Haruhiko MARUYAMA Atsuhiko HASEGAWA Hiroshi KAMATA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.783-785, 2012 (Released:2012-07-04)

参考文献数

15

被引用文献数

1

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The small molecule inhibitor, ABT-737, inhibits Bcl-2 that is overexpressed in many tumor cell lines and, in combination with an anticancer drug, can strongly enhance proapoptotic activity. In the present study, we evaluated the inhibitory activity of ABT-737 on the survival of a canine melanoma cell line (MCM-N1). MCM-N1 cell viability was decreased following 24- and 48-hr culture with ABT-737, depending on ABT-737 concentration, while cell viability was unchanged in controls. ABT-737 synergized with carboplatin to promote cell death. Notably, approximately 50% of MCM-N1 cells survived following culture with 2-4 μg/ml of carboplatin; whereas, less than 20% of MCM-N1 cells survived following culture with ABT-737 (1 mM) plus carboplatin (2-10 μg/ml).

著者

野田 弘志 三原 捷宏 堀 研 大矢 英雄 友安 一成 吉井 章 森永 昌司 NODA Hiroshi MIHARA Katsuhiro HORI Ken OHYA Hideo TOMOYASU Kazunari YOSHII Akira MORINAGA Shoji ノダ ヒロシ ミハラ カツヒロ ホリ ケン オオヤ ヒデオ トモヤス カズナリ ヨシイ アキラ モリナガ ショウジ

出版者

広島市立大学芸術学部

雑誌

広島市立大学芸術学部紀要

巻号頁・発行日

no.9, pp.68-76, 2004-03

著者

大歳 克衞 野田 弘志 三原 捷宏 堀 研 友安 一成 吉井 章 森永 昌司 保苅 瑞穂 米倉 守 OTOSHI Katsue NODA Hiroshi MIHARA Katsuhiro HORI Ken TOMOYASU Kazunari YOSHII Akira MORINAGA Shoji HOKARI Mizuho YONEKURA Mamoru オオトシ カツエ ノダ ヒロシ ミハラ カツヒロ ホリ ケン トモヤス カズナリ ヨシイ アキラ モリナガ ショウジ ホカリ ミズホ ヨネクラ マモル

出版者

広島市立大学芸術学部

雑誌

広島市立大学芸術学部紀要

巻号頁・発行日

no.5, pp.60-83, 2000-03

著者

Takuma Iwai Hiroshi Yoshida Tadashi Yokoyama Hiroshi Maruyama Seiji Suzuki Takeshi Matsutani Akira Matsushita Atsushi Hirakata Koji Sasajima Eiji Uchida

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.78, no.3, pp.189-193, 2011 (Released:2011-06-30)

参考文献数

17

被引用文献数

3 5 3

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We describe a patient in whom a fish bone penetrated the duodenum and migrated into the right renal vein. The bone was successfully removed with surgery. The 75-year-old man was admitted to Nippon Medical School Tama Nagayama Hospital because of right upper abdominal pain persisting for 7 days. The patient's medical history was not relevant to the current disorder. Plain radiography showed no abnormalities. Computed tomography revealed a linear object of high intensity that had penetrated the duodenum and migrated into the right renal vein with thrombus. The object was surrounded by a low-density area, suggesting severe inflammation. The patient had eaten fish 1 day before the onset of abdominal pain. We diagnosed duodenal penetration caused by an ingested fish bone. Endoscopic examination showed erosion, but no fish bone or ulceration was detected in the duodenum. The patient was treated conservatively with fasting, peripheral parental nutrition, and intravenous antibiotics. Three days after admission, non-contrast-enhanced computed tomography showed no movement of the foreign body. The patient continued to have pain, and the decision was made to surgically explore the abdomen. Intraoperative ultrasonography showed that the foreign body had migrated completely into the right renal vein with thrombus. Severe inflammation of the right renal vein was observed. Because we could not remove the foreign body without seriously injuring the right renal vein, right nephrectomy was performed. Macroscopic examination of the surgical specimen confirmed the presence of a fish bone with thrombus in the right renal vein. The patient was discharged 9 days after operation, with no complications.

著者

Takei Toshiharu Odake Hiroshi Miura Kazuaki TAKAGI Yutaka

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.55, no.3, pp.121-126, 2006

被引用文献数

4

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This paper reports the ecotoxicological study of "tetradecanoic acid, 2-sulfo-, 1-methylester, sodium salt (C14MES)". This salt was synthesized by sulfonating 1-methyl tetradecanoic acid derived from palm oil and coconut oil with sulfur trioxide. The tests were attempted in accordance with the OECD (Organization for Economic Cooperation and Development) Guidelines for the Testing of Chemicals. The 72 h ErC₅₀ exceeded 100 mg/L in the alga growth inhibition test. In the daphnia acute immobilization and reproduction tests, 17.2 mg/L of 48 h EC₅₀ and 4.10 mg/L of NOEC were derived, respectively. These ecotoxicities of C14MES were equivalent to or lower than that of other similar anionic surfactants, such as LAS (linear alkylbenzene sulfonate) or AOS (alpha olefin sulfonate).<br>

著者

Thinh Cong NGUYEN Ying-Chun LI Patrice MAKOULOUTOU Lea Angsinco JIMENEZ Hiroshi SATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0025, (Released:2012-06-01)

