著者

Shin-ichi NAKAMURA Takamitsu TSUKAHARA

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

pp.2018-0060, (Released:2019-06-06)

被引用文献数

1

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Herein, we describe the case of a 6-year-old female ferret that died within a few days of the onset of anorexia and reduced spontaneous locomotor activity. Necropsy revealed a dark red abdominal mass of unknown origin between the right lobes of the pancreas and the proximal jejunum, with massive blood retention in the peritoneal cavity. Histopathologically, spindle-shaped or sometimes polygonal tumor cells were proliferating with irregularly shaped vascular spaces containing blood components and surrounding-tissue infiltration. In some areas, tumor cells formed distinctly dilated blood vessel-like structures. Immunohistochemically, most of the tumor cells were strongly positive for CD31, but factor VIII-related antigen immunoreactivity was confined to the area with dilated blood vessel-like structures. Based on these findings, the tumor was diagnosed as an abdominal hemangiosarcoma. Abdominal hemangiosarcoma excluding cases of the liver and spleen are rare in ferrets.

著者

SHIN Uju LEE Tae-Young PARK Sang-Hun

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-036, (Released:2019-02-19)

被引用文献数

10

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An investigation has been carried out using rainfall observation data, National Centers for Environmental Prediction (NCEP) Climate Forecast System Reanalysis (CFSR) analysis and forecast data to explain the environment and processes that lead to heavy rainfall in the early morning over the Korean peninsula during episodes of cloud clusters (CCs) associated with mesoscale troughs (CCMTs). For this study, nine episodes with maximum hourly rainfall amount in the early morning (i.e., 0300–0900 LST) are selected from seventeen heavy-rainfall episodes associated with CCMTs during 2001–2011. Case studies on two episodes have revealed that, for both episodes, 1) a low-level trough develops over eastern China and its coastal area during the daytime; 2) the strong southwesterly band (SWB; an area with wind speeds > 12.5 m s-1) on the pressure level 925 hPa over the East China Sea, which is located southeast of the trough, strengthens and expands at nighttime toward the southwestern Korean peninsula; 3) the SWB supplies large amount of moisture and increases convective instability over the southwestern Korean peninsula with a convection trigger mechanism (i.e., strong horizontal convergence); and 4) heavy rainfall occurs in the early morning over the southwestern Korean peninsula, where the exit region of the SWB is located. A mechanism for the SWB growth is presented. Furthermore, generality of the major results from the two case studies is verified using the results obtained for the composite fields of the 9 CCMT episodes.

著者

Atsushi Ishihara Kana Ando Anna Yoshioka Koichi Murata Yu Kokubo Noriko Morimoto Naoki Ube Yukinori Yabuta Makoto Ueno Shin-ichi Tebayashi Kotomi Ueno Kumiko Osaki-Oka

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D18-063, (Released:2019-03-12)

参考文献数

36

被引用文献数

10

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We investigated the effect of treatment with hot water extracts from the spent mushroom substrates (SMSs) of Lentinula edodes and Hypsizygus marmoreus on the resistance of rice leaves to Pyricularia oryzae infection. The spraying of the SMS extracts clearly suppressed the development of lesions caused by Py. oryzae infection. The accumulation of phytoalexins momilactones A and B, oryzalexin A, and sakuranetin was markedly induced by the spraying of extracts. The enhanced expression of defense related genes PR1b and PBZ was also found in leaves sprayed with the extracts. Treatments with the extracts also affected phytohormone levels. The levels of N6-(Δ2-isopentenyl)adenine and trans-zeatin markedly increased in response to treatment, whereas the levels of salicylic and jasmonic acids were largely unchanged.

著者

Shin Ito

出版者

The Ornithological Society of Japan

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.1, no.2, pp.159-162, 2002 (Released:2005-08-25)

参考文献数

16

被引用文献数

8

著者

TSUNEKAWA Shin KASUYA Atsuo NISHINA Yuichiro FUKUDA Tsuguo

出版者

社団法人 日本金属学会

雑誌

Materials transactions, JIM (ISSN:09161821)

巻号頁・発行日

vol.37, no.4, pp.650-654, 1996-04

参考文献数

14

被引用文献数

6

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LaNbO<SUB>4</SUB> crystals show three lineal structures associated with domain formation under high-resolution polarizing optical microscope. One has a width of the order of 10 microns and the others are in order of 1 micron wide. The former is a large scale multidomain structure formed by twinning deformation due to monoclinic spontaneous strains below phase transition temperature and the latters are a small scale multidomain structure comming from discommensuration due to incommensurate-commensurate phase transition. Spacings of these multidomain structures are discussed on basis of experimental results and theoretical consideration.

