著者

Shinohara Akio Kawada Shin-ichiro Yasuda Masatoshi LIAT Lim Boo

出版者

日本哺乳類学会

雑誌

Mammal study = The Continuation of the Journal of the Mammalogical Society of Japan (ISSN:13434152)

巻号頁・発行日

vol.29, no.2, pp.185-189, 2004-12-01

被引用文献数

7 11

著者

KAMIMATSUNO Shin ABE Hiroaki SEKI Takashi OKANUKA Toru

出版者

脳機能とリハビリテーション研究会

雑誌

Journal of Rehabilitation Neurosciences (ISSN:24342629)

巻号頁・発行日

vol.20, no.JPN, pp.31-37, 2020 (Released:2020-10-09)

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Repeated gait training with a flexible knee brace and an oil damper hinged ankle-foot orthosis (GSD, Gaitsolution Design, Kawamura Gishi, Osaka, Japan) improved the gait abnormalities and speed in a stroke patient with ataxic hemiparesis. Here, we report on a female in her 50s with a cerebral infarction in the posterolateral thalamus. She had ataxic hemiparesis in her lower left leg. While walking, her knee was bending at initial contact and loading response due to the ataxic hemiparesis, and her gait speed remained at 52.2 m/min. To reconstruct the inverted pendulum model, we provided gait training with a flexible knee brace and GSD. As a result, her gait abnormalities were resolved and her gait speed improved up to 72.6 m/min. We speculated that the one of the reasons for the improvement in gait speed was the adjustment of the task difficulty to address the gait abnormality due to the ataxic hemiplegia, and repeating gait training with an inverted pendulum model. We concluded that providing repeated gait training with a flexible knee brace and GSD to construct the inverted pendulum model may improve the gait abnormalities and speed in patients with ataxic hemiparesis.

著者

Satoshi Nishimura Takuya Ohzono Kohei Shoji Shin Yagihara Masafumi Hayashi Hisao Tanaka

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.66, no.3, pp.235-249, 2017 (Released:2017-03-01)

参考文献数

39

被引用文献数

2 2

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Interfacial tension between edible oil and saline was measured under applied electric fields to understand the electrocapillary phenomena at the edible oil/saline interfaces. The electric responses of saline droplets in edible oil were also observed microscopically to examine the relationship between the electrocapillary phenomena and interfacial polarization. When sodium oleate (SO) was added to edible oil (SO-oil), the interfacial tension between SO-oil and saline decreased. However, no decrease was observed for additive-free oil or oleic acid (OA)-added oil (OA-oil). Microscopic observations suggested that the magnitude of interfacial polarization increased in the order of additive-free oil < OA-oil < SO-oil. The difference in electrocapillary phenomena between OA- and SO-oils was closely related to the polarization magnitude. In the case of SO-oil, the decrease in interfacial tension was remarkably larger for saline (pH 5.4~5.6) than that for phosphate-buffered saline (PBS, pH 7.2~7.4). However, no difference was observed between the electric responses of PBS and saline droplets in SO-oil. The difference in electrocapillary phenomena for PBS and saline could not be simply explained in terms of polarization magnitude. The ratio of ionized and non-ionized OA at the interfaces changed with the saline pH, possibly leading to the above difference.

著者

Satoshi Ujigawa Hiroyuki Nakata Shin Shimakura

出版者

Society of Atmospheric Electricity of Japan

雑誌

Journal of Atmospheric Electricity (ISSN:09192050)

巻号頁・発行日

vol.29, no.2, pp.115-123, 2009 (Released:2011-04-12)