被引用文献数

3 13 2

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The northern snakehead Channa argus, native to China, Russia and Korea, is currently found widespread throughout Japan following its original introduction during the 1920s. A parasitological study of 10 snakeheads fished from the Fushinogawa River running through Yamaguchi City, Japan, detected 2–101 (average, 23.7) metacercariae per 100 g of trunk muscle from each fish. The trematode was identified as metacercariae of Posthodiplostomum sp. (Strigeidida: Diplostomidae) morphologically and characterized genetically based on the ribosomal RNA gene (rDNA). Phylogenetic trees were constructed on the basis of either the 18S, ITS or 28S region of rDNA to assess the relationship among members of the family Diplostomidae. The addition of genetic data from more diplostomid taxa, particularly Posthodiplostomum cuticola recorded from a variety of freshwater fish in Eurasia, would facilitate the precise identification of the present species.

著者

目代 邦康 池田 宏 飯島 英夫 Kuniyasu MOKUDAI Hiroshi IKEDA Hideo IIJIMA 筑波大 筑波大 筑波大

雑誌

地形 = Transactions, Japanese Geomorphological Union (ISSN:03891755)

巻号頁・発行日

vol.25, no.3, 2004-07-25

著者

Sasaki Hideki Akiyama Hiroshi Yoshida Yoshifumi KONDO Kazunari AMAKURA Yoshiaki KASAHARA Yoshimasa MAITANI Tamio

出版者

公益社団法人日本薬学会

雑誌

Biological & pharmaceutical bulletin (ISSN:09186158)

巻号頁・発行日

vol.29, no.12, pp.2514-2518, 2006-12-01

被引用文献数

4 20

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In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in 'Probably Toxic' sugihiratake collected from the area of encephalopathy outbreaks, and 'Probably Safe' sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.

著者

Junko DOI Junichi HIROTA Akihiko MORITA Kanae FUKUSHIMA Hiromi KAMIJYO Hiroshi OHTA Masahiro YAMASAKI Toru TAKAHASHI Ken KATAKURA Yuzaburo OKU

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.413-417, 2012 (Released:2012-04-29)

参考文献数

19

被引用文献数

7 21

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Tritrichomonas suis (=T. foetus) has recently been reported to be a causative agent of chronic large-bowel diarrhea in cats. While the disease was previously attributed to Pentatrichomonas hominis, the etiologic agent for feline trichomonal diarrhea was identified as T. suis. Although feline trichomonosis due to T. suis has been reported at prevalences ranging from 14 to 31% in Europe and the U.S., no reports of the pathogen have been published to date in Japan. In 2008, however, we encountered a case of feline trichomonosis at the Veterinary Teaching Hospital of Hokkaido University. The parasite was identified as T. suis by nested PCR amplification of partial internal transcribed spacer region 1 and 5.8S ribosomal RNA gene sequences with T. suis-specific primers and DNA sequencing of the amplified products. We then conducted surveys for feline trichomonosis in three different animal hospitals using either cultivation and/or PCR-based assays. The results revealed that 13 of 147 samples (8.8%) were positive for T. suis, and that 5 of the 13 infected cats, which ranged between 1 month and 7.5 years-old, showed chronic diarrhea. Seven of the infected cats were purebred and 6 were mixed breed. These findings suggested that feline trichomonosis is prevalent in Japan, and that T. suis may play a role as a causative agent of feline chronic diarrhea.

著者

Harada Hiroshi Inoue Masahiro Itasaka Satoshi Hirota Kiichi Morinibu Akiyo Shinomiya Kazumi Zeng Lihua Ou Guangfei Zhu Yuxi Yoshimura Michio McKenna W. Gillies Muschel Ruth J. Hiraoka Masahiro

出版者

Nature Publishing Group

雑誌

Nature Communications (ISSN:20411723)

巻号頁・発行日

vol.3, pp.1-10, 2012-04-17

被引用文献数

141

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放射線治療後のがんの再発メカニズムの解明. 2012-4-18.

著者

ISHII Hiroshi

出版者

一般社団法人電子情報通信学会

雑誌

IEICE transactions on information and systems (ISSN:09168532)

巻号頁・発行日

vol.87, no.6, pp.1299-1311, 2004-06-01

被引用文献数

2

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This paper first discusses the misinterpretation of the concept of "ubiquitous computing" that Mark Weiser originally proposed in 1991. Weiser's main message was not the ubiquity of computers, but the transparency of interface that determines users' perception of digital technologies embedded in our physical environment seamlessly. To explore Weiser's philosophy of transparency in interfaces, this paper presents the design of an interface that uses glass bottles as "containers" and "controls" for digital information. The metaphor is a perfume bottle: Instead of scent, the bottles have been filled with music - classical, jazz, and techno music. Opening each bottle releases the sound of a specific instrument accompanied by dynamic colored light. Physical manipulation of the bottles - opening and closing - is the primary mode of interaction for controlling their musical contents. The bottles illustrates Mark Weiser's vision of the transparent (or invisible) interface that weaves itself into the fabric of everyday life. The bottles also exploits the emotional aspects of glass bottles that are tangible and visual, and evoke the smell of perfume and the taste of exotic beverages. This paper describes the design goals of the bottle interface, the arrangement of musical content, the implementation of the wireless electromagnetic tag technology, and the feedback from users who have played with the system.