著者

Jaesung Choi Ji-Yeob Choi Aesun Shin Sang-Ah Lee Kyoung-Mu Lee Juhwan Oh Joo Yong Park Jong-koo Lee Daehee Kang

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.29, no.4, pp.125-132, 2019-04-05 (Released:2019-04-05)

参考文献数

46

被引用文献数

14

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Background: We aimed to report the prevalence and correlates of high-risk alcohol consumption and types of alcoholic beverages.Methods: The baseline data of the Health Examinees-Gem (HEXA-G) study participants, including 43,927 men and 85,897 women enrolled from 2005 through 2013, were used for analysis. Joinpoint regression was performed to estimate trends in the age-standardized prevalence of alcohol consumption. Associations of demographic and behavioral factors, perceived health-related effects, social relationships, and the diagnostic history of diseases with alcohol consumption were assessed using multinomial logistic regression.Results: The prevalence of alcohol consumption remained higher in men during the study period and increased in women. The amount of alcohol consumed has increased in women, especially that from beer and makgeolli, a traditional Korean fermented rice wine. Older participants were less likely to be high-risk drinkers (men and women who drink more than 40 or 20 g/day of alcohol, respectively) and drink Soju, a distilled liquor, and beer, and more likely to drink makgeolli. Educational level was negatively associated with high-risk drinking. However, it was positively associated with the consumption of strong spirits and wine. Smoking was associated with high-risk drinking and the consumption of soju and strong spirits. Engaging in regular exercise and having stress were associated with drinking all types of beverages except for soju.Conclusions: Sex-specific trends in alcohol consumption were influenced by demographic, behavioral, and perceived health-related factors. The findings will help improve the understanding of alcohol-related problems and provide evidence for establishing country-specific policies and campaigns in Korea.

著者

SUGIMOTO Toshihiko UMEZAKI Toshiro TAKAGI Seiji NARIKAWA Keita SHIN Takemoto

雑誌

Neuroscience research : the official journal of the Japan Neuroscience Society (ISSN:01680102)

巻号頁・発行日

vol.30, no.3, pp.235-245, 1998-03

参考文献数

26

被引用文献数

3

著者

Mitsue Rikimaru Yutaka Ohsawa Alexander M. Wolf Kiyomi Nishimaki Harumi Ichimiya Naomi Kamimura Shin-ichiro Nishimatsu Shigeo Ohta Yoshihide Sunada

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.51, no.24, pp.3351-3357, 2012 (Released:2012-12-15)

参考文献数

14

被引用文献数

10 51

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Objective Post-transcriptional taurine modification at the first anticodon ("wobble") nucleotide is deficient in A3243G-mutant mitochondrial (mt) tRNALeu(UUR) of patients with myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Wobble nucleotide modifications in tRNAs have recently been identified to be important in the accurate and efficient deciphering of codons. We herein examined whether taurine can alleviate mitochondrial dysfunction in patient-derived pathogenic cells and prevent clinical symptoms in MELAS patients. Methods and Results The addition of taurine to the culture media ameliorated the reduced oxygen consumption, decreased the mitochondrial membrane potential, and increased the oxidative stress in MELAS patient-derived cells. Moreover, high dose oral administration of taurine (0.25 g/kg/day) completely prevented stroke-like episodes in two MELAS patients for more than nine years. Conclusion Taurine supplementation may be a novel potential treatment option for preventing the stroke-like episodes associated with MELAS.

著者

Yukihiro Koretsune Takuma Etoh Yousuke Katsuda Tetsuro Suetsugu Kenshi Kumeda Ichiro Sakuma Kenichi Eshima Mitsuhiro Shibuya Shin-ichi Ando Naoto Yokota Shinya Goto Karen S. Pieper Jagan Allu Ajay K. Kakkar for the GARFIELD-AF Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.1, pp.67-74, 2018-12-25 (Released:2018-12-25)

参考文献数

20

被引用文献数

11

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Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9.3%) were recruited in Japan (2010–2016). In cohort 1 (2010–2011), few patients were on non-vitamin K antagonist oral anticoagulants (NOAC) globally. From cohort 2 onwards (2011–2016), however, there was a rapid increase in NOAC use around the globe, especially in Japan. By the last year of enrolment (2015–2016), 67.9% of patients in Japan and 43.1% of patients globally were on NOAC±antiplatelet therapy (AP). In Japan and globally, 17.0% and 12.2% of patients, respectively, did not receive stroke prevention treatment. Few patients in Japan (5.7%) received AP only. Compared with the other countries, the unadjusted rates of all-cause mortality and major bleeding were low, while rates of stroke/systemic embolism were similar after 1 year of follow-up. Conclusions: GARFIELD-AF continues to provide important information on the homogeneity and heterogeneity of baseline characteristics and treatment patterns in patients with newly diagnosed NVAF. This diversity reflects the differences in outcomes in Japan compared with the rest of the world.