参考文献数

10

被引用文献数

1 1

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Observation of 48.25-MHz radio waves transmitted from Bangkok, Thailand, was carried out at Tateyama, Japan, during 2001. Since the radio wave propagates through a crest of equatorial anomaly, which disturbs stratified structure of the ionosphere, it is conceivable that the propagation of the radio wave is affected by three-dimensional structure of the ionosphere. Seasonal and diurnal variations of the signal intensity are quite similar to ƒ0F2 above Guangzhou and also Okinawa, which are located on the great circle path between Bangkok and Tateyama. Using ray-tracing calculations with the distribution of the electron density determined by IRI model, it is also confirmed that the radio wave propagates to Tateyama because of one-hop reflection in the ionosphere and that MUF is mainly dependent on ƒ0F2 above the midpoint between Bangkok and Tateyama. Although the value of ƒ0F2 is almost constant, MUF calculated by the ray-tracing treatment decreases around 14 JST in fall and winter. This decrease is also detected in the observational result of the signal intensity of the radio wave received at Tateyama. The ray tracing calculation shows that the decrease of MUF is due to tilt of the distribution of electron density, which is noticeable in developing the equatorial anomaly. Then discussing the propagation characteristics of 48.25-MHz radio waves crossing equatorial anomaly region, it is important to consider not only the parameters of the ionosphere, e.g. ƒ0F2, but also the tilt of the distribution of electron density.

著者

Shin-ichiro SASAHARA Yuichi OI Shotaro DOKI Daisuke HORI Yuh OHTAKI Christina-Sylvia ANDREA Tsukasa TAKAHASHI Nagisa SHIRAKI Yu IKEDA Tomohiko IKEDA Ryutaro IZUMI Tamaki SAITO Ichiyo MATSUZAKI

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.18, no.5, pp.180-185, 2020 (Released:2020-09-04)

参考文献数

32

被引用文献数

1

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Over the past few years, the number of Japanese astronauts recruited for a long-term stay in the International Space Station (ISS) has increased. Being on a prolonged mission with the same people, in the same room, should impose psychosocial stress on the astronauts, possibly causing feelings of “psychological suffocation”. Several confinement studies have been conducted to simulate the conditions of the ISS, the Mir space station, and potential habitats on Mars, and to survey psychological interpersonal communication between the crew in a confined environment, including the Isolation Study for European Manned Space Infrastructure, Experimental Campaign for the European Manned Space Infrastructure, Simulation of Flight of International Crew on Space Station, Human Behavior in Extended Spaceflight, Mars-500, and Hawaii Space Exploration Analog and Simulation. Here, the findings from these studies were integrated into a structured review according to an evidence-based set of items for reporting in systematic reviews and meta-analyses. The results indicated that metaanalyses would not always be appropriate because it is difficult to design a research protocol with a high level of evidence in this field. Therefore, future research in this field should be focused on the following three points: 1) developing more accurate parameters for monitoring stress levels in long-term confinement environments; 2) analyzing stress levels in such situations with higher precision; and 3) accumulating and assembling existing and future data from long-term confinement environments.

著者

Yoshitaka Hirasawa Atsushi Fujiwara Kazuya Tabata Kenji Yoshida Tsutomu Negama Takayuki Anzai Shin-ichi Sato

出版者

The Japanese Society of Toxicology

雑誌

Fundamental Toxicological Sciences (ISSN:2189115X)

巻号頁・発行日

vol.7, no.2, pp.105-114, 2020 (Released:2020-03-27)

参考文献数

33

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The purpose of this study was to profile cytokine storms (cytokine release syndrome) in the LPS-induced disseminated intravascular coagulation (DIC)-cynomolgus monkey model by measuring changes in 22 cytokines using Luminex. In this study, increases were noted in 20 cytokines, excluding IL-4 and IL-17A. Specifically, IL-6, IL-8, G-CSF and TNF-α, pro-inflammatory cytokines, and IL-10, an anti-inflammatory cytokine, as well as MCP-1, markedly increased by 10,000 pg/mL or more. In addition to the marked increases in the pro-inflammatory cytokines IL-6 and G-CSF, the concentrations of IL-5, IL-18, IFN-γ, VEGF and IL-15 increased continuously. Also, in addition to the marked increases in the pro-inflammatory cytokine IL-8 as well as in MCP-1, the concentrations of IL-1ra, IL-2, IL-1β, IL-12/23 (p40), GM-CSF and TGF-α gradually decreased after initially increasing. On the other hand, in addition to the marked increases in the pro-inflammatory cytokine TNF-α and anti-inflammatory cytokine IL-10, MIP-1β and MIP-1α transiently increased and then rapidly disappeared from serum. IL-13 increased at 6 hr after administration only. Since the behavior of cytokines in this monkey model was similar to those noted in DIC in humans, this model will be useful for evaluating the efficacy of anti-DIC drugs. In addition, this model will also be useful for assessing the risk of cytokine storm development, which is a serious adverse effect of certain types of antibody drugs and CAR-T cell-based therapies.

