- 著者
- 高橋 悠子 中村 任 守屋 友加 白木 孝 林 伸英 熊谷 俊一 岡村 昇 八木 麻理子 竹島 泰弘 松尾 雅文 栄田 敏之 奥村 勝彦
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.32, no.11, pp.1111-1116, 2006-11-10
- 参考文献数
- 23
Recently, high dose gentamicin (GM) has started to be used for the treatment of Duchenne muscular dystrophy (DMD). Previously, since the intravenous infusion of GM for 1h once a week at a dose of 7.5mg/kg/day had caused no significant adverse events in a course of therapy lasting 6 months, we decided to try conducting such therapy for four courses in the present study. We continuously assessed renal function by monitoring serum creatinine, serum cystatin C (Cys-C), serum urea nitrogen (BUN), urinary β_2-microglobulin and urinary N-acetyl-β-D-glucosaminidase (NAG) activity. Serum creatinine levels were found to be much lower than the normal range, while, at 0.65 to 0.78μg/mL, serum Cys-C levels, were within the normal range and so was BUN, suggesting that the glomerular filtration rate in the DMD patients receiving GM therapy was being maintained in the normal range. Therapeutic drug monitoring of GM indicated that it was being rapidly eliminated from the systemic circulation though a slight elevation of urinary NAG activity in 1 patient indicated the possibility of impaired renal proximal tubules. It will thus be necessary to optimize our patient management strategy.
- 著者
- 本田 義輝 齋藤 秀之
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.31, no.5, pp.391-398, 2005-05-10
- 参考文献数
- 15
- 被引用文献数
- 8 11
Very little quality information is available for generic pharmaceutical preparations and this is particularly so for injectable preparations for which few quality studies have been conducted. With this in mind, we conducted an inter-lot quality variation investigation on nafamostat mesilate preparations for both the original and generic products and compared the results. The investigation involved measuring amounts of impurities other than those of the active ingredient by high performance liquid chromatography. For the nine generic products investigated, impurity amounts were about 2.4 times that of the original (min. 2.0 times-max. 3.1 times). We determined that these differences were not due to hydrolysates of the active ingredient but to unknown substances since the amounts of these unknown substances in the generic products were about 5.7 times (min. 4.7 times-max. 8.0 times) their amount in the original product. Concerning inter-lot variation (maximum value-minimum value), we found that the variation in total impurity amounts for the generic products was 1.8 times (min. 0.7 times-max. 2.8 times) that of the original product, while the variation in unknown substance amounts for the generics was 3.1 times (min. 1.0 times-max. 4.6 times) that for the original. The results of the present study suggest that it is necessary to take inter-lot variation into account in evaluating the quality of generic products. They also suggest that the higher contents of unknown impurities in the generics could be a cause of the in-circuit precipitation which has been reported with generic versions of nafamostat mesilate during blood purification in the clinical setting.
1 0 0 0 マルチビタミンを添加した高カロリー輸液中でのチアミンの安定性
- 著者
- 浅原 慶一 合田 泰志 下村 友紀 藤原 康浩 瀬川 和子 雀部 貴美代 山本 英二 塚口 裕子
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.21, no.1, pp.15-21, 1995-02-10
- 参考文献数
- 10
- 被引用文献数
- 4
As intravenous hyperalimentation (IVH) prepared from IVH basic solution and amino acid solution has become popular, lactic acidosis is receiving attention as a serious adverse reaction. Therefore, thiamine is added to IVH in order to prevent this adverse reaction. However, sodium sulfite (SS), added as a stabilizer to many IVH basic solutions and most amino acid solutions, degrades thiamine. Recently, since an amino acid solution without SS has been developed, it is now possible to prepare IVH without SS. In this study, we measured the time courses of the residual concentrations of both SS and thiamine in the 12 kinds of IVH containing multivitamin and investigated the relationship between the SS concentration and the stability of thiamine from the viewpoint of degradation kinetics. From the kinetic analysis results, the degradation rate of SS in the IVH stored in a bag was faster than that stored in a glass bottle. The degradation rate of SS in the IVH was very fast when SS is not included in the IVH basic solution. The degradation of thiamine in IVH was regarded as the apparent first-order degradation process and the degradation rate as being proportional to the SS concentration. The second-order degradation rate constant of thiamine by SS was not affected by the pH of IVH. Stabilization of thiamine by glucose was inferred by comparing the degradation rate of thiamine caused by SS in IVH and that in buffered solution without glucose.