著者

泊 晋 トマリ シン Shin Tomari

雑誌

社会学研究科年報

巻号頁・発行日

vol.25, pp.107-108, 2018

著者

Shuya Ishii Madoka Suzuki Shin’ichi Ishiwata Masataka Kawai

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.16, pp.28-40, 2019 (Released:2019-02-02)

参考文献数

77

被引用文献数

6

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The majority of hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere proteins. We examined tropomyosin (Tpm)’s HCM mutants in humans, V95A and D175N, with in vitro motility assay using optical tweezers to evaluate the effects of the Tpm mutations on the actomyosin interaction at the single molecular level. Thin filaments were reconstituted using these Tpm mutants, and their sliding velocity and force were measured at varying Ca2+ concentrations. Our results indicate that the sliding velocity at pCa ≥8.0 was significantly increased in mutants, which is expected to cause a diastolic problem. The velocity that can be activated by Ca2+ decreased significantly in mutants causing a systolic problem. With sliding force, Ca2+ activatable force decreased in V95A and increased in D175N, which may cause a systolic problem. Our results further demonstrate that the duty ratio determined at the steady state of force generation in saturating [Ca2+] decreased in V95A and increased in D175N. The Ca2+ sensitivity and cooperativity were not significantly affected by the mutations. These results suggest that the two mutants modulate molecular processes of the actomyosin interaction differently, but to result in the same pathology known as HCM.

著者

申 龍徹 申 龍徹 SHIN Yongcheol シン ヨンチョル Shin Yongchel

出版者

山梨県立大学

雑誌

山梨国際研究 : 山梨県立大学国際政策学部紀要 (ISSN:21874336)

巻号頁・発行日

vol.12, pp.45-56, 2017-03-05

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This paper is an international comparison of the common use of personal information in the common number system South Korea, Singapore, and Australia. To compare the institutional mechanism of the common use of summary and personal information of the common number system in these three countries. In the following, an overview of the common number system, the characteristics of the type described. Finally, the analysis of the joint-use system of personal information in South Korea summarized its suggestion.

著者

Toshihisa Ishida Shin-ichiro Miura Kanta Fujimi Takashi Ueda Yoko Ueda Takuro Matsuda Maaya Sakamoto Tadaaki Arimura Yuhei Shiga Ken Kitajima Keijiro Saku

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.57, no.5, pp.607-614, 2016 (Released:2016-09-28)

参考文献数

38

被引用文献数

3 8

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Visit-to-visit variability (VVV) in blood pressure (BP) has been shown to be a predictor of cardiovascular events. It is unknown whether CR can improve VVV in BP as well as reducing BP. We enrolled 84 patients who had cardiovascular disease (CVD) and participated in a 3-month CR program. We measured systolic and diastolic BP (SBP and DBP), pulse pressure (PP), and heart rate (HR) before exercise training at each visit and determined VVV in BP or HR expressed as the standard deviation of the average BP or HR. Patients who had uncontrolled BP at baseline and who did not change their antihypertensive drugs throughout the study period showed a significant reduction of both SBP and DBP with a decrease in PP after 3 months. Patients who did not change their antihypertensive drugs were divided into larger (L-) and smaller (S-) VVV in the SBP groups and L- and S-VVV in the DBP groups according to the average value of VVV in SBP or DBP. In the L-VVV in the SBP and DBP groups, VVV in SBP and DBP in the 1st month was significantly decreased after the 3rd month in both groups. HR at baseline was significantly decreased after 3 months. In addition, CR induced a significant increase in the level of high-density lipoprotein cholesterol (HDL-C) in blood. In conclusion, CR improved VVV in BP in patients with L-VVV in BP and evoked a significant reduction in HR and an increase in HDL-C. These effects due to the CR program may be cardioprotective.