著者

Hideki Okata Waku Hatta Katsunori Iijima Kiyotaka Asanuma Atsuki Tsuruya Naoki Asano Tomoyuki Koike Shin Hamada Toru Nakayama Atsushi Masamune Tooru Shimosegawa

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.244, no.4, pp.317-325, 2018 (Released:2018-04-20)

参考文献数

31

被引用文献数

4

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Ethanol is oxidized by alcohol dehydrogenase to acetaldehyde, a recognized carcinogen for the esophagus. However, no previous study has measured the acetaldehyde levels in the esophageal tissue. L-cysteine has been shown to reduce the acetaldehyde levels in the saliva; however, it is unknown whether L-cysteine intake affects the acetaldehyde concentration in the esophageal tissue. The aim of this study was to measure the acetaldehyde concentration in the esophageal tissue after ethanol drinking and evaluate the effect of L-cysteine intake on the acetaldehyde levels in the esophagus. We enrolled 10 male subjects with active acetaldehyde dehydrogenase-2*1/*1 (ALDH2*1/*1) genotype and 10 male subjects with the inactive acetaldehyde dehydrogenase-2*1/*2 (ALDH2*1/*2) genotype, the mean ages of whom were 25.6 and 27.9 years, respectively. In this prospective, single-blind, placebo-controlled study using L-cysteine and placebo lozenges (first and second examination), saliva and blood were collected before and after ethanol drinking. Esophageal tissue was obtained by endoscopic biopsy at 60 minutes after drinking, and the acetaldehyde and ethanol concentrations were measured. The acetaldehyde concentration of the saliva was significantly lower in those taking L-cysteine than in those taking the placebo. Acetaldehyde in the esophageal tissue was detected only in those taking L-cysteine lozenges. There were no correlations between the acetaldehyde concentrations in the esophageal tissue and saliva or blood. In conclusion, we detected acetaldehyde in the human esophageal tissue after ethanol drinking. Unexpectedly, intake of L-cysteine lozenges appears to contribute to detection of acetaldehyde in the esophageal tissue.

著者

池田 一貴 大友 季哉 武藤 俊介 折茂 慎一 IKEDA Kazutaka OTOMO Toshiya MUTO Shunsuke ORIMO Shin-ichi

出版者

日本セラミックス協会

雑誌

セラミックス : Ceramics Japan : Bulletin of the Ceramic Society of Japan (ISSN:0009031X)

巻号頁・発行日

vol.46, no.3, pp.174-177, 2011-03-01

著者

Yoko Kado Masayuki Tsujimoto Shin-ichi Fuchida Akira Okano Mayumi Hatsuse Satoshi Murakami Hikofumi Sugii Kumi Ueda Yuki Toda Tetsuya Minegaki Kohshi Nishiguchi Yuichi Muraki Chihiro Shimazaki Eishi Ashihara

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.8, pp.1253-1258, 2020-08-01 (Released:2020-08-01)