- 著者
- 添田 真司 小板橋 秀正 渡邊 昌之
- 出版者
- 日本医療薬学会
- 雑誌
- 日本医療薬学会年会講演要旨集
- 巻号頁・発行日
- vol.18, 2008-09-01
1 0 0 0 保険薬局および病院・診療所における学生実務実習の実態調査
- 著者
- 細見 光一 室井 延之 東 和夫 池田 りき子 魚本 智子 大川 恭子 三宅 圭一 中川 素子 河本 由紀子 清原 義史 金 啓二 沢崎 高志 小野 達也 西田 英之 大野 真理子 緒方 園子 福島 昭二 徳山 尚吾 大西 憲明 平井 みどり 松山 賢治
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.32, no.1, pp.64-72, 2006-01-10
- 被引用文献数
- 6 7
We conducted a survey on the practical training of pharmacy students in 47 community pharmacies and 76 hospital pharmacies in Hyogo Prefecture. Items surveyed included the acceptance system for pharmacy students, practical training curriculum, problems and difficulties. In many community pharmacies and hospital pharmacies, instruction in practical training was recognized as worthwhile despite the workload involved. Though the content of the practical training varied, dispensing and medication instruction were the most common items in the practical training for both community pharmacies and hospital pharmacies. Communication with patients and management of medication history were the focus of training in community pharmacies, while the major aspects of training in hospital pharmacies were dispensing of injections and TDM (therapeutic drug monitoring). Many pharmacists were of the opinion that the content and goals of the training should be reviewed and that it needed to be further evaluated. Revision of the practical training in universities was also recommended. Further, in order to achieve an efficient practical training curriculum it was felt that the training should be more linked to the special characteristics of community pharmacies and hospital pharmacies.
- 著者
- 倉本 加代 青山 隆夫 中島 克佳 中村 幸一 小滝 一 伊賀 立二
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.23, no.6, pp.491-496, 1997-12-10
- 被引用文献数
- 2
We studied the effects of various infusion containers materials on the fluid volumes, different infusion fluids and fluid concentrations of nartograstim (NT), a recombinant human granulocyte colony stimulating factor, on the adsorption of NT to containers, after adding NT preparations (Neu-up^<ss;[O!R}> for injection 100) into infusion fluids. The NT concentrations in the infusion fluids after adding NT to containers were determined by a high-performance liquid chromatographic method or bioassay. When 1000 ng of NT was added to 500 ml physiological saline in glass containers (final concentration : 200 ng/ml), the residual rates in the fluids was to 89.5% immediately after addition, and thereafter decreased 73.3% at 6 hr and 59.1% at 24 hr. Similarly, when NT was added to the same solution in polypropylene containers, the residual rates was 74.2% immediately after adding, and 37.5% at 6 hr, and 27.8% at 24 hr. The results in the ethylenvinyl acetate and polyethylene containers were also similar to those in the polypropylene containers. No influence of the volumes (100 and 250 ml) or the kinds of fluids (physiological saline, 5% glucose solution and ringer lactate solution) on the residual rates of NT in fluids was observed. As the fluid concentrations of NT were higher, the residual rates were found to be larger within the range of 100- 1200 ng/ml. These decreases in the NT concentrations in the infusion fluids could be prevented almost completely by adding commercially available total-vitamin injections containing polysorbate surfactants.
1 0 0 0 27-03-08 味センサを用いたクラリスロマイシンの苦味評価
1 0 0 0 IR 臨床データ利用における個人非特定化に潜む危険性 : イニシャルは非特定化のために有効か?
- 著者
- 佐藤 美佳 古川 裕之 松嶋 由紀子 横井 祐子 宮本 謙一
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.33, no.3, pp.245-250, 2007-03-10
- 被引用文献数
- 2 1
In clinical trials,patient name,date of birth,and sex are items of medical information used to refer to patients.Generally speaking,patient names are indicated by their initials.However,there are doubts as to whether patients may remain completely unidentified when initials are used.In this study,we investigated the identification levels of patients through the combination of the above three patient data items in post marketing surveillance data.We also investigated the necessity of items recorded in case registration forms for pharmaceutical companies and medical institutions.We investigated combinations of"K.K"and"Jan.2,1947"which were assumed to relate to the largest populations in the database of patient medical information at Kanazawa University Hospital.The total number of patients in the database with combinations of the above was 358,251.The number of patients with the initials"K.K."was 7,892(1/45),that with the initials"K.K"and"1947"was 173(1/2000),and that with the initials"K.K","1947" and"Jan"was 23,while there were only 4 patients(1/8500)with the initials"K.K.""1947","Jan"and "2".These results indicate that it would be possible to identify patients from the combination of their initials and their date of birth(DD/MM/YY).However,the size of the patient population in each medical institution's database would be an important factor since it would determine the extent to which this could be done.From the point of view of protecting personal information,it is thus necessary to consider whether it is appropriate to use patients' initials and dates of birth based on the size of patient population.