著者

Kohei Takata Satoshi Imaizumi Emi Kawachi Yasunori Suematsu Tomohiko Shimizu Satomi Abe Yoshino Matsuo Hitomi Tsukahara Keita Noda Eiji Yahiro Bo Zhang Yoshinari Uehara Shin-ichiro Miura Keijiro Saku

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.78, no.12, pp.2955-2962, 2014-11-25 (Released:2014-11-25)

参考文献数

47

被引用文献数

23 48

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Background:Smoking cessation reduces the risk of cardiovascular disease (CVD) and improves clinical outcomes in public health. We studied the effect of smoking cessation on high-density lipoprotein (HDL) functionality.Methods and Results:We randomly treated 32 smokers with varenicline or a transdermal nicotine patch as part of a 12-week smoking cessation program (The VN-SEESAW Study). The plasma lipid profiles, plasma and HDL malondialdehyde (MDA) levels, HDL subfractions as analyzed by capillary isotachophoresis, cholesterol efflux capacity, and antiinflammatory activity of HDL were measured before and after the anti-smoking intervention. After smoking cessation, HDL-C, apoA-I levels and HDL subfractions were not significantly different from the respective baseline values. However, cholesterol efflux capacity and the HDL inflammatory index (HII) were significantly improved after smoking cessation. The changes in both parameters (%∆ cholesterol efflux capacity and ∆HII) were also significantly improved in the successful smoking cessation group compared with the unsuccessful group. The changes in cholesterol efflux capacity and HII also correlated with those in end-expiratory CO concentration and MDA in HDL, respectively.Conclusions:Our findings indicate that smoking cessation leads to improved HDL functionality, increased cholesterol efflux capacity and decreased HII, without changing HDL-C or apoA-I levels or HDL subfractions. This may be one of the mechanisms by which smoking cessation improves the risk of CVD. (Circ J 2014; 78: 2955–2962)

著者

Honma Takeru Okazaki Masao Homma Shinsuke Tanaka Kazuhiko Tanaka Shin-ichi

出版者

筑波大学

雑誌

Tsukuba English studies (ISSN:09116184)

巻号頁・発行日

vol.9, pp.369-371, 1990

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In this talk, we focused upon wanna-contraction as exemplified below, and argued that it is possible to characterize the phenomenon as one of the cases for which any version of prosodic theory is responsible. ...

著者

小池 太 小森 伸一 山田 亮 KOIKE Futoshi KOMORI Shin-ichi YAMADA Ryo 小池 太(パタゴニア・インターナショナルインク日本支社) 小森 伸一(東京学芸大学 健康・スポーツ科学講座 体育学分野) 山田 亮(北海道教育大学岩見沢校)

出版者

東京学芸大学学術情報委員会

雑誌

東京学芸大学紀要. 芸術・スポーツ科学系 (ISSN:18804349)

巻号頁・発行日

vol.70, pp.137-161, 2018-10-31

著者

Takaaki Murakami Tomonobu Hatoko Takuo Nambu Yuki Matsuda Koji Matsuo Shin Yonemitsu Seiji Muro Shogo Oki

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.61, no.8, pp.773-779, 2014 (Released:2014-08-30)

参考文献数

24

被引用文献数

2 5

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Central diabetes insipidus (CDI) is a rare disease characterized by polyuria and polydipsia. Patients with CDI have been successfully treated with desmopressin administered either by intranasal instillation or oral tablets. Recently, a desmopressin orally disintegrating tablet (ODT) was approved as the first oral desmopressin tablet for CDI treatment in Japan. We conducted a retrospective single-center study of 15 Japanese CDI patients treated with desmopressin ODT therapy, which aimed to evaluate the efficacy and safety of switching to desmopressin ODT and to analyze the clinical factors that affect the desmopressin ODT dose in Japanese patients. The daily mean dose of desmopressin ODT was 104 ± 46.30 μg and the mean ratio of oral to nasal desmopressin dose was 17.0 ± 7.6, both of which are considerably smaller than those of previous dose-titration study. Moreover, the nasal spray group needed significantly smaller ratios of nasal to oral desmopressin than the nasal drop group (11.7 ± 6.5 vs 21.0 ± 5.5, p = 0.02). The ratio of oral to nasal desmopressin dose had a significant inverse correlation with the required nasal desmopressin dose. Multiple regression analysis demonstrated the ratios of nasal to oral desmopressin dose depended on intranasal formulations. In conclusion, desmopressin ODT was safe and effective in the treatment of Japanese adult CDI patients. When switching to ODT, we should care about the possibility that patients require smaller ODT doses than what was initially expected based on previously published data and also nasal formulations in terms of their differences of expected switching ratio.