参考文献数

19

被引用文献数

1

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Long-term combination treatment with lenalidomide and low-dose dexamethasone is important to achieve a curative effect in patients with multiple myeloma (MM). In this study, the plasma concentration of lenalidomide was measured at 3 h after oral administration, when the drug is in the elimination phase and can be easily measured in outpatients, to identify factors that may lead to the discontinuation of this combination therapy. Patients were assigned to continuation or discontinuation of therapy groups, and the baseline characteristics of patients, lenalidomide concentration, and concentration/dose (C/D) ratios reflecting oral clearance were compared between the two groups. The efficacy and severity of adverse events were also compared. The results showed that patients who discontinued or modified treatment had low plasma concentrations of lenalidomide and C/D ratios, indicating high oral clearance of lenalidomide. The estimated creatinine clearance rate was negatively correlated with the C/D ratio. The plasma concentrations of lenalidomide were independent from kidney function and differed significantly among patients. Taken together, the results indicate that low plasma concentrations of lenalidomide and low C/D ratios may lead to discontinuation of combination therapy in patients with MM. This suggests that early measurement of lenalidomide plasma continuation would help to prevent discontinuation of therapy or a delay in modifying the dose of lenalidomide.

著者

ISHIMARU Shin-ichi

出版者

北海道大學

雑誌

北海道大學理學部紀要 (ISSN:03682188)

巻号頁・発行日

vol.24, no.1, pp.43-69, 1985-03

著者

Shin Sugiyama Masahiro Minowa

雑誌

JpGU-AGU Joint Meeting 2020

巻号頁・発行日

2020-03-13

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Subglacial environment of the Antarctic ice sheet is one of the least investigated areas on the Earth. Base of the ice sheet forms an important boundary, which controls ice dynamics and thermal conditions. Existence of subglacial channels and lakes poses important questions about basal hydrology and microbial ecosystem under several-kilometer-thick ice. Recent mass loss of the ice sheet is driven by the melting of ice shelves, which occurs at the basal boundary of floating ice. Sensing physical properties beneath the ice is possible by using seismic and electromagnetic waves, but in-situ measurements and sampling are required to answer many of the questions. Hot-water drilling is a powerful tool to provide an access to the bed of glaciers and ice sheets. In this contribution, I introduce recent progress in our understanding of subglacial environment of the Antarctic ice sheet based on direct observations through boreholes, including our project in Langhovde Glacier in East Antarctica.Langhovde Glacier is a 3-km wide outlet glacier located 20 km south of the Japanese Syowa Station in East Antarctica. Lower 2–3 km of the glacier forms a floating tongue, which feeds into the Lützow-holm bay. To study basal melting and subshelf ocean environment, we drilled four boreholes in January 2018 using a hot-water drilling system. The boreholes were utilized to measure spatial variations of temperature, salinity and current under the ice. Two of the boreholes were equipped with a temperature and CTD/current sensors for year-round observations. Potential temperature of the seawater underneath the ice was between −1.4 and −1.1°C, approximately 1°C warmer than the freezing temperature. Water temperature within several hundred meters from the grounding line was −1.2°C in January 2018. Temperature dropped to −1.6°C from January to May, which was followed by gradual warming to −1.55°C in December. The temperature in January 2018 (−1.2°C) was significantly warmer than that in the summer 2019 (−1.55°C), as well as temperature measured at the same location in 2012 and 2013 (−1.55°C). A possible interpretation of the unusually warm water in 2018 was break-up of land-fast sea ice in the Lützow-holm bay in 2016. Presumably, open water near the glacier front facilitated transport of heat to the grounding line. Our subshelf observations implied significant amount of basal melting occurs under the entire ice shelf of Langhove Glacier, and thermal conditions near the grounding line is susceptible to changes in the ocean.