著者

Shin-ichi Watanabe Masanori Matsuo Hiroaki Kitazawa Machiko Fukuda Atsushi Yamasaki Atsuko Uragami

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-161, (Released:2018-11-15)

被引用文献数

1

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In this study, we investigated the effect of high temperature on spear sprouting and elongation in asparagus to explore new approaches to control the harvest period in asparagus production. Four-year-old rootstocks of ‘UC157’ were grown in chambers in the dark at 30°C (30°C treatment), 34°C (34°C treatment), 38°C (38°C treatment), and 42°C (42°C treatment) for 14 days, and then at 25°C for 18 days. In the 42°C treatment, no spear sprouting was detected, and all rootstocks died. During the high temperature period, the number of sprouted spears was significantly lower in the 38°C treatment than in the 30°C treatment, whereas after the high temperature periods, the number was significantly higher in the 38°C treatment than in the 30°C and 34°C treatments. The total number of sprouted spears during and after the high temperature periods was not significantly different between the 30°C, 34°C, and 38°C treatments. The elongation rate of the spears during the high temperature period was significantly lower in the 38°C treatment than in the 30°C and 34°C treatments, whereas there were no significant differences in the mean spear elongation rate after the three high temperature treatments. These results suggest that a temperature of 38°C can be used to control spear sprouting reversibly by its application and cancellation.

著者

Young-Shin Cho Soo-Jin Park Sang-Hun Jang Young-Chul Choi Jung-Ho Lee Jin-Sang Kim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.24, no.12, pp.1319-1323, 2012 (Released:2013-01-17)

参考文献数

18

被引用文献数

7 30

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[Purpose] In order to develop a more effective treatment method for pain and function in myofascial pain syndrome, we examined the effects of ESWT, stability exercises, and combined treatment. [Subjects] The subjects were randomly divided into a stabilization exercise group (n=12), an ESWT (Extracorporeal Shock Wave Therapy) group (n=12), and a combined treatment group (n=12). [Methods] The stabilization exercise group performed shoulder joint stabilization exercises. The ESWT group received ESWT for the upper trapezius. The combined treatment group received a combined treatment of shoulder joint stabilization exercises and ESWT. Pain and function were measured using the visual analog scale (VAS), pressure pain threshold (PPT), neck disability index (NDI), and the Constant Murley Scale (CMS). [Results] The VAS Score showed statistically significant improvements in all of the groups. All of the CMS evaluation items except muscle strength in the stabilization exercise group, and all of the CMS items in the ESWT group and the combined treatment group, exhibited statistically significant improvements. The combined treatment group of ESWT and stabilization exercises showed statistically significant improvements in all VAS of CMS evaluation items, and the NDI test after the four-week intervention. [Conclusion] The combined treatment was more effective at reducing pain than ESWT, and stabilization exercise would be useful for physical therapists treating myofascial pain syndrome in a clinical setting.

著者

Hiroyuki Tsutsui Shin-ichi Momomura Yoshihiko Saito Hiroshi Ito Kazuhiro Yamamoto Tomomi Ohishi Naoko Okino Toshihito Kitamura Weinong Guo

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.82, no.10, pp.2575-2583, 2018-09-25 (Released:2018-09-25)

参考文献数

17

被引用文献数

1 15

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Background: The objective of the present analyses was to describe the baseline characteristics and treatment of the Japanese patients with HFrEF in THE PARALLEL-HF study. Methods and Results: Key demographic, clinical and laboratory findings, along with treatment, were reported and compared with patients enrolled in the PARADIGM-HF trial and other contemporary randomized clinical trials and registries of Japanese patients with HFrEF. In addition, the MAGGIC and EMPHASIS-HF risk scores were calculated. A total of 225 Japanese patients were randomized in PARALLEL-HF with a mean age of 67.9 years and the majority of the patients being male (85.8%) and in NYHA Class II (93.8%). Key baseline characteristics in PARALLEL-HF were generally comparable with PARADIGM-HF, and other contemporary clinical trials and registries of Japanese HFrEF patients. Patients enrolled in PARALLEL-HF were well treated with conventional evidence-based therapy at baseline (angiotensin-converting enzyme inhibitor inhibitor/angiotensin receptor blocker, 62.7%/37.3%; β-blockers, 94.7%; mineralocorticoid receptor antagonist, 59.1%). Despite the evidence-based treatment and most patients being in NYHA Class II, these patients had a low LVEF (mean 28.1%) and were at high risk of cardiovascular mortality and morbidity as assessed by the MAGGIC and EMPHASIS-HF risk scores. Conclusions: Overall, the patients in PARALLEL-HF were largely representative of contemporary ambulatory patients with HFrEF who are well treated with evidence-based therapies. PARALLEL-HF will determine whether sacubitril/valsartan provides similar improvements in clinical outcomes in Japanese HFrEF patients as observed in the PARADIGM-HF study.