著者

YEFAN WANG Shin Sugiyama Daiki Sakakibara

雑誌

JpGU-AGU Joint Meeting 2020

巻号頁・発行日

2020-03-13

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In recent decades, the Greenland Ice Sheet has been a major contributor to global sea-level rise as a consequence of accelerating mass loss. Numerous studies have described spatiotemporal heterogeneity in glacier terminus retreat, flow speed variations, surface elevation change in a scale covering the entire ice sheet. However, details of the changes and heterogeneity of individual glaciers remain uncertain. Therefore, detailed investigations in a finer spatial scale are required. Here we show the surface elevation changes of 16 outlet glaciers along the coast of Prudhoe Land, northwestern Greenland, derived from multi-source DEMs (digital elevation models) (1985 (t0) aerial photograph DEM, ASTER DEMs in 2001–2003 (t1) and 2016–2018 (t2)), for the last 30 years.We observed a mean surface lowering rate of −0.55±0.22 m a−1 over the past three decades (t0–t2) for the whole studied glaciers. The most rapid surface lowering (−3.08 m a−1) was observed near the glacier termini (elevation band 0–50 m), and the slowest surface lowering rate (−0.14 m a−1) is found on the elevation band 800–850 m. The rates varied among the periods. The mean rate showed a slightly positive value of 0.14±0.16 m a−1 during t0 – t1, and no distinct altitudinal variations was observed in this period. Strongly negative elevation change rates (−1.31±0.19 m a−1) were detected during the second subperiod (t1– t2). The most rapid thinning (−5.47 m a−1) occurred near the frontal areas (elevation band 0–50 m), and slower but significant thinning at a rate −0.57 m a−1 was observed inland areas (elevation band 800–850 m). For individual glaciers, most glaciers have exhibited no significant change or slight surface thickening during the period t0 – t1. Obvious thinning happened only in the frontal areas of Tracy, Farquhar, Sharp and Sun Glaciers. During the period t1– t2, all the studied glaciers experienced thinning in different magnitudes. Tracy (−3.91±0.12 m a−1) and Farquhar (−2.91±0.15 m a−1) Glaciers experienced most significant thinning, while Heilprin Glacier, adjacent to Tracy, showed a moderate thinning rate (−0.51±0.12 m a−1). Interestingly, there is no obvious change at Verhoeff Glacier both in t0 – t1 and t1– t2. Outlet glaciers terminating in Inglefield Bredning showed a mean thinning rate of −1.07 ± 0.18 m a−1, which was 67% greater than those of glaciers terminating in Baffin Bay (−0.64 ± 0.24 m a−1) during t1–t2.The elevation changes are generally correlated with atmospheric and oceanic warming in the region. Nevertheless, considerably large heterogeneity was observed among individual glaciers, which may be attributed to the control of the fjord bathymetry and glacier bed topography on the submarine melting and ice dynamics.

著者

Ihara Shin-Ichiro Yokonuma Takeo

出版者

Faculty of Science, The University of Tokyo

雑誌

Journal of the Faculty of Science, University of Tokyo. Sect. 1, Mathematics, astronomy, physics, chemistry = 東京大學理學部紀要. 第1類, 數學, 天文學, 物理學, 化學 (ISSN:03682269)

巻号頁・発行日

vol.11, no.2, pp.155-171, 1965-03-15

著者

Akira TSUJITA Asami NAGASAKA Hidehiko OKAZAKI Shin OGAWA Akinaga GOHDA Toshiro MATSUI

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

pp.20P042, (Released:2020-05-29)

被引用文献数

1

著者

申 義植 Shin Yishick

出版者

筑波大学 (University of Tsukuba)

巻号頁・発行日

2017

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2016

著者

Jun-ichi Takahashi Shin-ichi Akimoto Eisuke Hasegawa Jun Nakamura

出版者

JAPANESE SOCIETY OF APPLIED ENTOMOLOGY AND ZOOLOGY

雑誌

Applied Entomology and Zoology (ISSN:00036862)

巻号頁・発行日

vol.37, no.3, pp.481-486, 2002 (Released:2003-04-25)

参考文献数

29

被引用文献数

12 14

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Vespa ducalis is a monogynous hornet with an annual life cycle. Its colonies are the smallest in the genus Vespa. Generally, it is thought that the number of queen matings and colony size are positively correlated, so we analyzed the queen mating number and genetic relatedness between workers of V. ducalis using microsatellite DNA markers. We examined foundress queens and 20 workers from each of 20 colonies. All colonies were found to have one queen inseminated by one male. The genetic relatedness between workers was 0.724±0.0029 (mean±SE), which is not significantly different from the expected value of 0.75 for full sisters. This result suggests a possible conflict in male production between queens and workers based on kin selection prediction. Therefore, we performed microsatellite analysis of 400 males from 20 colonies to verify whether males are derived from either queens or from workers. No males could be assigned to workers developed ovaries were not found in a total of 880 mature workers. These results strongly suggest that queens dominate production of males in V. ducalis colonies.

著者

Akunna Francess UJUAGU Ziteng WANG Shin-ichi MORITA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.36, no.5, pp.511-514, 2020-05-10 (Released:2020-05-10)

参考文献数

13

被引用文献数

5

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Spectral pretreatments, such as background removal from Raman big data, are crucial to have a smooth link to advanced spectral analysis. Recently, we developed an automated background removal method, where we considered the shortest length of a spectrum by changing the scaling factor of the background spectrum. Here, we propose a practical way to correct the systematic error caused by noise from measurements. This correction has been realized to be more effective and accurate for automatic background removal.

著者

Mitsuyuki Kuroki Naoki Kamo Yonosuke Kobatake Yukichi Abe Shin-ichi Ishii

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

vol.11, no.2, pp.199-204, 1986 (Released:2008-04-18)

参考文献数

22

被引用文献数

2 2

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Stimulation of polymorphonuclear leukocytes (PMN) by tetravalent concanavalin A (α-ConA) induces membrane depolarization preceding the onset of superoxide anion (O2-) production. Both divalent and monovalent ConA analogues were studied to evaluate the role of valence. Monovalent ConA (m-ConA) was inactive in stimulating O2-production and divalent derivatives were less active than native a-ConA. Similarly, membrane depolarization was dependent on the valency of ConA. m-ConA did not induce a marked change in membrane potential, whereas sustained depolarization occurred with multivalent ConA. The formation of multiple linked interactions between surface receptors may be an important early event in the activation of PMN by ConA.

著者

Shin-ya Ohba Yoshio Tsuda

出版者

The Japan Society of Medical Entomology and Zoology

雑誌

衛生動物 (ISSN:04247086)

巻号頁・発行日

vol.67, no.1, pp.45-50, 2016-03-25 (Released:2016-09-25)

参考文献数

29

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The tsunami caused by the Great East Japan Earthquake on March 11, 2011 hit the Pacific coast and caused heavy destruction of natural and man-made environments in north-eastern Japan. This study focuses on mosquito larvae and their potential aquatic insect predators associated with ground pools and pools that appeared in the concrete foundations of destroyed houses (concrete pool) in inundated areas in Miyagi Prefecture, Japan. Field samplings were conducted on late July 2013. Culex inatomii, Cx. pipiens group, Cx. tritaeniorhynchus, and Cx. orientalis were collected from ground pools and concrete pools. The abundance of Cx. inatomii and Cx. pipiens groups in concrete pools was significantly greater than that in the ground pools. A large number of Hydroglyphus japonicus were collected as potential mosquito predators, followed by Micronecta spp., Enochrus japonicus, Rhantus sturalis, Aquarius paludm paludum and Hydrochara affinis, categorized as “flight dispersers,” which might immigrate rapidly from the non-inundated rice fields or wetlands. Stepwise generalized linear models suggested that larval abundance of Cx. inatomii in the pools studied was affected by the vegetation cover and habitat type (ground pool or concrete pool), but not by water depth, salinity, presence of predators, and bottom type (sand or concrete) of aquatic bodies. Concrete pools and covered with dense vegetation provide breeding habitat for Cx. inatomii along with their potential predators.

著者

竹田 伸一 Shin-ichi Takeda

出版者

金城学院大学

雑誌

金城学院大学論集. 人文科学編 = Treatises and studies by the Faculty of Kinjo Gakuin College (ISSN:04538862)

巻号頁・発行日

vol.2, no.1, pp.20-28, 2005